Detailed information for compound 1292207

Basic information

Technical information
  • TDR Targets ID: 1292207
  • Name: 2,6-dimethyl-4-(2-morpholin-4-yl-2-oxoethyl)- 1,4-benzoxazin-3-one
  • MW: 304.341 | Formula: C16H20N2O4
  • H donors: 0 H acceptors: 2 LogP: 0.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1Oc2ccc(cc2N(C1=O)CC(=O)N1CCOCC1)C
  • InChi: 1S/C16H20N2O4/c1-11-3-4-14-13(9-11)18(16(20)12(2)22-14)10-15(19)17-5-7-21-8-6-17/h3-4,9,12H,5-8,10H2,1-2H3
  • InChiKey: YIGAPJWVPWGKDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,6-dimethyl-4-(2-morpholino-2-oxo-ethyl)-1,4-benzoxazin-3-one
  • 2,6-dimethyl-4-(2-morpholino-2-oxoethyl)-1,4-benzoxazin-3-one
  • 4-(2-keto-2-morpholino-ethyl)-2,6-dimethyl-1,4-benzoxazin-3-one
  • 2,6-dimethyl-4-(2-morpholin-4-yl-2-oxo-ethyl)-1,4-benzoxazin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.1049 0.6342
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.0875 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.038 0.1194
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0558 0.0558
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1165 0.114
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1443 0.1443
Brugia malayi beta-lactamase family protein 0.0035 0.0365 0.0943
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.038 0.1194
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0573 0.197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0365 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.038 0.263
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0483 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0658 0.1699
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.0875 0.3226
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0082 0.1462
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0365 0.1136
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0875 0.085
Brugia malayi hypothetical protein 0.0043 0.0483 0.1247
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.038 0.038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0658 0.0632
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0082 0.0054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0693 0.2449
Schistosoma mansoni rab6-interacting 0.0043 0.0483 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Entamoeba histolytica cysteine protease, putative 0.0016 0.0082 0.0565
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0269 0.468
Schistosoma mansoni rab6-interacting 0.0043 0.0483 0.0483
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0269 0.5
Onchocerca volvulus 0.0035 0.0365 0.6549
Brugia malayi Ets-domain containing protein 0.0087 0.1165 0.3008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0558 0.0558
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0028 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0365 0.7068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0512 0.0512
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.2578 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0365 0.0365
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1443 0.3728
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.038 0.038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0365 0.0943
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0558 0.0531
Schistosoma mansoni lipoxygenase 0.0043 0.0483 0.0483
Onchocerca volvulus 0.0016 0.0082 0.1462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Onchocerca volvulus 0.0043 0.0483 0.866
Echinococcus multilocularis long chain fatty acid transport protein 4 0.018 0.2578 0.2558
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1443 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0558 0.144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0512 0.0485
Echinococcus granulosus RUN 0.0043 0.0483 0.0483
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.038 0.0353
Onchocerca volvulus 0.0035 0.0365 0.6549
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0558 0.0558
Schistosoma mansoni ets-related 0.0013 0.0028 0.0028
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0082 0.0211
Loa Loa (eye worm) inositol-1 0.008 0.1049 0.2709
Brugia malayi Ets-domain containing protein 0.0013 0.0028 0.0072
Echinococcus granulosus protein C ets 2 0.0013 0.0028 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0365 0.2531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0269 0.5
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0558 0.0558
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1443 0.1443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1443 0.1419
Leishmania major cathepsin L-like protease 0.0062 0.0775 0.2816
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0028 0.0028
Schistosoma mansoni FFA transport protein 0.018 0.2578 0.2578
Echinococcus granulosus long chain fatty acid transport protein 4 0.018 0.2578 0.2578
Leishmania major hypothetical protein, conserved 0.0035 0.0365 0.1153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0211
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.1049 0.3875
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.038 0.038
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0269 0.1942
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0028 0.0028
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0558 1
Schistosoma mansoni hypothetical protein 0.0043 0.0483 0.0483
Brugia malayi mbt repeat family protein 0.0048 0.0558 0.144
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0269 0.1867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Schistosoma mansoni inositol monophosphatase 0.008 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0054 0.0658 0.1699
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0365 0.2531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.038 0.1211
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.1049 0.7268
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0082 0.0565
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0775 0.2776
Schistosoma mansoni lipoxygenase 0.0119 0.1649 0.1649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0483 0.0456
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1165 0.3008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0186 0.2667 0.6888
Onchocerca volvulus 0.0016 0.0082 0.1462
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0365 0.2531
Schistosoma mansoni loxhd1 0.0043 0.0483 0.0483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0178 0.2542 0.7617
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0365 0.0943
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1443 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.038 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.038 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1165 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0775 0.2776
Brugia malayi beta-lactamase 0.0035 0.0365 0.0943
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0269 0.468
Brugia malayi beta-lactamase family protein 0.0035 0.0365 0.0943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0512 0.0512
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0483 0.0456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0028 0.0072
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.038 0.263
Brugia malayi Inositol-1 0.008 0.1049 0.2709
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0082 0.0565
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0082 0.0082
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.1049 0.297
Brugia malayi phosphofructokinase 0.0106 0.1443 0.3728
Brugia malayi Ets-domain containing protein 0.0087 0.1165 0.3008
Schistosoma mansoni hypothetical protein 0.0289 0.4229 0.4229
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.038 0.263
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0082 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1443 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0082 0.0054
Echinococcus multilocularis cysteine protease 0.0016 0.0082 0.0054
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0558 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Loa Loa (eye worm) hypothetical protein 0.0048 0.0558 0.144
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1443 0.5534
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0028 0.0072
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0036 0.038 0.098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0512 0.0512
