Detailed information for compound 1327910

Basic information

Technical information
  • TDR Targets ID: 1327910
  • Name: (5Z)-5-[(1,2-dimethylindol-3-yl)methylidene]i midazolidine-2,4-dione
  • MW: 255.272 | Formula: C14H13N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.56 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)/C(=C/c2c(C)n(c3c2cccc3)C)/N1
  • InChi: 1S/C14H13N3O2/c1-8-10(7-11-13(18)16-14(19)15-11)9-5-3-4-6-12(9)17(8)2/h3-7H,1-2H3,(H2,15,16,18,19)/b11-7-
  • InChiKey: IFIXUEROBQQWRK-XFFZJAGNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(1,2-dimethylindol-3-yl)methylidene]imidazolidine-2,4-dione
  • (5Z)-5-[(1,2-dimethylindol-3-yl)methylene]imidazolidine-2,4-dione
  • 5-[(1,2-dimethylindol-3-yl)methylene]imidazolidine-2,4-dione
  • 5-[(1,2-dimethyl-3-indolyl)methylene]imidazolidine-2,4-dione
  • (5Z)-5-[(1,2-dimethyl-3-indolyl)methylene]imidazolidine-2,4-dione
  • 5-[(1,2-dimethylindol-3-yl)methylene]hydantoin
  • (5Z)-5-[(1,2-dimethylindol-3-yl)methylene]hydantoin
  • 5-[(1,2-dimethyl-1H-indol-3-yl)methylene]-2,4-imidazolidinedione
  • MLS001180501
  • SMR000477447
  • ZINC02092483
  • STK009750

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0145 0.0358
Trichomonas vaginalis dexras1, putative 0.021 0.2786 0.6188
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0177 0.0397
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0549 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Schistosoma mansoni hypothetical protein 0.0727 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Loa Loa (eye worm) Ras protein let-60 0.021 0.2786 0.6248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0145 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0455 0.1327
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0455 0.0873
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0549 0.052
Toxoplasma gondii exonuclease III APE 0.0021 0.0145 0.1539
Onchocerca volvulus 0.0114 0.1435 0.3875
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0177 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0549 0.0547
Trypanosoma brucei unspecified product 0.0043 0.0444 0.1294
Schistosoma mansoni hypothetical protein 0.0039 0.0389 0.036
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0177 0.0175
Echinococcus granulosus dna polymerase eta 0.0043 0.0444 0.0442
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0549 0.0547
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0455 0.1016
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0217 0.0482
Onchocerca volvulus 0.0032 0.0297 0.0641
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0549 0.0547
Toxoplasma gondii hypothetical protein 0.0039 0.039 0.4836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0549 0.1228
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0725
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0242 0.3226 1
Schistosoma mansoni thyroid hormone receptor 0.005 0.0549 0.052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0455 0.0453
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0444 0.0415
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0217 0.0187
Echinococcus multilocularis cpg binding protein 0.0034 0.0323 0.0321
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0455 0.0453
Echinococcus multilocularis thioredoxin glutathione reductase 0.0031 0.0274 0.0272
Schistosoma mansoni coup transcription factor 0.005 0.0549 0.052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0549 0.0547
Leishmania major DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Brugia malayi ecdysone receptor 0.0024 0.0177 0.0397
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0217 0.0486
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.003 0.0268 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Brugia malayi hypothetical protein 0.0024 0.0177 0.0397
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0444 0.1294
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0069 0.0811 0.4496
Echinococcus multilocularis neuropeptide s receptor 0.0492 0.6725 0.6725
Brugia malayi Ras protein let-60 0.021 0.2786 0.6249
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0034 0.032 0.0906
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0325 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0525 0.0496
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0549 0.0547
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0444 0.0442
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0145 0.0371
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0444 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0549 0.1232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0525 0.0496
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0177 0.0397
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0774 0.1678
Echinococcus granulosus single minded 2 0.0029 0.0248 0.0246
Brugia malayi nuclear hormone receptor 0.005 0.0549 0.1232
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0212 0.0211
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0444 0.0996
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0444 0.1294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0455 0.1327
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Loa Loa (eye worm) hypothetical protein 0.0131 0.1672 0.3748
Trichomonas vaginalis set domain proteins, putative 0.0268 0.3589 0.8019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0177 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0549 0.1232
Entamoeba histolytica Ras family GTPase 0.021 0.2786 0.8913
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1488 0.3335
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0444 0.0934
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.1445 0.4426
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0077 0.0918 0.5224
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0177 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0549 0.1232
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0455 0.0873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0525 0.0496
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0774 0.0772
Brugia malayi glutaminase DH11.1 0.033 0.4458 1
Echinococcus multilocularis neuropeptide receptor A26 0.0492 0.6725 0.6725
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0069 0.0811 0.4496
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0774 0.0772
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0549 0.0547
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0177 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0177 0.0147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0549 0.052
