Detailed information for compound 1274974

Basic information

Technical information
  • TDR Targets ID: 1274974
  • Name: 3-(1H-benzimidazol-2-yl)chromen-2-one
  • MW: 262.263 | Formula: C16H10N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc2ccccc2cc1c1nc2c([nH]1)cccc2
  • InChi: 1S/C16H10N2O2/c19-16-11(9-10-5-1-4-8-14(10)20-16)15-17-12-6-2-3-7-13(12)18-15/h1-9H,(H,17,18)
  • InChiKey: YRFHFTBLQARMCG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(1H-benzimidazol-2-yl)-2-chromenone
  • 3-(1H-benzimidazol-2-yl)coumarin
  • Oprea1_837045
  • EU-0043920
  • BAS 01020189
  • 3-(1H-Benzoimidazol-2-yl)-chromen-2-one
  • ST076513
  • ZINC00146101
  • MLS001205135
  • SMR000515825
  • ChemDiv3_003054
  • CBDivE_000072
  • Oprea1_425804

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0071 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0323 0.0844
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Plasmodium vivax protein kinase Crk2 0.0097 0.0874 1
Leishmania major hypothetical protein, conserved 0.0029 0.0174 0.0469
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Brugia malayi cyclin fold protein 1 variant b 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin y 0.0029 0.0172 0.0172
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0071 0.0193
Schistosoma mansoni cyclin k 0.0029 0.0172 0.0449
Trypanosoma cruzi cyclin 6, putative 0.0231 0.226 1
Brugia malayi CHE-14 protein 0.0051 0.0401 0.1088
Echinococcus multilocularis G1:S specific cyclin D1 0.0029 0.0172 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0874 0.367
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus multilocularis protein dispatched 1 0.0058 0.0476 0.0476
Echinococcus granulosus G1:S specific cyclin D1 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Echinococcus granulosus cyclin G2 0.0029 0.0172 0.0449
Echinococcus granulosus cyclin dependent kinase 5 0.0097 0.0874 0.2284
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Entamoeba histolytica cyclin family protein 0.0119 0.1108 0.4491
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0874 0.367
Echinococcus multilocularis muscleblind protein 1 0.018 0.1739 0.1739
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Giardia lamblia G2/mitotic-specific cyclin B 0.0231 0.226 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0022
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0029 0.0172 0.0172
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0029 0.0172 0.0449
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0323 0.0323
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Schistosoma mansoni patched 1 0.0051 0.0401 0.1048
Loa Loa (eye worm) hypothetical protein 0.0111 0.1025 0.278
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1103 0.2882
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.099
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0071 0.0071
Echinococcus multilocularis cyclin B 0.0231 0.226 0.226
Toxoplasma gondii hypothetical protein 0.0029 0.0172 0.1253
Schistosoma mansoni hypothetical protein 0.0382 0.3829 1
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Plasmodium falciparum protein kinase 5 0.0097 0.0874 0.7743
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0874 0.367
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.017 1
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0874 0.367
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0401 0.1048
Echinococcus multilocularis muscleblind protein 0.018 0.1739 0.1739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Trichomonas vaginalis cyclins, putative 0.014 0.1323 0.5514
Brugia malayi hypothetical protein 0.0029 0.0174 0.0471
Brugia malayi hypothetical protein 0.0019 0.0067 0.0183
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0029 0.0172 0.1253
Trypanosoma brucei cyclin 3 0.0029 0.0172 0.046
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Brugia malayi hypothetical protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin t1 0.0029 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0192
Loa Loa (eye worm) CYL-1 protein 0.0029 0.0172 0.0466
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0029 0.0172 0.097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Schistosoma mansoni cyclin d 0.0029 0.0172 0.0449
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0071 0.0186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0496 0.1346
Trichomonas vaginalis cyclin A, putative 0.0231 0.226 1
Brugia malayi Cyclin C 0.0029 0.0172 0.0466
Trypanosoma cruzi CYC2-like cyclin, putative 0.0231 0.226 1
Echinococcus granulosus Cyclin L1 0.0029 0.0172 0.0449
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0095 0.2422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0418 0.0418
Plasmodium falciparum cyclin 1 0.0029 0.0172 0.097
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0874 0.337
Schistosoma mansoni hypothetical protein 0.0041 0.0299 0.0782
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0185
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Schistosoma mansoni hypothetical protein 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0864 0.2342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0471
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0071 0.0193
Loa Loa (eye worm) hypothetical protein 0.0041 0.0299 0.0812
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0029 0.0172 0.0449
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Echinococcus granulosus cyclins 0.0029 0.0172 0.0449
Echinococcus granulosus cyclin dependent kinase 0.0097 0.0874 0.2284
Echinococcus granulosus cyclin y 0.0029 0.0172 0.0449
Echinococcus multilocularis cyclin b3 0.0119 0.1108 0.1108
