TDR Targets

Basic information

Technical information

TDR Targets ID: 1308924
Name: N-[2-(4-methylpiperazin-1-yl)-5-piperidin-1-y lsulfonylphenyl]-3-nitrobenzamide
MW: 487.572 | Formula: C23H29N5O5S
H donors: 1 H acceptors: 5 LogP: 2.51 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1ccc(cc1NC(=O)c1cccc(c1)[N+](=O)[O-])S(=O)(=O)N1CCCCC1
InChi: 1S/C23H29N5O5S/c1-25-12-14-26(15-13-25)22-9-8-20(34(32,33)27-10-3-2-4-11-27)17-21(22)24-23(29)18-6-5-7-19(16-18)28(30)31/h5-9,16-17H,2-4,10-15H2,1H3,(H,24,29)
InChiKey: CYAJMCASGXENMM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(4-methylpiperazin-1-yl)-5-(1-piperidylsulfonyl)phenyl]-3-nitro-benzamide
N-[2-(4-methyl-1-piperazinyl)-5-(1-piperidylsulfonyl)phenyl]-3-nitrobenzamide
N-[2-(4-methylpiperazin-1-yl)-5-piperidinosulfonyl-phenyl]-3-nitro-benzamide
N-[2-(4-methylpiperazin-1-yl)-5-piperidin-1-ylsulfonyl-phenyl]-3-nitro-benzamide
SMR000371861
T5223101
MLS000776615

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0303	0.2895	0.2895
Giardia lamblia	GTOR	0.0903	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0303	0.2895	0.2895
Schistosoma mansoni	hypothetical protein	0.0205	0.1734	0.1734
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0171	0.1332	0.1332
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0058	0	0.5
Onchocerca volvulus		0.0058	0	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0375	0.375	0.375
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0058	0	0.5
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0903	1	1
Onchocerca volvulus		0.0058	0	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0903	1	1
Echinococcus multilocularis	muscleblind protein 1	0.018	0.1447	0.1447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0539	0.5698	0.5698
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0303	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2895	0.2895
Echinococcus granulosus	snurportin 1	0.0372	0.3713	0.3713
Echinococcus multilocularis	muscleblind protein	0.018	0.1447	0.1447
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0303	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2895	0.2895
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0903	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0718	0.7813	0.7813
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.019	0.1563	0.2153
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0903	1	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0303	0.2895	0.2895
Echinococcus multilocularis	snurportin 1	0.0372	0.3713	0.3713
Entamoeba histolytica	protein kinase rad3, putative	0.0171	0.1332	0.1332
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0058	0	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.3713	0.3713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0718	0.7813	0.7813
Plasmodium vivax	hypothetical protein	0.0058	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0873	0.0873
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0058	0	0.5
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0058	0	0.5
Echinococcus multilocularis	serine protein kinase ATM	0.0171	0.1332	0.1332
Schistosoma mansoni	hypothetical protein	0.0132	0.0873	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1489	0.1489
Brugia malayi	Muscleblind-like protein	0.018	0.1447	0.1447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0642	0.0642
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0903	1	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0132	0.0873	0.0873
Brugia malayi	FAT domain containing protein	0.0132	0.0873	0.0873
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5082	0.5082
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0171	0.1332	0.1332
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0671	0.7261	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0171	0.1332	0.1332
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0171	0.1332	0.1332
Brugia malayi	RNA, U transporter 1	0.0099	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.018	0.1447	0.1447
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0303	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5082	0.5082
Echinococcus granulosus	muscleblind protein	0.018	0.1447	0.1447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0534	0.5634	0.5634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2895	0.2895
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0112	0.0642	0.0642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0718	0.7813	0.7813
Trypanosoma cruzi	target of rapamycin kinase 3	0.0719	0.7822	0.7822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5074	0.5074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0171	0.1332	0.1332
Entamoeba histolytica	hypothetical protein	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0903	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0539	0.5698	0.5698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5082	0.5082
Echinococcus multilocularis	geminin	0.0205	0.1734	0.1734
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.0873	0.0873
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0771	0.8437	0.8437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2895	0.2895
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0171	0.1332	0.1332
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0303	0.2895	0.2895
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0903	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0903	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0058	0	0.5
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0903	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0642	0.0642
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0903	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0058	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0718	0.7813	0.7813
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0058	0	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0427	0.4366	0.4366
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0903	1	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5082	0.5082
Echinococcus granulosus	geminin	0.0205	0.1734	0.1734
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.019	0.1563	0.1563
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0718	0.7813	0.7813
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5074	0.5074
Toxoplasma gondii	FATC domain-containing protein	0.0171	0.1332	0.1835
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0605	0.6481	0.6481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.018	0.1447	0.1447
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0303	0.2895	0.2895
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0171	0.1332	0.1332
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0719	0.7822	0.7822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0534	0.5634	0.5634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0487	0.5074	0.5074
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0303	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0539	0.5698	0.5698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0671	0.7261	0.7261
Schistosoma mansoni	hypothetical protein	0.0372	0.3713	0.3713
Plasmodium vivax	hypothetical protein, conserved	0.0058	0	0.5
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0903	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0303	0.2895	0.2895
Echinococcus granulosus	serine protein kinase ATM	0.0171	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0242	0.2178	0.2178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.625	0.625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0171	0.1332	0.1332
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0903	1	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0642	0.0642
Schistosoma mansoni	hypothetical protein	0.0205	0.1734	0.1734
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0171	0.1332	0.1332
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1563	0.1563
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2895	0.2895
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0132	0.0873	0.0873
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0058	0	0.5
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0303	0.2895	0.2895
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0903	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0719	0.7822	0.7822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0903	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0119 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	3.2643 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	14.1254 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1423177

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1308924