Detailed information for compound 1363618

Basic information

Technical information
  • TDR Targets ID: 1363618
  • Name: 2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimi din-2-yl)sulfanyl]-N-(furan-2-ylmethyl)acetam ide
  • MW: 317.366 | Formula: C14H15N5O2S
  • H donors: 1 H acceptors: 4 LogP: 1.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)CSc1nn2c(n1)nc(cc2C)C
  • InChi: 1S/C14H15N5O2S/c1-9-6-10(2)19-13(16-9)17-14(18-19)22-8-12(20)15-7-11-4-3-5-21-11/h3-6H,7-8H2,1-2H3,(H,15,20)
  • InChiKey: QEONRLOLEIBUAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(2-furylmethyl)acetamide
  • 2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-(2-furylmethyl)acetamide
  • 2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(furan-2-ylmethyl)ethanamide
  • SMR000031725
  • A3674/0155796
  • ZINC03039240
  • EU-0030320
  • 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-(2-furylmethyl)acetamide
  • MLS000046116

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0102 0.0041 0.0042
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0247 0.0882 0.09
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1629 0.8881 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1629 0.8881 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0247 0.0882 0.1415
Echinococcus granulosus histone deacetylase 1 0.0255 0.0926 0.0888
Trypanosoma cruzi histone deacetylase, putative 0.0196 0.0589 0.0922
Onchocerca volvulus 0.011 0.0091 1
Echinococcus granulosus histone deacetylase 3 0.0255 0.0926 0.0888
Echinococcus granulosus carboxylesterase 5A 0.0132 0.0216 0.0176
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0694 0.347 0.3844
Loa Loa (eye worm) histone deacetylase 1 0.0255 0.0926 0.0961
Trypanosoma brucei histone deacetylase, putative 0.0196 0.0589 0.055
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.011 0.0091 0.005
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.0216 0.0176
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0247 0.0882 0.09
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0091 0.0052
Trypanosoma cruzi acetyl-CoA carboxylase 0.1129 0.5982 1
Plasmodium vivax histone deacetylase, putative 0.0196 0.0589 0.062
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0694 0.347 0.3844
Loa Loa (eye worm) hypothetical protein 0.0115 0.012 0.0125
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0694 0.347 0.3844
Plasmodium falciparum carbamoyl phosphate synthetase 0.0157 0.036 0.0307
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0247 0.0882 0.09
Loa Loa (eye worm) oxidoreductase 0.011 0.0091 0.0094
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.1629 0.8881 1
Trypanosoma cruzi histone deacetylase, putative 0.0196 0.0589 0.0922
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0247 0.0882 0.09
Trypanosoma brucei pteridine reductase 1 0.011 0.0091 0.005
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0694 0.347 0.3443
Schistosoma mansoni dihydropteridine reductase 0.011 0.0091 0.005
Brugia malayi histone deacetylase 3 (HD3) 0.0255 0.0926 0.0923
Loa Loa (eye worm) carboxylesterase 0.0132 0.0216 0.0224
Plasmodium falciparum histone deacetylase, putative 0.0196 0.0589 0.0566
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.011 0.0091 0.0084
Plasmodium falciparum histone deacetylase 1 0.0255 0.0926 0.095
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0247 0.0882 0.09
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0694 0.347 0.3844
Echinococcus granulosus acetylcholinesterase 0.0132 0.0216 0.0176
Chlamydia trachomatis biotin carboxylase 0.0631 0.31 0.3424
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0247 0.0882 0.0844
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0694 0.347 0.3844
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0247 0.0882 0.0798
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.0216 0.0224
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0694 0.347 0.5771
Trypanosoma cruzi histone deacetylase, putative 0.0196 0.0589 0.0922
Schistosoma mansoni histone deacetylase 4 5 0.0196 0.0589 0.055
Trypanosoma brucei histone deacetylase 3 0.0196 0.0589 0.055
Schistosoma mansoni pyruvate carboxylase 0.0694 0.347 0.3443
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0247 0.0882 0.09
Leishmania major histone deacetylase, putative 0.0196 0.0589 0.0502
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1319 0.7085 0.7957
Schistosoma mansoni aspartate carbamoyltransferase 0.0157 0.036 0.0321
Trypanosoma cruzi histone deacetylase 1, putative 0.0255 0.0926 0.1489
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0694 0.347 0.3443
Toxoplasma gondii pyruvate carboxylase 0.0694 0.347 0.3443
Brugia malayi Carboxylesterase family protein 0.0132 0.0216 0.0182
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0247 0.0882 0.09
Brugia malayi Carboxyl transferase domain containing protein 0.1759 0.9631 1
Trypanosoma brucei unspecified product 0.0456 0.2094 0.2061
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.011 0.0091 0.005
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1823 1 1
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1823 1 1
Entamoeba histolytica histone deacetylase, putative 0.0255 0.0926 0.7196
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1629 0.8881 1
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0157 0.036 0.0307
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0157 0.036 0.0538
Brugia malayi Carboxylesterase family protein 0.0132 0.0216 0.0182
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0247 0.0882 0.0844
Leishmania major carbamoyl-phosphate synthase, putative 0.0157 0.036 0.0272
Loa Loa (eye worm) retinol dehydrogenase 12 0.011 0.0091 0.0094
Trypanosoma brucei acetyl-CoA carboxylase 0.1823 1 1
Echinococcus multilocularis histone deacetylase 1 0.0255 0.0926 0.0888
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.011 0.0091 0.005
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0216 0.0176
Brugia malayi Histone deacetylase family protein 0.0196 0.0589 0.0571
Brugia malayi histone deacetylase 1 (HD1) 0.0255 0.0926 0.0923
Trypanosoma cruzi oxidoreductase-like protein, putative 0.011 0.0091 0.0084
