Detailed information for compound 1376748

Basic information

Technical information
  • TDR Targets ID: 1376748
  • Name: [2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl] 4-[ (3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzoat e
  • MW: 361.389 | Formula: C19H23NO6
  • H donors: 0 H acceptors: 3 LogP: 3.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC(C)(C)C)COC(=O)c1ccc(cc1)OCc1c(C)noc1C
  • InChi: 1S/C19H23NO6/c1-12-16(13(2)26-20-12)10-23-15-8-6-14(7-9-15)18(22)24-11-17(21)25-19(3,4)5/h6-9H,10-11H2,1-5H3
  • InChiKey: AJGPHQYJPBGFIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2-tert-butoxy-2-oxo-ethyl) 4-[(3,5-dimethylisoxazol-4-yl)methoxy]benzoate
  • 4-[(3,5-dimethyl-4-isoxazolyl)methoxy]benzoic acid (2-tert-butoxy-2-oxoethyl) ester
  • 4-[(3,5-dimethylisoxazol-4-yl)methoxy]benzoic acid (2-tert-butoxy-2-keto-ethyl) ester
  • [2-[(2-methylpropan-2-yl)oxy]-2-oxo-ethyl] 4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzoate
  • SMR000384196
  • MLS001005936
  • T0517-8860
  • ZINC03327066

