Detailed information for compound 1411036

Basic information

Technical information
  • TDR Targets ID: 1411036
  • Name: N-[4-[(benzoylamino)carbamoyl]phenyl]propanam ide
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 3 H acceptors: 3 LogP: 2.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
  • InChi: 1S/C17H17N3O3/c1-2-15(21)18-14-10-8-13(9-11-14)17(23)20-19-16(22)12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,18,21)(H,19,22)(H,20,23)
  • InChiKey: WXGNABBZSGWVCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-[oxo-[N'-(oxo-phenylmethyl)hydrazino]methyl]phenyl]propanamide
  • N-[4-[(benzoylamino)carbamoyl]phenyl]propionamide
  • N-[4-[(phenylcarbonylamino)carbamoyl]phenyl]propanamide
  • MLS000709100
  • SMR000282967
  • BAS 00394846
  • N-[4-(N'-Benzoyl-hydrazinocarbonyl)-phenyl]-propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli O157:H7 Shiga toxin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis imidazolonepropionase Shiga toxin   89 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis coatomer beta subunit, putative Shiga toxin   89 aa 87 aa 27.6 %
Schistosoma mansoni katanin P80 subunit Shiga toxin   89 aa 72 aa 23.6 %
Schistosoma japonicum Katanin p80 WD40-containing subunit B1, putative Shiga toxin   89 aa 72 aa 23.6 %
Echinococcus granulosus imidazolonepropionase Shiga toxin   89 aa 94 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0368 0.2339
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0044 0.0047
Echinococcus granulosus protein MICAL 3 0.0093 0.1574 0.171
Mycobacterium tuberculosis Possible oxidoreductase 0.0093 0.1574 0.9408
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0368 0.2339
Loa Loa (eye worm) endoplasmin 0.0032 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0545 1
Schistosoma mansoni opsin-like receptor 0.0015 0.0044 0.0047
Schistosoma mansoni neuropeptide receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis 0.0098 0.1666 0.1811
Onchocerca volvulus 0.0015 0.0044 0.0044
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0115 0.0125
Brugia malayi putative neuropeptide receptor 0.0015 0.0044 0.0044
Schistosoma mansoni amine GPCR 0.0015 0.0044 0.0047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0088 0.0088
Echinococcus multilocularis protoporphyrinogen oxidase 0.0098 0.1666 0.1811
Onchocerca volvulus 0.0015 0.0044 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Mycobacterium ulcerans hypothetical protein 0.0093 0.1574 0.9408
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0368 0.5981
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0127 0.2332
Brugia malayi neuropeptide F receptor 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni amine GPCR 0.0015 0.0044 0.0047
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1574 0.9408
Plasmodium falciparum protoporphyrinogen oxidase 0.0098 0.1666 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Entamoeba histolytica hypothetical protein 0.0041 0.0545 1
Schistosoma mansoni neuropeptide receptor 0.0015 0.0044 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0105 0.1934
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Entamoeba histolytica SWIRM domain protein 0.0041 0.0545 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.2081 0.2262
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0115 0.073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0044 0.0044
Brugia malayi SWIRM domain containing protein 0.0041 0.0545 0.0544
Echinococcus granulosus lamin 0.0033 0.0385 0.0419
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0044 0.0047
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0105 0.1934
Echinococcus granulosus neuropeptide receptor 0.0015 0.0044 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Brugia malayi Dopamine receptor protein 1 0.0015 0.0044 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0044 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0115 0.073
Echinococcus multilocularis musashi 0.0033 0.0385 0.0419
Schistosoma mansoni hypothetical protein 0.0093 0.1574 0.171
Echinococcus multilocularis cpg binding protein 0.0059 0.0909 0.0988
Onchocerca volvulus 0.0521 1 1
Brugia malayi ORL1-like opioid receptor 0.0015 0.0044 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0115 0.006
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0044 0.0047
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0368 0.6759
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0018 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0086 0.0093
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0044 0.0044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0115 0.2107
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0241 0.0924
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0138 0.2466 0.2466
Schistosoma mansoni amine GPCR 0.0015 0.0044 0.0047
Echinococcus granulosus g protein coupled receptor 0.0015 0.0044 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0044 0.0047
Trypanosoma cruzi UDP-galactopyranose mutase 0.0098 0.1666 1
Schistosoma mansoni heat shock protein 0.0032 0.0368 0.04
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0044 0.0047
Echinococcus granulosus g protein coupled receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Toxoplasma gondii FAD binding domain-containing protein 0.0093 0.1574 0.8591
Echinococcus multilocularis geminin 0.0205 0.377 0.4098
Echinococcus multilocularis heat shock protein 0.0032 0.0368 0.04
Toxoplasma gondii exonuclease III APE 0.0018 0.0105 0.0575
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0368 0.2209
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0545 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0044 0.0044
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0098 0.1666 1
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0044 0.0047
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0044 0.0047
Echinococcus granulosus hypothetical protein 0.0015 0.0044 0.0047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0044 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0105 0.0105
Trypanosoma brucei kynurenine 3-monooxygenase, putative 0.0093 0.1574 1
Entamoeba histolytica SWIRM domain protein 0.0041 0.0545 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0044 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0241 0.087
Schistosoma mansoni amine oxidase 0.0098 0.1666 0.1811
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0098 0.1666 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0105 0.0632
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0115 0.2107
