Detailed information for compound 1320066

Basic information

Technical information
  • TDR Targets ID: 1320066
  • Name: 5-ethyl-1-(1-phenylethyl)-1,3,5-triazinane-2- thione
  • MW: 249.375 | Formula: C13H19N3S
  • H donors: 0 H acceptors: 0 LogP: 2.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CN=C(N(C1)C(c1ccccc1)C)S
  • InChi: 1S/C13H19N3S/c1-3-15-9-14-13(17)16(10-15)11(2)12-7-5-4-6-8-12/h4-8,11H,3,9-10H2,1-2H3,(H,14,17)
  • InChiKey: OHZVZCBIKHMPBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000220139
  • STOCK3S-55303
  • EU-0082323
  • 5-Ethyl-1-(1-phenyl-ethyl)-[1,3,5]triazinane-2-thione
  • MLS000588173

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1502 0.9555 1
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0034 0.0174 0.0367
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0034 0.0174 0.0367
Echinococcus multilocularis carbonic anhydrase II 0.1288 0.8187 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0035 0.000000000091924
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0037 0.0038
Brugia malayi hypothetical protein 0.0101 0.0605 0.0739
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0122 0.0228
Brugia malayi steroid hormone receptor 0.0012 0.0037 0.0045
Schistosoma mansoni hypothetical protein 0.0036 0.0192 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0037 0.0045
Echinococcus granulosus carbonic anhydrase 0.0605 0.3823 0.467
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0101 0.0605 0.0576
Entamoeba histolytica hypothetical protein 0.0101 0.0605 0.0576
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0036 0.0192 0.0141
Echinococcus multilocularis carbonic anhydrase 0.0605 0.3823 0.467
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0036 0.0192 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0037 0.0045
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0035 0.0043
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0036 0.0192 0.0234
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0037 0.0038
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0036 0.0192 0.0135
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0144 0.0176
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0036 0.0192 0.0413
Schistosoma mansoni hypothetical protein 0.0605 0.3823 0.4001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0037 0.0045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0037 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0037 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0037 0.0045
Leishmania major arginine N-methyltransferase, type I 0.0036 0.0192 0.0141
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0144 0.0087
Brugia malayi ecdysteroid receptor 0.0012 0.0037 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0037 0.0045
Brugia malayi Protein arginine N-methyltransferase 0.0036 0.0192 0.0234
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0065 0.0372 0.0389
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0037 0.0038
Brugia malayi Carm1-pending protein 0.0036 0.0192 0.0234
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0035 0.5
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1288 0.8187 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0037 0.0045
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0101 0.0605 0.0673
Echinococcus granulosus carbonic anhydrase 0.0605 0.3823 0.467
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0037 0.0045
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0105 0.011
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0037 0.0045
Schistosoma mansoni carbonic anhydrase 0.0605 0.3823 0.4001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0043
Chlamydia trachomatis sulfate transporter 0.0034 0.0174 0.5
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.3823 0.467
Loa Loa (eye worm) carbonic anhydrase 3 0.1288 0.8187 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0174 0.0144
Echinococcus granulosus carbonic anhydrase II 0.1288 0.8187 1
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0036 0.0192 0.0165
Toxoplasma gondii bicoid-interacting protein BIN3 0.0036 0.0192 0.0413
Echinococcus granulosus methyltransferase protein 5 0.0036 0.0192 0.0234
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0037 0.0045
Leishmania major arginine N-methyltransferase-like protein 0.0065 0.0372 0.0331
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0037 0.0045
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0035 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0037 0.0038
Echinococcus granulosus protein arginine N methyltransferase 7 0.0036 0.0192 0.0234
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0065 0.0372 0.0389
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0037 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0037 0.0038
Schistosoma mansoni DNA helicase recq1 0.0012 0.0035 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0037 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0037 0.0045
Echinococcus granulosus bloom syndrome protein 0.0029 0.0144 0.0176
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1288 0.8187 0.8568
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0037 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0083 0.0125
Toxoplasma gondii hypothetical protein 0.0605 0.3823 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0037 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0037 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0037 0.0038
Echinococcus multilocularis carbonic anhydrase 0.0605 0.3823 0.467
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0036 0.0192 0.0234
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0037 0.0045
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0036 0.0192 0.0135
Loa Loa (eye worm) hypothetical protein 0.0101 0.0605 0.0739
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0036 0.0192 0.0165
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0037 0.0045
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0037 0.0038
Leishmania major carbonic anhydrase-like protein 0.1288 0.8187 0.8559
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Plasmodium vivax sulfate transporter, putative 0.0034 0.0174 0.3138
