Detailed information for compound 1388828

Basic information

Technical information
  • TDR Targets ID: 1388828
  • Name: 2-[2-(azepan-1-yl)-2-oxoethyl]sulfanylpyridin e-3-carboxylic acid
  • MW: 294.369 | Formula: C14H18N2O3S
  • H donors: 1 H acceptors: 4 LogP: 1.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCCC1)CSc1ncccc1C(=O)O
  • InChi: 1S/C14H18N2O3S/c17-12(16-8-3-1-2-4-9-16)10-20-13-11(14(18)19)6-5-7-15-13/h5-7H,1-4,8-10H2,(H,18,19)
  • InChiKey: KYXUJVSRUDFCHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(azepan-1-yl)-2-oxo-ethyl]sulfanylpyridine-3-carboxylic acid
  • 2-[[2-(1-azepanyl)-2-oxoethyl]thio]-3-pyridinecarboxylic acid
  • 2-[[2-(azepan-1-yl)-2-keto-ethyl]thio]nicotinic acid
  • SMR000031846
  • EU-0030563
  • 2-[(2-azepan-1-yl-2-oxoethyl)thio]nicotinic acid
  • MLS000046235

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0103 0.0576 0.177
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0137 0.1488
Echinococcus granulosus neuropeptide receptor 0.0081 0.044 0.1351
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0013 0.0095
Plasmodium falciparum glutathione reductase 0.0094 0.0522 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0687 0.211
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0081 0.044 0.132
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0351 0.2131 0.6554
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0053
Mycobacterium ulcerans lipase LipD 0.0071 0.0382 0.5271
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0382 0.5355
Echinococcus multilocularis somatostatin receptor 0.0081 0.044 0.0439
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus multilocularis expressed conserved protein 0.0183 0.1082 0.1081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Echinococcus granulosus fmrfamide receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Loa Loa (eye worm) TYRA-2 protein 0.0081 0.044 0.1351
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.1156 0.3555
Brugia malayi Myosin head containing protein 0.0012 0.0008 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.1275 0.4504
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0319 0.0982
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0021 0.0062 0.0189
Echinococcus multilocularis chromobox protein 1 0.0077 0.0416 0.0415
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0258 0.0791
Echinococcus granulosus g-protein coupled receptor 0.0081 0.044 0.1351
Brugia malayi CXXC zinc finger family protein 0.0035 0.0151 0.0464
Schistosoma mansoni opsin-like receptor 0.0081 0.044 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0081 0.044 0.0439
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0227 0.0699
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi neuropeptide F receptor 0.0081 0.044 0.1354
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0687 0.5895
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0137 0.1853
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0078 0.0566
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0081 0.044 0.0439
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0382 0.1171
Mycobacterium tuberculosis Conserved protein 0.0071 0.0382 0.1272
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0013 0.0036
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0078 0.0566
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0081 0.044 0.132
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0021 0.0062 0.0189
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 1
Brugia malayi CHE-14 protein 0.0084 0.0458 0.1409
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Echinococcus granulosus neuropeptide FF receptor 2 0.0081 0.044 0.1351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0382 0.1139
Brugia malayi Protein cec-1. 0.0013 0.0013 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0416 0.5989
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0025 0.0074
Loa Loa (eye worm) melatonin receptor type 1A 0.0081 0.044 0.1351
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0137 0.1639
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0078 0.0572
Echinococcus granulosus serotonin receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0137 0.1639
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0237 0.0727
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0382 0.727
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0137 0.2515
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0137 0.2481
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.003 0.0089
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Onchocerca volvulus 0.0023 0.0078 0.104
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus multilocularis serotonin receptor 0.0081 0.044 0.0439
Onchocerca volvulus 0.0081 0.044 0.6406
Brugia malayi Thioredoxin reductase 0.0094 0.0522 0.1605
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Schistosoma mansoni neuropeptide receptor 0.0081 0.044 0.132
Brugia malayi AKH receptor 0.0081 0.044 0.1354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0089
Leishmania major trypanothione reductase 0.0094 0.0522 0.7492
Schistosoma mansoni neuropeptide F-like receptor 0.0081 0.044 0.132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.1275 0.4504
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0081 0.044 0.0439
Onchocerca volvulus 0.0013 0.0013 0.0072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0237
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0225 0.3147
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Brugia malayi ORL1-like opioid receptor 0.0081 0.044 0.1354