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0093 0.1574 0.9408
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0044 0.0047
Schistosoma mansoni biogenic amine receptor 0.0015 0.0044 0.0047
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0105 0.0632
Schistosoma mansoni heat shock protein 0.0032 0.0368 0.04
Mycobacterium ulcerans oxidoreductase 0.0098 0.1666 1
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0093 0.1574 0.171
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0098 0.1666 1
Onchocerca volvulus 0.0015 0.0044 0.0044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0044 0.0044
Echinococcus granulosus fmrfamide receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0044 0.0047
Echinococcus granulosus heat shock protein 0.0032 0.0368 0.04
Schistosoma mansoni histamine h1 receptor 0.0015 0.0044 0.0047
Echinococcus granulosus allatostatin A receptor 0.0015 0.0044 0.0047
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0241 0.4427
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0368 0.2209
Echinococcus granulosus lysine specific histone demethylase 1A 0.0481 0.92 1
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0044 0.0047
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0093 0.1574 0.9408
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0054 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus endoplasmin 0.0025 0.0241 0.0262
Loa Loa (eye worm) hypothetical protein 0.0098 0.1666 0.1666
Schistosoma mansoni hypothetical protein 0.0205 0.377 0.4098
Schistosoma mansoni monoxygenase 0.0093 0.1574 0.171
Mycobacterium tuberculosis Conserved hypothetical protein 0.0098 0.1666 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0093 0.1574 0.1574
Leishmania major DNA polymerase eta, putative 0.0019 0.0115 0.0689
Plasmodium vivax endoplasmin, putative 0.0032 0.0368 0.2209
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0115 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0044 0.0047
Echinococcus multilocularis protein MICAL 3 0.0093 0.1574 0.171
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0044 0.0047
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0044 0.0047
Echinococcus granulosus dna polymerase eta 0.0019 0.0115 0.0125
Leishmania major DNA polymerase kappa, putative 0.0019 0.0115 0.0689
Mycobacterium tuberculosis Possible oxidoreductase 0.0093 0.1574 0.9408
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.0545 0.2972
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0093 0.1574 0.9352
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0018 0.002
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0115 0.006
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0044 0.0047
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0044 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0105 0.1934
Echinococcus multilocularis serotonin receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0105 0.0114
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0044 0.0047
Giardia lamblia Grp94/Hsp90 0.0025 0.0241 0.3091
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0044 0.0047
Brugia malayi RE15519p 0.0015 0.0044 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0115 0.0689
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Leishmania major UDP-galactopyranose mutase 0.0098 0.1666 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0385 0.0385
Echinococcus granulosus heat shock protein 90 0.0032 0.0368 0.04
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Leishmania major hypothetical protein, conserved 0.0093 0.1574 0.9445
Brugia malayi Dopamine receptor 0.0015 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni myosin xvIII 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0044 0.0044
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0115 0.0689
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0105 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Echinococcus granulosus intermediate filament protein 0.0033 0.0385 0.0419
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0101 0.1733 0.9462
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0115 0.0125
Echinococcus granulosus g protein coupled receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0044 0.0047
Schistosoma mansoni amine GPCR 0.0015 0.0044 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0105 0.0105
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0241 0.4427
Onchocerca volvulus 0.0015 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis lamin 0.0033 0.0385 0.0419
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0081 0.0081
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0044 0.0047
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0044 0.0044
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0241 0.1447
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0115 0.0125
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0368 0.2209
Trypanosoma brucei Monooxygenase, putative 0.0093 0.1574 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0545 0.0544
Schistosoma mansoni amine oxidase 0.0098 0.1666 0.1811
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0044 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0018 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0044 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0098 0.1666 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0098 0.1666 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0054 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0044 0.0047
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0481 0.92 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0044 0.0047
Echinococcus granulosus sex peptide receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0044 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0115 0.0115
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0098 0.1666 1
Echinococcus granulosus serotonin receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0044 0.0044
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0127 0.2332
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni cpg binding protein 0.0059 0.0909 0.0988
Brugia malayi G protein-coupled receptor 0.0015 0.0044 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0044 0.0047
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0098 0.1666 0.1666
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0044 0.0047
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0044 0.0047
Plasmodium vivax FAD-dependent monooxygenase, putative 0.0093 0.1574 0.9445
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0241 0.1447