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.3823 0.467
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0035 0.0043
Echinococcus multilocularis carbonic anhydrase 0.0605 0.3823 0.467
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0037 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0037 0.0045
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0101 0.0605 0.0673
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0174 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Schistosoma mansoni DNA helicase recq5 0.0012 0.0035 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.1218 0.7744 0.9459
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0037 0.0045
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0036 0.0192 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0037 0.0045
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0036 0.0192 0.0234
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0101 0.0605 0.0673
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0605 0.3823 0.467
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1288 0.8187 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0037 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0037 0.0045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1288 0.8187 0.8568
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0036 0.0192 0.0141
Mycobacterium ulcerans carbonic anhydrase 0.1502 0.9555 0.9547
Onchocerca volvulus 0.0212 0.1312 1
Echinococcus granulosus carbonic anhydrase 0.0605 0.3823 0.467
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0065 0.0372 0.0316
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0144 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0037 0.0045
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0036 0.0192 0.0413
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0605 0.3823 0.467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0037 0.0045
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0065 0.0372 0.0889
Plasmodium falciparum carbonic anhydrase 0.0605 0.3823 1
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0036 0.0192 0.0165
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.3823 0.4001
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.3823 0.4001
Schistosoma mansoni carbonic anhydrase 0.1502 0.9555 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0037 0.0045
Leishmania major carbonic anhydrase family protein, putative 0.1502 0.9555 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0065 0.0372 1
Trichomonas vaginalis conserved hypothetical protein 0.1572 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1288 0.8187 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0037 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0037 0.0045
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0144 0.0087
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1288 0.8187 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0037 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0037 0.0045
Trypanosoma brucei carbonic anhydrase-like protein 0.1288 0.8187 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0045
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0036 0.0192 0.0234
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0036 0.0192 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0037 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0037 0.0045
Loa Loa (eye worm) RecQ helicase 0.0029 0.0144 0.0176
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.3823 0.4001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0037 0.0045
Schistosoma mansoni protein arginine n-methyltransferase 0.0036 0.0192 0.0201
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0035 0.0043
Loa Loa (eye worm) hypothetical protein 0.0605 0.3823 0.467
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0037 0.0045
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.3823 0.467
Schistosoma mansoni coup transcription factor 0.0012 0.0037 0.0038
Loa Loa (eye worm) Carm1-pending protein 0.0036 0.0192 0.0234
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0174 0.0144
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0065 0.0372 0.0455
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1288 0.8187 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0037 0.0045
Onchocerca volvulus Putative sulfate transporter 0.0212 0.1312 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0035 0.0043
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0065 0.0372 0.0316
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0807 0.5116 0.7358
Loa Loa (eye worm) hypothetical protein 0.0146 0.0891 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.1572 1 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0037 0.0045
Echinococcus granulosus protein arginine N methyltransferase 8 0.0065 0.0372 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0037 0.0045
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0939 0.5962 0.9089
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.3823 0.467
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1009 0.6406 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0065 0.0372 0.0316
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.3823 0.467
Entamoeba histolytica carbonic anhydrase, putative 0.1502 0.9555 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0035 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0037 0.0045
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0037 0.0038
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0035 0.0043
Brugia malayi nuclear hormone receptor 0.0012 0.0037 0.0045
Echinococcus multilocularis protein arginine methyltransferase 0.0065 0.0372 0.0455
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0037 0.0045
Echinococcus granulosus protein arginine methyltransferase 0.0065 0.0372 0.0455
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0065 0.0372 0.0389
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0065 0.0372 0.0889

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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