Detailed information for compound 131346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 762.897 | Formula: C35H58N10O9
  • H donors: 11 H acceptors: 9 LogP: -3.79 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H](C(=O)N[C@H](C(=O)CNC(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CCCN=C(N)N)CC(C)C)CC(C)C)Cc1ccccc1)N
  • InChi: 1S/C35H58N10O9/c1-19(2)13-25(41-17-28(47)24(43-30(49)22(36)18-46)15-21-9-6-5-7-10-21)32(51)44-26(14-20(3)4)33(52)42-23(11-8-12-40-35(38)39)31(50)45-27(34(53)54)16-29(37)48/h5-7,9-10,19-20,22-27,41,46H,8,11-18,36H2,1-4H3,(H2,37,48)(H,42,52)(H,43,49)(H,44,51)(H,45,50)(H,53,54)(H4,38,39,40)/t22-,23-,24-,25?,26-,27-/m0/s1
  • InChiKey: XEIPCRKHBIUXOB-BLBKDVNQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0124 0.0286
Schistosoma mansoni transient receptor potential channel 0.0095 0.0481 0.119
Onchocerca volvulus 0.0036 0.0124 0.0215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0561 0.1387
Brugia malayi eukaryotic initiation factor 4A 0.0595 0.3549 0.9917
Loa Loa (eye worm) hypothetical protein 0.06 0.3579 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0532 0.1487
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.106 0.2963
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0124 0.0334
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0124 0.0286
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0292 0.0816
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0124 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0088 0.0218
Brugia malayi beta-lactamase 0.0036 0.0124 0.0345
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0088 0.0113
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0124 0.0334
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.1615 0.3999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0088 0.0246
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0049
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0056
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0285 0.0706
Echinococcus multilocularis snurportin 1 0.031 0.1799 0.1799
Echinococcus multilocularis protein patched 0.0084 0.0416 0.0416
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0088 0.0088
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0186 0.0438
Brugia malayi beta-lactamase family protein 0.0036 0.0124 0.0345
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Schistosoma mansoni patched 1 0.0084 0.0416 0.103
Onchocerca volvulus 0.003 0.0088 0.0113
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0285 0.0797
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.1615 0.1615
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.106 0.106
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.106 0.2624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0059 0.0265 0.0741
Echinococcus multilocularis musashi 0.0027 0.0068 0.0068
Echinococcus multilocularis protein dispatched 1 0.0096 0.0489 0.0489
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0088 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0124 0.0286
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0124 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.106 0.2963
Schistosoma mansoni ran 0.0021 0.0032 0.008
Mycobacterium ulcerans beta-lactamase 0.0036 0.0124 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0124 0.0334
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0048 0.3297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0088 0.0246
Leishmania major hypothetical protein, conserved 0.0036 0.0124 0.0286
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0088 0.0218
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0416 0.103
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0048 0.0121
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0117 0.029
Brugia malayi hypothetical protein 0.0239 0.1364 0.3811
Brugia malayi Muscleblind-like protein 0.06 0.3579 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0088 0.0218
Schistosoma mansoni nuclear hormone receptor 0.003 0.0088 0.0218
Schistosoma mansoni lamin 0.0027 0.0068 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0285 0.0285
Treponema pallidum ATP-dependent RNA helicase 0.0595 0.3549 0.5
Schistosoma mansoni importin beta-1 0.0029 0.0079 0.0196
Echinococcus granulosus microtubule associated protein 2 0.0676 0.404 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0198 0.0491
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0117 0.0117
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.133 0.3716
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Mycobacterium leprae Probable lipase LipE 0.0036 0.0124 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0292 0.0816
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0124 1
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Brugia malayi MH2 domain containing protein 0.0233 0.133 0.3716
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0124 0.0306
Brugia malayi nuclear hormone receptor 0.003 0.0088 0.0246
Echinococcus granulosus FTZ F1 alpha 0.003 0.0088 0.0218
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0416 0.1163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0088 0.0246
Schistosoma mansoni transient receptor potential channel 0.0063 0.0285 0.0704
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0595 0.3549 1
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0461 0.1142
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Brugia malayi nuclear receptor NHR-88 0.003 0.0088 0.0246
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0088 0.0113
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0168
Loa Loa (eye worm) beta-lactamase 0.0036 0.0124 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Brugia malayi hypothetical protein 0.0108 0.0561 0.1566
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0416 0.0416
Schistosoma mansoni transient receptor potential channel 0.0063 0.0285 0.0704
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Loa Loa (eye worm) hypothetical protein 0.0239 0.1364 0.3811
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0046 0.0066
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0048 0.0073
Leishmania major eukaryotic initiation factor 4a, putative 0.0595 0.3549 1
Plasmodium vivax RNA helicase-1, putative 0.0595 0.3549 1
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Onchocerca volvulus 0.0036 0.0124 0.0215
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0481 0.119
