Detailed information for compound 1326462

Basic information

Technical information
  • TDR Targets ID: 1326462
  • Name: 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hy droxypropyl]-4-(4-hydroxyphenyl)azetidin-2-on e
  • MW: 409.425 | Formula: C24H21F2NO3
  • H donors: 2 H acceptors: 3 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C1C(CCC(c2ccc(cc2)F)O)C(=O)N1c1ccc(cc1)F
  • InChi: 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2
  • InChiKey: OLNTVTPDXPETLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)azetidin-2-one
  • 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
  • NCGC00095134-01
  • NCGC00095134-02

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0049 0.0371 0.0599
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0371 0.0572
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0248 0.0379
Schistosoma mansoni hypothetical protein 0.0086 0.0771 0.0764
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0371 0.0572
Leishmania major hypothetical protein, conserved 0.0023 0.0085 0.0964
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.007 0.0099
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.1576 0.2468
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.007 0.0125
Brugia malayi intermediate filament protein 0.0033 0.0191 0.0341
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Brugia malayi hypothetical protein 0.0535 0.5608 1
Echinococcus multilocularis c src tyrosine kinase 0.0026 0.0116 0.017
Echinococcus multilocularis serotonin receptor 0.0049 0.0371 0.0572
Schistosoma mansoni caspase-3 (C14 family) 0.0123 0.1163 0.1156
Schistosoma mansoni histamine h1 receptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.007 0.0125
Echinococcus granulosus ribonuclease H1 0.0023 0.0088 0.0127
Echinococcus granulosus neuropeptide receptor A26 0.0605 0.6362 1
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0088 0.5
Brugia malayi AKH receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0028 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0371 0.0572
Trypanosoma cruzi metacaspase, putative 0.0046 0.034 0.3862
Loa Loa (eye worm) hypothetical protein 0.0109 0.1017 0.1813
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0371 0.0572
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0371 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0573 0.1699
Brugia malayi G-protein coupled receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0371 0.0661
Giardia lamblia Kinase, PLK 0.0097 0.0881 0.2774
Echinococcus multilocularis geminin 0.0205 0.2047 0.3209
Schistosoma mansoni hypothetical protein 0.0043 0.0306 0.0299
Brugia malayi Sex muscle abnormal protein 5 0.0022 0.0081 0.0145
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0081 0.0145
Brugia malayi Troponin I 0.0109 0.1017 0.1813
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0527 0.5978
Trypanosoma cruzi metacaspase, putative 0.0046 0.034 0.3862
Echinococcus multilocularis tyrosine protein kinase Srms 0.0102 0.0944 0.1473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.5608 1
Brugia malayi jmjC domain containing protein 0.01 0.092 0.164
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.007 0.0125
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni jumonji domain containing protein 0.008 0.0698 0.0691
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0135 0.13 0.2266
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Brugia malayi RNase H family protein 0.0023 0.0088 0.0157
Entamoeba histolytica protein kinase, putative 0.0091 0.0821 0.2125
Schistosoma mansoni hypothetical protein 0.0038 0.0248 0.0241
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus 0.0049 0.0371 0.0599
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.119 0.2122
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0371 0.0572
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0371 0.0572
Onchocerca volvulus Alhambra homolog 0.0031 0.017 0.0238
Schistosoma mansoni hypothetical protein 0.006 0.0491 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0881 0.0874
Onchocerca volvulus 0.0049 0.0371 0.0599
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0527 0.052
Trypanosoma cruzi metacaspase, putative 0.0046 0.034 0.3862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Echinococcus multilocularis Protein lozenge 0.0067 0.0563 0.0875
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus 0.0049 0.0371 0.0599
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Brugia malayi MH2 domain containing protein 0.0125 0.119 0.2122
Schistosoma mansoni troponin I 0.0109 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0123 0.1163 0.1818
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2945 1
Onchocerca volvulus 0.0033 0.0191 0.0276
Plasmodium vivax metacaspase 1, putative 0.0046 0.034 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0371 0.0572
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni neuropeptide receptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.007 0.0099
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0371 0.0364
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0881 0.157
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0085 0.0964
Echinococcus granulosus tyrosine protein kinase HCK 0.0091 0.0821 0.1281
Echinococcus granulosus neuropeptide s receptor 0.0605 0.6362 1
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0371 0.0661
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.007 0.0063
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.034 0.5747
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0371 0.0572
Onchocerca volvulus Troponin I homolog 0.0109 0.1017 0.1758
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.007 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus 0.0049 0.0371 0.0599
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.2945 1
Schistosoma mansoni tsg101-related 0.0059 0.0478 0.0471
