Detailed information for compound 1367459

Basic information

Technical information
  • TDR Targets ID: 1367459
  • Name: 4-[[2-acetamido-3-(4-fluorophenyl)propanoyl]a mino]-N-(2-methylphenyl)piperidine-1-carboxam ide
  • MW: 440.51 | Formula: C24H29FN4O3
  • H donors: 3 H acceptors: 3 LogP: 2.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC(C(=O)NC1CCN(CC1)C(=O)Nc1ccccc1C)Cc1ccc(cc1)F
  • InChi: 1S/C24H29FN4O3/c1-16-5-3-4-6-21(16)28-24(32)29-13-11-20(12-14-29)27-23(31)22(26-17(2)30)15-18-7-9-19(25)10-8-18/h3-10,20,22H,11-15H2,1-2H3,(H,26,30)(H,27,31)(H,28,32)
  • InChiKey: BZXAASVDIZWKKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[[2-acetamido-3-(4-fluorophenyl)-1-oxopropyl]amino]-N-(2-methylphenyl)-1-piperidinecarboxamide
  • ASN 07027279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Echinococcus granulosus tubulin alpha 0.011 0.0347 0.4207
Loa Loa (eye worm) alpha-tubulin 0.0205 0.0824 1
Trypanosoma brucei beta tubulin 0.011 0.0347 0.1344
Echinococcus multilocularis tubulin alpha 0.011 0.0347 0.0768
Leishmania major beta tubulin 0.011 0.0347 0.1236
Loa Loa (eye worm) tubulin beta-2A chain 0.011 0.0347 0.3974
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.0347 0.3974
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Schistosoma mansoni tubulin subunit delta 0.0048 0.0032 0.0387
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0347 0.4207
Giardia lamblia Beta tubulin 0.011 0.0347 0.1236
Echinococcus multilocularis beta tubulin 0.011 0.0347 0.0768
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.0347 0.3974
Echinococcus multilocularis beta tubulin 0.011 0.0347 0.0768
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0336
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0177
Trypanosoma brucei alpha tubulin, putative 0.0062 0.0105 0.0407
Plasmodium vivax tubulin epsilon chain, putative 0.011 0.0347 0.1236
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus multilocularis tubulin alpha chain 0.0205 0.0824 0.1825
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Brugia malayi Telomerase reverse transcriptase 0.1471 0.7211 1
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0937 0.4517 1
Brugia malayi Tubulin alpha-2 chain 0.0205 0.0824 0.1143
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.1282 0.4971
Schistosoma mansoni tubulin subunit alpha 0.0205 0.0824 1
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0157 0.0583 0.6951
Echinococcus granulosus tubulin alpha 3 chain 0.0205 0.0824 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0142 0.0509 0.6026
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0048 0.0032 0.0004
Schistosoma mansoni tubulin subunit epsilon 0.011 0.0347 0.4207
Entamoeba histolytica tubulin family protein 0.011 0.0347 0.4207
Leishmania major beta tubulin 0.011 0.0347 0.1236
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Brugia malayi beta-tubulin, identical 0.011 0.0347 0.0481
Plasmodium falciparum tubulin epsilon chain, putative 0.011 0.0347 0.1236
Echinococcus granulosus beta tubulin 0.011 0.0347 0.4207
Trypanosoma cruzi zeta tubulin, putative 0.0048 0.0032 0.0123
Giardia lamblia Beta tubulin 0.011 0.0347 0.1236
Leishmania major beta tubulin 0.011 0.0347 0.1236
Trypanosoma brucei alpha tubulin 0.0205 0.0824 0.3195
Echinococcus multilocularis tubulin subunit TubB 0.0205 0.0824 0.1825
Schistosoma mansoni hypothetical protein 0.0166 0.0627 0.7611
Echinococcus granulosus tubulin subunit TubB 0.0205 0.0824 1
Mycobacterium leprae cell division protein FtsZ 0.0048 0.0032 0.5
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Entamoeba histolytica tubulin alpha-1 chain 0.0205 0.0824 1
Echinococcus multilocularis tubulin alpha chain 0.0205 0.0824 0.1825
Trypanosoma brucei alpha tubulin 0.0205 0.0824 0.3195
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Trypanosoma cruzi epsilon tubulin, putative 0.011 0.0347 0.1344
Entamoeba histolytica tubulin alpha chain, putative 0.0205 0.0824 1
Trypanosoma brucei zeta tubulin 0.0048 0.0032 0.0123
Echinococcus granulosus tubulin alpha 3 chain 0.0205 0.0824 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.0824 0.1825
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Echinococcus multilocularis tubulin delta chain 0.0048 0.0032 0.0071
Leishmania major beta tubulin 0.011 0.0347 0.1236
Brugia malayi tubulin alpha chain - mouse 0.0205 0.0824 0.1143