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0231 0.226 1
Echinococcus granulosus cyclin B3 1 0.0119 0.1108 0.2895
Plasmodium vivax cyclin 4, putative 0.0029 0.0172 0.1253
Leishmania major cyclin 9, putative 0.0029 0.0172 0.046
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0186
Trypanosoma cruzi cyclin, putative 0.0231 0.226 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0496 0.1346
Loa Loa (eye worm) hypothetical protein 0.0051 0.0401 0.1088
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0174 0.1279
Trypanosoma cruzi mitotic cyclin, putative 0.0029 0.0172 0.046
Onchocerca volvulus Cyclin L homolog 0.0029 0.0172 0.076
Onchocerca volvulus 0.0029 0.017 0.0752
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0401 0.11
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Echinococcus granulosus geminin 0.0382 0.3829 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0369 0.3688 0.3688
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0071 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0172 0.046
Trypanosoma brucei cdc2-related kinase 3 0.0097 0.0874 0.367
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0874 0.3364
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1631 0.1631
Brugia malayi Cyclin, N-terminal domain containing protein 0.0231 0.226 0.6127
Echinococcus granulosus cyclin t1 0.0029 0.0172 0.0449
Brugia malayi N-terminal motif family protein 0.02 0.1938 0.5255
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Schistosoma mansoni cyclin B 0.0231 0.226 0.5903
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0874 0.0874
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1631 0.426
Echinococcus granulosus cyclin dependent kinase 1 0.0097 0.0874 0.2284
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclin b3 0.0119 0.1108 0.2895
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Schistosoma mansoni hypothetical protein 0.0043 0.0323 0.0844
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0097 0.0874 0.2371
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0071 0.0192
Loa Loa (eye worm) hypothetical protein 0.0062 0.052 0.141
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0097 0.0874 0.367
Toxoplasma gondii cyclin dependent kinase binding protein 0.0029 0.0172 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0874 0.2284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.017 1
Brugia malayi hypothetical protein 0.0043 0.0323 0.0876
Schistosoma mansoni hypothetical protein 0.0029 0.0172 0.0449
Echinococcus multilocularis GPCR, family 2 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.02 0.1938 0.5255
Echinococcus granulosus cyclin A3 4 0.0029 0.0172 0.0449
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1103 0.1103
Entamoeba histolytica hypothetical protein 0.0029 0.0172 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Brugia malayi Cyclin, N-terminal domain containing protein 0.0231 0.226 0.6127
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0874 0.2371
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0095 0.5
Trypanosoma brucei mitotic cyclin 0.0029 0.0172 0.046
Trichomonas vaginalis cyclin B3, putative 0.0119 0.1108 0.4486
Echinococcus granulosus cyclin B 0.0231 0.226 0.5903
Trypanosoma brucei cdc2-related kinase 1 0.0097 0.0874 0.367
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0022
Echinococcus multilocularis Cyclin L1 0.0029 0.0172 0.0172
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0029 0.0172 0.046
Echinococcus multilocularis cyclin B3 1 0.0119 0.1108 0.1108
Echinococcus granulosus cyclin G2 0.0029 0.0172 0.0449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0418 0.1093
Trypanosoma cruzi cyclin 9, putative 0.0029 0.0172 0.046
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0097 0.0874 0.367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Schistosoma mansoni cyclin G 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclin D, putative 0.0119 0.1108 0.4486
Brugia malayi cell division control protein 2 homolog 0.0097 0.0874 0.2371
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0323 0.0844
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0095 0.0298
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0418 0.1093
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Loa Loa (eye worm) hypothetical protein 0.0231 0.226 0.6127
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.1938 0.8576
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Trypanosoma brucei mitotic cyclin 6 0.0231 0.226 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0466
Brugia malayi Cyclin, N-terminal domain containing protein 0.0369 0.3688 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1122 0.2931
Schistosoma mansoni cyclin G2 0.0029 0.0172 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0097 0.0874 0.0874
Echinococcus granulosus cyclin y 0.0029 0.0172 0.0449
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus granulosus expressed conserved protein 0.0112 0.1029 0.2687
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0874 0.3364
Onchocerca volvulus Protein CNPPD1 homolog 0.0029 0.0172 0.076
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0097 0.0874 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Entamoeba histolytica cyclin, putative 0.0231 0.226 1
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0174 0.1279
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0401 0.0401
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0418 0.1134
Schistosoma mansoni cyclins 0.0119 0.1108 0.2895
Entamoeba histolytica cyclin C, putative 0.0029 0.0172 0.0009
Schistosoma mansoni cyclin B3 0.0369 0.3688 0.9634
Schistosoma mansoni cyclin l 0.0029 0.0172 0.0449
