TDR Targets

Basic information

Technical information

TDR Targets ID: 1312242
Name: 3-[(3-morpholin-4-ylsulfonylbenzoyl)amino]-1- (oxolan-2-ylmethyl)thiourea
MW: 428.526 | Formula: C17H24N4O5S2
H donors: 3 H acceptors: 3 LogP: 0.32 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: S=C(NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)NCC1CCCO1
InChi: 1S/C17H24N4O5S2/c22-16(19-20-17(27)18-12-14-4-2-8-26-14)13-3-1-5-15(11-13)28(23,24)21-6-9-25-10-7-21/h1,3,5,11,14H,2,4,6-10,12H2,(H,19,22)(H2,18,20,27)
InChiKey: VJXGUZLKSIAWIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(3-morpholinosulfonylbenzoyl)amino]-1-(tetrahydrofuran-2-ylmethyl)thiourea
3-[[(3-morpholinosulfonylphenyl)-oxomethyl]amino]-1-(2-tetrahydrofuranylmethyl)thiourea
3-[(3-morpholinosulfonylbenzoyl)amino]-1-(tetrahydrofurfuryl)thiourea
3-[(3-morpholin-4-ylsulfonylphenyl)carbonylamino]-1-(oxolan-2-ylmethyl)thiourea
MLS000760406
SMR000369668
T5228423