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Giardia lamblia hypothetical protein 0.0041 0.0545 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0044 0.0047
Giardia lamblia DINP protein human, muc B family 0.0019 0.0115 0.0215
Schistosoma mansoni endoplasmin 0.0032 0.0368 0.04
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Chlamydia trachomatis protoporphyrinogen oxidase 0.0098 0.1666 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0115 0.2107
Brugia malayi hypothetical protein 0.0098 0.1666 0.1666
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0044 0.0047
Echinococcus granulosus somatostatin receptor 0.0015 0.0044 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0093 0.1574 0.171
Schistosoma mansoni ap endonuclease 0.0018 0.0105 0.0114
Echinococcus multilocularis heat shock protein 90 0.0025 0.0241 0.0262
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0044 0.0047
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0115 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0481 0.92 0.92
Brugia malayi G-protein coupled receptor 0.0015 0.0044 0.0044
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0093 0.1574 0.9445
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0115 0.073
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.759 0.825
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0056 0.0846 0.0846
Mycobacterium ulcerans oxidoreductase 0.0093 0.1574 0.9408
Mycobacterium ulcerans monoamine oxidase 0.0098 0.1666 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0098 0.1666 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0368 0.2209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis dna polymerase eta 0.0019 0.0115 0.0125
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0115 0.006
Brugia malayi sulfakinin receptor protein 0.0015 0.0044 0.0044
Echinococcus multilocularis sex peptide receptor 0.0015 0.0044 0.0047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.1832 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0044 0.0044
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0241 0.087
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0098 0.1666 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0115 0.0689
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Onchocerca volvulus 0.0015 0.0044 0.0044
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0368 0.0368
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0093 0.1574 1
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.0545 0.0592
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0093 0.1574 0.9445
Schistosoma mansoni DNA polymerase eta 0.0019 0.0115 0.0125
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0115 0.073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni intermediate filament proteins 0.0033 0.0385 0.0419
Echinococcus granulosus neuropeptide receptor 0.0015 0.0044 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Brugia malayi amine oxidase, flavin-containing family protein 0.0138 0.2466 0.2466
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0385 0.0385
Echinococcus granulosus cpg binding protein 0.0059 0.0909 0.0988
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0044 0.0047
Treponema pallidum heat shock protein 90 0.0025 0.0241 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0044 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0044 0.0047
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.0545 0.0592
Brugia malayi Serotonin receptor 0.0015 0.0044 0.0044
Mycobacterium tuberculosis Possible oxidoreductase 0.0093 0.1574 0.9408
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0368 0.2209
Echinococcus granulosus heat shock protein 90 0.0025 0.0241 0.0262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0086 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0115 0.073
Mycobacterium ulcerans dehydrogenase 0.0098 0.1666 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0044 0.0047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0105 0.0114
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0115 0.0115
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0241 0.1447
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0044 0.0047
Onchocerca volvulus 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis heat shock protein 90 0.0032 0.0368 0.04
Mycobacterium ulcerans hypothetical protein 0.0093 0.1574 0.9408
Schistosoma mansoni adenoreceptor 0.0015 0.0044 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0098 0.1666 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Plasmodium falciparum heat shock protein 90 0.0032 0.0368 0.2209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Schistosoma mansoni amine GPCR 0.0015 0.0044 0.0047
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0044 0.0047
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0241 0.0262
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0044 0.0047
Schistosoma mansoni biogenic amine receptor 0.0015 0.0044 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0044 0.0047
Onchocerca volvulus 0.0033 0.0385 0.0385
Schistosoma mansoni endoplasmin 0.0032 0.0368 0.04
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0368 0.2339
Onchocerca volvulus 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0093 0.1574 0.9408
Loa Loa (eye worm) hypothetical protein 0.0033 0.0385 0.0385
Echinococcus multilocularis somatostatin receptor 0.0015 0.0044 0.0047
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0044 0.0047
Mycobacterium ulcerans oxidoreductase GMC-type 0.0093 0.1574 0.9408
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0018 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0105 0.0632
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0044 0.0044
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0044 0.0047
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0368 0.6759
Trypanosoma cruzi Monooxygenase, putative 0.0093 0.1574 0.9445
Schistosoma mansoni cpg binding protein 0.0059 0.0909 0.0988
Brugia malayi heat shock protein 90 0.0032 0.0368 0.0368
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0113 0.0675
Brugia malayi neuropeptide F receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Onchocerca volvulus 0.0015 0.0044 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0846 0.0846
Mycobacterium tuberculosis Possible oxidoreductase 0.0098 0.1666 1
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.0545 0.0592
Schistosoma mansoni opsin-like receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis lamin dm0 0.0033 0.0385 0.0419
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0044 0.0047
