Detailed information for compound 1335358

Basic information

Technical information
  • TDR Targets ID: 1335358
  • Name: N-(4-diethylaminophenyl)-2-[(5,7-dimethyl-4-o xo-1H-pyrido[3,2-e]pyrimidin-2-yl)sulfanyl]ac etamide
  • MW: 411.521 | Formula: C21H25N5O2S
  • H donors: 2 H acceptors: 5 LogP: 4.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)NC(=O)CSc1nc(O)c2c(n1)nc(cc2C)C)CC
  • InChi: 1S/C21H25N5O2S/c1-5-26(6-2)16-9-7-15(8-10-16)23-17(27)12-29-21-24-19-18(20(28)25-21)13(3)11-14(4)22-19/h7-11H,5-6,12H2,1-4H3,(H,23,27)(H,22,24,25,28)
  • InChiKey: FEEKGIUFOWOQHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-diethylaminophenyl)-2-[(5,7-dimethyl-4-oxo-1H-pyrido[3,2-e]pyrimidin-2-yl)thio]acetamide
  • N-(4-diethylaminophenyl)-2-[(4-keto-5,7-dimethyl-1H-pyrido[3,2-e]pyrimidin-2-yl)thio]acetamide
  • N-(4-diethylaminophenyl)-2-[(5,7-dimethyl-4-oxo-1H-pyrido[3,2-e]pyrimidin-2-yl)sulfanyl]ethanamide
  • ZINC00798747
  • BAS 06195246

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0212 0.0181
Giardia lamblia Kinase, CMGC CDK 0.014 0.0636 0.4096
Brugia malayi hypothetical protein 0.0121 0.0538 0.0508
Giardia lamblia Aurora kinase 0.0072 0.0294 0.1078
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0173
Echinococcus multilocularis nervana 2 0.0088 0.0374 0.0456
Trichomonas vaginalis cyclin B, putative 0.0275 0.1304 0.8232
Loa Loa (eye worm) acetyltransferase 0.0175 0.0808 0.0778
Echinococcus multilocularis nervana 2 0.0088 0.0374 0.0456
Echinococcus granulosus cyclins 0.0223 0.1045 0.1276
Leishmania major mitotic cyclin, putative 0.0054 0.0204 0.1568
Echinococcus granulosus cyclin B 0.0275 0.1304 0.1593
Echinococcus granulosus serine:threonine protein kinase N2 0.0053 0.0203 0.0248
Trichomonas vaginalis cyclin B3, putative 0.0054 0.0204 0.1162
Trypanosoma cruzi Protein kinase B 0.0105 0.046 0.3528
Schistosoma mansoni cyclin G 0.0054 0.0204 0.025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0072 0.0294 0.0359
Brugia malayi serine/threonine protein kinase 6 0.0072 0.0294 0.0263
Trichomonas vaginalis cyclin B, putative 0.0054 0.0204 0.1162
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0636 0.4874
Onchocerca volvulus 0.0286 0.136 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0117 0.0085
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0053 0.0203 0.0248
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0091 0.006
Echinococcus multilocularis cyclin dependent kinase 0.014 0.0636 0.0776
Brugia malayi Hr1 repeat family protein 0.0053 0.0203 0.0171
Schistosoma mansoni cyclin B3 0.0223 0.1045 0.1276
Loa Loa (eye worm) hypothetical protein 0.0275 0.1304 0.1276
Entamoeba histolytica protein kinase, putative 0.0072 0.0294 0.2254
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0294 0.0263
Loa Loa (eye worm) cyclin domain-containing protein 0.2023 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Echinococcus multilocularis cyclin y 0.0054 0.0204 0.025
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0091 0.0112
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0054 0.0204 0.025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Schistosoma mansoni cyclin l 0.0054 0.0204 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0636 0.0606
Echinococcus multilocularis G1:S specific cyclin D1 0.0054 0.0204 0.025
Trichomonas vaginalis cyclin D, putative 0.0223 0.1045 0.6564
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.011 0.0134
Plasmodium vivax protein kinase Crk2 0.014 0.0636 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0054 0.0204 0.0173
Echinococcus multilocularis cyclin b3 0.0223 0.1045 0.1276
Echinococcus multilocularis cyclin k 0.0054 0.0204 0.025
Schistosoma mansoni serine/threonine-protein kinase 0.0105 0.046 0.0562
Trypanosoma cruzi cyclin, putative 0.0275 0.1304 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0416 0.0385
Echinococcus granulosus cyclins 0.0223 0.1045 0.1276
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0054 0.0204 0.263
Trichomonas vaginalis cyclins, putative 0.0054 0.0204 0.1162
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus cyclins 0.0223 0.1045 0.1276
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0017 0.0024 0.0182
Trypanosoma brucei mitotic cyclin 6 0.0275 0.1304 1
Schistosoma mansoni cyclin d 0.0054 0.0204 0.025
