TDR Targets

Basic information

Technical information

TDR Targets ID: 1376930
Name: N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-(4-fluoro phenyl)sulfonylpyrrolidine-2-carboxamide
MW: 384.449 | Formula: C15H17FN4O3S2
H donors: 1 H acceptors: 5 LogP: 2.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nnc(s1)NC(=O)C1CCCN1S(=O)(=O)c1ccc(cc1)F
InChi: 1S/C15H17FN4O3S2/c1-2-13-18-19-15(24-13)17-14(21)12-4-3-9-20(12)25(22,23)11-7-5-10(16)6-8-11/h5-8,12H,2-4,9H2,1H3,(H,17,19,21)
InChiKey: QFQCJYHUXCGWCZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-(4-fluorophenyl)sulfonyl-pyrrolidine-2-carboxamide
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-(4-fluorophenyl)sulfonyl-2-pyrrolidinecarboxamide
ASN 06349649
1-(4-Fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (5-ethyl-[1,3,4]thiadiazol-2-yl)-amide
MLS000074216
SMR000006355

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MH2 domain-containing protein	0.0276	0.0355	0.7337
Brugia malayi	TAR-binding protein	0.0071	0.0055	0.1466
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0147
Entamoeba histolytica	hypothetical protein	0.0043	0.0015	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0001	0.0002
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0031	0.0649
Schistosoma mansoni	hypothetical protein	0.0073	0.0058	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0018	0.0362
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0001	0.0013
Trypanosoma brucei	Peptide deformylase 2	0.2618	0.3786	1
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0055	0.0032	0.0855
Schistosoma mansoni	hypothetical protein	0.0043	0.0015	0.0069
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0001	0.0015
Plasmodium vivax	peptide deformylase, putative	0.686	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.1489	0.2132	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0001	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0001	0.001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0073	0.0058	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Brugia malayi	cytoplasmic intermediate filament protein	0.0033	0	0.0003
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0055	0.0032	0.0017
Schistosoma mansoni	hypothetical protein	0.0064	0.0045	0.0212
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0001	0.0002
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.0369	0.1732
Onchocerca volvulus		0.0265	0.0339	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0001	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0055	0.0257
Brugia malayi	Matrixin family protein	0.0045	0.0018	0.0468
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0073	0.0058	0.0272
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0051	0.0237
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0062	0.0043	0.0881
Brugia malayi	Hemopexin family protein	0.0064	0.0045	0.1209
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0001	0.0013
Echinococcus multilocularis	GPCR, family 2	0.0073	0.0058	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0055	0.0257
Onchocerca volvulus		0.0034	0.0001	0.0015
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0048	0.0021	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0018	0.0362
Echinococcus granulosus	tar DNA binding protein	0.0071	0.0055	0.0257
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.0051	0.0095
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0001	0.0002
Onchocerca volvulus		0.0058	0.0036	0.1073
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0001	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0001	0.0013
Brugia malayi	RNA binding protein	0.0071	0.0055	0.1466
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.0055	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0058	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0001	0.001
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0015	0.0069
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0001	0.0015
Brugia malayi	Matrixin family protein	0.0045	0.0018	0.0468
Onchocerca volvulus	Matrilysin homolog	0.0045	0.0018	0.0516
Schistosoma mansoni	hypothetical protein	0.0073	0.0058	0.0272
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0001	0.0001
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.0055	0.1135
Brugia malayi	MH2 domain containing protein	0.0276	0.0355	0.9479
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.686	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0231	0.0289	0.7718
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0231	0.0289	0.7718
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.686	1	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0358	0.0344
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Brugia malayi	hypothetical protein	0.0286	0.0369	0.9868
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0001	0.0002
Treponema pallidum	polypeptide deformylase (def)	0.686	1	0.5
Brugia malayi	Matrixin family protein	0.011	0.0112	0.2984
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.686	1	1
Schistosoma mansoni	coup transcription factor	0.0034	0.0001	0.0002
Mycobacterium ulcerans	peptide deformylase	0.686	1	1
Onchocerca volvulus		0.0043	0.0015	0.0435
Schistosoma mansoni	microtubule-associated protein tau	0.1489	0.2132	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0001	0.0002
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0051	0.0237
Trypanosoma cruzi	Peptide deformylase 2, putative	0.2618	0.3786	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0031	0.0147