Onchocerca volvulus 0.0268 0.3589 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0212 0.0462
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0145 0.0258
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0455 0.0873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0525 0.0523
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Loa Loa (eye worm) glutathione reductase 0.003 0.0268 0.0597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0525 0.0523
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0212 0.0473
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0268 0.0743
Echinococcus granulosus ras gtpase 0.021 0.2786 0.2785
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0444 0.1294
Schistosoma mansoni DNA polymerase eta 0.0043 0.0444 0.0415
Echinococcus multilocularis geminin 0.0727 1 1
Trichomonas vaginalis ras-dva small GTPase, putative 0.021 0.2786 0.6188
Schistosoma mansoni flap endonuclease-1 0.0024 0.0177 0.0147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0096 0.0216
Schistosoma mansoni alpha glucosidase 0.0044 0.0455 0.0425
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0455 0.0873
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.1445 0.4426
Brugia malayi MH2 domain containing protein 0.0118 0.1488 0.3338
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0034 0.032 0.0906
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0258 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0869
Mycobacterium ulcerans glutaminase 0.033 0.4458 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0549 0.1357
Trypanosoma brucei unspecified product 0.003 0.0258 0.0712
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0177 0.0397
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0525 0.1174
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0444 0.1294
Toxoplasma gondii thioredoxin reductase 0.003 0.0268 0.3196
Schistosoma mansoni hypothetical protein 0.0018 0.0096 0.0066
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0145 0.0321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0145 0.0358
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0774 0.0745
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0444 0.0849
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0482
Echinococcus granulosus neuropeptide receptor A26 0.0492 0.6725 0.6725
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0177 0.0175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0641 0.1438
Trichomonas vaginalis rap1 and, putative 0.021 0.2786 0.6188
Schistosoma mansoni single-minded 0.0039 0.0389 0.036
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0549 0.052
Loa Loa (eye worm) glutaminase 2 0.033 0.4458 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0482
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0455 0.102
Entamoeba histolytica ras-1, putative 0.021 0.2786 0.8913
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2594 0.5817
Brugia malayi Pre-SET motif family protein 0.0034 0.0325 0.0729
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0177 0.0147
Schistosoma mansoni nuclear hormone receptor 0.005 0.0549 0.052
Schistosoma mansoni glutaminase 0.033 0.4458 0.4442
Echinococcus granulosus FTZ F1 alpha 0.005 0.0549 0.0547
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Brugia malayi tailless protein 0.0024 0.0177 0.0397
Schistosoma mansoni alpha-glucosidase 0.0169 0.2211 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0549 0.1232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0482
Loa Loa (eye worm) thioredoxin reductase 0.003 0.0268 0.0597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0641 0.1438
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0072 0.0129
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0549 0.1228
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0258 0.0712
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0774 0.2325
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0145 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0455 0.1327
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0217 0.0215
Brugia malayi nuclear receptor RXR 0.0024 0.0177 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0774 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0096 0.0095
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0177 0.0175
Schistosoma mansoni cpg binding protein 0.0034 0.0323 0.0293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0298 0.0296
Schistosoma mansoni alpha-glucosidase 0.0169 0.2211 0.2188
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0177 0.0299
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Schistosoma mansoni hypothetical protein 0.0727 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0455 0.0873
Brugia malayi nuclear hormone receptor 0.0024 0.0177 0.0397
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0034 0.032 0.0906
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Brugia malayi bHLH-PAS transcription factor 0.0029 0.0248 0.0555
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Trichomonas vaginalis GTP-binding protein rit, putative 0.021 0.2786 0.6188
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0177 0.0175
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0297 0.0663
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0234 0.3117 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0325 0.0323
Brugia malayi Flap endonuclease-1 0.0026 0.0212 0.0477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0096 0.0095
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0212 0.057
Trichomonas vaginalis rheb, putative 0.021 0.2786 0.6188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0096 0.0095
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.6294 0.6293
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0444 0.1294
Mycobacterium ulcerans hypothetical protein 0.0127 0.1626 0.3603
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0549 0.052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0774 0.1678
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0774 0.1678
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0549 0.1232
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0212 0.057
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0145 0.024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0127 0.1626 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0455 0.1257
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0177 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0774 0.0745