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0021
Entamoeba histolytica hypothetical protein 0.0071 0.038 0.3216
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0062 0.0731
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.038 0.0379
Loa Loa (eye worm) G-protein coupled receptor 0.0081 0.044 0.1351
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0017 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0687 1
Echinococcus granulosus tm gpcr rhodopsin 0.0081 0.044 0.1351
Onchocerca volvulus 0.0081 0.044 0.6406
Schistosoma mansoni opsin-like receptor 0.0081 0.044 0.132
Brugia malayi Dopamine receptor 0.0081 0.044 0.1354
Echinococcus multilocularis protein dispatched 1 0.0096 0.0532 0.0531
Schistosoma mansoni adenoreceptor 0.0081 0.044 0.132
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0137 0.2515
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0687 0.211
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0081 0.044 0.1351
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0522 0.1603
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0137 0.1488
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0258 0.0825
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.0431
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0687 1
Echinococcus granulosus expressed conserved protein 0.0183 0.1082 0.3325
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0566
Echinococcus multilocularis sex peptide receptor 0.0081 0.044 0.0439
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0081 0.044 0.1351
Brugia malayi isocitrate dehydrogenase 0.0015 0.003 0.0092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0258 0.1335
Loa Loa (eye worm) phosphofructokinase 0.012 0.0687 0.211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 1
Mycobacterium leprae Probable lipase LipE 0.0071 0.0382 0.2253
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0078 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0081 0.044 0.132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0529 0.3251 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0382 0.1272
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0382 0.5271
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.038 0.1167
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Schistosoma mansoni hypothetical protein 0.0081 0.0439 0.1317
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0237
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0687 0.2081
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0397
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0081 0.044 0.0439
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.003 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.1275 0.4504
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0094 0.0285
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0083 0.0256
Schistosoma mansoni cpg binding protein 0.0035 0.0151 0.0427
Schistosoma mansoni cpg binding protein 0.0037 0.0163 0.0465
Loa Loa (eye worm) hypothetical protein 0.012 0.0683 0.2098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Onchocerca volvulus Huntingtin homolog 0.012 0.0683 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0062 0.0731
Brugia malayi hypothetical protein 0.012 0.0683 0.21
Echinococcus multilocularis neuropeptide receptor A26 0.0081 0.044 0.0439
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0081 0.044 0.1351
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0137 0.1639
Plasmodium falciparum thioredoxin reductase 0.0094 0.0522 1
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0522 1
Onchocerca volvulus Poor gastrulation protein homolog 0.0013 0.0015 0.0109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0081 0.044 0.132
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0137 0.1088
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1373 0.4222
Treponema pallidum NADH oxidase 0.0033 0.0137 0.0573
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.003 0.0429
Brugia malayi neuropeptide F receptor 0.0081 0.044 0.1354
Echinococcus granulosus sex peptide receptor 0.0081 0.044 0.1351
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Onchocerca volvulus 0.0035 0.0151 0.2122
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0081 0.044 0.132
Toxoplasma gondii hypothetical protein 0.0027 0.0104 0.1874
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.2795 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0125
Brugia malayi putative neuropeptide receptor 0.0081 0.044 0.1354
Onchocerca volvulus 0.0081 0.044 0.6406
Brugia malayi Tachykinin-like peptides receptor 99D 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0081 0.044 0.132
Echinococcus granulosus tachykinin peptides receptor 99D 0.0081 0.044 0.1351
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0081 0.044 0.132
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0382 0.5355
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0522 0.7492
Brugia malayi beta-lactamase family protein 0.0071 0.0382 0.1173
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.038 0.1135
Brugia malayi Melatonin receptor type 1A 0.0081 0.044 0.1354
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0104 0.0194
Brugia malayi CHD4 protein 0.0015 0.0025 0.0077
Brugia malayi hypothetical protein 0.023 0.1373 0.4224
Echinococcus multilocularis g protein coupled receptor 0.0081 0.044 0.0439
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0428 0.2601
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0021
Echinococcus multilocularis cpg binding protein 0.0037 0.0163 0.0162
Echinococcus granulosus neuropeptide receptor 0.0081 0.044 0.1351