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0694 0.347 0.5771
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0216 0.0176
Echinococcus multilocularis histone deacetylase 6 0.0196 0.0589 0.055
Plasmodium falciparum histone deacetylase 2 0.0196 0.0589 0.0566
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0694 0.347 0.3443
Leishmania major histone deacetylase, putative 0.0196 0.0589 0.0502
Leishmania major histone deacetylase, putative 0.0255 0.0926 0.0843
Trypanosoma cruzi histone deacetylase 1, putative 0.0255 0.0926 0.1489
Loa Loa (eye worm) hypothetical protein 0.0255 0.0926 0.0961
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0216 0.0176
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0311 0.1251 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0694 0.347 0.3443
Trichomonas vaginalis hypothetical protein 0.1629 0.8881 1
Echinococcus multilocularis histone deacetylase 6 0.0217 0.0709 0.067
Plasmodium vivax histone deacetylase 2, putative 0.0196 0.0589 0.062
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0091 0.0052
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0247 0.0882 0.09
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0157 0.036 0.0321
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.011 0.0091 0.005
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0694 0.347 0.3443
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.011 0.0091 0.005
Loa Loa (eye worm) histone deacetylase 11 0.0102 0.0041 0.0042
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.011 0.0091 0.005
Brugia malayi Histone deacetylase 1 0.0255 0.0926 0.0923
Loa Loa (eye worm) hypothetical protein 0.011 0.0091 0.0094
Toxoplasma gondii carbamoylphosphate synthetase 0.0157 0.036 0.0321
Echinococcus multilocularis histone deacetylase 0.0196 0.0589 0.055
Echinococcus multilocularis histone deacetylase 7 0.0196 0.0589 0.055
Echinococcus granulosus histone deacetylase 6 0.0196 0.0589 0.055
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0247 0.0882 0.09
Leishmania major acetyl-CoA carboxylase, putative 0.1823 1 1
Echinococcus granulosus histone deacetylase 6 0.0217 0.0709 0.067
Trypanosoma brucei oxidoreductase-like protein 0.011 0.0091 0.005
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.011 0.0091 0.0056
Echinococcus granulosus histone deacetylase 6 0.0196 0.0589 0.055
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0694 0.347 0.3844
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0694 0.347 0.3844
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1823 1 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1629 0.8881 1
Leishmania major histone deacetylase, putative 0.0255 0.0926 0.0843
Echinococcus granulosus acetylcholinesterase 0.0132 0.0216 0.0176
Toxoplasma gondii histone deacetylase HDAC2 0.0255 0.0926 0.0888
Leishmania major carboxylase, putative 0.0694 0.347 0.341
Loa Loa (eye worm) hypothetical protein 0.0132 0.0216 0.0224
Plasmodium falciparum enoyl-acyl carrier reductase 0.1629 0.8881 1
Loa Loa (eye worm) histone deacetylase 7A 0.0196 0.0589 0.0611
Echinococcus multilocularis histone deacetylase 3 0.0255 0.0926 0.0888
Schistosoma mansoni histone deacetylase 4 5 0.0196 0.0589 0.055
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1319 0.7085 0.7969
Toxoplasma gondii histone deacetylase HDAC1 0.0196 0.0589 0.055
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.011 0.0091 0.0084
Schistosoma mansoni histone deacetylase 0.0255 0.0926 0.0888
Plasmodium vivax histone deacetylase 1, putative 0.0255 0.0926 0.1001
Trypanosoma brucei histone deacetylase 1 0.0255 0.0926 0.0888
Onchocerca volvulus 0.011 0.0091 1
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0247 0.0882 0.0844
Echinococcus multilocularis histone deacetylase 6 0.0196 0.0589 0.055
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.0091 0.0094
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0157 0.036 0.0307
Loa Loa (eye worm) hypothetical protein 0.0132 0.0216 0.0224
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0157 0.036 0.0538
Trypanosoma brucei histone deacetylase 4 0.0196 0.0589 0.055
Echinococcus granulosus histone deacetylase 0.0196 0.0589 0.055
Echinococcus granulosus histone deacetylase 7 0.0196 0.0589 0.055
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0247 0.0882 0.09
Mycobacterium ulcerans pyruvate carboxylase 0.0694 0.347 0.3844
Loa Loa (eye worm) histone deacetylase 0.0196 0.0589 0.0611
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0247 0.0882 0.09
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0247 0.0882 0.09
Schistosoma mansoni acetyl-CoA carboxylase 0.1823 1 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0157 0.036 0.0321
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0694 0.347 0.3443
Toxoplasma gondii histone deacetylase HDAC3 0.0255 0.0926 0.0888
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0694 0.347 0.341
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1629 0.8881 1
Loa Loa (eye worm) histone deacetylase 3 0.0255 0.0926 0.0961
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0157 0.036 0.0361
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0247 0.0882 0.1415
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0247 0.0882 0.0844
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0247 0.0882 0.0798
Schistosoma mansoni histone deacetylase 0.0255 0.0926 0.0888
Brugia malayi Histone deacetylase family protein 0.0196 0.0589 0.0571
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1629 0.8881 0.8876
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0247 0.0882 0.1415
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.011 0.0091 0.005
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1759 0.9631 1
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0247 0.0882 0.09
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0247 0.0882 0.0844
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0311 0.1251 1
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0157 0.036 0.0321
Schistosoma mansoni histone deacetylase hda2 0.0217 0.0709 0.067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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