TDR Targets

Basic information

Technical information

TDR Targets ID: 1291165
Name: 1-[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl)s ulfonyl]-N-(3,5-dimethylphenyl)piperidine-4-c arboxamide
MW: 469.596 | Formula: C25H31N3O4S
H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1ccc2c(c1)CC(N2C(=O)C)C)Nc1cc(C)cc(c1)C
InChi: 1S/C25H31N3O4S/c1-16-11-17(2)13-22(12-16)26-25(30)20-7-9-27(10-8-20)33(31,32)23-5-6-24-21(15-23)14-18(3)28(24)19(4)29/h5-6,11-13,15,18,20H,7-10,14H2,1-4H3,(H,26,30)
InChiKey: AUGOMZZKCZKSOG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(1-acetyl-2-methyl-indolin-5-yl)sulfonyl-N-(3,5-dimethylphenyl)piperidine-4-carboxamide
1-[(1-acetyl-2-methyl-5-indolinyl)sulfonyl]-N-(3,5-dimethylphenyl)-4-piperidinecarboxamide
1-(1-acetyl-2-methyl-indolin-5-yl)sulfonyl-N-(3,5-dimethylphenyl)isonipecotamide
N-(3,5-dimethylphenyl)-1-[(1-ethanoyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]piperidine-4-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	protein jagged 1	0.0017	0.0456	0.1537
Echinococcus multilocularis	protein jagged 1	0.0017	0.0456	0.1537
Schistosoma mansoni	slit	0.0017	0.0456	0.159
Onchocerca volvulus		0.0017	0.0456	0.2437
Echinococcus granulosus	protein jagged 1	0.0017	0.0456	0.1537
Treponema pallidum	nitrogen fixation protein (rnfC)	0.0018	0.0489	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0218	0.0201
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.0079	0.2868	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0141	0.0434
Schistosoma mansoni	acyl carrier protein	0.0005	0.0018	0.0062
Brugia malayi	Delta serrate ligand family protein	0.0017	0.0456	0.0439
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.0079	0.2868	0.2856
Onchocerca volvulus	Peroxidase homolog	0.0052	0.1816	1
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Chlamydia trachomatis	acyl carrier protein	0.0005	0.0018	0.5
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0017	0.0456	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.1816	0.1802
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Echinococcus granulosus	peroxidasin	0.0052	0.1816	0.6309
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.0079	0.2868	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0017	0.0456	0.1537
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0005	0.0018	0.5
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0017	0.0456	0.159
Schistosoma mansoni	hypothetical protein	0.0005	0.0018	0.0062
Schistosoma mansoni	peroxidasin	0.0052	0.1816	0.6332
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0079	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.1816	0.1802
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0005	0.0018	0.5
Brugia malayi	CXXC zinc finger family protein	0.0035	0.1154	0.1138
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Schistosoma mansoni	cell polarity protein	0.0017	0.0456	0.159
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0141	0.0493
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.1816	1
Brugia malayi	Peroxidasin	0.0052	0.1816	0.1802
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.1816	0.1802
Onchocerca volvulus		0.0017	0.0456	0.2437
Echinococcus granulosus	neurogenic locus notch protein 4	0.0017	0.0456	0.1537
Brugia malayi	Muscle positioning protein 4	0.0017	0.0456	0.0439
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.1816	0.1802
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	cpg binding protein	0.0037	0.1231	0.4255
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0005	0.0018	0.5
Schistosoma mansoni	cpg binding protein	0.0037	0.1231	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	fibropellin Ia	0.0017	0.0456	0.1537
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Echinococcus granulosus	protein jagged 2	0.0017	0.0456	0.1537
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.1154	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0079	0.2868	1
Plasmodium vivax	acyl carrier protein, putative	0.0005	0.0018	0.5
Echinococcus multilocularis	neurogenic locus protein delta	0.0017	0.0456	0.1537
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0005	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0224	0.0722
Onchocerca volvulus		0.0052	0.1816	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0005	0.0018	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Onchocerca volvulus	Neurogenic locus notch homolog	0.0017	0.0456	0.2437
Onchocerca volvulus		0.0052	0.1816	1
Echinococcus multilocularis	slit 2 protein	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Brugia malayi	Blistered cuticle protein 3	0.0052	0.1816	0.1802
Schistosoma mansoni	septate junction protein	0.0017	0.0456	0.159
Echinococcus multilocularis	protein jagged 2	0.0017	0.0456	0.1537
Echinococcus multilocularis	notch	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Brugia malayi	GCC2 and GCC3 family protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.0079	0.2868	1
Onchocerca volvulus	Peroxidase homolog	0.0052	0.1816	1
Plasmodium falciparum	acyl carrier protein	0.0005	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Echinococcus granulosus	notch	0.0017	0.0456	0.1537
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0456	0.0439
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0017	0.0456	0.2437
