Detailed information for compound 135034

Basic information

Technical information
  • TDR Targets ID: 135034
  • Name: 5-(4-methylphenyl)sulfanylquinazoline-2,4-dia mine
  • MW: 282.363 | Formula: C15H14N4S
  • H donors: 2 H acceptors: 2 LogP: 3.28 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Sc1cccc2c1c(N)nc(n2)N
  • InChi: 1S/C15H14N4S/c1-9-5-7-10(8-6-9)20-12-4-2-3-11-13(12)14(16)19-15(17)18-11/h2-8H,1H3,(H4,16,17,18,19)
  • InChiKey: UOJFGEAPSYQDIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine
  • 5-(p-tolylsulfanyl)quinazoline-2,4-diamine
  • 5-(p-tolylthio)quinazoline-2,4-diamine
  • [2-amino-5-(p-tolylthio)quinazolin-4-yl]amine
  • 5-[(4-methylphenyl)thio]quinazoline-2,4-diamine
  • [2-amino-5-[(4-methylphenyl)thio]quinazolin-4-yl]amine
  • MWP 01127
  • IDI1_015751
  • SR-01000634510-1
  • TQ4
  • 5-(4-Methylphenylthio)quinazoline-2,4-diamine
  • AIDS-032352
  • AIDS032352
  • Oprea1_160965
  • ZINC00172633
  • Maybridge3_004364