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0096 0.0416 0.0509
Entamoeba histolytica cyclin C, putative 0.0054 0.0204 0.1568
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0416 0.3188
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0072 0.0294 0.2254
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0017 0.0024 0.0182
Echinococcus multilocularis aurora kinase A 0.0072 0.0294 0.0359
Schistosoma mansoni serine/threonine-protein kinase 0.0105 0.046 0.0562
Schistosoma mansoni hypothetical protein 0.0041 0.0142 0.0173
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0203 0.115
Leishmania major serine/threonine-protein kinase a, putative 0.0017 0.0024 0.0182
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0031 0.0091 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0204 0.1162
Echinococcus granulosus roundabout 2 0.0031 0.0091 0.0112
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0053 0.0203 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.1659 0.8188 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0117 0.0142
Trichomonas vaginalis cyclin A, putative 0.0054 0.0204 0.1162
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4082 0.4985
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0039
Loa Loa (eye worm) cyclin domain-containing protein 0.0054 0.0204 0.0173
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0017 0.0024 0.0182
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.014 0.0636 0.8176
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0636 0.0776
Trichomonas vaginalis cyclin B3, putative 0.0054 0.0204 0.1162
Loa Loa (eye worm) cyclin C 0.0054 0.0204 0.0173
Echinococcus granulosus Immunoglobulin 0.0031 0.0091 0.0112
Trichomonas vaginalis cyclin B, putative 0.0275 0.1304 0.8232
Loa Loa (eye worm) hypothetical protein 0.0121 0.0538 0.0508
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1187 0.1159
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Trichomonas vaginalis cyclin D, putative 0.0054 0.0204 0.1162
Entamoeba histolytica protein kinase, putative 0.0053 0.0203 0.1554
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0017 0.0024 0.0182
Brugia malayi Protein kinase domain containing protein 0.014 0.0636 0.0606
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0252 0.1193 0.1457
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0294 0.0359
Brugia malayi cyclin fold protein 1 variant b 0.0054 0.0204 0.0173
Trichomonas vaginalis cyclins, putative 0.0223 0.1045 0.6564
Trichomonas vaginalis cyclin D, putative 0.0223 0.1045 0.6564
Trichomonas vaginalis cyclin B, putative 0.0054 0.0204 0.1162
Brugia malayi cell division control protein 2 homolog 0.014 0.0636 0.0606
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1659 0.8188 1
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0416 0.3188
Loa Loa (eye worm) hypothetical protein 0.0121 0.0538 0.0508
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0031 0.0091 0.0112
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0053 0.0203 0.0171
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0223 0.1045 0.1276
Entamoeba histolytica protein kinase, putative 0.0096 0.0416 0.3188
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0088 0.0374 0.0456
Loa Loa (eye worm) hypothetical protein 0.0132 0.0593 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0204 0.2953
Brugia malayi p70 ribosomal S6 kinase beta 0.0141 0.0639 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Trypanosoma cruzi cyclin 6, putative 0.0275 0.1304 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0783 0.0957
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0193 0.277
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0054 0.0204 0.0173
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.014 0.0636 0.0606
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0032 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0237 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0636 0.0776
Entamoeba histolytica cyclin family protein 0.0223 0.1045 0.801
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Trypanosoma cruzi CYC2-like cyclin, putative 0.0275 0.1304 1
Trichomonas vaginalis cyclins, putative 0.0275 0.1304 0.8232
Schistosoma mansoni cyclin k 0.0054 0.0204 0.025
Schistosoma mansoni hypothetical protein 0.0074 0.0305 0.0373
