TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.391 | Formula: C18H27N2O6P
H donors: 3 H acceptors: 5 LogP: -1.25 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COP(=O)(C(N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C)CCc1ccccc1)O
InChi: 1S/C18H27N2O6P/c1-13(17(21)20-12-6-9-15(20)18(22)23)19-16(27(24,25)26-2)11-10-14-7-4-3-5-8-14/h3-5,7-8,13,15-16,19H,6,9-12H2,1-2H3,(H,22,23)(H,24,25)/t13-,15-,16?/m0/s1
InChiKey: HIPGEDJGPPKXTE-JFXOEICMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	angiotensin I converting enzyme	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Angiotensin-converting enzyme family protein	Get druggable targets OG5_131988	All targets in OG5_131988
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	Get druggable targets OG5_131988	All targets in OG5_131988

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	transcription factor SMAD2	0.0241	0.0473	0.0473
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Echinococcus granulosus	acetylcholinesterase	0.0136	0.0228	0.1103
Plasmodium vivax	amine transporter, putative	0.0156	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0054	0.0054
Echinococcus granulosus	MAM	0.026	0.0518	0.2508
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0658	0.1453	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0342	0.0342
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.004	0.0002	0.5
Echinococcus granulosus	insulin receptor	0.0791	0.1766	0.8552
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.012	0.0189	0.0915
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0228	0.0228
Echinococcus granulosus	twitchin	0.005	0.0024	0.0115
Echinococcus granulosus	epidermal growth factor receptor	0.0367	0.077	0.3728
Brugia malayi	hypothetical protein	0.026	0.0518	0.0518
Echinococcus multilocularis	epidermal growth factor receptor	0.0367	0.077	0.3728
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	0.0273
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0919	0.2065	0.2065
Loa Loa (eye worm)	TK/ALK protein kinase	0.219	0.505	0.505
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.004	0.0002	0.001
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.004	0.0002	0.5
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Brugia malayi	Carboxylesterase family protein	0.0136	0.0228	0.0228
Echinococcus granulosus	epidermal growth factor receptor	0.0367	0.077	0.3728
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0101	0.0101
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0919	0.2065	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	0.0273
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0367	0.077	0.077
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	0.0273
Echinococcus granulosus	roundabout 2	0.0062	0.0054	0.0261
Loa Loa (eye worm)	TK/INSR protein kinase	0.0791	0.1766	0.1766
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Brugia malayi	Furin-like cysteine rich region family protein	0.0367	0.077	0.077
Brugia malayi	Carboxylesterase family protein	0.0136	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.026	0.0518	0.2508
Onchocerca volvulus		0.026	0.0518	0.25
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	0.0273
Echinococcus multilocularis	acetylcholinesterase	0.0136	0.0228	0.1103
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Loa Loa (eye worm)	acetylcholinesterase 1	0.0136	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0101	0.0488
Loa Loa (eye worm)	hypothetical protein	0.026	0.0518	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0089	0.0116	0.056
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0089	0.0116	0.0114
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0722	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.026	0.0518	0.0518
Echinococcus granulosus	acetylcholinesterase	0.0136	0.0228	0.1103
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0101	0.0488
Schistosoma mansoni	lipoxygenase	0.0084	0.0104	0.0504
Echinococcus multilocularis	epidermal growth factor receptor	0.0367	0.077	0.3728
Echinococcus multilocularis	acetylcholinesterase	0.0136	0.0228	0.1103
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0156	0.0273	0.1324
Brugia malayi	Serine protease Z688.6 precursor	0.004	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0054	0.0054
Onchocerca volvulus	Putative nachr subunit	0.0082	0.0101	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0052	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0342	0.0342
Brugia malayi	SWIRM domain containing protein	0.0089	0.0116	0.0116
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.1742	0.3999	0.3999
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0156	0.0273	0.1324