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0371 0.0599
Schistosoma mansoni biogenic amine receptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.0302
Loa Loa (eye worm) hypothetical protein 0.0049 0.0369 0.0659
Echinococcus granulosus g protein coupled receptor 0.0049 0.0371 0.0572
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0028 0.005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.007 0.0125
Echinococcus granulosus sex peptide receptor 0.0049 0.0371 0.0572
Brugia malayi RNase H family protein 0.0023 0.0088 0.0157
Echinococcus multilocularis caspase 0.0123 0.1163 0.1818
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0371 0.0364
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0154 0.1505 0.2683
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0299 0.0458
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0299 0.0458
Schistosoma mansoni thyroid hormone receptor 0.0021 0.007 0.0063
Onchocerca volvulus 0.0049 0.0371 0.0599
Brugia malayi Cell death protein 3 precursor 0.009 0.0806 0.1437
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.092 0.1436
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Echinococcus granulosus tyrosine protein kinase Blk 0.0102 0.0944 0.1473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0113 0.1063 0.1661
Schistosoma mansoni lamin 0.0033 0.0191 0.0184
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.007 0.0125
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.007 0.0059
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Brugia malayi larval opioid receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus 0.0049 0.0371 0.0599
Onchocerca volvulus 0.0033 0.0191 0.0276
Brugia malayi PHD-finger family protein 0.0031 0.017 0.0302
Schistosoma mansoni nck2/grb4 0.0022 0.0081 0.0074
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0371 0.0661
Echinococcus granulosus c src tyrosine kinase 0.0026 0.0116 0.017
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0109 0.1241
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0009 0.0003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.017 0.0255
Brugia malayi RNase H family protein 0.0023 0.0088 0.0157
Schistosoma mansoni lamin 0.0033 0.0191 0.0184
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0371 0.0572
Schistosoma mansoni neuropeptide receptor 0.0049 0.0371 0.0364
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0007 0.0013
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0371 0.0364
Brugia malayi Melatonin receptor type 1A 0.0049 0.0371 0.0661
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0081 0.0145
Brugia malayi ORL1-like opioid receptor 0.0049 0.0371 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0113 0.1063 0.1661
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Schistosoma mansoni hypothetical protein 0.0205 0.2047 0.2041
Brugia malayi DnaJ domain containing protein 0.006 0.0491 0.0875
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0081 0.0074
Brugia malayi jmjC domain containing protein 0.0037 0.0239 0.0426
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0371 0.0364
Brugia malayi SRC-1 0.0113 0.1063 0.1895
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0881 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus granulosus g protein coupled receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0032 0.0185 0.0329
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0081 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.007 0.0063
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0371 0.0364
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0371 0.0364
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0582 0.6117 1
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0088 0.1001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.034 0.5747
Plasmodium vivax hypothetical protein, conserved 0.0046 0.034 1
Echinococcus multilocularis neuropeptide s receptor 0.0605 0.6362 1
Onchocerca volvulus 0.0049 0.0371 0.0599
Echinococcus multilocularis caspase 2 0.009 0.0806 0.1257
Schistosoma mansoni amine GPCR 0.0049 0.0371 0.0364
Brugia malayi Niemann-Pick C1 protein precursor 0.0093 0.0842 0.1502
Brugia malayi Serotonin receptor 0.0049 0.0371 0.0661
Echinococcus granulosus tyrosine protein kinase Src42A 0.0113 0.1063 0.1661
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.007 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.007 0.0059
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0371 0.0572
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0248 0.0241
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0364
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1357 0.2218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.007 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0371 0.0572
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0009 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.007 0.0125
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0371 0.0572
Schistosoma mansoni phosphoglucomutase 0.0023 0.0088 0.0081
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Schistosoma mansoni adapter molecule crk 0.0022 0.0081 0.0074
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.1576 0.2468
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Brugia malayi sulfakinin receptor protein 0.0049 0.0371 0.0661
Schistosoma mansoni tyrosine kinase 0.0113 0.1063 0.1056
Loa Loa (eye worm) TK protein kinase 0.0102 0.0944 0.1683
Plasmodium falciparum metacaspase-like protein 0.0046 0.034 1
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0371 0.0572
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) troponin T 0.0065 0.0538 0.0959
Echinococcus granulosus g protein coupled receptor 0.0049 0.0371 0.0572
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0371 0.0364
Brugia malayi hypothetical protein 0.0043 0.0306 0.0545
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0371 0.0364
