TDR Targets

Basic information

Technical information

TDR Targets ID: 1296796
Name: 2-methoxy-5-methyl-N-(3-methylphenyl)benzenes ulfonamide
MW: 291.365 | Formula: C15H17NO3S
H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1S(=O)(=O)Nc1cccc(c1)C)C
InChi: 1S/C15H17NO3S/c1-11-5-4-6-13(9-11)16-20(17,18)15-10-12(2)7-8-14(15)19-3/h4-10,16H,1-3H3
InChiKey: DNSBTCBITLRNQM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000676370
SMR000301150
ZINC00583205

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0509	0.8543	0.8543
Plasmodium falciparum	ataxin-2 like protein, putative	0.0154	0.2462	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0498	0.834	0.834
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0129	0.0153
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1005	0.1183
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.8278	1
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0013	0.004	0.0046
Loa Loa (eye worm)	nuclear factor I	0.0019	0.014	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0129	0.0127
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0018	0.0129	0.0153
Brugia malayi	hypothetical protein	0.01	0.1525	0.1525
Loa Loa (eye worm)	MH2 domain-containing protein	0.0015	0.0078	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8543	0.8542
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0015	0.0078	0.0092
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0018	0.0129	0.0121
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.008	0.1189	0.3939
Brugia malayi	MH1 domain containing protein	0.0034	0.0399	0.0399
Schistosoma mansoni	dishevelled	0.0018	0.0129	0.0121
Brugia malayi	MH1 domain containing protein	0.0034	0.0399	0.0399
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0161	0.2579	0.2579
Brugia malayi	hypothetical protein	0.0018	0.0129	0.0129
Echinococcus granulosus	GPCR family 2	0.0161	0.2579	0.3114
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0399	0.0449
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0129	0.0153
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0013	0.004	0.0013
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0399	0.048
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0161	0.2579	0.3114
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.1005	0.1212
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0399	0.048
Schistosoma mansoni	smad	0.0034	0.0399	0.0449
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0183	0.2957	0.2929
Echinococcus granulosus	smad	0.0034	0.0399	0.048
Trypanosoma cruzi	hypothetical protein, conserved	0.0183	0.2957	1
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0018	0.0129	0.009
Brugia malayi	isocitrate dehydrogenase	0.008	0.1189	0.1189
Plasmodium falciparum	ataxin-2 like protein, putative	0.0154	0.2462	1
Schistosoma mansoni	hypothetical protein	0.0161	0.2579	0.3091
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0129	0.0129
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.8278	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.2462	0.2461
Echinococcus granulosus	mothers against decapentaplegic 2	0.0015	0.0078	0.0092
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.004	0.0038
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0765	0.0921
Schistosoma mansoni	hypothetical protein	0.0348	0.5782	0.6975
Schistosoma mansoni	Smad4	0.0015	0.0078	0.0059
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0399	0.0449
Brugia malayi	N-terminal motif family protein	0.0013	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1005	0.1183
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.004	0.0038
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0015	0.0078	0.0092
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1078	0.1272
Brugia malayi	regulator of G-protein signaling egl-10	0.0018	0.0129	0.0129
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0183	0.2957	0.2929
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.004	0.0013
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0129	0.0153
Brugia malayi	RasGEF domain containing protein	0.0013	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1005	0.1183
Onchocerca volvulus		0.0035	0.0413	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0129	0.0127
Schistosoma mansoni	hypothetical protein	0.0161	0.2579	0.3091
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0069	0.1004	0.1211
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.1005	0.1005
Schistosoma mansoni	dep domain containing protein	0.0018	0.0129	0.0121
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.1005	0.1003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0161	0.2579	0.2577
Trypanosoma cruzi	PAB1-binding protein , putative	0.0154	0.2462	0.8304
Echinococcus multilocularis	ras GTP exchange factor	0.0013	0.004	0.0046
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.1005	0.1003
Echinococcus multilocularis	cpg binding protein	0.0037	0.0446	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0129	0.0127
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.008	0.1189	0.1434
Schistosoma mansoni	hypothetical protein	0.0494	0.8278	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0348	0.5782	0.5782
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.008	0.1189	0.1406
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0765	0.0762
Brugia malayi	hypothetical protein	0.0154	0.2462	0.2462
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0399	0.0397
Brugia malayi	RasGEF domain containing protein	0.0013	0.004	0.004
Schistosoma mansoni	hypothetical protein	0.0161	0.2579	0.3091
Schistosoma mansoni	dishevelled	0.0018	0.0129	0.0121
Loa Loa (eye worm)	MH1 domain-containing protein	0.0015	0.0078	0.0076
Brugia malayi	Smad1	0.0034	0.0399	0.0399
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0018	0.0129	0.0153
Leishmania major	hypothetical protein, conserved	0.0183	0.2957	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0154	0.2462	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0129	0.0153
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0765	0.0891
Schistosoma mansoni	z-protein (S1r protein)	0.0018	0.0129	0.0121
Plasmodium vivax	ataxin-2 like protein, putative	0.0154	0.2462	1
Echinococcus multilocularis	son of sevenless 1	0.0013	0.004	0.0046
Echinococcus granulosus	son of sevenless 1	0.0013	0.004	0.0046
Schistosoma mansoni	hypothetical protein	0.0069	0.1004	0.1182
Brugia malayi	MH1 domain containing protein	0.0019	0.014	0.014