Onchocerca volvulus 0.0036 0.0124 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Schistosoma mansoni kinase 0.0096 0.049 0.1214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0088 0.0218
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0561 0.1387
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0273
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0327
Schistosoma mansoni ran 0.0021 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0222
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.5
Brugia malayi steroid hormone receptor 0.003 0.0088 0.0246
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0088 0.0218
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1799 0.5028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.132 0.3709
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0088 0.0246
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0023
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.106 0.2943
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0088 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.404 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0595 0.3549 0.8785
Entamoeba histolytica hypothetical protein 0.0024 0.0046 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0088 0.0218
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1101 0.3058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1114 0.3112
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0088 0.0246
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Brugia malayi CHE-14 protein 0.0084 0.0416 0.1163
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0088 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.133 0.3716
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0475 0.1283
Echinococcus multilocularis GPCR, family 2 0.0063 0.0285 0.0285
Schistosoma mansoni lamin 0.0027 0.0068 0.0168
Leishmania major eukaryotic initiation factor 4a, putative 0.0595 0.3549 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0461 0.0461
Echinococcus granulosus tar DNA binding protein 0.0064 0.0292 0.0723
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0285 0.0704
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0048 0.3297
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0088 0.0218
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0186 0.0521
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0088 0.0246
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.106 0.2943
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0088 0.0246
Schistosoma mansoni coup transcription factor 0.003 0.0088 0.0218
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.404 0.404
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1119 0.2771
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0124 0.0318
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Trypanosoma brucei polo-like protein kinase 0.0189 0.106 0.2943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0561 0.0561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0088 0.0088
Leishmania major importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Echinococcus granulosus muscleblind protein 0.06 0.3579 0.8858
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0595 0.3549 0.9917
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0117 0.0327
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0124 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Mycobacterium ulcerans hypothetical protein 0.0036 0.0124 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0079 0.0222
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0285 0.0285
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0088 0.0246
Echinococcus multilocularis lamin 0.0027 0.0068 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1364 0.3376
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1101 0.1101
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.1018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1114 0.3112
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0088 0.0246
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0088 0.0218
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0028
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.106 0.2891
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0088 0.0088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0285 0.0706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0088 0.0218
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Echinococcus granulosus GPCR family 2 0.0063 0.0285 0.0706
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0049
Echinococcus granulosus expressed protein 0.0046 0.0186 0.0461
Trichomonas vaginalis esterase, putative 0.0036 0.0124 0.0286
Echinococcus multilocularis expressed conserved protein 0.0184 0.1028 0.1028
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Schistosoma mansoni hypothetical protein 0.0049 0.02 0.0495
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0595 0.3549 1
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0595 0.3549 0.8785
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0088 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0088 0.0246
Giardia lamblia Kinase, PLK 0.0189 0.106 0.2943
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0088 0.0246
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0595 0.3549 0.8785
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0285 0.0797
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0196 0.1101 0.3076
Brugia malayi ecdysteroid receptor 0.003 0.0088 0.0246
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.1018
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0595 0.3549 0.3549
Loa Loa (eye worm) hypothetical protein 0.0095 0.0481 0.1343
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0079 0.0079
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0124 0.0306
Echinococcus granulosus eukaryotic initiation factor 4A 0.0595 0.3549 0.8785
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0416 0.1116
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0088 0.0218
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0416 0.103
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.106 0.2624
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0595 0.3549 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0285 0.0797
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0124 0.0124
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0088 0.0088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Mycobacterium ulcerans lipase LipD 0.0036 0.0124 1
