TDR Targets

Basic information

Technical information

TDR Targets ID: 1411644
Name: 2-[(4-chlorophenyl)sulfonylamino]-N-(cyclohex ylmethyl)pentanediamide
MW: 415.935 | Formula: C18H26ClN3O4S
H donors: 3 H acceptors: 4 LogP: 2.47 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(NS(=O)(=O)c1ccc(cc1)Cl)CCC(=O)N)NCC1CCCCC1
InChi: 1S/C18H26ClN3O4S/c19-14-6-8-15(9-7-14)27(25,26)22-16(10-11-17(20)23)18(24)21-12-13-4-2-1-3-5-13/h6-9,13,16,22H,1-5,10-12H2,(H2,20,23)(H,21,24)
InChiKey: IAEHWGONAGJJNB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-chlorophenyl)sulfonylamino]-N-(cyclohexylmethyl)glutaramide
T5254698

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.011	0.0535
Toxoplasma gondii	FAD binding domain-containing protein	0.0094	0.1567	0.8594
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0025	0.0245	0.1222
Mycobacterium ulcerans	FAD-dependent oxidoreductase	0.0094	0.1567	0.9326
Echinococcus granulosus	dna polymerase eta	0.0019	0.012	0.0124
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0552	0.2813
Echinococcus multilocularis	heat shock protein	0.0032	0.0371	0.0397
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0025	0.0245	0.0727
Toxoplasma gondii	heat shock protein 90, putative	0.0032	0.0371	0.2009
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.1961	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.012	0.0114
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.011	0.0626
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.011	0.0114
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0846	0.4313
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0099	0.1672	0.1813
Mycobacterium tuberculosis	Possible oxidoreductase	0.0099	0.1672	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0094	0.1567	0.9326
Echinococcus granulosus	heat shock protein	0.0032	0.0371	0.0397
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.011	0.0104
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Echinococcus multilocularis	ubiquinone biosynthesis monooxygenase COQ6	0.0094	0.1567	0.1698
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0099	0.1672	1
Plasmodium vivax	hypothetical protein, conserved	0.0094	0.1567	0.9368
Mycobacterium tuberculosis	Possible oxidoreductase	0.0094	0.1567	0.9326
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.012	0.0583
Mycobacterium ulcerans	oxidoreductase	0.0094	0.1567	0.9326
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0371	0.1867
Plasmodium vivax	hypothetical protein, conserved	0.0099	0.1672	1
Mycobacterium ulcerans	membrane-associated oxidoreductase	0.0094	0.1567	0.9326
Schistosoma mansoni	SWI/SNF complex-related	0.0041	0.0552	0.0594
Schistosoma mansoni	cpg binding protein	0.006	0.0907	0.098
Brugia malayi	amine oxidase, flavin-containing family protein	0.014	0.2472	0.2467
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.1961	1
Echinococcus granulosus	protein MICAL 3	0.0094	0.1567	0.1698
Echinococcus multilocularis	heat shock protein 90	0.0032	0.0371	0.0397
Schistosoma mansoni	heat shock protein	0.0032	0.0371	0.0397
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0099	0.1672	1
Schistosoma mansoni	hypothetical protein	0.0166	0.2976	0.323
Mycobacterium tuberculosis	Possible oxidoreductase	0.0094	0.1567	0.9326
Mycobacterium ulcerans	hypothetical protein	0.0094	0.1567	0.9326
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0245	0.1248
Trypanosoma cruzi	Heat shock protein 83, putative	0.0032	0.0371	0.1866
Trypanosoma brucei	heat shock protein 84, putative	0.0013	0.0006	0.0001
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0371	0.1866
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.011	0.0626
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.012	0.0582
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Schistosoma mansoni	endoplasmin	0.0032	0.0371	0.0397
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Wolbachia endosymbiont of Brugia malayi	2-polyprenyl-6-methoxyphenol 4-hydroxylase	0.0094	0.1567	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.1961	1
Toxoplasma gondii	FAD binding domain-containing protein	0.0094	0.1567	0.8594
Plasmodium vivax	endoplasmin, putative	0.0032	0.0371	0.219
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0107	0.1822	1
Brugia malayi	Endoplasmin precursor	0.0032	0.0371	0.0365
Entamoeba histolytica	SWIRM domain protein	0.0041	0.0552	0.2792
Plasmodium falciparum	heat shock protein 90	0.0032	0.0371	0.219
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.012	0.006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.012	0.0124