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0171	0.0509
Schistosoma mansoni	alpha glucosidase	0.0044	0.0171	0.0342
Brugia malayi	Pre-SET motif family protein	0.0061	0.0298	0.1013
Trichomonas vaginalis	glutaminase, putative	0.033	0.2247	0.6667
Plasmodium vivax	hypothetical protein, conserved	0.0109	0.0644	1
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0116	0.0231
Onchocerca volvulus		0.0109	0.0644	0.1912
Loa Loa (eye worm)	glutaminase 2	0.033	0.2247	0.7634
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0151	0.0302
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0057	0.0192
Trypanosoma brucei	hypothetical protein, conserved	0.0109	0.0644	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0116	0.0231
Trichomonas vaginalis	penicillin-binding protein, putative	0.0109	0.0644	0.1912
Mycobacterium tuberculosis	Probable esterase LipL	0.0109	0.0644	0.0561
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0372	0.2551	0.509
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0116	0.1253
Loa Loa (eye worm)	MH2 domain-containing protein	0.0123	0.0747	0.2538
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0334	0.0667
Echinococcus multilocularis	musashi	0.0028	0.0057	0.0113
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0334	0.0667
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1281	0.2556
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1082	0.216
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0104	0.0353
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0109	0.0644	0.1286
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0057	0.0271	0.2926
Brugia malayi	hypothetical protein	0.0148	0.0926	0.3144
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0696	0.4898	0.4852
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0171	0.0342
Mycobacterium ulcerans	transcriptional regulator	0.14	1	1
Onchocerca volvulus	Alhambra homolog	0.0029	0.0068	0.0202
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.18
Brugia malayi	PHD-finger family protein	0.0029	0.0068	0.0231
Schistosoma mansoni	microtubule-associated protein tau	0.0712	0.5011	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0148	0.0926	0.1847
Brugia malayi	jmjC domain containing protein	0.0096	0.0552	0.1877
Echinococcus granulosus	geminin	0.0681	0.479	0.9559
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0171	0.0509
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0171	0.0509
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0334	0.0667
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0334	0.0667
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0109	0.0644	0.0535
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0334	0.0667
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0057	0.0271	0.4199
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0104	0.0353
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.14	1	1
Entamoeba histolytica	hypothetical protein	0.0148	0.0926	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0116	0.0344
Brugia malayi	prolyl oligopeptidase family protein	0.0057	0.0271	0.0919
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0334	0.1136
Brugia malayi	hypothetical protein	0.01	0.058	0.197
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0068	0.0136
Echinococcus granulosus	lamin dm0	0.0028	0.0057	0.0113
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.089	0.1776
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0298	0.0595
Brugia malayi	TAR-binding protein	0.0066	0.0334	0.1136
Mycobacterium ulcerans	glutaminase	0.033	0.2247	0.2156
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0109	0.0644	0.0561
Loa Loa (eye worm)	hypothetical protein	0.01	0.058	0.197
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0171	0.1091	0.3237
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0045	0.018	0.036
Mycobacterium tuberculosis	Probable lipase LipE	0.0109	0.0644	0.0561
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0372	0.2551	0.509
Echinococcus multilocularis	geminin	0.0681	0.479	0.9559
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0109	0.0644	0.2189
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.089	0.1776
Plasmodium vivax	SET domain protein, putative	0.0061	0.0298	0.3992
Onchocerca volvulus		0.0109	0.0644	0.1912
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.089	0.1776
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0298	0.0595
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.1281	0.4351
Entamoeba histolytica	hypothetical protein	0.0148	0.0926	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0113	0.0225
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0171	0.1853
Mycobacterium leprae	Probable lipase LipE	0.0109	0.0644	0.0561
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0116	0.0344
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0057	0.0271	0.054
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0334	0.0667
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0644	0.1912
Toxoplasma gondii	ABC1 family protein	0.0109	0.0644	1
Schistosoma mansoni	glutaminase	0.033	0.2247	0.4484
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0298	0.0595
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0171	0.1091	0.2177
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0171	0.0509
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0068	0.1056
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0113	0.0383
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1082	0.216
Onchocerca volvulus		0.0028	0.0057	0.0168
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0298	0.0595
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0171	0.0509
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0116	0.0231
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0113	0.0225
Brugia malayi	hypothetical protein	0.0044	0.0173	0.0587
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.0552	0.1102
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0109	0.0644	0.0561
Onchocerca volvulus		0.0028	0.0057	0.0168
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0057	0.0271	0.2926
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0426	0.2944	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0171	0.2661
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0116	0.5
Leishmania major	hypothetical protein, conserved	0.01	0.058	0.878
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0053	0.018
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0171	0.2661
Mycobacterium ulcerans	hypothetical protein	0.0109	0.0644	0.0535
Echinococcus granulosus	lamin	0.0028	0.0057	0.0113
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0219	0.0745
Schistosoma mansoni	lamin	0.0028	0.0057	0.0113
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0171	0.2661
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0116	0.0344
Brugia malayi	glutaminase DH11.1	0.033	0.2247	0.7634
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0298	0.1013
Loa Loa (eye worm)	beta-lactamase	0.0109	0.0644	0.2189
Trypanosoma brucei	glucosidase, putative	0.0044	0.0171	0.105
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0298	0.0595
Mycobacterium tuberculosis	Probable lipase LipD	0.0109	0.0644	0.0561
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0282	0.0562
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0057	0.0192
Echinococcus granulosus	intermediate filament protein	0.0028	0.0057	0.0113
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.18
Onchocerca volvulus		0.0109	0.0644	0.1912
Echinococcus multilocularis	lamin	0.0028	0.0057	0.0113
Mycobacterium ulcerans	lipase LipD	0.0109	0.0644	0.0535
Brugia malayi	follicle stimulating hormone receptor	0.0228	0.1507	0.5118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0192
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0109	0.0644	0.0561
Schistosoma mansoni	hypothetical protein	0.0148	0.0926	0.1847