Schistosoma mansoni	tyrosine kinase	0.0348	0.0724	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0791	0.1766	0.8552
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0797	0.1778	0.8614
Toxoplasma gondii	hypothetical protein	0.0156	0.0273	1
Loa Loa (eye worm)	norepinephrine transporter	0.0919	0.2065	0.2065
Onchocerca volvulus		0.0156	0.0273	0.1315
Onchocerca volvulus		0.0156	0.0273	0.1315
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0101	0.0101
Onchocerca volvulus		0.0089	0.0116	0.055
Plasmodium falciparum	transporter, putative	0.0156	0.0273	1
Echinococcus multilocularis	serotonin transporter	0.0919	0.2065	1
Schistosoma mansoni	amine oxidase	0.0089	0.0116	0.056
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0634	0.1395	1
Toxoplasma gondii	hypothetical protein	0.0156	0.0273	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0185	0.0342	0.1656
Schistosoma mansoni	lipoxygenase	0.012	0.0189	0.0915
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0722	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Loa Loa (eye worm)	carboxylesterase	0.0136	0.0228	0.0228
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0342	0.0342
Schistosoma mansoni	tyrosine kinase	0.0367	0.077	0.3728
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.004	0.0002	0.001
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0089	0.0116	0.056
Echinococcus granulosus	carboxylesterase 5A	0.0136	0.0228	0.1103
Schistosoma mansoni	tyrosine kinase	0.0791	0.1766	0.8552
Brugia malayi	MH2 domain containing protein	0.0241	0.0473	0.0473
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0156	0.0273	0.1324
Schistosoma mansoni	nephrin	0.005	0.0024	0.0115
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0082	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Plasmodium vivax	hypothetical protein, conserved	0.0156	0.0273	1
Brugia malayi	NNMT/PNMT/TEMT family protein	0.1742	0.3999	0.3999
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0156	0.0273	0.0273
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0089	0.0116	0.056
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0002	0.5
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.1742	0.3999	0.3999
Schistosoma mansoni	tyrosine kinase	0.0791	0.1766	0.8552
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0919	0.2065	0.2065
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0089	0.0116	0.056
Loa Loa (eye worm)	hypothetical protein	0.0919	0.2065	0.2065
Brugia malayi	hypothetical protein	0.0089	0.0116	0.0116
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Schistosoma mansoni	sodium/chloride dependent transporter	0.0156	0.0273	0.1324
Loa Loa (eye worm)	MH2 domain-containing protein	0.0241	0.0473	0.0473
Schistosoma mansoni	tyrosine kinase	0.0367	0.077	0.3728
Brugia malayi	Serine protease Z688.6 precursor	0.004	0.0002	0.0002
Echinococcus granulosus	neuroglian	0.005	0.0024	0.0115
Echinococcus granulosus	sodium and chloride dependent glycine	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	0.0273
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0101	0.0488
Giardia lamblia	Serine peptidase, putative	0.004	0.0002	0.5
Echinococcus multilocularis		0.0089	0.0116	0.056
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.004	0.0002	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0367	0.077	0.3728
Echinococcus multilocularis	roundabout 2	0.0062	0.0054	0.0261
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0919	0.2065	0.2065
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0052	0.003	0.0147
Echinococcus multilocularis	neuroglian	0.005	0.0024	0.0115
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0156	0.0273	0.1324
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.1742	0.3999	0.3999
Plasmodium falciparum	amino acid transporter, putative	0.0156	0.0273	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.004	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0116	0.0116
Treponema pallidum	sodium- and chloride- dependent transporter	0.0919	0.2065	0.5
Trypanosoma brucei	C-8 sterol isomerase, putative	0.4297	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.191	0.4393	0.4393
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0089	0.0116	0.056
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.4297	1	1
Giardia lamblia	Thymus-specific serine protease precursor	0.004	0.0002	0.5
Schistosoma mansoni	hypothetical protein	0.0334	0.0692	0.3353
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0002	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Echinococcus multilocularis		0.0102	0.0146	0.0707
Schistosoma mansoni	tyrosine kinase	0.0348	0.0724	0.3505
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0089	0.0116	0.4183