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0082 0.1462
Onchocerca volvulus 0.0016 0.0082 0.1462
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0875 0.2217
Loa Loa (eye worm) hypothetical protein 0.0075 0.0972 0.251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0512 0.0512
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0365 0.2531
Echinococcus granulosus cathepsin l1 0.0016 0.0082 0.0082
Onchocerca volvulus 0.0048 0.0558 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0082 0.0211
Echinococcus multilocularis RUN 0.0043 0.0483 0.0456
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.2578 1
Onchocerca volvulus 0.0043 0.0483 0.866
Loa Loa (eye worm) fibroinase 0.0016 0.0082 0.0211
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0775 0.2776
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1443 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0512 0.1322
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0922 0.2556
Brugia malayi hypothetical protein 0.0043 0.0483 0.1247
Loa Loa (eye worm) beta-lactamase 0.0035 0.0365 0.0943
Loa Loa (eye worm) cysteine protease 0.0016 0.0082 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1443 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi Doublecortin family protein 0.0043 0.0483 0.1247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0028 0.0072
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0805 0.208
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0658 0.0658
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.2683 0.2663
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0269 0.1942
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0943
Leishmania major fatty acid transporter protein-like protein 0.0178 0.2542 1
Echinococcus multilocularis cysteine protease 0.0016 0.0082 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0365 0.0338
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.1049 0.7268
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0082 0.0565
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0658 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0483 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1443 0.3772
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Onchocerca volvulus 0.0016 0.0082 0.1462
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0922 0.1947
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.1049 0.7268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0082 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0365 0.2531
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0558 0.0558
Loa Loa (eye worm) MBCTL1 0.0054 0.0658 0.1699
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0028 0.0072
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0483 0.0456
Loa Loa (eye worm) hypothetical protein 0.0043 0.0483 0.1247
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1443 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0875 0.2217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.1049 0.7268
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0269 0.1942
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Loa Loa (eye worm) hypothetical protein 0.0043 0.0483 0.1247
Trichomonas vaginalis esterase, putative 0.0035 0.0365 0.2531
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0875 0.0875
Brugia malayi transcription factor E74 isoform 0.0013 0.0028 0.0072
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0483 0.0483
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0269 0.468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0512 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Onchocerca volvulus 0.0016 0.0082 0.1462
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0775 0.2776
Leishmania major cathepsin L-like protease 0.0062 0.0775 0.2816
Schistosoma mansoni inositol monophosphatase 0.008 0.1049 0.1049
Schistosoma mansoni ets-related 0.0265 0.3872 0.3872
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0082 0.0565
Brugia malayi Fli-1 protein 0.0265 0.3872 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0082 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0186 0.2667 0.6888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0269 0.468
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0658 0.0658
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0186 0.2667 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0483 0.0483
Schistosoma mansoni elf1 0.0013 0.0028 0.0028
Schistosoma mansoni ets 0.0013 0.0028 0.0028
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0178 0.2542 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.038 0.098
Leishmania major cathepsin L-like protease 0.0062 0.0775 0.2816
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1443 0.5454
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3223 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1443 0.3728
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0082 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1443 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.038 0.0353
Brugia malayi 6-phosphofructokinase 0.0106 0.1443 0.3728
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1443 0.3728
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1443 0.4684
Loa Loa (eye worm) fli-1 protein 0.0265 0.3872 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.038 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.0875 0.2261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Brugia malayi 6-phosphofructokinase 0.0106 0.1443 0.3728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.038 0.038
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0082 0.1462
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0082 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0365 0.1136
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0365 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Onchocerca volvulus 0.0016 0.0082 0.1462
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0082 0.0565
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0028 0.0028
Onchocerca volvulus 0.0013 0.003 0.053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0512 0.0485
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.038 0.263
Brugia malayi mbt repeat family protein 0.0048 0.0558 0.144
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.2683 0.2683
Onchocerca volvulus 0.0016 0.0082 0.1462
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0072
Schistosoma mansoni polycystin 1-related 0.0043 0.0483 0.0483
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0512 0.1322
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.1049 0.3931
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.1049 1
Echinococcus granulosus inositol monophosphatase 1 0.008 0.1049 0.1049
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.1049 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.1867
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0483 0.0483
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.1649 0.1649
Schistosoma mansoni gabp alpha 0.0087 0.1165 0.1165
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.038 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.1049 0.3875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1443 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0269 0.1867
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.1649 0.1626
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0483 0.1247
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.1049 0.1024
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0028 0.0072
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1443 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0082 0.0082
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1443 0.1443
Toxoplasma gondii ABC1 family protein 0.0035 0.0365 0.2933
Onchocerca volvulus 0.0035 0.0365 0.6549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0775 0.3797
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.0016 0.0082 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0658 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0082 0.0565
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1443 0.4952

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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