Detailed information for compound 1280939

Basic information

Technical information
  • TDR Targets ID: 1280939
  • Name: methyl (E)-4-hydroxy-4-(4-methylphenyl)-2-oxo but-3-enoate
  • MW: 220.221 | Formula: C12H12O4
  • H donors: 1 H acceptors: 3 LogP: 2.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(=O)/C=C(\c1ccc(cc1)C)/O
  • InChi: 1S/C12H12O4/c1-8-3-5-9(6-4-8)10(13)7-11(14)12(15)16-2/h3-7,13H,1-2H3/b10-7+
  • InChiKey: KAQIFZRTEIWJID-JXMROGBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (E)-4-hydroxy-4-(4-methylphenyl)-2-oxo-but-3-enoate
  • (E)-4-hydroxy-4-(4-methylphenyl)-2-oxobut-3-enoic acid methyl ester
  • (E)-4-hydroxy-2-keto-4-(4-methylphenyl)but-3-enoic acid methyl ester
  • methyl 2-hydroxy-4-(4-methylphenyl)-4-oxo-2-butenoate
  • MLS000572483
  • SMR000194441
  • BIM-0002150.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0361 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.024 0.2151
Schistosoma mansoni hypothetical protein 0.001 0.0019 0.0019
Echinococcus granulosus geminin 0.0167 0.4481 0.4481
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0012 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0386 0.1225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.3089 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0239 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0683 0.6451
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2751 0.8899
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Schistosoma mansoni glycogen phosphorylase 0.0121 0.3154 0.3154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0162 0.0162
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0501 0.1078
Giardia lamblia Glycogen phosphorylase 0.0121 0.3154 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0272 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Schistosoma mansoni ran 0.0022 0.0348 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0272 0.0272
Onchocerca volvulus Glycogen phosphorylase homolog 0.0121 0.3154 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0239 0.0239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1005 0.1005
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0272 0.0272
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0272 0.0272
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0265 0.2389
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.024 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2751 0.8899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Echinococcus granulosus importin subunit beta 1 0.0034 0.0683 0.0683
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.024 0.024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1116 0.3537
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0272 0.0861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1005 0.1005
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.024 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0386 0.31
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0272 0.0861
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0683 0.6451
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0181 0.1573
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0272 0.0272
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0037
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0272 0.0861
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Onchocerca volvulus 0.0023 0.0386 0.1225
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.3089 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1573
Onchocerca volvulus 0.0018 0.0239 0.0759
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2751 0.8899
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0239 0.0759
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0239 0.0239
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0058 0.0185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0218 0.065
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.024 0.1868
Plasmodium vivax importin-beta 2, putative 0.0034 0.0683 0.5789
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0239 0.0239
Plasmodium vivax glutathione reductase, putative 0.0047 0.1049 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.3089 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0052 0.1205 0.382
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0265 0.0265
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0218 0.043
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0058 0.0185
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.15 0.15
Brugia malayi steroid hormone receptor 0.0019 0.0272 0.0861
Echinococcus granulosus Glycosyl transferase family 35 0.0121 0.3154 0.3154
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0239 0.0239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0272 0.0272
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0386 0.31
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.024 0.0762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0239 0.0239
Brugia malayi Cytochrome P450 family protein 0.0019 0.0265 0.0839
Brugia malayi Cytochrome P450 family protein 0.0019 0.0265 0.0839
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Echinococcus multilocularis geminin 0.0167 0.4481 0.4481
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.024 0.02
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.024 0.0762
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Schistosoma mansoni coup transcription factor 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0033 0.0674 0.0674
Toxoplasma gondii exonuclease III APE 0.0018 0.024 0.2151
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0239 0.0759
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2751 0.8899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0181 0.1366
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0181 0.1573
Leishmania major importin beta-1 subunit, putative 0.0027 0.0501 0.4684
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0239 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0272 0.0861
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.1049 0.3355
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Brugia malayi TAR-binding protein 0.0062 0.15 0.4756
Schistosoma mansoni ran 0.0022 0.0348 0.0348
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0239 0.0759
Echinococcus granulosus GPCR family 2 0.0015 0.0162 0.0162
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0239 0.0759
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Echinococcus granulosus tar DNA binding protein 0.0062 0.15 0.15
