Detailed information for compound 1327847

Basic information

Technical information
  • TDR Targets ID: 1327847
  • Name: 8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazol o[4,3-a][1,4]benzodiazepine
  • MW: 329.183 | Formula: C16H10Cl2N4
  • H donors: 0 H acceptors: 2 LogP: 3.46 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(=NCc1n2cnn1)c1ccccc1Cl
  • InChi: 1S/C16H10Cl2N4/c17-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)18)19-8-15-21-20-9-22(14)15/h1-7,9H,8H2
  • InChiKey: BDQFWTZESHZRGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • AE-641/00613051
  • ZINC00346674
  • SMR000113869
  • MLS000546747

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0198 1 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0029 0.0359 0.5328
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0035 0.0674 0.0674
Brugia malayi hypothetical protein 0.0035 0.0685 0.0685
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0029 0.0359 0.5328
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.132 0.132
Schistosoma mansoni tar DNA-binding protein 0.0198 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1772 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0674 1
Brugia malayi MH2 domain containing protein 0.0119 0.5475 0.5475
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0035 0.0674 0.3804
Plasmodium vivax RNA helicase-1, putative 0.0029 0.0359 0.2027
Mycobacterium tuberculosis Conserved protein 0.0035 0.0674 0.1082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.132 0.132
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0035 0.0674 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0522 0.0522
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0029 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0179 0.8896 0.8896
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0029 0.0359 0.5328
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0035 0.0674 0.3804
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0029 0.0359 0.0359
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Echinococcus multilocularis ETHE1 protein 0.0035 0.0674 0.0674
Trypanosoma brucei glyoxalase II 0.0035 0.0674 0.2907
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.132 0.132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0522 0.0522
Trypanosoma brucei beta lactamase 0.0063 0.2318 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0101 0.4443 0.4443
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0081 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0198 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.5475 0.5475
Brugia malayi metallo-beta-lactamase superfamily protein 0.0035 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0174 0.8639 0.8639
Brugia malayi RNA recognition motif domain containing protein 0.0198 1 1
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0035 0.0674 0.3804
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0674 0.1082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.132 0.132
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0035 0.0674 0.3804
Echinococcus granulosus geminin 0.0174 0.8639 0.8639
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.132 0.132
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.1772 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0674 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.132 0.132
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0522
Brugia malayi ethe1-prov protein 0.0035 0.0674 0.0674
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0035 0.0674 0.3804
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0035 0.0674 0.0674
Leishmania major hypothetical protein, conserved 0.0035 0.0674 0.3804
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.5475 0.5475
Mycobacterium ulcerans hypothetical protein 0.0035 0.0674 0.1082
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0132 0.6231 1
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0035 0.0674 0.2907
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0035 0.0674 0.0674
Entamoeba histolytica type A flavoprotein, putative 0.0035 0.0674 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0029 0.0359 0.2027
Mycobacterium ulcerans hydrolase 0.0035 0.0674 0.1082
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0674 1
Schistosoma mansoni hypothetical protein 0.0035 0.0674 0.0674
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 1 1
Onchocerca volvulus 0.0035 0.0674 0.0369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0522 0.0522
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.8896 1
Treponema pallidum ribonuclease Z 0.0035 0.0674 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0035 0.0674 0.0674
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0035 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0069 0.2628 0.2628
Loa Loa (eye worm) hypothetical protein 0.0032 0.0522 0.0522
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0035 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0522
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0029 0.0359 0.0359
Echinococcus multilocularis geminin 0.0174 0.8639 0.8639
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0029 0.0359 0.0576
Mycobacterium tuberculosis Possible hydrolase 0.0035 0.0674 0.1082
Mycobacterium ulcerans beta lactamase-like protein 0.0035 0.0674 0.1082
Loa Loa (eye worm) RNA binding protein 0.0198 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0522 0.0522
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0674 0.1082
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1772 1
Brugia malayi eukaryotic initiation factor 4A 0.0029 0.0359 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0035 0.0674 0.2907
Chlamydia trachomatis ribonuclease Z 0.0035 0.0674 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0674 1
Schistosoma mansoni hypothetical protein 0.0024 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0035 0.0674 0.0674
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0035 0.0674 0.0674
Trichomonas vaginalis apoptosis inducing factor, putative 0.0035 0.0674 1
Loa Loa (eye worm) TAR-binding protein 0.0198 1 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0063 0.2318 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0674 0.0674
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0081 0.0081
Trypanosoma cruzi glyoxalase II 0.0035 0.0674 0.3804
Echinococcus granulosus GPCR family 2 0.0032 0.0522 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.132 0.132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0674 0.1082