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0137 0.0566
Trypanosoma brucei trypanothione reductase 0.0094 0.0522 0.7492
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Echinococcus granulosus tm gpcr rhodopsin 0.0081 0.044 0.1351
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0137 0.1853
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.1425 0.5046
Onchocerca volvulus 0.0081 0.044 0.6406
Schistosoma mansoni neuropeptide receptor 0.0081 0.044 0.132
Brugia malayi Patched related family protein 4 0.0012 0.0008 0.0024
Echinococcus granulosus Chromo domain 0.0013 0.0013 0.0036
Toxoplasma gondii ABC1 family protein 0.0071 0.0382 0.727
Schistosoma mansoni biogenic amine receptor 0.0081 0.044 0.132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0319 0.0947
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.023 0.1373 0.4222
Loa Loa (eye worm) neuropeptide F receptor 0.0081 0.044 0.1351
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0078 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Echinococcus granulosus g protein coupled receptor 0.0081 0.044 0.1351
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0687 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0125
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0039 0.0392
Schistosoma mansoni histamine h1 receptor 0.0081 0.044 0.132
Schistosoma mansoni hypothetical protein 0.0081 0.044 0.132
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0529 0.3251 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0382 0.1171
Brugia malayi Cytochrome P450 family protein 0.0026 0.0094 0.0288
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0081 0.044 0.0439
Schistosoma mansoni biogenic amine receptor 0.0081 0.044 0.132
Schistosoma mansoni hypothetical protein 0.0071 0.038 0.1135
Schistosoma mansoni biogenic amine (5HT) receptor 0.0081 0.044 0.132
Brugia malayi SET domain containing protein 0.0013 0.0017 0.0053
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0382 0.1272
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Echinococcus granulosus peptide allatostatin:somatostatin 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi RNA binding protein 0.0062 0.0319 0.0982
Schistosoma mansoni myosin xvIII 0.0081 0.044 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0081 0.044 0.0439
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0319 0.098
Echinococcus granulosus neuropeptides capa receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0382 0.5474
Schistosoma mansoni chromobox protein 0.0077 0.0416 0.1246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0137 0.2515
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.0062 0.0192
Schistosoma mansoni amine GPCR 0.0081 0.044 0.132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0319 0.0947
Schistosoma mansoni alpha-1 adrenergic receptor 0.0081 0.044 0.132
Echinococcus granulosus neuropeptide s receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.003 0.0089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0078 0.0566
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi glutathione reductase 0.0094 0.0522 0.1605
Brugia malayi hypothetical protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Mycobacterium tuberculosis Conserved protein 0.0071 0.0382 0.1272
Brugia malayi phosphofructokinase 0.012 0.0687 0.2112
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0084 0.0458 0.1407
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0104 0.1874
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0081 0.044 0.132
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.003 0.0429
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0382 0.1272
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.003 0.0029
Echinococcus granulosus alpha 1A adrenergic receptor 0.0081 0.044 0.1351
Brugia malayi 6-phosphofructokinase 0.012 0.0687 0.2112
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3029 0.9316
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0025 0.0038
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0137 0.2515
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0382 0.1139
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0013 0.0095
Entamoeba histolytica hypothetical protein 0.0071 0.038 0.3216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Schistosoma mansoni amine GPCR 0.0081 0.044 0.132
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0392
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0382 0.1272
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0522 0.1779
Brugia malayi Dopamine receptor protein 2 0.0081 0.044 0.1354
Brugia malayi Serotonin receptor 0.0081 0.044 0.1354
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0013 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.003 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Onchocerca volvulus 0.0071 0.0382 0.5538
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0847 0.0846
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0237
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0141 0.0434
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0428 0.8181
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0687 1
Brugia malayi follicle stimulating hormone receptor 0.0081 0.044 0.1354
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0081 0.044 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0021
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0458 0.0457
Schistosoma mansoni cpg binding protein 0.0037 0.0163 0.0465
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0382 0.5474
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0382 0.5474