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0239 0.0239
Onchocerca volvulus 0.0019 0.0272 0.0861
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0181 0.1573
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0239 0.0759
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0265 0.0265
Trichomonas vaginalis glycogen phosphorylase, putative 0.0121 0.3154 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0272 0.0861
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Plasmodium falciparum thioredoxin reductase 0.0047 0.1049 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.024 0.2151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0239 0.0239
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0386 0.1225
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0265 0.2389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0272 0.0272
Loa Loa (eye worm) cytochrome P450 0.001 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0272 0.0861
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0181 0.1366
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0181 0.0573
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0272 0.0272
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.1927
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.024 0.0686
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Brugia malayi nuclear receptor RXR 0.001 0.0012 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0272 0.0272
Plasmodium falciparum glutathione reductase 0.0047 0.1049 1
Brugia malayi cytochrome P450 0.001 0.0019 0.0059
Mycobacterium ulcerans hypothetical protein 0.0023 0.0386 0.31
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0239 0.0239
Onchocerca volvulus 0.0018 0.0239 0.0759
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3075 0.3075
Echinococcus multilocularis glycogen phosphorylase 0.0121 0.3154 0.3154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0181 0.1573
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0386 0.1198
Loa Loa (eye worm) TAR-binding protein 0.0062 0.15 0.15
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.15 0.4756
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Brugia malayi carbohydrate phosphorylase 0.0121 0.3154 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.024 0.02
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0181 0.0528
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0272 0.0272
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0218 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0272 0.0272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0239 0.0239
Trichomonas vaginalis ran, putative 0.0022 0.0348 0.0562
Echinococcus multilocularis 0.001 0.0019 0.0019
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0239 0.0759
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0162 0.0162
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0272 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0181 0.1573
Echinococcus multilocularis nAChR subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.024 0.024
Brugia malayi ecdysteroid receptor 0.0019 0.0272 0.0861
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Leishmania major trypanothione reductase 0.0047 0.1049 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Echinococcus multilocularis snurportin 1 0.0361 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0272 0.0272
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0239 0.0239
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Echinococcus multilocularis GPCR, family 2 0.0015 0.0162 0.0162
Brugia malayi hypothetical protein 0.001 0.0012 0.0037
Schistosoma mansoni glycogen phosphorylase 0.0052 0.1205 0.1205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1005 0.3188
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0265 0.2075
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1366
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3075 0.3075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.024 0.2151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0272 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0272 0.0272
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0348 0.3197
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Echinococcus granulosus glycogen phosphorylase 0.0121 0.3154 0.3154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0501 0.1078
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Brugia malayi Cytochrome P450 family protein 0.0048 0.1091 0.3458
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0272 0.0861
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.1049 0.1049
Brugia malayi Importin beta-1 subunit 0.0034 0.0683 0.2166
Entamoeba histolytica glycogenphosphorylase, putative 0.0052 0.1205 0.382
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0272 0.0861
Brugia malayi RNA, U transporter 1 0.0096 0.2459 0.7794
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Loa Loa (eye worm) hypothetical protein 0.0034 0.0683 0.0683
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0272 0.0861
Onchocerca volvulus 0.0018 0.0239 0.0759
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Brugia malayi MH2 domain containing protein 0.0118 0.3075 0.9747
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0272 0.0272
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0272 0.0861
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0218 0.1681
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0239 0.0239
Toxoplasma gondii thioredoxin reductase 0.0047 0.1049 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0218 0.043
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.1049 0.1049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.024 0.2151
Schistosoma mansoni hypothetical protein 0.0033 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0272 0.0272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0386 0.1225
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Loa Loa (eye worm) hypothetical protein 0.0015 0.0162 0.0162
Brugia malayi Cytochrome P450 family protein 0.001 0.0019 0.0059
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2751 0.8899
Trichomonas vaginalis glycogen phosphorylase, putative 0.0121 0.3154 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0052 0.1205 0.3864
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.1049 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0501 0.4684
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0386 0.31
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0162 0.0513
