Detailed information for compound 1351511

Basic information

Technical information
  • TDR Targets ID: 1351511
  • Name: 2-(2-methylphenoxy)-N-[(4-pyrrolidin-1-ylphen yl)carbamothioyl]acetamide
  • MW: 369.481 | Formula: C20H23N3O2S
  • H donors: 2 H acceptors: 1 LogP: 4.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(=S)Nc1ccc(cc1)N1CCCC1)COc1ccccc1C
  • InChi: 1S/C20H23N3O2S/c1-15-6-2-3-7-18(15)25-14-19(24)22-20(26)21-16-8-10-17(11-9-16)23-12-4-5-13-23/h2-3,6-11H,4-5,12-14H2,1H3,(H2,21,22,24,26)
  • InChiKey: ALBOINWLZZARAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-methylphenoxy)-N-[[(4-1-pyrrolidinylphenyl)amino]-thioxomethyl]acetamide
  • 2-(2-methylphenoxy)-N-[(4-pyrrolidin-1-ylphenyl)thiocarbamoyl]acetamide
  • 2-(2-methylphenoxy)-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]ethanamide
  • ZINC04754520
  • 2-(2-methylphenoxy)-N-({[4-(1-pyrrolidinyl)phenyl]amino}carbonothioyl)acetamide
  • MLS000678677
  • SMR000269739
  • Oprea1_530405

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0021 0.0078
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0018 0.0038 0.6905
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0021 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0021 0.023
Schistosoma mansoni cpg binding protein 0.0035 0.0086 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0021 0.023
Onchocerca volvulus 0.0012 0.0021 0.1228
Brugia malayi hypothetical protein 0.0286 0.0813 1
Brugia malayi hypothetical protein 0.0018 0.0038 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0021 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0035
Giardia lamblia Translation initiation factor 0.0018 0.0038 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0021 0.0087
Brugia malayi hypothetical protein 0.0018 0.0038 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0021 0.023
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.24 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0004 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.0038 0.0157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0021 0.0087
Mycobacterium tuberculosis Conserved hypothetical protein 0.0349 0.0996 0.0962
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0021 0.023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0021 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0021 0.023
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1416 0.5899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0021 0.023
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0018 0.0038 0.0157
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.3457 1 1
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.3457 1 1
Brugia malayi nuclear receptor RXR 0.0006 0.0004 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0021 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0004 0.0025
Mycobacterium ulcerans hypothetical protein 0.0349 0.0996 0.0962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0021 0.023
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0023 0.0051 1
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0023 0.0051 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0021 0.0078
Brugia malayi hypothetical protein 0.0006 0.0004 0.0025
Trypanosoma brucei nucleotidyl transferase, putative 0.0023 0.0051 1
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0023 0.0051 0.0212
Schistosoma mansoni survival motor neuron protein 0.0058 0.0154 0.0643
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0086 0.1034
Brugia malayi Nucleotidyl transferase family protein 0.0023 0.0051 0.0599
Schistosoma mansoni hypothetical protein 0.0058 0.0154 0.0643
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0025
Loa Loa (eye worm) dynactin 5 0.0018 0.0038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0021 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0021 0.023
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0021 0.0078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0011 0.0035
Brugia malayi hypothetical protein 0.0018 0.0038 0.0437
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0002 0.0009
Echinococcus granulosus dynactin 5 p25 0.0018 0.0038 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0021 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0021 0.023
Loa Loa (eye worm) hypothetical protein 0.0286 0.0813 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0021 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0038 0.6905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0021 0.0078
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0021 0.1228
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0021 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0021 0.0087
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Brugia malayi hypothetical protein 0.0006 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0002 0.0009
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.0051 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0021 0.023
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0021 0.023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0021 0.0078
Brugia malayi zgc:92842 0.0018 0.0038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Echinococcus granulosus cpg binding protein 0.0037 0.0092 0.0373
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0023 0.0051 1
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0023 0.0051 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0011 0.0044
Schistosoma mansoni coup transcription factor 0.0012 0.0021 0.0087
Schistosoma mansoni cpg binding protein 0.0037 0.0092 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0021 0.0078
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0349 0.0996 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0021 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0021 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0437
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0017 0.006
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0018 0.0038 0.6905
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0021 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0021 0.0087
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0023 0.0051 1
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0023 0.0051 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0021 0.023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0021 0.0087
Brugia malayi hypothetical protein 0.0018 0.0038 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0021 0.023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0004 0.0018
Schistosoma mansoni nuclear receptor 0.0006 0.0002 0.0009
Echinococcus multilocularis dynactin 5 p25 0.0018 0.0038 0.0148
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0021 0.1228
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.24 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0092 0.0373
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0021 0.023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0004 0.0025
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.3457 1 1
Schistosoma mansoni dynactin subunit P25 0.0018 0.0038 0.0157
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0021 0.0087
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0018 0.0038 0.5
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0023 0.0051 0.0212
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0016 0.0173
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0025
Brugia malayi GDP-mannose pyrophosphorylase B 0.0023 0.0051 0.0599
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0002 0.0009
Brugia malayi steroid hormone receptor 0.0012 0.0021 0.023
Onchocerca volvulus 0.0035 0.0086 0.5511
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0021 0.0087
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0025
Brugia malayi CXXC zinc finger family protein 0.0035 0.0086 0.1034
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0018 0.0038 0.0437
Brugia malayi nuclear receptor NHR-88 0.0012 0.0021 0.023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0349 0.0996 0.0962
Brugia malayi nuclear hormone receptor 0.0012 0.0021 0.023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0021 0.023
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0154 0.1876
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0021 0.023
Schistosoma mansoni zinc finger protein 0.0006 0.0002 0.0009
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0023 0.0051 1
Treponema pallidum licC protein (licC) 0.0349 0.0996 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0021 0.0078
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0349 0.0996 0.0962
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0021 0.023
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0004 0.0008
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0018 0.0038 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0021 0.023
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0018 0.0038 0.0148
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0023 0.0051 0.0212
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0023 0.0051 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0021 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0021 0.023
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0021 0.023
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1416 0.5899
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0021 0.0078
Loa Loa (eye worm) nucleotidyl transferase 0.0023 0.0051 0.0599
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0199 0.0828
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0004 0.0008
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0023 0.0051 1
Brugia malayi ecdysteroid receptor 0.0012 0.0021 0.023
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0023 0.0051 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0176 0.1442
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0813 0.3381
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0813 0.3381
Onchocerca volvulus 0.0058 0.0154 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0021 0.0078
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0018 0.0038 0.5
Schistosoma mansoni nuclear receptor 0.0006 0.0002 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0021 0.0078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0021 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0021 0.1228
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.0051 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.24 1
Schistosoma mansoni cpg binding protein 0.0037 0.0092 0.0382
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0018 0.0038 0.6905
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0017 0.006
Schistosoma mansoni hypothetical protein 0.0494 0.1416 0.5903
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0023 0.0051 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0035
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0017 0.0178
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0021 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0021 0.0087
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0018 0.0038 0.0437
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0011 0.0035
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0023 0.0051 0.0137
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0023 0.0051 0.0202
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0021 0.023
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0023 0.0051 0.0202
Mycobacterium ulcerans hypothetical protein 0.0349 0.0996 0.0962
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0021 0.0087
Leishmania major GDP-mannose pyrophosphorylase 0.0023 0.0051 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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