TDR Targets

Basic information

Technical information

TDR Targets ID: 131668
Name: N-cyclopropyl-10,10-dioxophenoxathiine-3-carb oxamide
MW: 315.344 | Formula: C16H13NO4S
H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)Oc1c(S2(=O)=O)cccc1)NC1CC1
InChi: 1S/C16H13NO4S/c18-16(17-11-6-7-11)10-5-8-15-13(9-10)21-12-3-1-2-4-14(12)22(15,19)20/h1-5,8-9,11H,6-7H2,(H,17,18)
InChiKey: WTDQBJOLASHHIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclopropyl-10,10-dioxo-phenoxathiine-3-carboxamide
N-cyclopropyl-10,10-dioxo-3-phenoxathiinecarboxamide
N-cyclopropyl-10,10-diketo-phenoxathiine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable oxidoreductase	0.0114	0.2108	0.4476
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0088	0.0054
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.1782	0.1734
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0514	0.0514
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0559	0.2329
Toxoplasma gondii	FAD binding domain-containing protein	0.0114	0.2108	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0514	0.0943
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0514	0.8978
Schistosoma mansoni	hypothetical protein	0.0182	0.3511	0.3919
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2434	0.239
Chlamydia trachomatis	monooxygenase	0.0114	0.2108	1
Echinococcus granulosus	ubiquinone biosynthesis monooxygenase COQ6	0.0114	0.2108	0.2038
Mycobacterium ulcerans	monoamine oxidase	0.0026	0.03	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0514	0.8978
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0514	0.0487
Leishmania major	hypothetical protein, conserved	0.0114	0.2108	0.3513
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0514	0.0782
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0396	0.0396
Mycobacterium ulcerans	oxidoreductase GMC-type	0.0114	0.2108	0.6962
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0088	0.0054
Schistosoma mansoni	cpg binding protein	0.0031	0.0392	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0495	1	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0559	0.0505
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0514	0.0943
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0559	0.9866
Loa Loa (eye worm)	hypothetical protein	0.0026	0.03	0.0244
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.1948	0.4121
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0088	0.0088
Schistosoma mansoni	amine oxidase	0.0026	0.03	0.0242
Schistosoma mansoni	amine oxidase	0.0026	0.03	0.0242
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.2193	0.4664
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0514	0.0429
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0717	0.0634
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0129	0.2434	0.2366
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0619	0.0962
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0559	0.1622
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0514	0.0459
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0026	0.03	0.1045
Mycobacterium ulcerans	FAD-dependent oxidoreductase	0.0114	0.2108	0.6962
Mycobacterium tuberculosis	Possible oxidoreductase	0.0114	0.2108	0.4476
Mycobacterium ulcerans	dehydrogenase	0.0026	0.03	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Trichomonas vaginalis	esterase, putative	0.0037	0.0514	0.8978
Leishmania major	UDP-galactopyranose mutase	0.0026	0.03	0.0415
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.1948	0.4121
Trypanosoma brucei	Monooxygenase, putative	0.0114	0.2108	0.3513
Schistosoma mansoni	hypothetical protein	0.0031	0.0396	0.0353
Schistosoma mansoni	alpha glucosidase	0.0039	0.0566	0.0547
Brugia malayi	Thioredoxin reductase	0.0046	0.0717	0.0717
Echinococcus multilocularis	geminin	0.0182	0.3511	0.3453
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0717	0.311
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0719	0.0666
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0514	0.1466
Plasmodium falciparum	protoporphyrinogen oxidase	0.0026	0.03	0.1045
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0088	0.0054
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0566	0.0871
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0088	0.0054
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0026	0.03	0.0415
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0088	0.0615
Trypanosoma brucei	kynurenine 3-monooxygenase, putative	0.0114	0.2108	0.3513
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0514	0.0943
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0396	0.0311
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0396	0.0311
Brugia malayi	glutathione reductase	0.0046	0.0717	0.0717
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0719	0.0636
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0297	0.5896	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.2193	0.4664
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0717	0.311
Plasmodium vivax	FAD-dependent monooxygenase, putative	0.0114	0.2108	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0514	0.1466
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0514	0.0943
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0559	0.0859
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0514	0.8978
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0129	0.2434	0.2686
Schistosoma mansoni	hypothetical protein	0.0101	0.1845	0.2012
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0026	0.03	0.0468
Mycobacterium ulcerans	hypothetical protein	0.0156	0.299	1
Echinococcus granulosus	geminin	0.0182	0.3511	0.3453
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0559	0.0859
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.2193	1
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.03	0.1045
Trypanosoma brucei	trypanothione reductase	0.0046	0.0717	0.113
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0719	0.0719
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0088	0.0054
Leishmania major	hypothetical protein, conserved	0.0037	0.0514	0.0782
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.3408	0.3349
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0566	0.2363
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0396	0.0396
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0514	0.0782
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0566	0.0566
