TDR Targets

Basic information

Technical information

TDR Targets ID: 1400624
Name: N-[(1-morpholin-4-ylcyclohexyl)methyl]-1-benz ofuran-2-carboxamide
MW: 342.432 | Formula: C20H26N2O3
H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc2c(o1)cccc2)NCC1(CCCCC1)N1CCOCC1
InChi: 1S/C20H26N2O3/c23-19(18-14-16-6-2-3-7-17(16)25-18)21-15-20(8-4-1-5-9-20)22-10-12-24-13-11-22/h2-3,6-7,14H,1,4-5,8-13,15H2,(H,21,23)
InChiKey: OCDCXZBHRUOETK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(1-morpholinocyclohexyl)methyl]benzofuran-2-carboxamide
N-[(1-morpholinocyclohexyl)methyl]-2-benzofurancarboxamide
MLS000567210
SMR000153904
T5525445

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	fmrfamide receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0111	0.0111
Trichomonas vaginalis	esterase, putative	0.0043	0.0115	0.0115
Schistosoma mansoni	neuropeptide F-like receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	neuropeptide Y receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0042	0.0042
Echinococcus granulosus	allatostatin A receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0115	0.0115
Echinococcus multilocularis	sex peptide receptor	0.0043	0.0111	0.0111
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0012	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.013
Brugia malayi	Dopamine receptor protein 1	0.0043	0.0111	0.0111
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0115	0.0115
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0043	0.0111	0.0111
Brugia malayi	beta-lactamase family protein	0.0043	0.0115	0.0115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	zinc finger protein	0.0024	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	g-protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0043	0.0111	0.0111
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0115	0.0115
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0043	0.0111	0.0111
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0111	0.0111
Brugia malayi	RE15519p	0.0043	0.0111	0.0111
Brugia malayi	putative neuropeptide receptor NPR1	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Echinococcus granulosus	zinc finger protein	0.0024	0.0009	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0028	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0115	0.0115
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0115	0.0115
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	biogenic amine 5HT receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0319	0.1592	0.1592
Echinococcus multilocularis	neuropeptide receptor A26	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	G protein coupled receptor 139	0.0043	0.0111	0.0111
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0043	0.0111	0.0111
Echinococcus granulosus	fmrfamide receptor	0.0043	0.0111	0.0111
Plasmodium vivax	importin-beta 2, putative	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0111	0.0111
Brugia malayi	PHD-finger family protein	0.003	0.0043	0.0043
Schistosoma mansoni	hypothetical protein	0.0025	0.0016	0.0016
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0043	0.0111	0.0111
Echinococcus granulosus	sex peptide receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	snurportin 1	0.0319	0.1592	0.1592
Brugia malayi	Melatonin receptor type 1A	0.0043	0.0111	0.0111
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0043	0.0111	0.0111
Schistosoma mansoni	histamine h1 receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	somatostatin receptor	0.0043	0.0111	0.0111
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0115	0.0115
Schistosoma mansoni	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0111	0.0111
Onchocerca volvulus		0.0043	0.0115	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0043	0.0111	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0115	0.0115
Echinococcus granulosus	G protein coupled receptor 139	0.0043	0.0111	0.0111
Loa Loa (eye worm)	TYRA-2 protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0043	0.0111	0.0111
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	somatostatin receptor	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0043	0.0111	0.0111
Echinococcus multilocularis	fmrfamide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	dro:myosuppressin receptor	0.0043	0.0111	0.0111
Brugia malayi	GnHR receptor homolog	0.0043	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Echinococcus granulosus	importin subunit beta 1	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0158
Brugia malayi	sulfakinin receptor protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0146	0.0146
Schistosoma mansoni	myosin xvIII	0.0043	0.0111	0.0111
Brugia malayi	ORL1-like opioid receptor	0.0043	0.0111	0.0111
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0043	0.0111	0.0111
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0115	0.0115
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	AKH receptor	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	G-protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Brugia malayi	Serotonin receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	RNA, U transporter 1	0.0085	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Echinococcus multilocularis	neuropeptides capa receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0012	0.0012
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0043	0.0111	0.0111
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0115	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	snurportin 1	0.0319	0.1592	0.1592
Brugia malayi	G protein-coupled receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	neuropeptide F receptor	0.0043	0.0111	0.0111
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0012	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	MH2 domain containing protein	0.0144	0.0655	0.0655
Schistosoma mansoni	amine GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0111	0.0111
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0115	0.0115
Brugia malayi	Dopamine receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	orexin receptor type 2	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	beta-lactamase	0.0043	0.0115	0.0115
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptide FF receptor 2	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	neuropeptide F receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0043	0.0111	0.0111
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0012	0.0012