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dihydrofolate reductase Starlite/ChEMBL References
Candida albicans dihydrofolate reductase Starlite/ChEMBL References
Escherichia coli Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   157 aa 165 aa 24.2 %
Leishmania donovani serine carboxypeptidase (CBP1), putative Dihydrofolate reductase   157 aa 159 aa 23.3 %
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase Dihydrofolate reductase   157 aa 127 aa 19.7 %
Schistosoma mansoni dihydrofolate reductase Dihydrofolate reductase   157 aa 147 aa 28.6 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 156 aa 27.6 %
Chlamydia trachomatis dihydrofolate reductase Dihydrofolate reductase   157 aa 133 aa 24.8 %
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 21.4 %
Candida albicans hypothetical protein Dihydrofolate reductase   157 aa 149 aa 29.5 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase dihydrofolate reductase 187 aa 202 aa 29.7 %
Mycobacterium ulcerans dihydrofolate reductase DfrA Dihydrofolate reductase   157 aa 159 aa 28.3 %
Trypanosoma cruzi ATP- dependent RNA helicase, putative Dihydrofolate reductase   157 aa 140 aa 22.9 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 172 aa 23.8 %
Plasmodium yoelii hypothetical protein Dihydrofolate reductase   157 aa 132 aa 24.2 %
Dictyostelium discoideum dihydrofolate reductase Dihydrofolate reductase   157 aa 146 aa 27.4 %
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Dihydrofolate reductase   157 aa 160 aa 29.4 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 156 aa 27.6 %
Onchocerca volvulus Germline survival defective-1 homolog Dihydrofolate reductase   157 aa 165 aa 24.8 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 172 aa 23.8 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 172 aa 23.3 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 172 aa 23.3 %
Cryptosporidium parvum mannose-1-phosphate guanylyltransferase Dihydrofolate reductase   157 aa 139 aa 27.3 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 137 aa 29.2 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Leishmania infantum serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 23.3 %
Plasmodium vivax hypothetical protein, conserved Dihydrofolate reductase   157 aa 127 aa 26.8 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 172 aa 23.3 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   157 aa 171 aa 32.2 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   157 aa 178 aa 23.6 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   157 aa 169 aa 32.0 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   157 aa 178 aa 23.6 %
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Dihydrofolate reductase   157 aa 158 aa 29.1 %
Cryptosporidium hominis GDP-mannose pyrophosphorylase (4N40) Dihydrofolate reductase   157 aa 139 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0398 0.0416
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0291 0.0305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0728 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0118 0.0123
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0238 0.4431 1
Schistosoma mansoni hypothetical protein 0.0037 0.0398 0.0297
Schistosoma mansoni hypothetical protein 0.0197 0.3608 0.3694
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Onchocerca volvulus 0.0031 0.0291 0.1492
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0238 0.4431 1
Schistosoma mansoni hypothetical protein 0.0056 0.0786 0.0708
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0495 0.9566 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0728 0.0646
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0118 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1282 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0118 0.0123
Schistosoma mansoni hypothetical protein 0.0079 0.125 0.1199
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.4431 1
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.5168 0.5345
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0118 0.0123
Echinococcus granulosus geminin 0.0197 0.3608 0.3694
Brugia malayi dihydrofolate reductase family protein 0.0495 0.9566 1
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2443 0.2554
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0118 0.0123
Brugia malayi nuclear hormone receptor 0.0023 0.0118 0.0123
Echinococcus multilocularis lamin dm0 0.0031 0.0291 0.0184
Onchocerca volvulus 0.0081 0.1282 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Echinococcus granulosus GPCR family 2 0.0037 0.0398 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1282 0.5
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.4431 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.0262
Loa Loa (eye worm) hypothetical protein 0.0275 0.5168 0.5403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1282 0.1232
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0118 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.125 0.1307
Echinococcus multilocularis lamin 0.0031 0.0291 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0118 0.0123
Schistosoma mansoni hypothetical protein 0.0197 0.3608 0.3694
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0291 0.0305
Brugia malayi Dihydrofolate reductase 0.0495 0.9566 1
Brugia malayi beta-lactamase family protein 0.0081 0.1282 0.134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0118 0.0123
Brugia malayi ecdysteroid receptor 0.0023 0.0118 0.0123
Chlamydia trachomatis dihydrofolate reductase 0.0495 0.9566 0.5
Onchocerca volvulus 0.0056 0.0786 0.5745
Schistosoma mansoni hypothetical protein 0.0037 0.0398 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0118 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0118 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1282 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.028 0.0293
Plasmodium vivax hypothetical protein, conserved 0.0081 0.1282 0.2466
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0238 0.4431 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.1282 0.134
Echinococcus granulosus dihydrofolate reductase 0.0495 0.9566 1
Onchocerca volvulus 0.0081 0.1282 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.0786 0.0708
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2443 0.2554
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1282 0.1232
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0495 0.9566 1
Brugia malayi beta-lactamase 0.0081 0.1282 0.134
Brugia malayi hypothetical protein 0.0019 0.0043 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Trichomonas vaginalis esterase, putative 0.0081 0.1282 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0118 0.0123
Schistosoma mansoni hypothetical protein 0.0037 0.0398 0.0297
Loa Loa (eye worm) beta-lactamase 0.0081 0.1282 0.134
Toxoplasma gondii ABC1 family protein 0.0081 0.1282 0.2466
Loa Loa (eye worm) hypothetical protein 0.0079 0.125 0.1307
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0786 0.0822
Echinococcus multilocularis musashi 0.0031 0.0291 0.0184
Brugia malayi nuclear receptor NHR-88 0.0023 0.0118 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0118 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.1985 0.2075
Echinococcus granulosus intermediate filament protein 0.0031 0.0291 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0398 0.0416
Echinococcus multilocularis dihydrofolate reductase 0.0495 0.9566 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1282 0.2466
Schistosoma mansoni intermediate filament proteins 0.0031 0.0291 0.0184
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0238 0.4431 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0118 0.0123
Onchocerca volvulus 0.0081 0.1282 1
Brugia malayi intermediate filament protein 0.0031 0.0291 0.0305
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Echinococcus granulosus lamin dm0 0.0031 0.0291 0.0184
Echinococcus multilocularis geminin 0.0197 0.3608 0.3694
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0118 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.1282 0.2466
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0118 0.0123
Leishmania major hypothetical protein, conserved 0.0081 0.1282 0.2466
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0291 0.0305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0398 0.0297
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.1282 0.1232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0728 0.0762
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0495 0.9566 0.9502
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0118 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0728 0.0646
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.1985 0.2075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0118 0.0123
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.1282 0.1232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0118 0.0123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.1282 0.134
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0398 0.0297
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0291 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0728 0.0646
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0118 0.0123
Brugia malayi beta-lactamase family protein 0.0081 0.1282 0.134
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1282 0.2466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0118 0.0123
Schistosoma mansoni lamin 0.0031 0.0291 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0728 0.0646
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0728 0.0762
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.5168 0.5345
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0398 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1282 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Echinococcus granulosus lamin 0.0031 0.0291 0.0184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0118 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1282 0.5
Brugia malayi hypothetical protein 0.0275 0.5168 0.5403
Loa Loa (eye worm) dihydrofolate reductase 0.0495 0.9566 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0728 0.0646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.1985 0.2075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0118 0.0123
Loa Loa (eye worm) hypothetical protein 0.0081 0.1282 0.134
Brugia malayi hypothetical protein 0.0029 0.025 0.0262
Onchocerca volvulus 0.0031 0.0291 0.1492
Brugia malayi steroid hormone receptor 0.0023 0.0118 0.0123
Schistosoma mansoni lamin 0.0031 0.0291 0.0184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0398 0.0416
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0398 0.0297
Schistosoma mansoni dihydrofolate reductase 0.0495 0.9566 1
Echinococcus multilocularis GPCR, family 2 0.0037 0.0398 0.0297
Brugia malayi MH2 domain containing protein 0.0139 0.2443 0.2554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0728 0.0646
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0118 0.0123
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0398 0.0416
Loa Loa (eye worm) hypothetical protein 0.0116 0.1985 0.2075
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0118 0.0123
Schistosoma mansoni hypothetical protein 0.0037 0.0398 0.0297