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.03	0.1045
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0514	0.1132
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0514	0.0782
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0717	0.0634
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0514	0.0943
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0566	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0719	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0026	0.03	0.0244
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0088	0.0054
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0026	0.03	0.1045
Trypanosoma cruzi	Monooxygenase, putative	0.0114	0.2108	0.3513
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0559	0.1043
Echinococcus multilocularis	survival motor neuron protein 1	0.0495	1	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0514	0.0943
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.299	0.6429
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0566	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0037	0.0526	0.0526
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0026	0.03	0.0728
Onchocerca volvulus		0.0101	0.1845	0.6867
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.114	0.114
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0566	1
Echinococcus multilocularis	protein MICAL 3	0.0114	0.2108	0.2038
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Toxoplasma gondii	ABC1 family protein	0.0037	0.0514	0.2106
Echinococcus multilocularis	ubiquinone biosynthesis monooxygenase COQ6	0.0114	0.2108	0.2038
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0566	1
Echinococcus multilocularis	dnaJ subfamily B	0.0438	0.882	0.881
Onchocerca volvulus		0.0037	0.0514	0.1754
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0514	0.0943
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0514	0.1132
Echinococcus granulosus	dnaJ subfamily B	0.0438	0.882	0.881
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0088	0.0054
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0566	1
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0514	0.0943
Leishmania major	mitochondrial DNA polymerase beta	0.0297	0.5896	1
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0717	0.0663
Schistosoma mansoni	monoxygenase	0.0114	0.2108	0.2313
Toxoplasma gondii	exonuclease III APE	0.0039	0.0559	0.2329
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.1948	0.8708
Onchocerca volvulus		0.0031	0.0392	0.1285
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0297	0.5896	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2662	0.446
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0566	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.1948	0.4121
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0619	0.0962
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.1948	0.4121
Onchocerca volvulus		0.014	0.266	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.0514	0.1466
Brugia malayi	beta-lactamase family protein	0.0037	0.0514	0.0514
Schistosoma mansoni	cpg binding protein	0.0033	0.0428	0.0389
Schistosoma mansoni	hypothetical protein	0.0438	0.882	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0026	0.03	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2434	0.239
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1105	0.1165
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.1782	0.1782
Mycobacterium tuberculosis	Probable reductase	0.0106	0.1948	0.4121
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2662	0.446
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0129	0.2434	0.2366
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0026	0.03	0.1045
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0961	0.432
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0559	0.0559
Brugia malayi	beta-lactamase	0.0037	0.0514	0.0514
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0392	0.0392
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0297	0.5896	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0015	0.0057	0.0057
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0619	0.0962
Trypanosoma cruzi	hypothetical protein, conserved	0.0114	0.2108	0.3513
Mycobacterium ulcerans	oxidoreductase	0.0114	0.2108	0.6962
Mycobacterium ulcerans	membrane-associated oxidoreductase	0.0114	0.2108	0.6962
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0566	0.0482
Mycobacterium tuberculosis	Possible oxidoreductase	0.0114	0.2108	0.4476
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0566	0.0512
Toxoplasma gondii	hypothetical protein	0.0048	0.0746	0.3254
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0514	0.0487
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0559	0.9866
Plasmodium vivax	hypothetical protein, conserved	0.0114	0.2108	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0719	0.0636
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0392	0.0337
Echinococcus multilocularis		0.0026	0.03	0.0213
Mycobacterium ulcerans	oxidoreductase	0.0114	0.2108	0.6962
Mycobacterium leprae	possibleputative FAD-linked oxidoreductase	0.0114	0.2108	0.9552
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0559	0.9866
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0559	0.0859
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0566	0.0482
Schistosoma mansoni	hypothetical protein	0.0031	0.0396	0.0353
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0619	0.0962
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0026	0.03	0.0213
Trypanosoma brucei	glucosidase, putative	0.0039	0.0566	0.0871
Mycobacterium ulcerans	hypothetical protein	0.0114	0.2108	0.6962
Mycobacterium ulcerans	oxidoreductase	0.0026	0.03	0.0728
Echinococcus granulosus	survival motor neuron protein 1	0.0495	1	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0514	0.0514
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0088	0.0054
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0514	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0396	0.0341
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0396	0.0311
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0717	0.311
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.3408	0.3349
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0514	0.8978
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0808	0.1285