Trypanosoma cruzi tubulin delta chain 0.0048 0.0032 0.0123
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0347 0.4207
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0037 0.0059
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Trichomonas vaginalis tubulin, putative 0.0062 0.0105 0.0924
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Schistosoma mansoni hypothetical protein 0.0166 0.0627 0.7611
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0758
Trypanosoma brucei tubulin gamma chain 0.011 0.0347 0.1344
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0364 0.4418
Loa Loa (eye worm) hypothetical protein 0.0114 0.0364 0.4194
Brugia malayi tubulin alpha-2 chain 0.0205 0.0824 0.1143
Trichomonas vaginalis tubulin alpha chain, putative 0.011 0.0347 0.3974
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0347 0.4207
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.0824 0.1825
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.061 0.1351
Trypanosoma brucei telomerase reverse transcriptase 0.0553 0.2579 1
Echinococcus granulosus tubulin alpha chain 0.0205 0.0824 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.0105 0.0924
Echinococcus multilocularis tubulin epsilon chain 0.011 0.0347 0.0768
Brugia malayi CHE-14 protein 0.0049 0.0037 0.0051
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus granulosus expressed conserved protein 0.0107 0.0329 0.3996
Trypanosoma brucei beta tubulin 0.011 0.0347 0.1344
Loa Loa (eye worm) tubulin alpha chain 0.0205 0.0824 1
Echinococcus multilocularis tubulin alpha chain 0.0205 0.0824 0.1825
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0046 0.0177
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Echinococcus granulosus tubulin alpha chain 0.0205 0.0824 1
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus granulosus geminin 0.0166 0.0627 0.7611
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0553 0.2579 1
Loa Loa (eye worm) tubulin beta-1 chain 0.011 0.0347 0.3974
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.0347 0.3974
Schistosoma mansoni alpha tubulin 0.0205 0.0824 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.0105 0.0924
Echinococcus multilocularis protein dispatched 1 0.0056 0.0071 0.0158
Leishmania major beta tubulin 0.011 0.0347 0.1236
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus granulosus beta tubulin 0.011 0.0347 0.4207
Plasmodium vivax tubulin beta chain, putative 0.011 0.0347 0.1236
Plasmodium vivax telomerase reverse transcriptase, putative 0.0553 0.2579 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0496 0.1823
Loa Loa (eye worm) tubulin alpha 2 0.0095 0.0268 0.2977
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Schistosoma mansoni alpha tubulin 0.0205 0.0824 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0046 0.0178
Echinococcus multilocularis tubulin, beta 4A class IVa 0.011 0.0347 0.0768
Trichomonas vaginalis tubulin, putative 0.011 0.0347 0.3974
Entamoeba histolytica tubulin family protein 0.011 0.0347 0.4207
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0205 0.0824 1
Leishmania major telomerase reverse transcriptase, putative 0.0553 0.2579 1
Echinococcus multilocularis expressed conserved protein 0.0107 0.0329 0.0729
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.011 0.0347 0.1239
Schistosoma mansoni tubulin subunit alpha 0.0205 0.0824 1
Brugia malayi Tubulin alpha chain 0.0205 0.0824 0.1143
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0048 0.0032 0.5
Plasmodium falciparum telomerase reverse transcriptase 0.0553 0.2579 1
Echinococcus granulosus peroxisome assembly protein 26 0.0205 0.0824 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0062 0.0105 0.0924
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Toxoplasma gondii beta-1 tubulin, putative 0.011 0.0347 0.1239
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.0824 1
Treponema pallidum cell division protein FtsZ 0.0048 0.0032 0.5
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.0824 0.1825
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.061 0.7406
Trypanosoma brucei epsilon tubulin 0.011 0.0347 0.1344
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0142 0.0509 0.6026
Loa Loa (eye worm) tubulin gamma chain 0.011 0.0347 0.3974
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0059