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0874 0.337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Loa Loa (eye worm) cyclin domain-containing protein 0.0369 0.3688 1
Echinococcus granulosus GPCR family 2 0.0019 0.0071 0.0185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0299 0.0812
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0469
Plasmodium falciparum cyclin 0.0119 0.1108 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.099
Echinococcus granulosus cyclin k 0.0029 0.0172 0.0449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Mycobacterium ulcerans hypothetical protein 0.0029 0.017 1
Echinococcus multilocularis cyclin G2 0.0029 0.0172 0.0172
Schistosoma mansoni Cyclin fold protein 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0071 0.0193
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0029 0.0172 0.1253
Echinococcus multilocularis protein patched 0.0051 0.0401 0.0401
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0172 0.1253
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0469
Toxoplasma gondii cyclin 4, putative 0.0029 0.0172 0.1253
Onchocerca volvulus Cyclin L homolog 0.0029 0.0172 0.076
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.0172 0.0009
Trichomonas vaginalis cyclins, putative 0.0119 0.1108 0.4486
Entamoeba histolytica cyclin, putative 0.0119 0.1108 0.4491
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.017 1
Trypanosoma cruzi cyclin, putative 0.0231 0.226 1
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Echinococcus multilocularis cyclin G2 0.0029 0.0172 0.0172
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1103 0.2991
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0008
Trichomonas vaginalis cyclin B, putative 0.0119 0.1108 0.4486
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0097 0.0874 0.2284
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0369 0.3688 0.9634
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0095 0.0231
Trypanosoma cruzi mitotic cyclin, putative 0.0029 0.0172 0.046
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0071 0.0192
Onchocerca volvulus 0.0231 0.226 1
Loa Loa (eye worm) cyclin C 0.0029 0.0172 0.0466
Leishmania major mitotic cyclin, putative 0.0029 0.0172 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclin 0.0029 0.0172 0.0449
Giardia lamblia Hypothetical protein 0.0119 0.1108 0.4486
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0029 0.0172 0.1253
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0874 0.0874
Echinococcus multilocularis cyclin A3 4 0.0029 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.006 0.0496 0.1346
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Toxoplasma gondii hypothetical protein 0.0091 0.0811 0.9206
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0029 0.0172 0.097
Trichomonas vaginalis cyclin D, putative 0.0119 0.1108 0.4486
Echinococcus granulosus muscleblind protein 0.018 0.1739 0.4543
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1103 0.4466
Brugia malayi hypothetical protein 0.0029 0.0172 0.0466
Brugia malayi Muscleblind-like protein 0.018 0.1739 0.4715
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Loa Loa (eye worm) hypothetical protein 0.018 0.1739 0.4715
Echinococcus multilocularis cyclin dependent kinase 0.0097 0.0874 0.0874
Echinococcus multilocularis cyclin y 0.0029 0.0172 0.0172
Trypanosoma brucei cyclin 9 0.0029 0.0172 0.046
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0174 0.0469
Schistosoma mansoni g1/s-specific cyclin C 0.0029 0.0172 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0874 0.2371
Leishmania major cyclin 0.0231 0.226 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.226 0.6127
Entamoeba histolytica cyclin family protein 0.0119 0.1108 0.4491
Giardia lamblia Cyclin A 0.0119 0.1108 0.4486
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0874 0.2284
Brugia malayi Protein kinase domain containing protein 0.0097 0.0874 0.2371
Loa Loa (eye worm) hypothetical protein 0.018 0.1739 0.4715
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.017 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0418 0.1134
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0496 0.1346
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin k 0.0029 0.0172 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Leishmania major mitotic cyclin, putative 0.0029 0.0172 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.1108 0.4486
Echinococcus multilocularis expressed conserved protein 0.0112 0.1029 0.1029
Echinococcus multilocularis geminin 0.0382 0.3829 0.3829
Echinococcus multilocularis cyclin 0.0029 0.0172 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Schistosoma mansoni hypothetical protein 0.0382 0.3829 1
Plasmodium vivax cyclin homologue, putative 0.0029 0.0172 0.1253
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0401 0.1088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.017 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0029 0.0172 0.0466
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.0172 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0029 0.0172 0.0172
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0401 0.1048
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Loa Loa (eye worm) hypothetical protein 0.0119 0.1103 0.2991
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Onchocerca volvulus 0.0029 0.0172 0.076

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 67.476 uM PubChem BioAssay. Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR).. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 0.7308 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.9196 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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