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.024 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0272 0.0861
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0272 0.0272
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0272 0.0272
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0272 0.0272
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0272 0.0272
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0683 0.0683
Schistosoma mansoni ap endonuclease 0.0018 0.024 0.024
Brugia malayi hypothetical protein 0.001 0.0012 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0674 0.2137
Echinococcus multilocularis Glycosyl transferase, family 35 0.0121 0.3154 0.3154
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0348 0.0348
Schistosoma mansoni ap endonuclease 0.0018 0.024 0.024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0239 0.0759
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0272 0.0272
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Entamoeba histolytica glycogen phosphorylase, putative 0.0052 0.1205 0.382
Onchocerca volvulus Putative nachr subunit 0.0018 0.0239 0.0759
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0239 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Brugia malayi nuclear hormone receptor 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0181 0.1573
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0272 0.0861
Loa Loa (eye worm) glycogen phosphorylase 0.0121 0.3154 0.3154
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0272 0.0272
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0239 0.0239
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0386 0.1198
Onchocerca volvulus 0.0018 0.0239 0.0759
Schistosoma mansoni glycogen phosphorylase 0.0121 0.3154 0.3154
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.1091 0.1091
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Entamoeba histolytica Ran family GTPase 0.0022 0.0348 0.1103
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0272 0.0272
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.1103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1116 0.3537
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0167 0.4481 0.4481
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0272 0.0272
Schistosoma mansoni cytochrome P450 0.001 0.0019 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.3089 1
Leishmania major GTP-binding protein, putative 0.0022 0.0348 0.3197
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0239 0.0239
Schistosoma mansoni importin beta-1 0.0034 0.0683 0.0683
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0272 0.0272
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0052 0.1205 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0239 0.0759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Trypanosoma brucei trypanothione reductase 0.0047 0.1049 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0501 0.1078
Schistosoma mansoni hypothetical protein 0.0167 0.4481 0.4481
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Brugia malayi glutathione reductase 0.0047 0.1049 0.3325
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.0562
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0272 0.0861
Brugia malayi nuclear receptor NHR-88 0.0019 0.0272 0.0861
Entamoeba histolytica glycogen phosphorylase, putative 0.0121 0.3154 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.1049 1
Onchocerca volvulus 0.0018 0.0239 0.0759
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1005 0.1005
Brugia malayi RNA binding protein 0.0062 0.15 0.4756
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0181 0.1573
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0386 0.1198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0272 0.0861
Brugia malayi Thioredoxin reductase 0.0047 0.1049 0.3325
Onchocerca volvulus 0.0018 0.0239 0.0759
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0239 0.0239
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0348 0.1927
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0162 0.0513
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0239 0.0239
Loa Loa (eye worm) glutathione reductase 0.0047 0.1049 0.1049
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0265 0.2389
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0181 0.1573
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus multilocularis tar DNA binding protein 0.0062 0.15 0.15
Leishmania major cytochrome p450-like protein 0.0019 0.0265 0.2389
Echinococcus granulosus glycogen phosphorylase 0.0121 0.3154 0.3154
Plasmodium falciparum importin beta, putative 0.0034 0.0683 0.5789
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0265 0.0265
Echinococcus granulosus nAChR subunit 0.0018 0.0239 0.0239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0272 0.0861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1005 0.1005
Chlamydia trachomatis glycogen phosphorylase 0.0121 0.3154 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2751 0.8899
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable reductase 0.0106 0.2751 0.8899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0012 0.0012
Echinococcus multilocularis glycogen phosphorylase 0.0121 0.3154 0.3154
Loa Loa (eye worm) RNA binding protein 0.0062 0.15 0.15
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0049 0.1116 0.1116
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.024 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.024 0.0686
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0272 0.0272
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0683 0.6451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1005 0.1005
Entamoeba histolytica hypothetical protein 0.0027 0.0501 0.1589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0272 0.0272
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0386 0.1198
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0239 0.0239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0386 0.31
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1116 0.1116
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1573
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0272 0.0272
Entamoeba histolytica glycogen phosphorylase, putative 0.0121 0.3154 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0272 0.0861

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 12 % Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver at 10 microM ChEMBL. 10633043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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