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0017	0.0456	0.1537
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0141	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Echinococcus granulosus	neurogenic locus notch protein	0.0017	0.0456	0.1537
Echinococcus granulosus	protein jagged 2	0.0017	0.0456	0.1537
Onchocerca volvulus		0.0052	0.1816	1
Echinococcus granulosus	neurogenic locus notch protein	0.0017	0.0456	0.1537
Loa Loa (eye worm)	Notch2	0.0017	0.0456	0.0439
Onchocerca volvulus	Chorion peroxidase homolog	0.0052	0.1816	1
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	neurogenic locus protein delta	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0456	0.0439
Brugia malayi	EGF-like domain containing protein	0.0017	0.0456	0.0439
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Onchocerca volvulus		0.0017	0.0456	0.2437
Schistosoma mansoni	peroxidasin	0.0052	0.1816	0.6332
Echinococcus multilocularis	protein jagged 1	0.0017	0.0456	0.1537
Loa Loa (eye worm)	blistered cuticle protein 3	0.0052	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Toxoplasma gondii	EGF family domain-containing protein	0.0017	0.0456	0.1872
Giardia lamblia	High cysteine protein	0.0017	0.0456	0.5
Echinococcus granulosus	neurogenic locus protein delta	0.0017	0.0456	0.1537
Onchocerca volvulus		0.0035	0.1154	0.6317
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0141	0.0434
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0005	0.0018	0.5
Brugia malayi	hypothetical protein	0.0052	0.1816	0.1802
Mycobacterium ulcerans	membrane protein ComEA	0.0018	0.0489	0.1654
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0224	0.0206
Onchocerca volvulus	Putative cubilin	0.0017	0.0456	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.2664	0.9288
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Brugia malayi	Cadherin domain containing protein	0.0017	0.0456	0.0439
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0005	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0079	0.2868	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.2359	1
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0141	0.0434
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0079	0.2868	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0018	0.0489	0.1654
Echinococcus granulosus	cpg binding protein	0.0037	0.1231	0.4255
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.0079	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Echinococcus multilocularis	neurogenic locus notch protein	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Echinococcus granulosus	slit 2 protein	0.0017	0.0456	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0005	0.0018	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.1816	0.1802
Brugia malayi	notch-like transmembrane receptor	0.0017	0.0456	0.0439
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.0079	0.2868	0.2856
Echinococcus granulosus	fibropellin Ia	0.0017	0.0456	0.1537
Echinococcus multilocularis	peroxidasin	0.0052	0.1816	0.6309
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Loa Loa (eye worm)	notch protein	0.0017	0.0456	0.0439
Schistosoma mansoni	notch	0.0017	0.0456	0.159
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0005	0.0018	0.5
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0042	0.1448	0.7951
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Schistosoma mansoni	laminin gamma-3 chain	0.0017	0.0456	0.159
Mycobacterium leprae	conserved hypothetical protein	0.0005	0.0018	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0224	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.0079	0.2868	1
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.0079	0.2868	1
Echinococcus granulosus	neural cadherin	0.0017	0.0456	0.1537
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.1816	0.1802
Echinococcus multilocularis	neural cadherin	0.0017	0.0456	0.1537
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.0079	0.2868	1
Onchocerca volvulus		0.0017	0.0456	0.2437
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0005	0.0018	0.5
Onchocerca volvulus	Dual oxidase homolog	0.0052	0.1816	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0005	0.0018	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0456	0.159
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.1816	0.1802
Onchocerca volvulus		0.0017	0.0456	0.2437
Schistosoma mansoni	cpg binding protein	0.0037	0.1231	0.4291
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.1816	1
Echinococcus granulosus	delta-like protein 1	0.0017	0.0456	0.1537
Brugia malayi	Cadherin domain containing protein	0.0017	0.0456	0.0439
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0079	0.2868	1
Schistosoma mansoni	cpg binding protein	0.0035	0.1154	0.4023
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1816	0.1802
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.0079	0.2868	1
Mycobacterium leprae	Polyketide synthase Pks13	0.0005	0.0018	0.5
Onchocerca volvulus	Slit protein homolog	0.0017	0.0456	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0456	0.0439

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	75.193 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1403239

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1291165