Echinococcus granulosus neuropeptide Y receptor 0.0081 0.044 0.1351
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0041 0.0656
Onchocerca volvulus 0.0071 0.0382 0.5538
Schistosoma mansoni biogenic amine receptor 0.0081 0.044 0.132
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0081 0.044 0.1351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Schistosoma mansoni neuropeptide receptor 0.0081 0.044 0.132
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0566
Loa Loa (eye worm) glutathione reductase 0.0094 0.0522 0.1603
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0137 0.247
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Brugia malayi protein C24B5.3 0.0012 0.0008 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0078 0.0572
Schistosoma mansoni growth hormone secretagogue receptor 0.0081 0.044 0.132
Echinococcus granulosus dro:myosuppressin receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0151 0.0462
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0237 0.0729
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0395 0.1179
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.003 0.0429
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0458 0.1407
Brugia malayi Isocitrate dehydrogenase 0.0015 0.003 0.0092
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0013 0.0095
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0081 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi beta-lactamase 0.0071 0.0382 0.1173
Echinococcus multilocularis serotonin receptor 0.0081 0.044 0.0439
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus multilocularis neuropeptide FF receptor 2 0.0081 0.044 0.0439
Echinococcus granulosus GPCR family 3 C terminal 0.0013 0.0015 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0204 0.2842
Loa Loa (eye worm) hypothetical protein 0.0195 0.1156 0.3553
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Brugia malayi hypothetical protein 0.0135 0.0777 0.2389
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus multilocularis G protein coupled receptor 139 0.0081 0.044 0.0439
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0687 0.5895
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0137 0.2523
Echinococcus granulosus neuropeptide Y receptor 0.0081 0.044 0.1351
Brugia malayi protein C24B5.3 0.0012 0.0008 0.0024
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0053
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0081 0.044 0.1354
Echinococcus multilocularis chromobox protein 1 0.0077 0.0416 0.0415
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Schistosoma mansoni amine GPCR 0.0081 0.044 0.132
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0458 0.1407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Echinococcus granulosus orexin receptor type 2 0.0081 0.044 0.1351
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0319 0.0318
Echinococcus multilocularis neuropeptide s receptor 0.0081 0.044 0.0439
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0089
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0428 0.1284
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Schistosoma mansoni hypothetical protein 0.0081 0.044 0.132
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0081 0.044 0.0439
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0137 0.2515
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Schistosoma mansoni hypothetical protein 0.0081 0.044 0.132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0204 0.0625
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0137 0.0137
Schistosoma mansoni metabotropic glutamate receptor 0.0067 0.0354 0.1054
Loa Loa (eye worm) G-protein coupled receptor 0.0081 0.044 0.1351
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0428 0.8181
Schistosoma mansoni neuropeptide receptor 0.0081 0.044 0.132
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0013 0.0012
Brugia malayi Heterochromatin protein 1 0.0077 0.0416 0.128
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0041 0.0042
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0091 0.0504 0.1518
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.1156 0.1155
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0137 0.1639
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0137 0.2515
Brugia malayi chromobox protein homolog 3 0.0043 0.0204 0.0628
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0137 0.1639
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus granulosus biogenic amine 5HT receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0382 0.5355
Echinococcus granulosus tm gpcr rhodopsin 0.0081 0.044 0.1351
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0428 0.1315
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0013 0.0095
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.168 0.168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.003 0.0053
Brugia malayi 6-phosphofructokinase 0.012 0.0687 0.2112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0081 0.044 0.0439
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0428 0.8181
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0104 0.1874
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Onchocerca volvulus 0.0047 0.0227 0.3252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0081 0.044 0.132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.0733
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0041 0.0656
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0345 0.6567
Schistosoma mansoni hypothetical protein 0.0081 0.0439 0.1317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Schistosoma mansoni neuropeptide f receptor 76f 0.0081 0.044 0.132