Entamoeba histolytica protein kinase domain containing protein 0.0072 0.0294 0.2254
Brugia malayi DnaJ domain containing protein 0.0074 0.0305 0.0274
Toxoplasma gondii protein kinase domain-containing protein 0.0017 0.0024 0.0305
Loa Loa (eye worm) hypothetical protein 0.0031 0.0092 0.006
Schistosoma mansoni hypothetical protein 0.0054 0.0204 0.025
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0088 0.0374 0.0456
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0252 0.1193 0.1457
Schistosoma mansoni cyclins 0.0223 0.1045 0.1276
Leishmania major cyclin 9, putative 0.0054 0.0204 0.1568
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0808 0.0778
Plasmodium vivax cyclin homologue, putative 0.0054 0.0204 0.2953
Echinococcus multilocularis cyclin t1 0.0054 0.0204 0.025
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0017 0.0024 0.0182
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0096 0.0416 0.3193
Echinococcus granulosus cyclin G2 0.0054 0.0204 0.025
Echinococcus multilocularis roundabout 2 0.0031 0.0091 0.0112
Loa Loa (eye worm) AGC/AKT protein kinase 0.015 0.0683 0.0653
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0203 0.115
Echinococcus granulosus cyclins 0.0223 0.1045 0.1276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0117 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0636 0.3934
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0032 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0212 0.0259
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0172 0.1645
Echinococcus multilocularis serine:threonine protein kinase N2 0.0053 0.0203 0.0248
Trypanosoma cruzi NIMA-related kinase, putative 0.0017 0.0024 0.0182
Plasmodium falciparum calcium-dependent protein kinase 7 0.0017 0.0024 0.0227
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0039
Toxoplasma gondii cyclin 4, putative 0.0054 0.0204 0.263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0212 0.0259
Echinococcus granulosus cyclin y 0.0054 0.0204 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0204 0.1162
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus serine threonine protein kinase nrc 0.0096 0.0416 0.0509
Giardia lamblia Cyclin B-like protein 0.0054 0.0204 0.0288
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0416 0.3188
Trypanosoma cruzi cyclin, putative 0.0275 0.1304 1
Entamoeba histolytica hypothetical protein 0.0017 0.0024 0.0182
Loa Loa (eye worm) hypothetical protein 0.0052 0.0197 0.0165
Brugia malayi serine/threonine kinase 12 0.0072 0.0294 0.0263
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0017 0.0024 0.0182
Echinococcus granulosus cyclin t1 0.0054 0.0204 0.025
Trichomonas vaginalis cyclins, putative 0.0106 0.0464 0.283
Brugia malayi Protein kinase domain containing protein 0.0096 0.0416 0.0385
Schistosoma mansoni serine/threonine kinase 0.0053 0.0203 0.0248
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0275 0.1304 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0373 0.0342
Entamoeba histolytica protein kinase , putative 0.0072 0.0294 0.2254
Echinococcus multilocularis Cyclin L1 0.0054 0.0204 0.025
Leishmania major cyclin 0.0275 0.1304 1
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Trichomonas vaginalis glutaminase, putative 0.033 0.1579 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0212 0.0181
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0117 0.0142
Echinococcus granulosus twitchin 0.004 0.0134 0.0164
Loa Loa (eye worm) cyclin domain-containing protein 0.0054 0.0204 0.0173
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0294 0.0263
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0636 0.3934
Echinococcus multilocularis cyclin 0.0054 0.0204 0.025
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0204 0.1162
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0294 0.0263
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus cyclin dependent kinase 1 0.014 0.0636 0.0776
Plasmodium falciparum cyclin 1 0.0054 0.0204 0.1957
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0053 0.0203 0.0248
Schistosoma mansoni glutaminase 0.033 0.1579 0.1929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0212 0.0259
Echinococcus multilocularis serine:threonine protein kinase 38 0.0053 0.0203 0.0248
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0017 0.0024 0.0182