Schistosoma mansoni tubulin subunit alpha 0.0205 0.0824 1
Giardia lamblia Beta tubulin 0.011 0.0347 0.1236
Trichomonas vaginalis tubulin alpha chain, putative 0.011 0.0347 0.3974
Toxoplasma gondii alpha-tubulin I, putative 0.0205 0.0824 0.3113
Trypanosoma brucei epsilon tubulin 0.011 0.0347 0.1344
Loa Loa (eye worm) tubulin alpha 2 0.0157 0.0583 0.6951
Toxoplasma gondii beta-tubulin, putative 0.011 0.0347 0.1239
Trypanosoma brucei beta tubulin 0.011 0.0347 0.1344
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Brugia malayi Tubulin beta chain 0.0062 0.0105 0.0146
Trichomonas vaginalis tubulin beta chain, putative 0.0062 0.0105 0.0924
Echinococcus multilocularis tubulin beta 1 chain 0.011 0.0347 0.0768
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0336
Loa Loa (eye worm) tubulin alpha 2 0.0157 0.0583 0.6951
Schistosoma mansoni tubulin subunit gamma 0.011 0.0347 0.4207
Echinococcus multilocularis tubulin alpha 1C chain 0.0205 0.0824 0.1825
Trypanosoma brucei tubulin delta chain 0.0048 0.0032 0.0123
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.0824 1
Trypanosoma cruzi beta tubulin, putative 0.011 0.0347 0.1344
Echinococcus multilocularis peroxisome assembly protein 26 0.0205 0.0824 0.1825
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1282 0.4971
Brugia malayi Tubulin gamma chain 0.011 0.0347 0.0481
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Trypanosoma brucei epsilon tubulin 0.011 0.0347 0.1344
Toxoplasma gondii alpha tubulin TUBA1 0.0205 0.0824 0.3113
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0576 1
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0037 0.0444
Echinococcus multilocularis tubulin alpha 3 chain 0.0205 0.0824 0.1825
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0347 0.0768
Giardia lamblia Gamma tubulin 0.011 0.0347 0.1236
Schistosoma mansoni alpha tubulin 0.0205 0.0824 1
Brugia malayi Cell division protein ftsZ 0.0048 0.0032 0.0044
Echinococcus granulosus tubulin alpha 1C chain 0.0205 0.0824 1
Echinococcus multilocularis tubulin alpha chain 0.0205 0.0824 0.1825
Brugia malayi Tubulin alpha chain 0.0048 0.0032 0.0044
Leishmania major epsilon tubulin, putative 0.011 0.0347 0.1236
Giardia lamblia Alpha-tubulin 0.0205 0.0824 0.311
Leishmania major beta tubulin 0.011 0.0347 0.1236
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0347 0.0768
Plasmodium falciparum alpha tubulin 2 0.0205 0.0824 0.311
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0364 0.0505
Loa Loa (eye worm) BEN-1 protein 0.011 0.0347 0.3974
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0553 0.2579 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0037 0.0059
Toxoplasma gondii RNA-directed DNA polymerase 0.0553 0.2579 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0496 0.1924
Leishmania major beta tubulin 0.011 0.0347 0.1236
Brugia malayi Tubulin beta chain 0.0048 0.0032 0.0044
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Echinococcus granulosus tubulin alpha chain 0.0205 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0824 1
Echinococcus granulosus alpha tubulin 0.0205 0.0824 1
Plasmodium vivax tubulin alpha chain, putative 0.0205 0.0824 0.311
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0157 0.0583 0.6951
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.0824 1
Trypanosoma brucei beta tubulin 0.011 0.0347 0.1344
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0364 0.0806
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0336
Leishmania major beta tubulin 0.011 0.0347 0.1236
Loa Loa (eye worm) tubulin beta chain 0.011 0.0347 0.3974
Echinococcus granulosus tubulin beta 1 chain 0.011 0.0347 0.4207
Plasmodium falciparum tubulin beta chain 0.011 0.0347 0.1236
Loa Loa (eye worm) alpha-tubulin 0.0205 0.0824 1
Echinococcus multilocularis tubulin alpha chain 0.0205 0.0824 0.1825
Schistosoma mansoni tubulin subunit beta 0.0048 0.0032 0.0387
Trypanosoma brucei alpha tubulin 0.0205 0.0824 0.3195
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.0824 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.0824 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.0105 0.0924
Toxoplasma gondii beta tubulin 0.011 0.0347 0.1239
Echinococcus granulosus tubulin alpha chain 0.0205 0.0824 1
Trypanosoma cruzi tubulin gamma chain 0.011 0.0347 0.1344
Plasmodium vivax tubulin alpha chain, putative 0.0205 0.0824 0.311