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.0733
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0237 0.0729
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0416 0.5989
Mycobacterium ulcerans hypothetical protein 0.0071 0.0382 0.5271
Entamoeba histolytica hypothetical protein 0.0071 0.038 0.3216
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0081 0.044 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0566
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.1156 0.3553
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Brugia malayi hypothetical protein 0.0012 0.0008 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0687 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0522 0.1603
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0081 0.044 0.1354
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0083 0.0256
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0081 0.044 0.1354
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0687 0.5895
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0081 0.044 0.0439
Echinococcus multilocularis neuropeptides capa receptor 0.0081 0.044 0.0439
Brugia malayi Patched protein homolog 1 0.0012 0.0008 0.0024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0687 0.2375
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0013 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0125
Brugia malayi Metabotropic glutamate receptor precursor. 0.008 0.0435 0.1339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) RNA binding protein 0.0062 0.0319 0.098
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0225 0.3147
Echinococcus granulosus GPCR family 2 0.0015 0.003 0.0089
Onchocerca volvulus 0.0081 0.044 0.6406
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0137 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0382 0.1171
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.1275 0.4504
Echinococcus granulosus neuropeptides capa receptor 0.0081 0.044 0.1351
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.3251 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0382 0.1272
Onchocerca volvulus 0.0081 0.044 0.6406
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0137 0.0386
Echinococcus granulosus hypothetical protein 0.0081 0.044 0.1351
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.003 0.0429
Schistosoma mansoni amine GPCR 0.0081 0.044 0.132
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0073 0.0388 0.1194
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0081 0.044 0.132
Schistosoma mansoni hypothetical protein 0.0047 0.0227 0.0663
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Leishmania major hypothetical protein, conserved 0.0071 0.0382 0.5355
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0125
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0081 0.044 0.1354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Onchocerca volvulus Neuropeptide F receptor homolog 0.0081 0.044 0.6406
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0137 0.2515
Echinococcus multilocularis fmrfamide receptor 0.0081 0.044 0.0439
Echinococcus multilocularis Chromo domain 0.0013 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0494 0.3029 0.9314
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0382 0.5474
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0081 0.044 0.1351
Schistosoma mansoni survival motor neuron protein 0.0047 0.0227 0.0663
Brugia malayi beta-lactamase family protein 0.0071 0.0382 0.1173
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Onchocerca volvulus 0.0071 0.0382 0.5538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0529 0.3251 0.3251
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0081 0.044 0.132
Onchocerca volvulus 0.0013 0.0017 0.0143
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0137 0.2523
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Entamoeba histolytica hypothetical protein 0.0071 0.038 0.3216
Brugia malayi G protein-coupled receptor F59B2.13 0.0081 0.044 0.1354
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0013 0.0015 0.0109
Brugia malayi hypothetical protein 0.0012 0.0008 0.0024
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 0.5997
Echinococcus granulosus g protein coupled receptor 0.0081 0.044 0.1351
Echinococcus multilocularis GPCR, family 2 0.0015 0.003 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0137 0.1639
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.1425 1
Schistosoma mansoni hypothetical protein 0.0081 0.0439 0.1317
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0382 0.0381
Brugia malayi metabotropic glutamate receptor type 2 0.0039 0.0178 0.0548
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.0733
Echinococcus granulosus chromobox protein 2 0.0013 0.0013 0.0036
Echinococcus multilocularis muscleblind protein 0.0146 0.0847 0.0846
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.0089
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Onchocerca volvulus 0.0081 0.044 0.6406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0137 0.1639
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.024
Onchocerca volvulus 0.0081 0.044 0.6406
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.1275 0.8889
Echinococcus granulosus g protein coupled receptor 0.0081 0.044 0.1351
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0137 0.1846
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Mycobacterium ulcerans hypothetical protein 0.0023 0.0078 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.167