Toxoplasma gondii	histone lysine-specific demethylase	0.0026	0.03	0.1045
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0514	0.1466
Mycobacterium ulcerans	hypothetical protein	0.0114	0.2108	0.6962
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0026	0.03	0.0728
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.3408	0.337
Brugia malayi	hypothetical protein	0.0026	0.03	0.03
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.3408	0.3408
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0514	0.2106
Echinococcus multilocularis	cpg binding protein	0.0033	0.0428	0.0343
Onchocerca volvulus		0.0037	0.0514	0.1754
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0719	0.0722
Plasmodium falciparum	glutathione reductase	0.0046	0.0717	0.311
Echinococcus granulosus	GPCR family 2	0.0031	0.0396	0.0311
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0717	0.113
Mycobacterium ulcerans	hypothetical protein	0.0114	0.2108	0.6962
Schistosoma mansoni	survival motor neuron protein	0.0101	0.1845	0.2012
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0514	0.0459
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0396	0.0311
Schistosoma mansoni	hypothetical protein	0.0031	0.0396	0.0353
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Toxoplasma gondii	FAD binding domain-containing protein	0.0114	0.2108	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0396	0.0311
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0514	0.0429
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0719	0.0636
Schistosoma mansoni	alpha-glucosidase	0.0152	0.2899	0.3219
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0028	0.0338	0.1237
Loa Loa (eye worm)	hypothetical protein	0.014	0.266	0.2618
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0559	0.0475
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0026	0.03	0.1045
Schistosoma mansoni	cpg binding protein	0.0033	0.0428	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0526	0.0472
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0559	0.2329
Leishmania major	trypanothione reductase	0.0046	0.0717	0.113
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0566	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0566	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2108	0.2063
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.2193	0.4664
Mycobacterium ulcerans	FAD-linked oxidoreductase	0.0114	0.2108	0.6962
Schistosoma mansoni	hypothetical protein	0.0067	0.114	0.1205
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0234	0.4602	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0114	0.2108	0.4476
Brugia malayi	SWIRM domain containing protein	0.014	0.266	0.266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0719	0.0722
Schistosoma mansoni	hypothetical protein	0.0182	0.3511	0.3919
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0101	0.1845	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0566	0.0871
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0566	0.0871
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0514	0.0943
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0026	0.03	0.1045
Schistosoma mansoni	ap endonuclease	0.0039	0.0559	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0459
Mycobacterium tuberculosis	Possible oxidoreductase	0.0114	0.2108	0.4476
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0026	0.03	0.0242
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0559	1
Schistosoma mansoni	alpha-glucosidase	0.0152	0.2899	0.3219
Schistosoma mansoni	ap endonuclease	0.0039	0.0559	0.0539
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0559	0.0475
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.1948	0.4121
Wolbachia endosymbiont of Brugia malayi	2-polyprenyl-6-methoxyphenol 4-hydroxylase	0.0114	0.2108	1
Onchocerca volvulus		0.0102	0.1868	0.6956
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.1782	0.1782
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0559	0.2329
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0559	0.0859
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0026	0.03	0.0415
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0396	0.0341
Schistosoma mansoni	hypothetical protein	0.0114	0.2108	0.2313
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0566	1
Leishmania major	hypothetical protein, conserved	0.0114	0.2108	0.3513
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0717	0.311
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0026	0.03	0.0213
Echinococcus granulosus	protein MICAL 3	0.0114	0.2108	0.2038
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0719	0.0636
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0088	0.0054
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0717	0.1392
Echinococcus granulosus	cpg binding protein	0.0033	0.0428	0.0343
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0088	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1782	0.1734
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0088	0.0054
Onchocerca volvulus		0.0037	0.0514	0.1754
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0514	0.0943
Plasmodium falciparum	FAD-dependent monooxygenase, putative	0.0114	0.2108	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.114	0.109
Mycobacterium tuberculosis	Possible oxidoreductase	0.0026	0.03	0.0468
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0566	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0514	0.8978
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.3408	0.3349
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.2662	0.446
Schistosoma mansoni	hypothetical protein	0.0031	0.0396	0.0353
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0566	1
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0717	0.0663
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0559	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	uM	Inhibition of Monoamine oxidase A (MAO A) in rat brain at 0.1 uM	ChEMBL.	9258353
IC50 (binding)	0 uM	Inhibition of Monoamine oxidase A (MAO A) in rat brain at 0.1 uM	ChEMBL.	9258353
Inhibition (binding)	= 10 %	Inhibition of Monoamine oxidase B (MAO B) in rat brain at 0.1 uM	ChEMBL.	9258353
Inhibition (binding)	= 10 %	Inhibition of Monoamine oxidase B (MAO B) in rat brain at 0.1 uM	ChEMBL.	9258353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL81619
PubChem: 10663142

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 131668