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0001	0.0002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0001	0.0002
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0001	0.0001
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0001	0.0002
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0001	0.0002
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0001	0.0002
Brugia malayi	intermediate filament protein	0.0062	0.0043	0.1139
Brugia malayi	beta-lactamase family protein	0.0043	0.0015	0.0394
Schistosoma mansoni	hypothetical protein	0.0058	0.0036	0.0171
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0033	0	0.0002
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0073	0.0058	0.0272
Brugia malayi	nuclear hormone receptor	0.0034	0.0001	0.0013
Loa Loa (eye worm)	RNA binding protein	0.0071	0.0055	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Toxoplasma gondii	ABC1 family protein	0.0043	0.0015	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0001	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0001	0.0002
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0231	0.0289	0.5974
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0015	0.0305
Echinococcus granulosus	snurportin 1	0.0364	0.0484	0.2268
Brugia malayi	Matrixin family protein	0.0045	0.0018	0.0468
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0001	0.0002
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0101	0.0098	0.2901
Brugia malayi	Pre-SET motif family protein	0.0233	0.0292	0.7805
Echinococcus multilocularis	snurportin 1	0.0364	0.0484	0.2268
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0031	0.0839
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0001	0.0002
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.0339	0.9026
Brugia malayi	RNA, U transporter 1	0.0097	0.0093	0.2482
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0165	0.0193	0.0903
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0031	0.0147
Schistosoma mansoni	importin beta-1	0.0034	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Toxoplasma gondii	hypothetical protein	0.686	1	1
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0165	0.0193	0.0903
Onchocerca volvulus	Matrilysin homolog	0.0101	0.0098	0.2901
Schistosoma mansoni	hypothetical protein	0.0158	0.0182	0.0854
Schistosoma mansoni	intermediate filament proteins	0.0062	0.0043	0.02
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0001	0.0013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0001	0.001
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0286	0.0369	0.7638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.0051	0.0237
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0289	0.0374	0.7741
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0015	0.0069
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0001	0.0002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0001	0.0002
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0051	0.0036
Brugia malayi	beta-lactamase	0.0043	0.0015	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Brugia malayi	Latrophilin receptor protein 2	0.0073	0.0058	0.1549
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0001	0.0013
Onchocerca volvulus		0.0064	0.0045	0.1334
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0001	0.0013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0031	0.0147
Schistosoma mansoni	hypothetical protein	0.0073	0.0058	0.0272
Brugia malayi	steroid hormone receptor	0.0034	0.0001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Onchocerca volvulus	Glucosylceramidase homolog	0.019	0.0229	0.6743
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0001	0.0002
Brugia malayi	beta-lactamase family protein	0.0043	0.0015	0.0394
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0289	0.0374	1
Echinococcus granulosus	lamin	0.0062	0.0043	0.02
Echinococcus multilocularis	lamin	0.0062	0.0043	0.02
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Loa Loa (eye worm)	matrix metalloproteinase	0.0045	0.0018	0.0362
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.0051	0.0051
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0001	0.0002
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.0051	0.0036
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0001	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.0244	0.6368
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0001	0.0013
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0045	0.0018	0.0082
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0001	0.0002
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0001	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0055	0.0257
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0147
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0073	0.0058	0.1199
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0001	0.0013
Brugia malayi	hypothetical protein	0.0043	0.0015	0.0393
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0001	0.001
Brugia malayi	Matrixin family protein	0.0045	0.0018	0.0468
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.2618	0.3786	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0031	0.0147
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0001	0.0002
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0015	0.0069
Echinococcus multilocularis	musashi	0.0062	0.0043	0.02
