Detailed information for compound 1329163

Basic information

Technical information
  • TDR Targets ID: 1329163
  • Name: N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl] -2-(4-methyl-2-oxopyrimido[1,2-b]indazol-6-yl )acetamide
  • MW: 418.445 | Formula: C23H22N4O4
  • H donors: 1 H acceptors: 2 LogP: 2.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c2ccccc2c2n1c(C)cc(=O)n2)NC(c1ccc2c(c1)OCCO2)C
  • InChi: 1S/C23H22N4O4/c1-14-11-21(28)25-23-17-5-3-4-6-18(17)26(27(14)23)13-22(29)24-15(2)16-7-8-19-20(12-16)31-10-9-30-19/h3-8,11-12,15H,9-10,13H2,1-2H3,(H,24,29)
  • InChiKey: ONIPSXUZWFHOPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl]-2-(4-methyl-2-oxo-pyrimido[1,2-b]indazol-6-yl)acetamide
  • N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl]-2-(4-methyl-2-oxo-6-pyrimido[1,2-b]indazolyl)acetamide
  • N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl]-2-(2-keto-4-methyl-pyrimido[1,2-b]indazol-6-yl)acetamide
  • N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl]-2-(4-methyl-2-oxo-pyrimido[1,2-b]indazol-6-yl)ethanamide
  • ChemDiv2_008029
  • IDI1_006744

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0048 0.0048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0896 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0266 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0583 0.0583
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0156 0.1737
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1011 0.1011
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1629 0.1886
Schistosoma mansoni cpg binding protein 0.0037 0.047 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0118 0.0118
Brugia malayi jmjC domain containing protein 0.0057 0.0768 0.089
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0048 0.0048
Schistosoma mansoni Smad4 0.0008 0.0048 0.0048
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0266 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0156 0.018
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0266 0.0308
Schistosoma mansoni lamin 0.0026 0.0316 0.0316
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0266 1
Echinococcus multilocularis microtubule associated protein 2 0.0687 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0583 0.0583
Brugia malayi hypothetical protein 0.0594 0.8635 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0266 1
Echinococcus multilocularis cpg binding protein 0.0037 0.047 0.047
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0138 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0059 0.0059
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0156 0.0156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0583 0.0675
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Echinococcus granulosus lamin 0.0026 0.0316 0.0316
Echinococcus multilocularis vesicular acetylcholine transporter 0.0431 0.6254 0.6254
Echinococcus multilocularis lamin 0.0026 0.0316 0.0316
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0156 0.0156
Brugia malayi vesicular acetylcholine transporter unc-17 0.0431 0.6254 0.7244
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Toxoplasma gondii exonuclease III APE 0.0023 0.0266 0.2966
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0583 0.0583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0316 0.0366
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0048 0.0048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0048 0.0056
Onchocerca volvulus 0.0026 0.0316 0.0366
Loa Loa (eye worm) histone methyltransferase 0.0011 0.009 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0309 0.0358
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0316 0.0366
Echinococcus granulosus vesicular acetylcholine transporter 0.0431 0.6254 0.6254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.018
Onchocerca volvulus 0.0026 0.0316 0.0366
Schistosoma mansoni cpg binding protein 0.0037 0.047 0.047
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0431 0.6254 0.7244
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0048
Brugia malayi jmjC domain containing protein 0.0015 0.0156 0.018
Brugia malayi jmjC domain containing protein 0.0015 0.0156 0.018
Schistosoma mansoni lamin 0.0026 0.0316 0.0316
Brugia malayi CXXC zinc finger family protein 0.0035 0.0441 0.0511
Schistosoma mansoni intermediate filament proteins 0.0026 0.0316 0.0316
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0441 0.0511
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0797 0.0797
Echinococcus granulosus cpg binding protein 0.0037 0.047 0.047
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0156 0.0156
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0768 0.0768
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0156 0.0156
Schistosoma mansoni smad 0.0008 0.0048 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0266 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0048 0.1806
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0768 0.0768
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0797 0.0923
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0797 0.0797
Schistosoma mansoni microtubule-associated protein tau 0.0687 1 1
Loa Loa (eye worm) hypothetical protein 0.0594 0.8635 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.018
Schistosoma mansoni cpg binding protein 0.0035 0.0441 0.0441
Echinococcus granulosus phd:f box containing protein 0.0015 0.0156 0.0156
Echinococcus granulosus lamin dm0 0.0026 0.0316 0.0316
Brugia malayi MH2 domain containing protein 0.0116 0.1629 0.1886
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0088 0.0102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0316 0.0366
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0768 0.0768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0583 0.0583
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0316 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Onchocerca volvulus 0.0035 0.0441 0.0511
Loa Loa (eye worm) Smad1 0.0008 0.0048 0.0056
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0156 0.5857
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0266 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0012 0.0111 0.0128
Leishmania major hypothetical protein, conserved 0.0015 0.0156 0.5857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0583 0.0583
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0266 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0048
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0156 0.0156
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0266 0.0266
Trichomonas vaginalis helicase, putative 0.0008 0.0048 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0266 0.0308
Brugia malayi jmjC domain containing protein 0.0015 0.0156 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0797 0.0797
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0023 0.0266 0.0266
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0156 0.1737
Onchocerca volvulus 0.0594 0.8635 1
Brugia malayi MH2 domain containing protein 0.0008 0.0048 0.0056
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0266 0.5
Brugia malayi MH2 domain containing protein 0.0008 0.0048 0.0056
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0431 0.6254 0.7244
Echinococcus multilocularis Smad4 0.0008 0.0048 0.0048
Echinococcus granulosus Smad4 0.0008 0.0048 0.0048
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.009 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1629 0.1886
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0185 0.0185
Brugia malayi MH1 domain containing protein 0.0008 0.0048 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus multilocularis musashi 0.0026 0.0316 0.0316
Brugia malayi intermediate filament protein 0.0026 0.0316 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0583 0.0583
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0156 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0048 0.1806
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0266 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Schistosoma mansoni vesicular acetylcholine transporter 0.0431 0.6254 0.6254
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0156 0.5857
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0583 0.0583
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0048
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0156 0.0156
Echinococcus granulosus intermediate filament protein 0.0026 0.0316 0.0316
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0583 0.0675
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0156 0.5857
Brugia malayi MH1 domain containing protein 0.0008 0.0048 0.0056
Plasmodium vivax JmjC domain containing protein 0.0015 0.0156 0.5857
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0266 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0156 0.018
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0185 0.0185
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0156 0.5857
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0266 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.0266 0.0266
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0048 0.1806
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0266 1
Brugia malayi Smad1 0.0008 0.0048 0.0056
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0156 0.0156
Echinococcus granulosus smad 0.0008 0.0048 0.0048
Echinococcus multilocularis smad 0.0008 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0048 0.1806
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0156 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0156 0.018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0266 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Brugia malayi jmjC domain containing protein 0.0059 0.0797 0.0923
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0048 0.0056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0138 0.016
Echinococcus multilocularis lamin dm0 0.0026 0.0316 0.0316
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0156 0.0156
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0012 0.0111 0.0128
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0048 0.0048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0266 1
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0118 0.0136
Brugia malayi jmjC domain containing protein 0.0015 0.0156 0.018

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3371 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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