Onchocerca volvulus 0.0049 0.0371 0.0599
Brugia malayi CHE-14 protein 0.0068 0.0573 0.1023
Schistosoma mansoni thyroid hormone receptor 0.0021 0.007 0.0063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.017 0.0162
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0371 0.0572
Echinococcus granulosus lamin 0.0033 0.0191 0.0289
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0239 0.0364
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2945 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.007 0.0099
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0371 0.0661
Trichomonas vaginalis hypothetical protein 0.0035 0.0213 0.0437
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.017 0.0255
Echinococcus multilocularis protein patched 0.0068 0.0573 0.0891
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.007 0.0125
Schistosoma mansoni nuclear hormone receptor 0.0021 0.007 0.0063
Echinococcus granulosus geminin 0.0205 0.2047 0.3209
Schistosoma mansoni hypothetical protein 0.0109 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.007 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Brugia malayi hypothetical protein 0.0065 0.0538 0.0959
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0371 0.0572
Trypanosoma brucei ribonuclease H1 0.0023 0.0088 0.1001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.007 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.007 0.0125
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0881 0.2345
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0527 0.0861
Echinococcus multilocularis troponin i 0.0109 0.1017 0.1588
Schistosoma mansoni coup transcription factor 0.0021 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.0806 0.138
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0881 0.157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Echinococcus granulosus troponin i 0.0109 0.1017 0.1588
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0109 0.1017 0.1813
Schistosoma mansoni troponin I 0.0109 0.1017 0.101
Schistosoma mansoni opsin-like receptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0491 0.0875
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0371 0.0572
Schistosoma mansoni patched 1 0.0068 0.0573 0.0566
Brugia malayi protein-tyrosine kinase 0.0102 0.0944 0.1683
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0093 0.0842 0.1502
Schistosoma mansoni biogenic amine receptor 0.0049 0.0371 0.0364
Brugia malayi RE15519p 0.0049 0.0371 0.0661
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0371 0.0572
Loa Loa (eye worm) TK protein kinase 0.0091 0.0821 0.1465
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0123 0.1163 0.1818
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0102 0.0944 0.1473
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0573 0.0891
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Schistosoma mansoni phosphoglucomutase 0.0023 0.0088 0.0081
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0527 0.0817
Echinococcus granulosus peregrin 0.0031 0.017 0.0255
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0527 0.0861
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0191 0.0341
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Giardia lamblia PHD finger protein 15 0.0031 0.017 0.0285
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0007 0.0013
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0371 0.0572
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Echinococcus granulosus lamin dm0 0.0033 0.0191 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Loa Loa (eye worm) troponin 0.0065 0.0538 0.0959
Echinococcus multilocularis lamin dm0 0.0033 0.0191 0.0289
Trypanosoma brucei metacaspase 5, putative 0.0046 0.034 0.3862
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0582 0.6117 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0371 0.0364
Brugia malayi Troponin family protein 0.0109 0.1017 0.1813
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0371 0.0572
Brugia malayi ecdysteroid receptor 0.0021 0.007 0.0125
Brugia malayi putative neuropeptide receptor 0.0049 0.0371 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Brugia malayi Dopamine receptor protein 2 0.0049 0.0371 0.0661
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.007 0.0125
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2945 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.007 0.0125
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0606 0.0942
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0202 0.036
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0026 0.0116 0.017
Echinococcus granulosus intermediate filament protein 0.0033 0.0191 0.0289
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.007 0.0125
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0371 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.007 0.0125
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Loa Loa (eye worm) hypothetical protein 0.0033 0.0191 0.0341
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.007 0.0099
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0371 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Echinococcus multilocularis protein dispatched 1 0.0078 0.0677 0.1054
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0371 0.0572
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0239 0.0232
Echinococcus granulosus tyrosine kinase 0.0102 0.0944 0.1473
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Echinococcus multilocularis tyrosine protein kinase Abl 0.0026 0.0116 0.017
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0364
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.119 0.2122
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Brugia malayi Dopamine receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Echinococcus multilocularis ribonuclease H1 0.0023 0.0088 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.007 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Brugia malayi nuclear receptor NHR-88 0.0021 0.007 0.0125