Loa Loa (eye worm)	G-protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0028	0.0028
Echinococcus multilocularis	neuropeptide s receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0115	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptides capa receptor	0.0043	0.0111	0.0111
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0012	0.0012
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0111	0.0111
Schistosoma mansoni	opsin-like receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0115	0.0115
Toxoplasma gondii	ABC1 family protein	0.0043	0.0115	0.0115
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0043	0.0111	0.0111
Brugia malayi	Importin beta-1 subunit	0.003	0.0042	0.0042
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0043	0.0111	0.0111
Echinococcus multilocularis	g-protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	orexin receptor type 2	0.0043	0.0111	0.0111
Schistosoma mansoni	growth hormone secretagogue receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	neuropeptide F-like receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	neuropeptide f receptor 76f	0.0043	0.0111	0.0111
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0085	0.034	0.034
Brugia malayi	putative neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0016	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0111	0.0111
Mycobacterium ulcerans	hypothetical protein	0.0824	0.4299	1
Echinococcus granulosus	neuropeptides capa receptor	0.0043	0.0111	0.0111
Brugia malayi	Serotonin receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	G-protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptide receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0115	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptide Y receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0043	0.0111	0.0111
Brugia malayi	Bromodomain containing protein	0.0046	0.013	0.013
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0043	0.0111	0.0111
Brugia malayi	G protein-coupled receptor F59B2.13	0.0043	0.0111	0.0111
Echinococcus multilocularis	dro:myosuppressin receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0115	0.0115
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0043	0.0111	0.0111
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0655	0.0655
Echinococcus multilocularis	neuropeptide Y receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0292	0.0292
Leishmania major	hypothetical protein, conserved	0.0043	0.0115	0.0115
Echinococcus multilocularis	serotonin receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptide receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Brugia malayi	beta-lactamase family protein	0.0043	0.0115	0.0115
Loa Loa (eye worm)	melatonin receptor type 1A	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	allatostatin A receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	serotonin receptor	0.0043	0.0111	0.0111
Brugia malayi	follicle stimulating hormone receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0655	0.0655
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0028	0.0028
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0111	0.0111
Brugia malayi	larval opioid receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0319	0.1592	0.1592
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0043	0.0111	0.0111
Brugia malayi	Bromodomain containing protein	0.0091	0.0367	0.0367
Echinococcus granulosus	neuropeptide receptor A26	0.0043	0.0111	0.0111
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0115	0.0115
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0043	0.0111	0.0111
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0042	0.0042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	amine GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	importin beta-1	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	opsin-like receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	7tm_1 domain containing protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Entamoeba histolytica	hypothetical protein	0.0024	0.0012	0.0012
Onchocerca volvulus		0.0043	0.0115	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.1371	0.3
Onchocerca volvulus		0.0043	0.0115	1
Plasmodium falciparum	importin beta, putative	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0111	0.0111
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0043	0.0111	0.0111
Echinococcus granulosus	7TM GPCR rhodopsin	0.0043	0.0111	0.0111
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	Dopamine receptor protein 2	0.0043	0.0111	0.0111
Brugia malayi	neuropeptide F receptor	0.0043	0.0111	0.0111
Brugia malayi	G-protein coupled receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0115	0.0115
Schistosoma mansoni	hypothetical protein	0.0043	0.0111	0.0111
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0043	0.0111	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0115	0.0115
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0268	0.0268
Schistosoma mansoni	adenoreceptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0043	0.0111	0.0111
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0043	0.0111	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0111	0.0111
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0043	0.0111	0.0111
Echinococcus multilocularis	neuropeptides capa receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0824	0.4299	1
Brugia malayi	neuropeptide F receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0115	0.0115
Echinococcus granulosus	serotonin receptor	0.0043	0.0111	0.0111
Schistosoma mansoni	opsin-like receptor	0.0043	0.0111	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0111	0.0111
Echinococcus granulosus	neuropeptide s receptor	0.0043	0.0111	0.0111
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0043	0.0111	0.0111
Schistosoma mansoni	zinc finger protein	0.0024	0.0009	0.0009
Echinococcus granulosus	neuropeptide Y receptor	0.0043	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0043	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0043	0.0111	0.0111
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0115	0.0115
Schistosoma mansoni	amine GPCR	0.0043	0.0111	0.0111
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0043	0.0111	0.0111

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3548 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1517839

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1400624