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0053 0.0203 0.0171
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.0305 0.0373
Echinococcus granulosus dual specificity 0.0096 0.0416 0.0508
Echinococcus granulosus cyclin dependent kinase 0.014 0.0636 0.0776
Brugia malayi Protein kinase domain containing protein 0.015 0.0683 0.0653
Entamoeba histolytica p21-activated kinase 0.0017 0.0024 0.0182
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0072 0.0294 0.4416
Echinococcus granulosus G1:S specific cyclin D1 0.0054 0.0204 0.025
Plasmodium vivax cyclin 4, putative 0.0054 0.0204 0.2953
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0072 0.0294 0.2254
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0053 0.0203 0.0248
Plasmodium falciparum serine/threonine protein kinase, putative 0.0072 0.0294 0.2814
Onchocerca volvulus 0.0275 0.1304 0.9551
Entamoeba histolytica cyclin, putative 0.0275 0.1304 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0193 0.109
Entamoeba histolytica protein kinase, putative 0.015 0.0683 0.5235
Entamoeba histolytica protein kinase, putative 0.0017 0.0024 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0294 0.1737
Echinococcus granulosus GPCR family 2 0.0019 0.0032 0.0039
Brugia malayi Protein kinase domain containing protein 0.0053 0.0203 0.0171
Brugia malayi glutaminase DH11.1 0.033 0.1579 0.1552
Brugia malayi Cyclin, N-terminal domain containing protein 0.0275 0.1304 0.1276
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0072 0.0294 0.2254
Onchocerca volvulus Cyclin L homolog 0.0054 0.0204 0.0707
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0203 0.115
Trichomonas vaginalis cyclins, putative 0.0275 0.1304 0.8232
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0141 0.0639 0.0609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0808 0.0987
Loa Loa (eye worm) cyclin domain-containing protein 0.0054 0.0204 0.0173
Leishmania major protein kinase, putative 0.0072 0.0294 0.2254
Schistosoma mansoni cell adhesion molecule 0.0031 0.0091 0.0112
Giardia lamblia Cyclin fold protein 1, putative 0.0054 0.0204 0.0288
Onchocerca volvulus Cyclin L homolog 0.0054 0.0204 0.0707
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0636 0.0606
Schistosoma mansoni nephrin 0.0031 0.0091 0.0112
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0636 0.4874
Entamoeba histolytica hypothetical protein 0.0017 0.0024 0.0182
Echinococcus granulosus nervana 2 0.0088 0.0374 0.0456
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0636 0.4874
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0053 0.0203 0.0171
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0172 0.1318
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0416 0.3188
Entamoeba histolytica protein kinase, putative 0.015 0.0683 0.5235
Echinococcus granulosus protein kinase C gamma type 0.0053 0.0203 0.0248
Giardia lamblia G2/mitotic-specific cyclin B 0.0275 0.1304 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0212 0.0259
Entamoeba histolytica protein kinase, putative 0.0141 0.0639 0.49
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0636 0.4874
Trypanosoma brucei aurora B kinase 0.0072 0.0294 0.2254
Loa Loa (eye worm) hypothetical protein 0.0252 0.1193 0.1165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0212 0.0259
Loa Loa (eye worm) hypothetical protein 0.0275 0.1304 0.1276
Echinococcus granulosus Glutaredoxin protein 5 0.0088 0.0374 0.0456
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0636 0.0776
Echinococcus granulosus cyclin b3 0.0223 0.1045 0.1276
Loa Loa (eye worm) CYL-1 protein 0.0054 0.0204 0.0173
Trichomonas vaginalis cyclin B, putative 0.0223 0.1045 0.6564
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Onchocerca volvulus 0.0054 0.0204 0.0707
Echinococcus multilocularis Immunoglobulin 0.0031 0.0091 0.0112
Giardia lamblia Hypothetical protein 0.0223 0.1045 0.7708
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0193 0.2485
Trypanosoma brucei cyclin 9 0.0054 0.0204 0.1568
Echinococcus granulosus NDR protein kinase 0.0053 0.0203 0.0248
Giardia lamblia Hypothetical protein 0.0054 0.0204 0.0288
Giardia lamblia Kinase, AGC PKA 0.0096 0.0416 0.216
Echinococcus granulosus aurora kinase A 0.0072 0.0294 0.0359
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0636 0.0776