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0065 0.0538 0.0899
Onchocerca volvulus 0.0049 0.0371 0.0599
Echinococcus granulosus caspase 0.0123 0.1163 0.1818
Brugia malayi Bromodomain containing protein 0.0031 0.017 0.0302
Trypanosoma brucei RNA helicase, putative 0.0086 0.0771 0.8756
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis tyrosine protein kinase HCK 0.0091 0.0821 0.1281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0371 0.0572
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0306 0.047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.007 0.0099
Echinococcus granulosus caspase 3 0.0076 0.0662 0.1031
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0371 0.0572
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0371 0.0572
Onchocerca volvulus 0.0021 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0083 0.0739 0.1317
Echinococcus multilocularis somatostatin receptor 0.0049 0.0371 0.0572
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0191 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Schistosoma mansoni opsin-like receptor 0.0049 0.0371 0.0364
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0026 0.0116 0.017
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0491 0.076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0881 0.1374
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0369 0.0659
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0239 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0355 0.0934
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.007 0.0099
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0371 0.0661
Brugia malayi neuropeptide F receptor 0.0049 0.0371 0.0661
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.034 0.3862
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Schistosoma mansoni hypothetical protein 0.0034 0.0202 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0052 0.0405 0.0722
Schistosoma mansoni kinase 0.0049 0.0369 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0017
Brugia malayi nuclear hormone receptor 0.0021 0.007 0.0125
Loa Loa (eye worm) hypothetical protein 0.0046 0.034 0.0606
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0043 0.0306 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.007 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0371 0.0572
Echinococcus multilocularis lamin 0.0033 0.0191 0.0289
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0491 0.1409
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0116 0.0108
Echinococcus granulosus tyrosine protein kinase Src42A 0.0099 0.0909 0.1419
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.007 0.0099
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0371 0.0364
Onchocerca volvulus 0.0049 0.0371 0.0599
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0371 0.0572
Onchocerca volvulus 0.0049 0.0371 0.0599
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0527 0.0861
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.034 0.5747
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0371 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Plasmodium falciparum metacaspase 1 0.0046 0.034 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0606 0.0942
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0113 0.1063 0.1661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Trypanosoma brucei polo-like protein kinase 0.0097 0.0881 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.007 0.0125
Echinococcus multilocularis caspase 3 0.0076 0.0662 0.1031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0371 0.0661
Onchocerca volvulus 0.0043 0.0306 0.0482
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0113 0.1063 0.1661
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0113 0.1063 0.1661
Echinococcus multilocularis serotonin receptor 0.0049 0.0371 0.0572
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Echinococcus granulosus Niemann Pick C1 protein 0.0093 0.0842 0.1314
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0081 0.0145
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0306 0.047
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0527 0.052
Echinococcus multilocularis peregrin 0.0031 0.017 0.0255
Echinococcus granulosus neuropeptide receptor 0.0049 0.0371 0.0572
Echinococcus granulosus expressed conserved protein 0.0083 0.0739 0.1151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.007 0.0125
Echinococcus granulosus hypothetical protein 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni troponin I 0.0109 0.1017 0.101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0239 0.0426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.007 0.0063
Echinococcus granulosus FTZ F1 alpha 0.0021 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0521 0.0928
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.017 0.1856
Echinococcus granulosus allatostatin A receptor 0.0049 0.0371 0.0572
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.092 0.1436
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0109 0.1241
Onchocerca volvulus 0.0049 0.0371 0.0599
Schistosoma mansoni tyrosine kinase 0.0026 0.0116 0.0108
Brugia malayi Tyrosine-protein kinase abl-1 0.0026 0.0116 0.0206
Schistosoma mansoni biogenic amine receptor 0.0049 0.0371 0.0364
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0582 0.6117 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0371 0.0364
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0535 0.5608 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0113 0.1063 0.1661
Schistosoma mansoni intermediate filament proteins 0.0033 0.0191 0.0184
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.007 0.0125
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0573 0.0891