Echinococcus granulosus tubulin epsilon chain 0.011 0.0347 0.4207
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0364 0.4418
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0347 0.0768
Echinococcus multilocularis protein patched 0.0049 0.0037 0.0081
Leishmania major beta tubulin 0.011 0.0347 0.1236
Leishmania major beta tubulin 0.011 0.0347 0.1236
Loa Loa (eye worm) BEN-1 protein 0.011 0.0347 0.3974
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0347 0.4207
Echinococcus multilocularis tubulin alpha 3 chain 0.0205 0.0824 0.1825
Trypanosoma brucei beta tubulin 0.011 0.0347 0.1344
Echinococcus granulosus tubulin subunit beta 0.011 0.0347 0.4207
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.0347 0.3974
Trypanosoma cruzi alpha tubulin, putative 0.0205 0.0824 0.3195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0046 0.0064
Brugia malayi alpha-tubulin 0.0205 0.0824 0.1143
Trichomonas vaginalis tubulin, putative 0.0062 0.0105 0.0924
Plasmodium falciparum tubulin gamma chain 0.011 0.0347 0.1236
Echinococcus granulosus tubulin delta chain 0.0048 0.0032 0.0387
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0048 0.0032 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0347 0.4207
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0037 0.0081
Loa Loa (eye worm) hypothetical protein 0.0157 0.0583 0.6951
Leishmania major gamma-tubulin 0.011 0.0347 0.1236
Mycobacterium ulcerans hypothetical protein 0.0156 0.0576 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0205 0.0824 0.1825
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.0824 1
Echinococcus granulosus tubulin gamma 1 chain 0.011 0.0347 0.4207
Trypanosoma cruzi tubulin delta chain 0.0048 0.0032 0.0123
Echinococcus granulosus tubulin alpha chain 0.0205 0.0824 1
Schistosoma mansoni patched 1 0.0049 0.0037 0.0444
Leishmania major beta tubulin 0.011 0.0347 0.1236
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0336
Giardia lamblia Telomerase catalytic subunit 0.0553 0.2579 1
Echinococcus multilocularis tubulin gamma 1 chain 0.011 0.0347 0.0768
Echinococcus multilocularis geminin 0.0166 0.0627 0.1389
Brugia malayi Tubulin alpha-2 chain 0.0205 0.0824 0.1143
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0037 0.0444
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0347 0.0768
Loa Loa (eye worm) tubulin beta-4 chain 0.011 0.0347 0.3974
Echinococcus multilocularis hypothetical protein 0.0205 0.0824 0.1825
Trypanosoma brucei alpha tubulin 0.0205 0.0824 0.3195
Echinococcus granulosus tubulin beta 4A class IVa 0.011 0.0347 0.4207
Entamoeba histolytica tubulin gamma chain 0.011 0.0347 0.4207
Trypanosoma cruzi zeta tubulin, putative 0.0048 0.0032 0.0123
Loa Loa (eye worm) tubulin alpha chain 0.0205 0.0824 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0046 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1282 0.4971
Plasmodium falciparum alpha tubulin 1 0.0205 0.0824 0.311
Giardia lamblia Alpha-tubulin 0.0205 0.0824 0.311
Loa Loa (eye worm) hypothetical protein 0.0142 0.0509 0.6026
Echinococcus granulosus tubulin alpha 1C chain 0.0205 0.0824 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0205 0.0824 1
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Schistosoma mansoni tubulin subunit alpha 0.0048 0.0032 0.0387
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.0347 0.3974
Plasmodium vivax tubulin gamma chain, putative 0.011 0.0347 0.1236
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.1282 0.4908
Echinococcus multilocularis tubulin subunit beta 0.011 0.0347 0.0768
Schistosoma mansoni tubulin subunit beta 0.011 0.0347 0.4207
Loa Loa (eye worm) beta-tubulin 0.011 0.0347 0.3974
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0496 0.1924
Leishmania major alpha tubulin 0.0205 0.0824 0.311
Leishmania major beta tubulin 0.011 0.0347 0.1236
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.0347 0.3974
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0373 0.4526
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0347 0.0768
Brugia malayi Tubulin beta-1 chain 0.011 0.0347 0.0481
Trypanosoma brucei zeta tubulin, putative 0.0048 0.0032 0.0123
Trypanosoma cruzi epsilon tubulin, putative 0.011 0.0347 0.1344
Leishmania major beta tubulin 0.011 0.0347 0.1236

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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