Onchocerca volvulus 0.0049 0.02 0.0433
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0017
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.0073
Echinococcus granulosus lamin 0.0027 0.0068 0.0168
Mycobacterium ulcerans hypothetical protein 0.0024 0.0048 0.3297
Schistosoma mansoni hypothetical protein 0.031 0.1799 0.4454
Onchocerca volvulus 0.0027 0.0068 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0048 0.3297
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0048 0.0121
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0292 0.0292
Echinococcus multilocularis muscleblind protein 0.06 0.3579 0.3579
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0088 0.0246
Entamoeba histolytica Ran family GTPase 0.0021 0.0032 0.0028
Plasmodium falciparum importin beta, putative 0.0029 0.0079 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.06 0.3579 1
Echinococcus multilocularis tumor protein p63 0.0331 0.1928 0.1928
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.006
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1101 0.2725
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0088 0.0218
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.02 0.0559
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0186 0.0461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.019
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1101 0.3076
Loa Loa (eye worm) hypothetical protein 0.0063 0.0285 0.0797
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.106 0.2943
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0481 0.0481
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0481 0.119
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0124 0.0334
Brugia malayi intermediate filament protein 0.0027 0.0068 0.019
Onchocerca volvulus 0.0048 0.0198 0.0428
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Loa Loa (eye worm) RNA binding protein 0.0064 0.0292 0.0816
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0495
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0438
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0088 0.0246
Schistosoma mansoni survival motor neuron protein 0.0049 0.02 0.0495
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0595 0.3549 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.006
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0595 0.3549 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0495
Echinococcus multilocularis expressed protein 0.0046 0.0186 0.0186
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0088 0.0088
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0124 0.0286
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0048 0.3297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0124 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0088 0.0246
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0088 0.0218
Echinococcus multilocularis muscleblind protein 1 0.06 0.3579 0.3579
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Echinococcus granulosus expressed conserved protein 0.0184 0.1028 0.2545
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0124 0.0334
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0088 0.0246
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0595 0.3549 0.3549
Onchocerca volvulus 0.0027 0.0068 0.0056
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0285 0.0285
Brugia malayi beta-lactamase family protein 0.0036 0.0124 0.0345
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0161
Loa Loa (eye worm) hypothetical protein 0.0048 0.0198 0.0554
Toxoplasma gondii ABC1 family protein 0.0036 0.0124 0.0259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0088 0.0246
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0056
Plasmodium vivax importin-beta 2, putative 0.0029 0.0079 0.0193
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0168
Brugia malayi RNA binding protein 0.0064 0.0292 0.0816
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0168
Brugia malayi RNA, U transporter 1 0.0083 0.0407 0.1138
Schistosoma mansoni thyroid hormone receptor 0.003 0.0088 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0088 0.0088
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0186 0.0521
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0124 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0088 0.0218
Loa Loa (eye worm) hypothetical protein 0.0084 0.0416 0.1163
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.073 0.204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0124 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0088 0.0246
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.106 0.2943
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0088 0.0218
Echinococcus granulosus tumor protein p63 0.0331 0.1928 0.4772
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1114 0.3112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Schistosoma mansoni thyroid hormone receptor 0.003 0.0088 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Plasmodium falciparum eukaryotic initiation factor 4A 0.0595 0.3549 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.073 0.204
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0088 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0475 0.1283
Echinococcus granulosus snurportin 1 0.031 0.1799 0.4454
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0124 0.0334
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0028
Brugia malayi TAR-binding protein 0.0064 0.0292 0.0816
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0088 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0088 0.0246
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1364 0.1364
Schistosoma mansoni hypothetical protein 0.0135 0.073 0.1807
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0079 0.0133
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0124 0.0286
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0285 0.0704
Schistosoma mansoni hypothetical protein 0.0108 0.0561 0.1387
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0198 0.1114 0.3112
Echinococcus granulosus importin subunit beta 1 0.0029 0.0079 0.0196
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0292 0.0816

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 1000 uM Agonist activity in human platelet aggregation ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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