Brugia malayi hypothetical protein 0.0038 0.0248 0.0443
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0371 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Schistosoma mansoni neuropeptide receptor 0.0049 0.0371 0.0364
Trypanosoma brucei metacaspase MCA2 0.0046 0.034 0.3862
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0881 0.1374
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0371 0.0661
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.034 0.3862
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0944 0.1473
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0371 0.0364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Onchocerca volvulus 0.0049 0.0371 0.0599
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0364
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0088 0.0092
Echinococcus granulosus caspase 8 0.0046 0.034 0.0524
Trypanosoma brucei unspecified product 0.0025 0.0109 0.1241
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0239 0.0232
Trypanosoma cruzi metacaspase, putative 0.0046 0.034 0.3862
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.017 0.1856
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0371 0.0572
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0099 0.0909 0.1419
Loa Loa (eye worm) SRC-1 0.0113 0.1063 0.1895
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis neuropeptide receptor A26 0.0605 0.6362 1
Brugia malayi hypothetical protein 0.0154 0.1505 0.2683
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.007 0.0099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0371 0.0661
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0371 0.0572
Onchocerca volvulus 0.0049 0.0371 0.0599
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0135 0.13 0.2034
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus granulosus tyrosine protein kinase Lyn 0.0114 0.1066 0.1666
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0371 0.0661
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0881 0.2774
Echinococcus multilocularis NCK adaptor protein 0.0022 0.0081 0.0116
Echinococcus multilocularis musashi 0.0033 0.0191 0.0289
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.007 0.0059
Brugia malayi hypothetical protein 0.0071 0.0606 0.1081
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0371 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0007 0.0013
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0371 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.007 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2945 1
Echinococcus granulosus oncosphere protein Tso22e 0.0135 0.13 0.2034
Schistosoma mansoni adenoreceptor 0.0049 0.0371 0.0364
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0371 0.0661
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0109 0.1241
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.007 0.0063
Schistosoma mansoni amine GPCR 0.0049 0.0371 0.0364
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0371 0.0572
Schistosoma mansoni tsg101-related 0.0059 0.0478 0.0471
Brugia malayi Troponin T 0.0065 0.0538 0.0959
Brugia malayi neuropeptide F receptor 0.0049 0.0371 0.0661
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0371 0.0572
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.007 0.0099
Onchocerca volvulus 0.0049 0.0371 0.0599
Schistosoma mansoni neuropeptide receptor 0.0049 0.0371 0.0364
Brugia malayi G-protein coupled receptor 0.0049 0.0371 0.0661
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0371 0.0572
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0081 0.0116
Echinococcus granulosus fmrfamide receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0191 0.0341
Brugia malayi Dopamine receptor protein 1 0.0049 0.0371 0.0661
Schistosoma mansoni tyrosine kinase 0.0026 0.0116 0.0108
Echinococcus multilocularis expressed conserved protein 0.0083 0.0739 0.1151
Schistosoma mansoni amine GPCR 0.0049 0.0371 0.0364
Schistosoma mansoni opsin-like receptor 0.0049 0.0371 0.0364
Onchocerca volvulus 0.0535 0.5608 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.007 0.0099
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0371 0.0572
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.034 0.0333
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni lozenge 0.0067 0.0563 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.007 0.0125
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0085 0.0964
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0369 0.0659
Trypanosoma brucei metacaspase MCA3 0.0046 0.034 0.3862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.007 0.0125
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.017 0.0302
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0573 0.1023
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.1163 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.1063 0.1661
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0068 0.0573 0.1023
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0573 0.0891
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.007 0.0099
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0361 0.0418
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Schistosoma mansoni tyrosine kinase 0.0113 0.1063 0.1056
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.007 0.0099
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0371 0.0572
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0248 0.0379
Loa Loa (eye worm) hypothetical protein 0.0065 0.0538 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.007 0.0125
Loa Loa (eye worm) troponin I 0.0109 0.1017 0.1813
Echinococcus granulosus tyrosine protein kinase Src64B 0.0113 0.1063 0.1661
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.034 0.0606
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0088 0.1001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Loa Loa (eye worm) hypothetical protein 0.0071 0.0606 0.1081
