Detailed information for compound 1395203

Basic information

Technical information
  • TDR Targets ID: 1395203
  • Name: ethyl N-(4,7-dimethyl-2-oxochromen-6-yl)carba mate
  • MW: 261.273 | Formula: C14H15NO4
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Nc1cc2c(C)cc(=O)oc2cc1C
  • InChi: 1S/C14H15NO4/c1-4-18-14(17)15-11-7-10-8(2)6-13(16)19-12(10)5-9(11)3/h5-7H,4H2,1-3H3,(H,15,17)
  • InChiKey: KRISPDMANDTCNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl N-(4,7-dimethyl-2-oxo-chromen-6-yl)carbamate
  • N-(4,7-dimethyl-2-oxo-6-chromenyl)carbamic acid ethyl ester
  • N-(2-keto-4,7-dimethyl-chromen-6-yl)carbamic acid ethyl ester
  • ZINC00485762
  • (4,7-Dimethyl-2-oxo-2H-chromen-6-yl)-carbamic acid ethyl ester
  • MLS000035366
  • SMR000012476
  • Oprea1_318189
  • BAS 03602997

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0263 0.0366
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0218 0.0439
Plasmodium vivax unspecified product 0.0489 0.4939 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0116 0.008
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0122 0.1147 0.2322
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0364 0.3644 0.7378
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1227 0.8837
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0328 0.0664
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0086 0.0018
Brugia malayi glutathione reductase 0.0057 0.0472 0.0955
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0615 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0116 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0472 0.2985
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0156
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0086 0.0172
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0086 0.0018
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0001
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0032 0.0064
Echinococcus granulosus protein kinase shaggy 0.0107 0.099 0.2004
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.0235
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0077 0.0154
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Giardia lamblia Kinase, CMGC CK2 0.0489 0.4939 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0364 0.3644 0.3644
Trypanosoma brucei Casein kinase II 0.0489 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0156
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0107 0.099 0.2004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0521 0.3369
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0122 0.1147 0.22
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0001 0.0002
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0857 0.1736
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0116 0.0233
Entamoeba histolytica protein kinase domain containing protein 0.0364 0.3644 0.7315
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0086 0.0018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1227 0.8837
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0156
Plasmodium falciparum thioredoxin reductase 0.002 0.0086 0.0172
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Brugia malayi MAP kinase sur-1 0.0122 0.1147 0.2322
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0086 0.0018
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0107 0.099 0.2002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0172
Plasmodium falciparum glutathione reductase 0.0057 0.0472 0.0953
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0116 0.0062
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0116 0.0235
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0116 0.0392
Plasmodium falciparum thioredoxin reductase 0.0057 0.0472 0.0953
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0489 0.4939 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0107 0.099 0.2004
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0077 0.0156
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0156
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0328 0.0664
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0107 0.099 0.1877
Brugia malayi jmjC domain containing protein 0.0071 0.0615 0.1246
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0116 0.0392
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0857 0.0857
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.1147 0.2322
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.099 0.1812
Loa Loa (eye worm) hypothetical protein 0.0094 0.0857 0.1736
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0122 0.1147 0.22
Echinococcus multilocularis mitogen activated protein kinase 0.0122 0.1147 0.1147
Mycobacterium tuberculosis Probable reductase 0.013 0.1227 0.8837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0086 0.0174
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0857 0.5514
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0077 0.0156
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0077 0.0156
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0077 0.0154
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0086 0.0172
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1378 1
Plasmodium falciparum glycogen synthase kinase 3 0.0107 0.099 0.2002
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0472 0.0955
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0364 0.3644 0.7378
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1378 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0615 0.1246
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.099 0.1863
Trypanosoma brucei trypanothione reductase 0.0057 0.0472 0.0811
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0472 0.0811
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1147 0.2186
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1227 0.8837
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0857 0.1736
Plasmodium falciparum casein kinase 2, alpha subunit 0.0489 0.4939 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1378 1
Giardia lamblia Kinase, CMGC GSK 0.0107 0.099 0.1863
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0615 0.0615
Echinococcus multilocularis protein kinase shaggy 0.0107 0.099 0.099
Echinococcus multilocularis expressed conserved protein 0.0012 0.0001 0.0001
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0077 0.0077
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0086 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1147 0.2186
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0521 0.0521
Echinococcus multilocularis mitogen activated protein kinase 3 0.0122 0.1147 0.1147
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0156
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0086 0.0172
Brugia malayi Thioredoxin reductase 0.0057 0.0472 0.0955
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.029 0.029
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0032 0.0064
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0472 0.0955
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0156
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0122 0.1147 0.232