Schistosoma mansoni opsin-like receptor 0.0081 0.044 0.132
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0137 0.042
Brugia malayi hypothetical protein 0.0071 0.038 0.117
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0081 0.044 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0081 0.044 0.0439
Echinococcus granulosus chromobox protein 1 0.0077 0.0416 0.1278
Echinococcus granulosus metabotropic glutamate receptor 2 0.0067 0.0354 0.1087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0137 0.1488
Brugia malayi G-protein coupled receptor 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.0081 0.044 0.0439
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 0.5567
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0081 0.044 0.132
Onchocerca volvulus 0.0034 0.0146 0.2044
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.1425 0.5046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0319 0.098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0319 0.0947
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0067 0.0354 0.0353
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0025 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0382 0.1272
Brugia malayi Latrophilin receptor protein 2 0.0015 0.003 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.1175 0.3588
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0137 0.2523
Echinococcus multilocularis neuropeptides capa receptor 0.0081 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.167
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0013 0.0015 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) glutamate receptor 0.0032 0.0131 0.0401
Brugia malayi Dopamine receptor protein 1 0.0081 0.044 0.1354
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0847 0.2603
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0137 0.0389
Echinococcus multilocularis GPCR, family 3, C terminal 0.0013 0.0015 0.0014
Onchocerca volvulus Huntingtin homolog 0.012 0.0683 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0081 0.044 0.1351
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0013 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0319 0.0947
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0013 0.0095
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0258 0.0825
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.003 0.0091
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0099 0.0551 0.0551
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0137 0.1639
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0458 0.661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Schistosoma mansoni metabotropic glutamate receptor 0.0039 0.0178 0.0511
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Echinococcus multilocularis g-protein coupled receptor 0.0081 0.044 0.0439
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0687 0.0686
Loa Loa (eye worm) helicase 0.0013 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0258 0.0257
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0013 0.0039
Mycobacterium ulcerans beta-lactamase 0.0071 0.0382 0.5271
Echinococcus granulosus neuropeptide receptor A26 0.0081 0.044 0.1351
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.168 0.5167
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.024
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0687 0.4518
Schistosoma mansoni patched 1 0.0084 0.0458 0.1376
Brugia malayi hypothetical protein 0.0013 0.0013 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0382 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0204 0.2842
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0062 0.0731
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0428 0.0427
Brugia malayi GnHR receptor homolog 0.0081 0.044 0.1354
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.003 0.0029
Echinococcus multilocularis G-protein coupled receptor, putative 0.0081 0.044 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0035 0.0339
Echinococcus multilocularis g protein coupled receptor 0.0081 0.044 0.0439
Trichomonas vaginalis esterase, putative 0.0071 0.0382 0.5474
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0382 0.5474
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0204 0.291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Echinococcus multilocularis neuropeptide Y receptor 0.0081 0.044 0.0439
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0382 0.1272
Loa Loa (eye worm) hypothetical protein 0.0034 0.0146 0.0446
Brugia malayi Patched related family protein 10 0.0012 0.0008 0.0024
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0025 0.0024
Brugia malayi hypothetical protein 0.0012 0.0008 0.0024
Brugia malayi G-protein coupled receptor 0.0081 0.044 0.1354
Loa Loa (eye worm) glutamate receptor 0.008 0.0435 0.1337
Brugia malayi Serotonin receptor 0.0081 0.044 0.1354
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0137 0.1846
Mycobacterium tuberculosis Conserved protein 0.0071 0.0382 0.1272
Onchocerca volvulus 0.0081 0.044 0.6406
Brugia malayi RE15519p 0.0081 0.044 0.1354
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0319 0.0947
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3029 0.3028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0125
Echinococcus granulosus 7tm_1 domain containing protein 0.0081 0.044 0.1351
Brugia malayi Patched family protein 0.0012 0.0008 0.0024
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0081 0.044 0.0439
Brugia malayi larval opioid receptor 0.0081 0.044 0.1354
Plasmodium falciparum glutathione reductase 0.0033 0.0137 0.2523