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0086 0.0093
Trypanosoma brucei unspecified product 0.0019 0.0115 0.073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0115 0.0689
Brugia malayi Dopamine receptor protein 2 0.0015 0.0044 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0098 0.1666 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0042
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0044 0.0047
Echinococcus granulosus lysine specific histone demethylase 1A 0.0098 0.1666 0.1811
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0115 0.0689
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0044 0.0047
Brugia malayi Melatonin receptor type 1A 0.0015 0.0044 0.0044
Schistosoma mansoni cpg binding protein 0.0056 0.0846 0.092
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Trypanosoma brucei heat shock protein 84, putative 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0044 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0115 0.006
Echinococcus granulosus orexin receptor type 2 0.0015 0.0044 0.0047
Brugia malayi Serotonin receptor 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Brugia malayi GnHR receptor homolog 0.0015 0.0044 0.0044
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0241 0.4427
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0044 0.0047
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0047
Trypanosoma brucei heat shock protein, putative 0.0032 0.0368 0.2339
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0044 0.0047
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Brugia malayi intermediate filament protein 0.0033 0.0385 0.0385
Schistosoma mansoni hypothetical protein 0.0205 0.377 0.4098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Plasmodium falciparum endoplasmin, putative 0.0019 0.0127 0.0762
Onchocerca volvulus 0.0033 0.0385 0.0385
Echinococcus granulosus dna polymerase kappa 0.0019 0.0115 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0374 0.0373
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0044 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0105 0.0632
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Mycobacterium ulcerans oxidoreductase 0.0093 0.1574 0.9408
Schistosoma mansoni biogenic amine receptor 0.0015 0.0044 0.0047
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0105 0.0632
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0044 0.0047
Toxoplasma gondii FAD binding domain-containing protein 0.0093 0.1574 0.8591
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0044 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1574 0.9408
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0044 0.0047
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0368 0.2009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis endoplasmin 0.0025 0.0241 0.0262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0044 0.0047
Brugia malayi AKH receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0044 0.0047
Schistosoma mansoni opsin-like receptor 0.0015 0.0044 0.0047
Onchocerca volvulus 0.0015 0.0044 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0044 0.0047
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0044 0.0047
Toxoplasma gondii histone lysine-specific demethylase 0.0098 0.1666 0.9095
Brugia malayi G-protein coupled receptor 0.0015 0.0044 0.0044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0044 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0044 0.0047
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0399 0.759 0.825
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0044 0.0047
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0098 0.1666 0.1811
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0385 0.0385
Onchocerca volvulus 0.0015 0.0044 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0044 0.0047
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0044 0.0047
Schistosoma mansoni lamin 0.0033 0.0385 0.0419
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0044 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0115 0.0689
Schistosoma mansoni ap endonuclease 0.0018 0.0105 0.0114
Echinococcus granulosus geminin 0.0205 0.377 0.4098
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0368 0.2009
Schistosoma mansoni lamin 0.0033 0.0385 0.0419
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0044 0.0047
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0368 0.2209
Schistosoma mansoni neuropeptide receptor 0.0015 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0115 0.0115
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0018 0.002
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0481 0.92 1
Plasmodium falciparum FAD-dependent monooxygenase, putative 0.0093 0.1574 0.9445
Schistosoma mansoni hypothetical protein 0.0399 0.759 0.825
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0044 0.0047
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0044 0.0047
Schistosoma mansoni neuropeptide receptor 0.0015 0.0044 0.0047
Echinococcus granulosus lamin dm0 0.0033 0.0385 0.0419
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0044 0.0044
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0098 0.1666 1
Brugia malayi Endoplasmin precursor 0.0032 0.0368 0.0368
Onchocerca volvulus 0.0015 0.0044 0.0044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0044 0.0047
Brugia malayi CXXC zinc finger family protein 0.0056 0.0846 0.0846
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0368 0.6759
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0093 0.1574 0.9408
Loa Loa (eye worm) hypothetical protein 0.0521 1 1
Leishmania major heat shock protein 83-1 0.0032 0.0368 0.2209
Brugia malayi larval opioid receptor 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0481 0.92 0.92
Echinococcus multilocularis serotonin receptor 0.0015 0.0044 0.0047
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0241 0.3091
Brugia malayi hypothetical protein 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0044
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0044 0.0047
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0044 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0044 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.1574 0.9445

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10.0469 um PUBCHEM_BIOASSAY: A qHTS for Small Molecule Inhibitors of Shiga Toxin (Confirmatory). (Class of assay: confirmatory) [Related pubchem assays: 2314, 2318, 2315 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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