Echinococcus granulosus	ras GTP exchange factor	0.0013	0.004	0.0046
Brugia malayi	RNA binding protein	0.0069	0.1005	0.1005
Echinococcus multilocularis	GPCR, family 2	0.0161	0.2579	0.3114
Brugia malayi	MH2 domain containing protein	0.0034	0.0399	0.0399
Echinococcus granulosus	tar DNA binding protein	0.0069	0.1005	0.1212
Brugia malayi	N-terminal motif family protein	0.0013	0.004	0.004
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0399	0.048
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.008	0.1189	0.1434
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0765	0.0921
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0509	0.8543	0.8542
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0183	0.2957	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0129	0.0153
Brugia malayi	N-terminal motif family protein	0.0369	0.6131	0.6131
Echinococcus multilocularis	isocitrate dehydrogenase	0.008	0.1189	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0161	0.2579	0.2577
Brugia malayi	hypothetical protein	0.0018	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1005	0.1183
Brugia malayi	TAR-binding protein	0.0069	0.1005	0.1005
Loa Loa (eye worm)	RNA binding protein	0.0069	0.1005	0.1003
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0399	0.048
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.008	0.1189	0.1434
Schistosoma mansoni	ras GTP exchange factor	0.0013	0.004	0.0013
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0013	0.004	0.0046
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0129	0.0129
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0765	0.0765
Brugia malayi	RasGEF domain containing protein	0.0013	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0369	0.6131	0.613
Loa Loa (eye worm)	MH2 domain-containing protein	0.0498	0.834	0.834
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0765	0.0921
Trypanosoma cruzi	PAB1-binding protein , putative	0.0154	0.2462	0.8304
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0765	0.0921
Schistosoma mansoni	cpg binding protein	0.0037	0.0446	0.0506
Brugia malayi	MH1 domain containing protein	0.0019	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0348	0.5782	0.5781
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0129	0.0153
Loa Loa (eye worm)	Smad1	0.0034	0.0399	0.0397
Trypanosoma brucei	PAB1-binding protein , putative	0.0154	0.2462	0.7202
Echinococcus multilocularis	Protein son of sevenless	0.0013	0.004	0.0046
Echinococcus multilocularis	smad	0.0034	0.0399	0.048
Brugia malayi	mothers against decapentaplegic homolog 3	0.0015	0.0078	0.0078
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0399	0.0449
Trypanosoma cruzi	hypothetical protein, conserved	0.0183	0.2957	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.004	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0013	0.004	0.0038
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.008	0.1189	0.1434
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.008	0.1189	0.1434
Echinococcus granulosus	mothers against decapentaplegic 6	0.0015	0.0078	0.0092
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0013	0.004	0.0046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0765	0.0891
Toxoplasma gondii	isocitrate dehydrogenase	0.008	0.1189	0.4542
Echinococcus granulosus	Smad4	0.0034	0.0399	0.048
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0015	0.0078	0.0038
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0013	0.004	0.0046
Brugia malayi	DIX domain containing protein	0.0018	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0019	0.014	0.0137
Schistosoma mansoni	Smad4	0.0034	0.0399	0.0449
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0129	0.0153
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0399	0.0397
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0944	0.3491
Brugia malayi	MH2 domain containing protein	0.0498	0.834	0.834
Echinococcus multilocularis	Smad4	0.0034	0.0399	0.048
Echinococcus granulosus	Protein son of sevenless	0.0013	0.004	0.0046
Echinococcus granulosus	cpg binding protein	0.0037	0.0446	0.0537
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0413	0.0413
Schistosoma mansoni	smad	0.0015	0.0078	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0078	0.0076
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0161	0.2579	0.3114
Brugia malayi	Latrophilin receptor protein 2	0.0161	0.2579	0.2579
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0509	0.8543	0.8543
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0129	0.0153
Toxoplasma gondii	isocitrate dehydrogenase	0.008	0.1189	0.4542
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0369	0.6131	0.6115
Loa Loa (eye worm)	isocitrate dehydrogenase	0.008	0.1189	0.1187
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0161	0.2579	0.3114
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0069	0.1004	0.1211
Brugia malayi	MH2 domain containing protein	0.0034	0.0399	0.0399
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.008	0.1189	0.3939
Schistosoma mansoni	hypothetical protein	0.0161	0.2579	0.3091
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0411	0.6861	1
Brugia malayi	Isocitrate dehydrogenase	0.008	0.1189	0.1189
Schistosoma mansoni	regulator of G protein signaling	0.0018	0.0129	0.0121
Leishmania major	hypothetical protein, conserved	0.0154	0.2462	0.7202
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0018	0.0129	0.0127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0765	0.0891
Schistosoma mansoni	cpg binding protein	0.0037	0.0446	0.0506
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0399	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0013	0.004	0.0038
Onchocerca volvulus		0.0018	0.0129	0.009
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0161	0.2579	0.3114
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1005	0.1183
Brugia malayi	MH2 domain containing protein	0.0015	0.0078	0.0078
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.004	0.0013
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.004	0.0013
Loa Loa (eye worm)	DIX domain-containing protein	0.0018	0.0129	0.0127
Schistosoma mansoni	Smad4	0.0015	0.0078	0.0059
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0413	0.041
Schistosoma mansoni	cpg binding protein	0.0035	0.0413	0.0465

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1406375

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1296796