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0185	0.0342	0.1656
Echinococcus multilocularis	insulin receptor	0.0791	0.1766	0.8552
Schistosoma mansoni	amine oxidase	0.0089	0.0116	0.056
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0749	0.1666	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0273	0.0273
Loa Loa (eye worm)	serotonin transporter b	0.0919	0.2065	0.2065
Leishmania major	C-8 sterol isomerase-like protein	0.4297	1	1
Brugia malayi	Protein kinase domain containing protein	0.0444	0.0949	0.0949
Brugia malayi	Angiotensin-converting enzyme family protein	0.0749	0.1666	0.1666
Loa Loa (eye worm)	hypothetical protein	0.2196	0.5066	0.5066
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0903	0.0903
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0185	0.0342	0.0342
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0101	0.0488
Echinococcus granulosus	geminin	0.0334	0.0692	0.3353
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0156	0.0273	1
Onchocerca volvulus		0.0586	0.1283	0.6213
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0156	0.0273	1
Schistosoma mansoni	cell adhesion molecule	0.0052	0.003	0.0147
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0101	0.0488
Schistosoma mansoni	hypothetical protein	0.026	0.0518	0.2508
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Brugia malayi	hypothetical protein	0.0156	0.0273	0.0273
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.004	0.0002	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0791	0.1766	0.8552
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0089	0.0116	0.0114
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0185	0.0342	0.1656
Schistosoma mansoni	sodium/chloride dependent transporter	0.0156	0.0273	0.1324
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0156	0.0273	0.1324
Brugia malayi	Protein kinase domain containing protein	0.0791	0.1766	0.1766
Loa Loa (eye worm)	hypothetical protein	0.026	0.0518	0.0518
Onchocerca volvulus		0.026	0.0518	0.25
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0089	0.0116	0.5
Onchocerca volvulus		0.0156	0.0273	0.1315
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0156	0.0273	0.1324
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Schistosoma mansoni	tyrosine kinase	0.0043	0.0007	0.0035
Echinococcus granulosus	sodium and chloride dependent glycine	0.0156	0.0273	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0605	0.0605
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.004	0.0002	0.001
Schistosoma mansoni	hypothetical protein	0.0334	0.0692	0.3353
Echinococcus multilocularis	geminin	0.0334	0.0692	0.3353
Schistosoma mansoni	tyrosine kinase	0.0367	0.077	0.3728
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0156	0.0273	0.1324
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0156	0.0273	0.1324
Brugia malayi	Protein kinase domain containing protein	0.219	0.5052	0.5052
Toxoplasma gondii	histone lysine-specific demethylase	0.0089	0.0116	0.4183
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0101	0.0488
Echinococcus multilocularis	carboxylesterase 5A	0.0136	0.0228	0.1103
Schistosoma mansoni	tyrosine kinase	0.0348	0.0724	0.3505
Loa Loa (eye worm)	hypothetical protein	0.4297	1	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0089	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0297	0.0605	0.0605
Loa Loa (eye worm)	hypothetical protein	0.004	0.0002	0.0002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0658	0.1453	0.1453
Schistosoma mansoni	sodium/chloride dependent transporter	0.0919	0.2065	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0136	0.0228	0.1103
Onchocerca volvulus		0.0919	0.2065	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0616	0.1353	0.6551
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.004	0.0002	0.5
Onchocerca volvulus		0.0297	0.0605	0.2921
Echinococcus granulosus	expressed protein	0.038	0.0799	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0919	0.2065	0.2065
Echinococcus multilocularis	MAM	0.026	0.0518	0.2508
Echinococcus granulosus	serotonin transporter	0.0919	0.2065	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.012	0.0189	0.0915
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.004	0.0002	0.5
Echinococcus multilocularis	expressed protein	0.038	0.0799	0.3869
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0089	0.0116	0.056

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.36	Inhibitory activity against angiotensin converting enzyme (ACE)	ChEMBL.	8360884
Log IC50 (functional)	= 6.36	Inhibitory activity against angiotensin converting enzyme (ACE)	ChEMBL.	8360884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 130285