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0204 0.1162
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0017 0.0024 0.0182
Entamoeba histolytica cyclin, domain containing protein 0.0054 0.0204 0.1568
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0142 0.011
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0193 0.0236
Loa Loa (eye worm) hypothetical protein 0.0088 0.0373 0.0342
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0054 0.0204 0.025
Echinococcus multilocularis cyclin B3 1 0.0223 0.1045 0.1276
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0054 0.0204 0.263
Loa Loa (eye worm) cyclin domain-containing protein 0.0223 0.1045 0.1016
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.0305 0.0373
Plasmodium falciparum cyclin 0.0223 0.1045 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0054 0.0204 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Trypanosoma cruzi NIMA-related kinase, putative 0.0017 0.0024 0.0182
Brugia malayi map kinase activated protein kinase protein 2 0.1659 0.8188 0.8182
Giardia lamblia Kinase, CMGC CDK 0.014 0.0636 0.4096
Echinococcus granulosus Cyclin L1 0.0054 0.0204 0.025
Entamoeba histolytica protein kinase, putative 0.0072 0.0294 0.2254
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Toxoplasma gondii AGC kinase 0.0141 0.0639 0.8221
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0054 0.0204 0.025
Schistosoma mansoni cyclin G2 0.0054 0.0204 0.025
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0054 0.0204 0.025
Loa Loa (eye worm) hypothetical protein 0.006 0.0237 0.0205
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0017 0.0024 0.0305
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Schistosoma mansoni cyclin B 0.0275 0.1304 0.1593
Brugia malayi hypothetical protein 0.0054 0.0204 0.0173
Echinococcus granulosus protein kinase c epsilon type 0.0053 0.0203 0.0248
Echinococcus multilocularis cyclins 0.0223 0.1045 0.1276
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0117 0.0142
Plasmodium falciparum protein kinase 5 0.014 0.0636 0.6085
Brugia malayi Cyclin C 0.0054 0.0204 0.0173
Brugia malayi hypothetical protein 0.0031 0.0091 0.006
Brugia malayi Protein kinase domain containing protein 0.0053 0.0203 0.0171
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0053 0.0203 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0204 0.1568
Echinococcus granulosus cyclins 0.0223 0.1045 0.1276
Schistosoma mansoni Cyclin fold protein 0.0054 0.0204 0.025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0182
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0193 0.109
Schistosoma mansoni g1/s-specific cyclin C 0.0054 0.0204 0.025
Echinococcus multilocularis Immunoglobulin 0.0031 0.0091 0.0112
Trypanosoma brucei cyclin 3 0.0054 0.0204 0.1568
Entamoeba histolytica hypothetical protein 0.0096 0.0416 0.3188
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0636 0.3934
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0416 0.3188
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0091 0.006
Echinococcus multilocularis rac serine:threonine kinase 0.0105 0.046 0.0562
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0096 0.0416 0.0509
Echinococcus granulosus protein kinase c iota type 0.0053 0.0203 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0212 0.0259
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.0305 0.0274
Trichomonas vaginalis set domain proteins, putative 0.0286 0.136 0.8591
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0035 0.0111 0.008
Trypanosoma brucei cdc2-related kinase 1 0.014 0.0636 0.4874
Brugia malayi Cyclin, N-terminal domain containing protein 0.0223 0.1045 0.1016
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.014 0.0636 0.4874
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0111 0.008
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1659 0.8188 0.8182
Leishmania major protein kinase, putative 0.0017 0.0024 0.0182
Schistosoma mansoni protein kinase 0.0072 0.0294 0.0359
Echinococcus granulosus serine/threonine protein kinase 0.0105 0.046 0.0562
Echinococcus multilocularis protein kinase c epsilon type 0.0053 0.0203 0.0248
Trichomonas vaginalis cyclin B, putative 0.0275 0.1304 0.8232
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Schistosoma mansoni atypical protein kinase C 0.0053 0.0203 0.0248