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0015	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0018	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0041	0.0847
Onchocerca volvulus		0.0062	0.0043	0.1256
Loa Loa (eye worm)	transcription factor SMAD2	0.0276	0.0355	0.7337
Onchocerca volvulus		0.0062	0.0043	0.1256
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.0292	0.6042
Onchocerca volvulus		0.0043	0.0015	0.0435
Leishmania major	polypeptide deformylase-like protein, putative	0.2618	0.3786	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0036	0.0972
Entamoeba histolytica	hypothetical protein	0.0043	0.0015	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0001	0.0013
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0051	0.0036
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.0051	0.0237
Trypanosoma brucei	Polypeptide deformylase 1	0.2618	0.3786	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Echinococcus granulosus	intermediate filament protein	0.0062	0.0043	0.02
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.0369	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0182	0.3764
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.2618	0.3786	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0015	0.0069
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0001	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0001	0.0013
Echinococcus granulosus	lamin dm0	0.0062	0.0043	0.02
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0001	0.0002
Entamoeba histolytica	hypothetical protein	0.0043	0.0015	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0015	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0001	0.0013
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0051	0.0036
Loa Loa (eye worm)	matrixin family protein	0.011	0.0112	0.231
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0055	0.0257
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0015	0.0394
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0055	0.0257
Brugia malayi	latrophilin 2 splice variant baaae	0.0158	0.0182	0.4862
Onchocerca volvulus		0.0045	0.0018	0.0516
Schistosoma mansoni	lamin	0.0062	0.0043	0.02
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0015	0.0036
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0001	0.0002
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0001	0.0002
Loa Loa (eye worm)	intermediate filament protein	0.0062	0.0043	0.0881
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.0055	0.1466
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0001	0.0013
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Brugia malayi	Importin beta-1 subunit	0.0034	0.0001	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0305
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0015	0.0305
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0001	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0001	0.0013
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.0229	0.5952
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0032	0.0662
Schistosoma mansoni	hypothetical protein	0.0364	0.0484	0.2268
Echinococcus granulosus	microtubule associated protein 2	0.1489	0.2132	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0001	0.0002
Trypanosoma cruzi	Peptide deformylase 2, putative	0.2618	0.3786	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0001	0.0013
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0073	0.0058	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.0374	1
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.0244	0.6368
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.002
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0364	0.0484	1
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0001	0.0004
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0015	0.0015
Plasmodium falciparum	peptide deformylase	0.686	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0001	0.0013
Entamoeba histolytica	hypothetical protein	0.0043	0.0015	0.5
Onchocerca volvulus		0.0043	0.0015	0.0435
Mycobacterium leprae	PROBABLE HYDROLASE	0.0055	0.0032	0.0017
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0036	0.0171
Brugia malayi	ecdysteroid receptor	0.0034	0.0001	0.0013
Loa Loa (eye worm)	matrixin family protein	0.0101	0.0098	0.2035
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0001	0.001
Mycobacterium ulcerans	hydrolase	0.0055	0.0032	0.0017
Schistosoma mansoni	lamin	0.0062	0.0043	0.02
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0015	0.0069
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0073	0.0058	0.1549
Schistosoma mansoni	hypothetical protein	0.0073	0.0058	0.0272
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0001	0.001
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0043	0.0881
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.0055	0.1135
Echinococcus multilocularis	lamin dm0	0.0062	0.0043	0.02
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0001	0.001
Brugia malayi	Intermediate filament tail domain containing protein	0.0062	0.0043	0.1139
Echinococcus granulosus	GPCR family 2	0.0073	0.0058	0.0272
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0289	0.5974

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.3981 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.631 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	1.4581 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	5.2213 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1508151

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1376930