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Brugia malayi glutathione reductase 0.003 0.0268 0.0601
Echinococcus multilocularis microtubule associated protein 2 0.0553 0.7572 0.7572
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Brugia malayi conserved hypotetical protein 0.0024 0.0177 0.0397
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0444 0.202
Schistosoma mansoni microtubule-associated protein tau 0.0553 0.7572 0.7565
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0072 0.0129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0145 0.4817
Echinococcus granulosus neuropeptide s receptor 0.0492 0.6725 0.6725
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0212 0.057
Brugia malayi nuclear receptor NHR-67 0.0024 0.0177 0.0397
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0549 0.052
Plasmodium falciparum flap endonuclease 1 0.0026 0.0212 0.7664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0549 0.0547
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0177 0.0175
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2594 0.2593
Brugia malayi ecdysteroid receptor 0.005 0.0549 0.1232
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0325 0.3963
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0096 0.0095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0072 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0096 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0549 0.1228
Leishmania major mitochondrial DNA polymerase beta 0.0242 0.3226 1
Schistosoma mansoni cpg binding protein 0.0032 0.0297 0.0268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0549 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Loa Loa (eye worm) hypoxia-induced factor 1 0.0121 0.153 0.343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0549 0.1357
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0549 0.0547
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0242 0.3226 1
Leishmania major DNA polymerase eta, putative 0.0043 0.0444 0.1294
Brugia malayi nuclear receptor NHR-88 0.0024 0.0177 0.0397
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2594 0.2593
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0444 0.0992
Plasmodium vivax thioredoxin reductase, putative 0.003 0.0268 0.8064
Trichomonas vaginalis glutaminase, putative 0.033 0.4458 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0641 0.1434
Onchocerca volvulus 0.0029 0.0248 0.05
Onchocerca volvulus 0.0024 0.0177 0.0299
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0234 0.3117 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0064
Mycobacterium ulcerans putative regulatory protein 0.0029 0.0248 0.049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0177 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0389 0.0872
Brugia malayi hypothetical protein 0.0024 0.0177 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0549 0.1232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0525 0.1178
Onchocerca volvulus 0.0024 0.0177 0.0299
Schistosoma mansoni nuclear receptor 0.0024 0.0177 0.0147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0482
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0424 0.1231
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0444 0.0442
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0549 0.0547
Loa Loa (eye worm) glutaminase 0.033 0.4458 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0077 0.0918 0.5224
Brugia malayi hypoxia-induced factor 1 0.0121 0.153 0.3433
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0145 0.0325
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0549 0.0547
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0549 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0325 0.0295
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0444 0.0996
Brugia malayi Pre-SET motif family protein 0.0235 0.3136 0.7034
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0115 0.1445 0.4426
Brugia malayi CXXC zinc finger family protein 0.0032 0.0297 0.0667
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.3136 0.7033
Echinococcus granulosus thioredoxin glutathione reductase 0.0031 0.0274 0.0272
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0145 0.3884
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0072 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0549 0.1232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Loa Loa (eye worm) hypothetical protein 0.021 0.2786 0.6248
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0482
Plasmodium vivax SET domain protein, putative 0.0034 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2594 0.2593
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0034 0.032 0.0906
Brugia malayi nuclear receptor NHR-88 0.005 0.0549 0.1232
Entamoeba histolytica Ras family GTPase 0.021 0.2786 0.8913
Mycobacterium tuberculosis Probable dehydrogenase 0.0069 0.0811 0.4496
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0549 0.1232
Echinococcus granulosus GPCR family 2 0.0018 0.0096 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0549 0.1232
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0325 0.0323
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0444 0.1294
Trypanosoma brucei glucosidase, putative 0.0044 0.0455 0.1327
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0177 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1488 0.3335
Echinococcus granulosus flap endonuclease 1 0.0026 0.0212 0.0211
Onchocerca volvulus 0.005 0.0549 0.1357
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0444 0.0849
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0325 0.0295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0822 0.0794
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.1228
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0242 0.3226 1
Leishmania major trypanothione reductase 0.003 0.0268 0.0743
Giardia lamblia DINP protein human, muc B family 0.0043 0.0444 0.134
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0549 0.052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0114 0.1443 0.8767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0641 0.1434
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0114 0.1443 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0177 0.0175
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0114 0.1443 0.319
Giardia lamblia Fructose-bisphosphate aldolase 0.0234 0.3117 1
Echinococcus multilocularis ras gtpase 0.021 0.2786 0.2785
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0177 0.0299
Schistosoma mansoni hypothetical protein 0.0461 0.6294 0.6283