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1373 0.1373
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0137 0.1639
Echinococcus granulosus G protein coupled receptor 139 0.0081 0.044 0.1351
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0382 0.1173
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0225 0.3214
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus granulosus Chromobox protein 3 0.0013 0.0013 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Echinococcus granulosus allatostatin A receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0081 0.044 0.132
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0137 0.0423
Echinococcus multilocularis protein patched 0.0084 0.0458 0.0457
Echinococcus granulosus muscleblind protein 0.0146 0.0847 0.2603
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.1275 0.4504
Brugia malayi Patched related family protein 12 0.0012 0.0008 0.0024
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0013 0.0095
Echinococcus granulosus metabotropic glutamate receptor 5 0.0099 0.0551 0.1694
Echinococcus multilocularis g protein coupled receptor 0.0081 0.044 0.0439
Schistosoma mansoni hypothetical protein 0.0081 0.044 0.132
Mycobacterium tuberculosis Probable reductase 0.0214 0.1275 0.4504
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 0.5997
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0081 0.044 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0081 0.044 0.0439
Echinococcus granulosus tar DNA binding protein 0.0062 0.0319 0.098
Echinococcus granulosus somatostatin receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0189
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0081 0.044 0.6406
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0687 1
Plasmodium falciparum thioredoxin reductase 0.0033 0.0137 0.2523
Echinococcus multilocularis orexin receptor type 2 0.0081 0.044 0.0439
Schistosoma mansoni hypothetical protein 0.0081 0.0439 0.1317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0099 0.0551 0.1694
Schistosoma mansoni amine GPCR 0.0081 0.044 0.132
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0416 0.1278
Brugia malayi G protein-coupled receptor 0.0081 0.044 0.1354
Onchocerca volvulus 0.0013 0.0013 0.0072
Brugia malayi sulfakinin receptor protein 0.0081 0.044 0.1354
Loa Loa (eye worm) hypothetical protein 0.0079 0.0428 0.1315
Echinococcus granulosus cpg binding protein 0.0037 0.0163 0.05
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0687 0.211
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0053
Schistosoma mansoni chromobox protein 0.0077 0.0416 0.1246
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0137 0.1639
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0081 0.044 0.1351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0081 0.044 0.0439
Echinococcus multilocularis neuropeptide receptor 0.0081 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Echinococcus multilocularis neuropeptide Y receptor 0.0081 0.044 0.0439
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0013 0.0095
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0048 0.0237 0.0727
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0687 0.2081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0137 0.2523
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.1171
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Plasmodium vivax glutathione reductase, putative 0.0094 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0683 0.2098
Toxoplasma gondii thioredoxin reductase 0.0094 0.0522 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0078 0.0572
Brugia malayi Probable ClpP-like protease 0.0079 0.0428 0.1317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0078 0.0566
Brugia malayi map kinase activated protein kinase protein 2 0.0529 0.3251 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Echinococcus granulosus chromobox protein 1 0.0077 0.0416 0.1278
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0081 0.044 0.1351
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0081 0.044 0.132
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0382 0.5271
Brugia malayi TAR-binding protein 0.0062 0.0319 0.0982
Onchocerca volvulus 0.0081 0.044 0.6406
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.1425 0.5046
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.1351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0081 0.044 0.132
Brugia malayi hypothetical protein 0.0081 0.044 0.1354
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0522 0.0521
Echinococcus multilocularis chromobox protein 2 0.0013 0.0013 0.0012
Echinococcus multilocularis allatostatin A receptor 0.0081 0.044 0.0439
Onchocerca volvulus 0.0081 0.044 0.6406
Onchocerca volvulus 0.0081 0.044 0.6406
Echinococcus multilocularis fmrfamide receptor 0.0081 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0146 0.0847 0.2603
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0137 0.247
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0137 0.2523
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0137 0.2523
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0081 0.044 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 1
Brugia malayi putative neuropeptide receptor NPR1 0.0081 0.044 0.1354
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0458 0.1407
Brugia malayi Muscleblind-like protein 0.0146 0.0847 0.2605
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0428 0.8181

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 1.1582 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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