Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0261 | 0.9019 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0188 | 0.6017 | 0.66 |
Onchocerca volvulus | 0.0058 | 0.0746 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0261 | 0.9019 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 0.6017 | 0.66 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0188 | 0.6017 | 0.66 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0188 | 0.6017 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0261 | 0.9019 | 0.9 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 0.6017 | 0.66 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0188 | 0.6017 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0188 | 0.6017 | 0.5939 |
Echinococcus granulosus | cyclin dependent kinase | 0.0188 | 0.6017 | 0.5939 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0188 | 0.6017 | 0.5939 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0261 | 0.9019 | 0.9 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0188 | 0.6017 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0188 | 0.6017 | 0.5939 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0188 | 0.6017 | 0.5939 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0188 | 0.6017 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0188 | 0.6017 | 0.5939 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0188 | 0.6017 | 0.5939 |
Giardia lamblia | Kinase, CMGC CDK | 0.0188 | 0.6017 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.019 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0188 | 0.6017 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0188 | 0.6017 | 0.5939 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.5836 | 0.5755 |
Plasmodium falciparum | protein kinase 5 | 0.0188 | 0.6017 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0188 | 0.6017 | 0.66 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0746 | 0.0566 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 0.9019 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0188 | 0.6017 | 0.5939 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0261 | 0.9019 | 0.9 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0746 | 0.0629 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0188 | 0.6017 | 0.5939 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0188 | 0.6017 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0261 | 0.9019 | 0.9 |
Plasmodium vivax | protein kinase Crk2 | 0.0188 | 0.6017 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0188 | 0.6017 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.019 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0188 | 0.6017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0261 | 0.9019 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0188 | 0.6017 | 0.5939 |
Brugia malayi | Protein kinase domain containing protein | 0.0188 | 0.6017 | 0.5939 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0188 | 0.6017 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0261 | 0.9019 | 0.9 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0188 | 0.6017 | 0.5939 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0188 | 0.6017 | 0.66 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0261 | 0.9019 | 0.9 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0188 | 0.6017 | 0.66 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0188 | 0.6017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0261 | 0.9019 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0746 | 0.0629 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 14.575 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.