Activities

Activity type Activity value Assay description Source Reference
I50 (binding) = 0.023 uM Inhibition of dihydrofolate reductase in C. albicans (in vitro). ChEMBL. 7658448
I50 (binding) = 0.94 uM In vitro inhibition of human dihydrofolate reductase ChEMBL. 7658448
IC50 (binding) = 310 nM Inhibition of E. coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductase ChEMBL. 12852950
IC50 (binding) = 310 nM Inhibition of E. coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductase ChEMBL. 12852950
IC50 (binding) = 820 nM Inhibition of E. coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductase ChEMBL. 12852950
IC50 (binding) = 820 nM Inhibition of E. coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductase ChEMBL. 12852950
IC50 (binding) = 0.023 uM Inhibitory activity against C. albicans Dihydrofolate Reductase (DHFR) ChEMBL. 11520201
IC50 (binding) = 0.023 uM Inhibition of dihydrofolate reductase in C. albicans (in vitro). ChEMBL. 7658448
IC50 (binding) = 0.023 uM Inhibitory activity against C. albicans Dihydrofolate Reductase (DHFR) ChEMBL. 11520201
IC50 (binding) = 0.94 uM Inhibitory activity against recombinant human dihydrofolate reductase ChEMBL. 11520201
IC50 (binding) = 0.94 uM In vitro inhibition of human dihydrofolate reductase ChEMBL. 7658448
IC50 (binding) = 0.94 uM Inhibitory activity against recombinant human dihydrofolate reductase ChEMBL. 11520201
Ki (binding) = 73 nM Inhibition constant of compound against dihydrofolate reductase ChEMBL. 12852950
Ki (binding) = 73 nM Inhibition constant of compound against dihydrofolate reductase ChEMBL. 12852950
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration required to inhibit C. albicans (in vitro) ChEMBL. 7658448
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration required to inhibit C. albicans (in vitro) ChEMBL. 7658448
Ratio (binding) = 2.6 Ratio of IC50 in presence of 100 uM Dihydrofolate reductase ChEMBL. 12852950
Selectivity index (binding) = 41 Ratio of I50 evaluated for inhibition of DHFR in humans to C. albicans ChEMBL. 7658448
SI (binding) = 41 Selective ratio of Human / C. albicans was determined ChEMBL. 11520201

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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