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni hypothetical protein 0.0205 0.2047 0.2041
Echinococcus granulosus growth factor receptor bound protein 2 0.0022 0.0081 0.0116
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0371 0.0661
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0371 0.0572
Loa Loa (eye worm) hypothetical protein 0.0034 0.0202 0.036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.034 0.0882
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0371 0.0572
Echinococcus granulosus neuropeptide receptor 0.0049 0.0371 0.0572
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0364
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0371 0.0572
Brugia malayi Troponin T 0.0065 0.0538 0.0959
Echinococcus granulosus orexin receptor type 2 0.0049 0.0371 0.0572
Brugia malayi hypothetical protein 0.0049 0.0371 0.0661
Trypanosoma brucei Metacaspase-4 0.0046 0.034 0.3862
Echinococcus granulosus somatostatin receptor 0.0049 0.0371 0.0572
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0371 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0355 0.0934
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0371 0.0572
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0371 0.0572
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.0806 0.0799
Echinococcus multilocularis Niemann Pick C1 protein 0.0093 0.0842 0.1314
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0371 0.0572
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0145
Schistosoma mansoni troponin t invertebrate 0.0135 0.13 0.1293
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Schistosoma mansoni troponin I 0.0109 0.1017 0.101
Brugia malayi G protein-coupled receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.009 0.0806 0.1437
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0113 0.1063 0.1661
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1357 0.1485
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.034 0.0882
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.007 0.0099
Leishmania major ribonuclease H1, putative 0.0023 0.0088 0.1001
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0371 0.0572
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0113 0.1063 0.1661
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0371 0.0364
Echinococcus multilocularis caspase 8 0.0046 0.034 0.0524
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0369 0.0659
Brugia malayi Serotonin receptor 0.0049 0.0371 0.0661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0371 0.0661
Echinococcus multilocularis sex peptide receptor 0.0049 0.0371 0.0572
Trypanosoma brucei metacaspase 0.0046 0.034 0.3862
Echinococcus multilocularis tyrosine protein kinase Blk 0.0102 0.0944 0.1473
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.007 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0371 0.0572
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0881 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.007 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0371 0.0364
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Schistosoma mansoni amine GPCR 0.0049 0.0371 0.0364
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0371 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.007 0.0125
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0527 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0371 0.0661
Schistosoma mansoni tsg101-related 0.0048 0.0361 0.0354
Loa Loa (eye worm) runx1 0.0067 0.0563 0.1005
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0109 0.1241
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.007 0.0063
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0161 0.1576 0.157
Onchocerca volvulus 0.0049 0.0371 0.0599
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0881 0.1514
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0371 0.0572
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0371 0.0364
Echinococcus granulosus serotonin receptor 0.0049 0.0371 0.0572
Echinococcus granulosus caspase 2 0.009 0.0806 0.1257
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0037 0.0066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0371 0.0572
Schistosoma mansoni phosphoglucomutase 0.0023 0.0088 0.0081
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0491 0.076
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0371 0.0364
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0093 0.0842 0.2202
Brugia malayi GnHR receptor homolog 0.0049 0.0371 0.0661
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0371 0.0572
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0081 0.0074
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0371 0.0364
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0081 0.0145
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0371 0.0572
Onchocerca volvulus 0.0154 0.1505 0.2635
Brugia malayi Troponin T 0.0065 0.0538 0.0959
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0527 0.0817
Leishmania major metacaspase, putative 0.0046 0.034 0.3862
Echinococcus granulosus NCK adaptor protein 0.0022 0.0081 0.0116
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Brugia malayi steroid hormone receptor 0.0021 0.007 0.0125
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0661
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0371 0.0599
Schistosoma mansoni myosin xvIII 0.0049 0.0371 0.0364
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0371 0.0572

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0056 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 13.3359 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.7851 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1477, AID1484] ChEMBL. No reference
Potency (functional) 25.0177 uM PubChem BioAssay. qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.1968 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.