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0053 0.0203 0.0171
Echinococcus multilocularis GPCR, family 2 0.0019 0.0032 0.0039
Trypanosoma brucei rac serine-threonine kinase, putative 0.015 0.0683 0.5235
Trichomonas vaginalis cyclin B, putative 0.0275 0.1304 0.8232
Trichomonas vaginalis cyclin A, putative 0.0275 0.1304 0.8232
Echinococcus granulosus cyclins 0.0054 0.0204 0.025
Entamoeba histolytica cyclin family protein 0.0223 0.1045 0.801
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0117 0.1499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0032 0.0039
Echinococcus granulosus cyclin 0.0054 0.0204 0.025
Entamoeba histolytica protein kinase, putative 0.0017 0.0024 0.0182
Trypanosoma cruzi aurora B kinase, putative 0.0072 0.0294 0.2254
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0054 0.0204 0.1568
Echinococcus granulosus cyclin y 0.0054 0.0204 0.025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0105 0.046 0.3528
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0294 0.1737
Echinococcus granulosus cyclin dependent kinase 5 0.014 0.0636 0.0776
Leishmania major folate/biopterin transporter, putative 0.0017 0.0024 0.0182
Echinococcus multilocularis serine threonine protein kinase 0.0053 0.0203 0.0248
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0072 0.0294 0.0359
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0237 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Echinococcus granulosus cyclin G2 0.0054 0.0204 0.025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0117 0.0142
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0045 0.016 0.0875
Echinococcus multilocularis protein kinase c iota type 0.0053 0.0203 0.0248
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0053 0.0203 0.0248
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0054 0.0204 0.025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0085
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0416 0.0508
Brugia malayi Cyclin, N-terminal domain containing protein 0.0054 0.0204 0.0173
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4082 0.4985
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0017 0.0024 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0117 0.0142
Toxoplasma gondii aurora kinase 0.0072 0.0294 0.3781
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0294 0.1737
Entamoeba histolytica cyclin, putative 0.0223 0.1045 0.801
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0039
Schistosoma mansoni hypothetical protein 0.0054 0.0204 0.025
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0223 0.1045 0.1276
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.0305 0.1809
Echinococcus multilocularis cyclin y 0.0054 0.0204 0.025
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0105 0.046 0.3528
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1659 0.8188 1
Echinococcus granulosus cyclin A3 4 0.0054 0.0204 0.025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0032 0.0039
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0636 0.4874
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.011
Trichomonas vaginalis cyclins, putative 0.0054 0.0204 0.1162
Entamoeba histolytica PH domain containing protein kinase, putative 0.0105 0.046 0.3528
Echinococcus granulosus cyclin B3 1 0.0223 0.1045 0.1276
Brugia malayi Pre-SET motif family protein 0.0251 0.1187 0.1159
Entamoeba histolytica protein kinase, putative 0.0096 0.0416 0.3188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0031 0.0091 0.0112
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0096 0.0416 0.6418
Trypanosoma brucei mitotic cyclin 0.0054 0.0204 0.1568
Entamoeba histolytica cyclin, domain containing protein 0.0054 0.0204 0.1568
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0182
Brugia malayi hypothetical protein 0.0054 0.0204 0.0173
Echinococcus granulosus Protein kinase C brain isozyme 0.0053 0.0203 0.0248
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0054 0.0204 0.2953
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0054 0.0204 0.1957
Echinococcus multilocularis cyclin dependent kinase 5 0.014 0.0636 0.0776
Loa Loa (eye worm) glutaminase 0.033 0.1579 0.1552
Toxoplasma gondii cyclin dependent kinase binding protein 0.0054 0.0204 0.263