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus low density lipoprotein receptor ldl 0.0036 0.0498 0.0498
Schistosoma mansoni cpg binding protein 0.0035 0.0467 0.0467
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1108 0.1108
Brugia malayi astacin protease protein 30 0.0016 0.0088 0.0124
Brugia malayi Trypsin family protein 0.0056 0.0912 0.1283
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0912 0.0912
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0142 0.02
Brugia malayi basement membrane proteoglycan precursor 0.0036 0.0498 0.07
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0036 0.0498 0.0498
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Schistosoma mansoni hypothetical protein 0.0036 0.0498 0.0498
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0942 0.0942
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1108 0.1108
Onchocerca volvulus 0.0238 0.4688 0.6598
Echinococcus granulosus glycoprotein Antigen 5 0.0056 0.0912 0.0912
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0912 0.0912
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0016 0.0088 0.0124
Loa Loa (eye worm) trypsin family protein 0.0056 0.0912 0.1283
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Onchocerca volvulus 0.0056 0.0912 0.1283
Onchocerca volvulus 0.0238 0.4688 0.6598
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0056 0.0912 0.1283
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1108 0.1108
Brugia malayi CUB domain containing protein 0.0016 0.0088 0.0124
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0407 0.8198 0.8198
Loa Loa (eye worm) CUB domain-containing protein 0.0016 0.0088 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0942 0.1326
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.006 0.0996 0.1402
Onchocerca volvulus 0.0056 0.0912 0.1283
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Brugia malayi Nematode astacin protease protein 30 0.0016 0.0088 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.016 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0056 0.0912 0.0912
Onchocerca volvulus 0.0355 0.7106 1
Loa Loa (eye worm) DPY-31 protein 0.0016 0.0088 0.0124
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1108 0.1108
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0912 0.0912
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0142 0.0142
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0601 0.0846
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0016 0.0088 0.0088
Echinococcus multilocularis CUB 0.0016 0.0088 0.0088
Echinococcus granulosus enteropeptidase 0.0056 0.0912 0.0912
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0088 0.0088
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0036 0.0498 0.07
Echinococcus multilocularis Mastin 0.0056 0.0912 0.0912
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0467 0.0657
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0036 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0041 0.0601 0.0846
Onchocerca volvulus Arrow homolog 0.0036 0.0498 0.07
Echinococcus multilocularis low density lipoprotein receptor protein 0.0036 0.0498 0.0498
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0053 0.0839 0.1181
Brugia malayi mbt repeat family protein 0.0058 0.0942 0.1326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0088 0.0124
Onchocerca volvulus 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0238 0.4688 0.4688
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0056 0.0912 0.1283
Schistosoma mansoni cpg binding protein 0.0037 0.0508 0.0508
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.016 0.0225
Onchocerca volvulus 0.0238 0.4688 0.6598
Echinococcus multilocularis GPCR, family 2 0.0019 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.002 0.016 0.016
Onchocerca volvulus 0.0238 0.4688 0.6598
Loa Loa (eye worm) CUB domain-containing protein 0.0016 0.0088 0.0124
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0016 0.0088 0.0088
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.016 0.5
Echinococcus multilocularis glycoprotein Antigen 5 0.0056 0.0912 0.0912
Leishmania major hypothetical protein, conserved 0.002 0.016 0.5
Echinococcus granulosus cubilin 0.0016 0.0088 0.0088
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0036 0.0498 0.0498
Mycobacterium ulcerans hypothetical protein 0.0056 0.0912 0.5
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0036 0.0498 0.0498
Echinococcus granulosus Tolloid protein 1 0.0016 0.0088 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0142 0.02
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Echinococcus granulosus CUB 0.0016 0.0088 0.0088
Brugia malayi Trypsin family protein 0.0355 0.7106 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0912 0.0912
Echinococcus multilocularis enteropeptidase 0.0056 0.0912 0.0912
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0942 0.0942
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.4459 0.4459
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0036 0.0498 0.0498
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0942 0.1326
Onchocerca volvulus Putative cubilin 0.0016 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.02
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0036 0.0498 0.07
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0016 0.0088 0.0088
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0996 0.1402
Brugia malayi CUB domain containing protein 0.0053 0.0839 0.1181
Onchocerca volvulus 0.0056 0.0912 0.1283
Schistosoma mansoni hypothetical protein 0.0056 0.0912 0.0912
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0056 0.0912 0.0912
Onchocerca volvulus 0.0056 0.0912 0.1283
Loa Loa (eye worm) hypothetical protein 0.0056 0.0912 0.1283
Loa Loa (eye worm) hypothetical protein 0.0238 0.4688 0.6598
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0996 0.1402
Onchocerca volvulus 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Onchocerca volvulus 0.0056 0.0912 0.1283
Loa Loa (eye worm) DOMON domain-containing protein 0.0238 0.4688 0.6598
Echinococcus multilocularis cpg binding protein 0.0037 0.0508 0.0508
Echinococcus granulosus basement membrane specific heparan sulfate 0.0036 0.0498 0.0498
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0996 0.1402
Onchocerca volvulus 0.0016 0.0088 0.0124
Brugia malayi Calcium binding EGF domain containing protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0142
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0088 0.0124
Brugia malayi Kringle domain containing protein 0.002 0.016 0.0225
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0142 0.0142
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0056 0.0912 0.0912
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0036 0.0498 0.0498
Onchocerca volvulus 0.002 0.016 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Brugia malayi CUB domain containing protein 0.0016 0.0088 0.0124
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0942 0.1326
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0056 0.0912 0.1283
Onchocerca volvulus 0.0035 0.0467 0.0657
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0498 0.0498
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1108 0.1108
Onchocerca volvulus 0.0058 0.0942 0.1326
Brugia malayi CUB domain containing protein 0.0016 0.0088 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0225
Schistosoma mansoni hypothetical protein 0.035 0.7016 0.7016
Loa Loa (eye worm) hypothetical protein 0.0238 0.4688 0.6598
Loa Loa (eye worm) hypothetical protein 0.0056 0.0912 0.1283
Brugia malayi Trypsin-like protease protein 5 0.0056 0.0912 0.1283
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0036 0.0498 0.0498
Brugia malayi Trypsin family protein 0.0056 0.0912 0.1283
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0942 0.0942
Brugia malayi hypothetical protein 0.0056 0.0912 0.1283
Echinococcus granulosus low density lipoprotein receptor ldl 0.0036 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.0016 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus 0.0016 0.0088 0.0124
Schistosoma mansoni hypothetical protein 0.0056 0.0912 0.0912
Echinococcus multilocularis cubilin 0.0016 0.0088 0.0088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0142 0.02
Onchocerca volvulus 0.0016 0.0088 0.0124
Brugia malayi enteropeptidase precursor 0.0036 0.0498 0.07
Brugia malayi Muscle positioning protein 4 0.0238 0.4688 0.6598
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0056 0.0912 0.0912
Brugia malayi CXXC zinc finger family protein 0.0035 0.0467 0.0657
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Echinococcus multilocularis cubilin 0.0016 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0036 0.0498 0.0498
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0942 0.0942
Echinococcus granulosus Mastin 0.0056 0.0912 0.0912
Loa Loa (eye worm) MBCTL1 0.0066 0.1108 0.1559
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0016 0.0088 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1111 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.016 0.5
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0016 0.0088 0.0124
Schistosoma mansoni hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Echinococcus granulosus basement membrane specific heparan sulfate 0.0036 0.0498 0.0498
Brugia malayi SEA domain containing protein 0.0238 0.4688 0.6598
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0016 0.0088 0.0088
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.016 0.016
Brugia malayi Trypsin family protein 0.0056 0.0912 0.1283
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0942 0.0942
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1108 0.1559
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0016 0.0088 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0355 0.7106 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0498 0.0498
Echinococcus granulosus tissue type plasminogen activator 0.002 0.016 0.016
Schistosoma mansoni cpg binding protein 0.0037 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.4459 0.4459
Brugia malayi Nematode astacin protease protein 30 0.0016 0.0088 0.0124
Brugia malayi Kelch motif family protein 0.0016 0.0088 0.0124
Echinococcus granulosus transmembrane protease serine 3 0.0056 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Brugia malayi Protein kinase domain containing protein 0.002 0.016 0.0225
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0142 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0073 0.1253 0.1253
Echinococcus granulosus cpg binding protein 0.0037 0.0508 0.0508
Brugia malayi hypothetical protein 0.0016 0.0088 0.0124
Echinococcus multilocularis transmembrane protease serine 3 0.0056 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus 0.0238 0.4688 0.6598
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0016 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0053 0.0839 0.1181
Onchocerca volvulus 0.0036 0.0498 0.07
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0016 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0056 0.0912 0.1283
Echinococcus granulosus low density lipoprotein receptor protein 0.0036 0.0498 0.0498
Brugia malayi CUB domain containing protein 0.0016 0.0088 0.0124
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0036 0.0498 0.07
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0036 0.0498 0.0498
Echinococcus granulosus cubilin 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0066 0.1108 0.1559
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0041 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0124
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0355 0.7106 0.7106
Brugia malayi mbt repeat family protein 0.0058 0.0942 0.1326
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0016 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0355 0.7106 1
Onchocerca volvulus 0.0016 0.0088 0.0124
Brugia malayi Lectin C-type domain containing protein 0.0016 0.0088 0.0124
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0942 0.0942
Echinococcus granulosus GPCR family 2 0.0019 0.0142 0.0142
Onchocerca volvulus 0.0036 0.0498 0.07
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0142
Onchocerca volvulus 0.0298 0.5941 0.836
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.07
Onchocerca volvulus 0.0036 0.0498 0.07
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0036 0.0498 0.0498
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0912 0.0912

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.5068 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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