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	0.1507	0.5118
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0298	0.0595
Echinococcus granulosus	beta LACTamase domain containing family member	0.0109	0.0644	0.1286
Brugia malayi	hypothetical protein	0.0065	0.0323	0.1097
Brugia malayi	Pre-SET motif family protein	0.0426	0.2944	1
Mycobacterium tuberculosis	Probable hydrolase	0.0109	0.0644	0.0561
Schistosoma mansoni	transcription factor LCR-F1	0.0148	0.0926	0.1847
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0068	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0068	0.0231
Brugia malayi	beta-lactamase	0.0109	0.0644	0.2189
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0171	0.0342
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0372	0.2551	0.509
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0171	0.0509
Toxoplasma gondii	LsmAD domain-containing protein	0.01	0.058	0.8999
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0057	0.0271	0.4199
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0171	0.105
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.089	0.1776
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.089	0.1776
Loa Loa (eye worm)	transcription factor SMAD2	0.0123	0.0747	0.2538
Brugia malayi	intermediate filament protein	0.0028	0.0057	0.0192
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0219	0.0745
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0045	0.018	0.036
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0173	0.0587
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0644	0.0561
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0057	0.0271	0.054
Brugia malayi	Inositol-1	0.0036	0.0116	0.0394
Echinococcus multilocularis	lamin dm0	0.0028	0.0057	0.0113
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.0552	0.1102
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0334	0.1136
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0334	0.0667
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0644	0.1912
Plasmodium falciparum	ataxin-2 like protein, putative	0.01	0.058	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0113	0.0225
Echinococcus granulosus	peregrin	0.0029	0.0068	0.0136
Trypanosoma cruzi	PAB1-binding protein , putative	0.01	0.058	0.8999
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0171	0.0583
Loa Loa (eye worm)	prolyl oligopeptidase	0.0171	0.1091	0.3706
Leishmania major	hypothetical protein, conserved	0.0109	0.0644	1
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0644	0.0561
Mycobacterium ulcerans	esterase/lipase LipP	0.0109	0.0644	0.0535
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.14	1	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Loa Loa (eye worm)	glutaminase	0.033	0.2247	0.7634
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0334	0.1136
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0143	0.089	0.3023
Schistosoma mansoni	hypothetical protein	0.0681	0.479	0.9559
Brugia malayi	prolyl oligopeptidase family protein	0.0171	0.1091	0.3706
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.089	0.1776
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0409	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0644	0.1912
Mycobacterium ulcerans	beta-lactamase	0.0109	0.0644	0.0535
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0143	0.089	0.3023
Trypanosoma cruzi	PAB1-binding protein , putative	0.01	0.058	0.8999
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0171	0.0509
Onchocerca volvulus		0.0485	0.3371	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0068	0.0136
Schistosoma mansoni	lamin	0.0028	0.0057	0.0113
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0171	0.0509
Brugia malayi	beta-lactamase family protein	0.0109	0.0644	0.2189
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0295	0.1001
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0068	0.1056
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0171	0.0583
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0057	0.0192
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0109	0.0644	0.1286
Echinococcus granulosus	microtubule associated protein 2	0.0712	0.5011	1
Entamoeba histolytica	hypothetical protein	0.0148	0.0926	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0109	0.0644	1
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0151	0.0302
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0068	0.0136
Plasmodium vivax	ataxin-2 like protein, putative	0.01	0.058	0.8881
Trichomonas vaginalis	penicillin-binding protein, putative	0.0109	0.0644	0.1912
Onchocerca volvulus		0.0114	0.068	0.2017
Trypanosoma cruzi	hypothetical protein, conserved	0.0109	0.0644	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0104	0.0208
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0109	0.0644	0.2189
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0298	0.0595
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.089	0.1776
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0148	0.0926	0.1847
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.1281	0.4351
Schistosoma mansoni	hypothetical protein	0.0681	0.479	0.9559
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Plasmodium falciparum	ataxin-2 like protein, putative	0.01	0.058	1
Brugia malayi	beta-lactamase family protein	0.0109	0.0644	0.2189
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0298	0.4627
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0334	0.1136
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0219	0.0745
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1281	0.2556
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0057	0.0271	0.2926
Schistosoma mansoni	hypothetical protein	0.0045	0.018	0.036
Loa Loa (eye worm)	hypothetical protein	0.005	0.022	0.0748
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0644	0.0561
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0057	0.0271	0.4199
Brugia malayi	RNA binding protein	0.0066	0.0334	0.1136
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0113	0.0225
Trichomonas vaginalis	esterase, putative	0.0109	0.0644	0.1912
Mycobacterium leprae	conserved hypothetical protein	0.0109	0.0644	0.0561
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0116	0.0231
Trypanosoma brucei	PAB1-binding protein , putative	0.01	0.058	0.878
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0116	0.18
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0171	0.1853
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0109	0.0644	0.1286
Echinococcus multilocularis	microtubule associated protein 2	0.0712	0.5011	1
Brugia malayi	Bromodomain containing protein	0.0029	0.0068	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0171	0.0509
Giardia lamblia	PHD finger protein 15	0.0029	0.0068	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0219	0.0745
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0057	0.0271	0.054
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0644	0.2189
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0068	0.0136
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.1281	0.2556
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0171	0.1091	0.2177
Brugia malayi	jmjC domain containing protein	0.0036	0.0113	0.0383
Mycobacterium ulcerans	TetR family transcriptional regulator	0.14	1	1
Trichomonas vaginalis	set domain proteins, putative	0.0485	0.3371	1
Onchocerca volvulus		0.0061	0.0298	0.0885
Brugia malayi	MH2 domain containing protein	0.0123	0.0747	0.2538
Entamoeba histolytica	hypothetical protein	0.0148	0.0926	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0057	0.0113
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0171	0.1091	0.2177
Loa Loa (eye worm)	inositol-1	0.0036	0.0116	0.0394
Echinococcus multilocularis	peregrin	0.0029	0.0068	0.0136

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.1135 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1458963

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1312242