Trypanosoma cruzi casein kinase II, putative 0.0489 0.4939 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0077 0.0154
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0077 0.0077
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0086 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0086 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0615 0.1246
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0263 0.0366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0116 0.008
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.0235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0122 0.1147 0.22
Brugia malayi Egg laying defective protein 4 0.0012 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0172
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0086 0.0172
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0086 0.0018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0615 0.0615
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0057 0.0472 0.0955
Trypanosoma brucei protein kinase, putative 0.0107 0.099 0.1877
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0116 0.0235
Entamoeba histolytica protein kinase domain containing protein 0.0489 0.4939 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1227 0.8705
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.029 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1147 0.2186
Toxoplasma gondii exonuclease III APE 0.0023 0.0116 0.0233
Entamoeba histolytica casein kinase, putative 0.0489 0.4939 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0001 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1378 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0116 0.0392
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0077 0.0077
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0077 0.0156
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0857 0.1734
Giardia lamblia Kinase, CMGC MAPK 0.0122 0.1147 0.2186
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0077 0.0156
Toxoplasma gondii CMGC kinase, CK2 family 0.0489 0.4939 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0615 0.1246
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.099 0.1863
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0077 0.0077
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.099 0.1812
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0521 0.1055
Toxoplasma gondii hypothetical protein 0.0033 0.0218 0.0439
Brugia malayi jmjC domain containing protein 0.0071 0.0615 0.1246
Entamoeba histolytica protein kinase, putative 0.0107 0.099 0.1812
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0077 0.0156
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0489 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0236 0.0479
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0086 0.0018
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0122 0.1147 0.22
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0001 0.0002
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0107 0.099 0.2002
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0107 0.099 0.2004
Echinococcus granulosus mitogen activated protein kinase 0.0122 0.1147 0.2322
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0122 0.1147 0.22
Leishmania major hypothetical protein, conserved 0.0019 0.0077 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0086 0.0018
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.0001 0.0002
Plasmodium vivax glycogen synthase kinase 3, putative 0.0107 0.099 0.1877
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0521 0.3369
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0086 0.0174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0218 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0615 0.1246
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.029 0.0588
Echinococcus multilocularis casein kinase ii subunit alpha 0.0489 0.4939 0.4939
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0107 0.099 0.2004
Plasmodium vivax glutathione reductase, putative 0.0057 0.0472 0.0811
Echinococcus granulosus phd:f box containing protein 0.0019 0.0077 0.0156
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0107 0.099 0.099
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.029 0.0588
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0116 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Trypanosoma brucei protein kinase, putative 0.0122 0.1147 0.22
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0472 0.0811
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0086 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0018
Plasmodium falciparum glutathione reductase 0.002 0.0086 0.0172
Brugia malayi Probable ClpP-like protease 0.0094 0.0857 0.1736
Leishmania major casein kinase II, putative 0.0489 0.4939 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0077 0.0156
Onchocerca volvulus 0.0107 0.099 0.5
Echinococcus granulosus casein kinase ii subunit alpha 0.0489 0.4939 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0077 0.0077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0086 0.0172
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1227 0.8837
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1227 0.8837
Schistosoma mansoni protein kinase 0.0489 0.4939 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0218 0.1708
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0857 0.1604
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0857 0.1734
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1147 0.2186
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0086 0.0172
Echinococcus granulosus mitogen activated protein kinase 3 0.0122 0.1147 0.2322
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 0.1734
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0077 0.0156
Giardia lamblia Kinase, CMGC GSK 0.0107 0.099 0.1863
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0156
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0615 0.1246
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0857 1
Brugia malayi Casein kinase II, alpha chain 0.0489 0.4939 1
Leishmania major trypanothione reductase 0.0057 0.0472 0.0953
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0364 0.3644 0.7378
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0472 0.0472
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0122 0.1147 0.232
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0062
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0122 0.1147 0.232
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0521 0.2616
Schistosoma mansoni serine/threonine protein kinase 0.0364 0.3644 0.7378
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0116 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0489 0.4939 1
Brugia malayi intracellular kinase 0.0107 0.099 0.2004
Toxoplasma gondii thioredoxin reductase 0.0057 0.0472 0.0953
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0116 0.0116
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0077 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0156

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0089 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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