Giardia lamblia Cyclin A 0.0223 0.1045 0.7708
Onchocerca volvulus Protein CNPPD1 homolog 0.0054 0.0204 0.0707
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Echinococcus multilocularis neuroglian 0.0031 0.0091 0.0112
Echinococcus granulosus cyclin k 0.0054 0.0204 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.1045 0.6564
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0636 0.4874
Toxoplasma gondii hypothetical protein 0.0169 0.0777 1
Trypanosoma cruzi mitotic cyclin, putative 0.0054 0.0204 0.1568
Leishmania major protein kinase, putative 0.0017 0.0024 0.0182
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0096 0.0416 0.3987
Mycobacterium ulcerans glutaminase 0.033 0.1579 0.5
Trypanosoma brucei cdc2-related kinase 3 0.014 0.0636 0.4874
Toxoplasma gondii hypothetical protein 0.0054 0.0204 0.263
Trypanosoma cruzi mitotic cyclin, putative 0.0054 0.0204 0.1568
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0252 0.1193 0.1457
Loa Loa (eye worm) AGC/NDR protein kinase 0.0053 0.0203 0.0171
Entamoeba histolytica protein kinase 2, putative 0.0096 0.0416 0.3193
Echinococcus multilocularis cyclin B 0.0275 0.1304 0.1593
Plasmodium vivax SET domain protein, putative 0.0036 0.0117 0.1516
Trichomonas vaginalis cyclins, putative 0.0275 0.1304 0.8232
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0237 0.0205
Giardia lamblia Hypothetical protein 0.0054 0.0204 0.0288
Leishmania major mitotic cyclin, putative 0.0054 0.0204 0.1568
Schistosoma mansoni vesicular amine transporter 0.0031 0.0091 0.0112
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0053 0.0203 0.0248
Trichomonas vaginalis cyclin B3, putative 0.0223 0.1045 0.6564
Brugia malayi protein kinase C II. 0.0053 0.0203 0.0171
Echinococcus multilocularis Glutaredoxin protein 5 0.0088 0.0374 0.0456
Trypanosoma brucei protein kinase, putative 0.0017 0.0024 0.0182
Trichomonas vaginalis AGC family protein kinase 0.015 0.0683 0.4237
Loa Loa (eye worm) glutaminase 2 0.033 0.1579 0.1552
Trypanosoma cruzi cyclin 9, putative 0.0054 0.0204 0.1568
Entamoeba histolytica protein kinase, putative 0.0017 0.0024 0.0182
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.014 0.0636 0.0776
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0182
Entamoeba histolytica protein kinase, putative 0.0017 0.0024 0.0182
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.014 0.0636 0.4874
Echinococcus multilocularis dual specificity 0.0096 0.0416 0.0508
Echinococcus granulosus nervana 2 0.0088 0.0374 0.0456
Echinococcus multilocularis cyclin A3 4 0.0054 0.0204 0.025
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0193 0.2485
Entamoeba histolytica protein kinase, putative 0.0017 0.0024 0.0182
Entamoeba histolytica hypothetical protein 0.0054 0.0204 0.1568
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0054 0.0204 0.1957
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4082 0.4985
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0246 0.1431
Echinococcus multilocularis serine:threonine protein kinase N2 0.0053 0.0203 0.0248
Loa Loa (eye worm) AGC/PKN protein kinase 0.0053 0.0203 0.0171
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0808 0.0987
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.006
Echinococcus granulosus neuroglian 0.0031 0.0091 0.0112
Echinococcus multilocularis cyclin G2 0.0054 0.0204 0.025
Echinococcus multilocularis cyclin G2 0.0054 0.0204 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0203 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0294 0.1737
Brugia malayi Cyclin, N-terminal domain containing protein 0.0275 0.1304 0.1276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0212 0.0259
Loa Loa (eye worm) hypothetical protein 0.0053 0.0203 0.0171
Brugia malayi serine/threonine-protein kinase 6 0.0072 0.0294 0.0263
Trichomonas vaginalis cyclins, putative 0.0275 0.1304 0.8232
Echinococcus granulosus defective proboscis extension response 0.0031 0.0091 0.0112
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0117 0.0142

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 50 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1903, AID1909, AID2501, AID2615, AID2775, AID435001, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) 10.16 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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