Onchocerca volvulus 0.0034 0.0325 0.072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0145 0.0143
Schistosoma mansoni thyroid hormone receptor 0.005 0.0549 0.052
Echinococcus granulosus cpg binding protein 0.0034 0.0323 0.0321
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0549 0.1232
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0444 0.0934
Mycobacterium tuberculosis Probable reductase 0.0069 0.0811 0.4496
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0549 0.0547
Plasmodium falciparum thioredoxin reductase 0.003 0.0268 1
Brugia malayi Ras-related protein R-Ras2 0.021 0.2786 0.6249
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0549 0.0547
Brugia malayi hypothetical protein 0.0027 0.0217 0.0486
Schistosoma mansoni aryl hydrocarbon receptor 0.0039 0.0389 0.036
Schistosoma mansoni zinc finger protein 0.0024 0.0177 0.0147
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0455 0.0873
Brugia malayi hypothetical protein 0.0027 0.0217 0.0486
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0177 0.0147
Schistosoma mansoni ap endonuclease 0.0021 0.0145 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0549 0.1228
Brugia malayi Thioredoxin reductase 0.003 0.0268 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0258 0.0712
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0444 0.202
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0069 0.0811 0.4496
Plasmodium vivax glutathione reductase, putative 0.003 0.0268 0.8064
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0069 0.0811 0.4496
Trichomonas vaginalis ral, putative 0.021 0.2786 0.6188
Echinococcus granulosus dna polymerase kappa 0.0043 0.0444 0.0442
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0177 0.0393
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0444 0.1223
Trypanosoma brucei trypanothione reductase 0.003 0.0268 0.0743
Plasmodium falciparum glutathione reductase 0.003 0.0268 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0525 0.0523
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0455 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0549 0.1232
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0455 0.5707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0549 0.1228
Echinococcus multilocularis dna polymerase eta 0.0043 0.0444 0.0442
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0212 0.6181
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0072 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0549 0.1232
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0455 0.0873
Schistosoma mansoni cpg binding protein 0.0034 0.0323 0.0293
Schistosoma mansoni ap endonuclease 0.0021 0.0145 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0444 0.0992
Loa Loa (eye worm) DR-78 0.0024 0.0177 0.0393
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0077 0.0918 0.5224
Schistosoma mansoni hypothetical protein 0.0018 0.0096 0.0066
Brugia malayi steroid hormone receptor 0.005 0.0549 0.1232
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0549 0.052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0217 0.0215
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0096 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0549 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0325 0.0295
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0217 0.0486
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0455 0.1257
Brugia malayi PAS domain containing protein 0.0039 0.0389 0.0873
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0549 0.052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0325 0.0295
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0145 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0177 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0525 0.0523
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0212 0.0321
Brugia malayi polk-prov protein 0.0013 0.003 0.0068
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0077 0.0918 0.1705
Echinococcus granulosus microtubule associated protein 2 0.0553 0.7572 0.7572
Treponema pallidum fructose-bisphosphate aldolase 0.0234 0.3117 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0096 0.0212
Schistosoma mansoni nuclear receptor 0.0024 0.0177 0.0147
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0549 0.0547
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0549 0.1232
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0145 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Echinococcus multilocularis transfer RNA-Lys 0.0029 0.0248 0.0246
Echinococcus granulosus dnaJ subfamily B 0.0461 0.6294 0.6293
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0549 0.1232
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0096 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0444 0.1294
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0212 0.2449
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0444 0.0442
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2594 0.5819
Schistosoma mansoni hypothetical protein 0.0018 0.0096 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0549 0.0547
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.072 0.9274
Brugia malayi hypothetical protein 0.0131 0.1672 0.375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0549 0.1357
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0177 0.0397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0217 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0393
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0177 0.0147
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0177 0.0393
Trypanosoma brucei unspecified product 0.003 0.0258 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0549 0.1228
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0549 0.1232
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0549 0.1232
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0145 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.3117 0.6943
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0177 0.0397
Brugia malayi nuclear receptor RXR 0.0027 0.0217 0.0486
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0774 0.4246
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0455 0.0873
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0212 0.059
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0549 0.0547
Schistosoma mansoni hypothetical protein 0.0018 0.0096 0.0066
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0549 0.052
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0145 0.0167

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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