Schistosoma mansoni hypothetical protein 0.0174 0.8639 0.8639
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.1772 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.132 0.132
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0522
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0035 0.0674 0.0674
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0029 0.0359 0.2027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.4443 0.4443
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0035 0.0674 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0029 0.0359 0.1549
Schistosoma mansoni tar DNA-binding protein 0.0198 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1772 0.1772
Trichomonas vaginalis A-type flavoprotein 0.0035 0.0674 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0035 0.0674 0.0674
Mycobacterium tuberculosis Conserved protein 0.0035 0.0674 0.1082
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0035 0.0674 1
Mycobacterium ulcerans hydrolase 0.0035 0.0674 0.1082
Mycobacterium ulcerans hypothetical protein 0.0035 0.0674 0.1082
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0035 0.0674 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0029 0.0359 0.2027
Onchocerca volvulus Putative hydrolase PNKD 0.0035 0.0674 0.0369
Brugia malayi N-terminal motif family protein 0.0179 0.8896 0.8896
Entamoeba histolytica alkyl sulfatase, putative 0.0035 0.0674 1
Onchocerca volvulus 0.0035 0.0674 0.0369
Trypanosoma cruzi glyoxalase II 0.0035 0.0674 0.3804
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0035 0.0674 0.0674
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0522 0.0522
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.2628 0.2628
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0674 1
Brugia malayi hypothetical protein 0.0054 0.1772 0.1772
Mycobacterium tuberculosis Possible hydrolase 0.0035 0.0674 0.1082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0522 0.0522
Mycobacterium tuberculosis Conserved protein 0.0035 0.0674 0.1082
Schistosoma mansoni zinc phosphodiesterase 0.0035 0.0674 0.0674
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0029 0.0359 0.0359
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1772 1
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0035 0.0674 0.3804
Echinococcus granulosus tar DNA binding protein 0.0198 1 1
Echinococcus granulosus zinc phosphodiesterase 0.0035 0.0674 0.0674
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0029 0.0359 0.2027
Echinococcus granulosus ETHE1 protein 0.0035 0.0674 0.0674
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0674 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1772 1
Mycobacterium tuberculosis Beta lactamase like protein 0.0035 0.0674 0.1082
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0029 0.0359 0.5328
Schistosoma mansoni hypothetical protein 0.0035 0.0674 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Leishmania major metallo-beta-lactamase family protein-like protein 0.0035 0.0674 0.3804
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0522
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0132 0.6231 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0674 1
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0035 0.0674 0.3804
Echinococcus multilocularis zinc phosphodiesterase 0.0035 0.0674 0.0674
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0063 0.2318 0.3721
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0035 0.0674 0.3804
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.1772 0.7641
Loa Loa (eye worm) hypothetical protein 0.0035 0.0674 0.0674
Mycobacterium ulcerans hydrolase 0.0035 0.0674 0.1082
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0674 1
Brugia malayi hypothetical protein 0.0035 0.0674 0.0674
Leishmania major eukaryotic initiation factor 4a, putative 0.0029 0.0359 0.2027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0359 0.0359
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0029 0.0359 0.0359
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0029 0.0359 0.2027
Plasmodium vivax unspecified product 0.0035 0.0674 0.3804
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0035 0.0674 0.0369
Leishmania major metallo-beta-lactamase family-like protein 0.0035 0.0674 0.3804
Schistosoma mansoni hypothetical protein 0.0069 0.2628 0.2628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0674 0.0674
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0035 0.0674 0.3804
Trypanosoma cruzi glyoxalase II 0.0035 0.0674 0.3804
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0035 0.0674 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0029 0.0359 0.5328
Mycobacterium ulcerans glyoxalase II, GloB 0.0035 0.0674 0.1082
Brugia malayi TAR-binding protein 0.0198 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.4443 0.4443
Treponema pallidum ATP-dependent RNA helicase 0.0029 0.0359 0.5328
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.4443 0.4443
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0035 0.0674 1
Schistosoma mansoni tar DNA-binding protein 0.0198 1 1
Schistosoma mansoni tar DNA-binding protein 0.0198 1 1
Leishmania major hypothetical protein, conserved 0.0054 0.1772 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0674 0.1082
Entamoeba histolytica type A flavoprotein, putative 0.0035 0.0674 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0035 0.0674 0.0674
Schistosoma mansoni zinc phosphodiesterase 0.0035 0.0674 0.0674
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0035 0.0674 1
Plasmodium falciparum cytosolic glyoxalase II 0.0035 0.0674 0.3804
Mycobacterium ulcerans hypothetical protein 0.0035 0.0674 0.1082
Mycobacterium ulcerans lipoprotein LpqF 0.0063 0.2318 0.3721
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0035 0.0674 0.2907
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0035 0.0674 0.3804
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.132 0.132
Echinococcus granulosus eukaryotic initiation factor 4A 0.0029 0.0359 0.0359
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0522 0.0522
Entamoeba histolytica alkyl sulfatase, putative 0.0035 0.0674 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0035 0.0674 0.3804
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0035 0.0674 0.1082

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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