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.012	0.207	0.2245
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0846	0.4313
Schistosoma mansoni	cpg binding protein	0.006	0.0907	0.098
Giardia lamblia	Kinase, PLK	0.0114	0.1961	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.011	0.0534
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.012	0.061
Trypanosoma cruzi	heat shock protein 85, putative	0.0025	0.0245	0.1222
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.012	0.061
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.012	0.006
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.012	0.0114
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0099	0.1672	0.1813
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0099	0.1672	0.1813
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.012	0.0114
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0845	0.084
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.1567	0.9326
Onchocerca volvulus		0.0529	1	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.012	0.0582
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.012	0.0583
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0086	0.008
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0041	0.0552	0.0594
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.011	0.0534
Leishmania major	UDP-galactopyranose mutase	0.0099	0.1672	0.8522
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0371	0.1866
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.012	0.0583
Echinococcus multilocularis		0.0099	0.1672	0.1813
Echinococcus granulosus	heat shock protein 90	0.0025	0.0245	0.026
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0024	0.002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0024	0.002
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.1567	0.9326
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.012	0.0582
Giardia lamblia	DINP protein human, muc B family	0.0019	0.012	0.0051
Onchocerca volvulus		0.0056	0.0845	0.084
Loa Loa (eye worm)	hypothetical protein	0.014	0.2472	0.2467
Brugia malayi	heat shock protein 90	0.0032	0.0371	0.0365
Loa Loa (eye worm)	heat shock protein 90	0.0032	0.0371	0.0365
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0132	0.0671
Mycobacterium ulcerans	oxidoreductase GMC-type	0.0094	0.1567	0.9326
Loa Loa (eye worm)	endoplasmin	0.0032	0.0371	0.0365
Plasmodium falciparum	protoporphyrinogen oxidase	0.0099	0.1672	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0099	0.1672	1
Brugia malayi	hypothetical protein	0.0099	0.1672	0.1668
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.012	0.0124
Echinococcus granulosus	heat shock protein 90	0.0032	0.0371	0.0397
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Trypanosoma cruzi	Monooxygenase, putative	0.0094	0.1567	0.7984
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0099	0.1672	0.8522
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0099	0.1672	0.8522
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.011	0.0114
Schistosoma mansoni	DNA polymerase eta	0.0019	0.012	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0488	0.9201	1
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.009	0.0085
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.1961	0.1957
Echinococcus multilocularis	endoplasmin	0.0025	0.0245	0.026
Plasmodium falciparum	endoplasmin, putative	0.002	0.0132	0.0756
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.0006	0.003
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.1961	0.1957
Toxoplasma gondii	heat shock protein HSP90	0.0032	0.0371	0.2009
Plasmodium vivax	FAD-dependent monooxygenase, putative	0.0094	0.1567	0.9368
Brugia malayi	SWIRM domain containing protein	0.0041	0.0552	0.0546
Mycobacterium ulcerans	hypothetical protein	0.0094	0.1567	0.9326
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0132	0.0671
Echinococcus granulosus	dnaJ subfamily B	0.0402	0.7533	0.8186
Leishmania major	DNA polymerase kappa, putative	0.0019	0.012	0.0582
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0552	0.2813
Schistosoma mansoni	amine oxidase	0.0099	0.1672	0.1813
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1672	0.1668
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.1961	0.2127
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.011	0.0562
Echinococcus granulosus	ubiquinone biosynthesis monooxygenase COQ6	0.0094	0.1567	0.1698
Plasmodium falciparum	FAD-dependent monooxygenase, putative	0.0094	0.1567	0.9368
Mycobacterium ulcerans	FAD-linked oxidoreductase	0.0094	0.1567	0.9326
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.1961	0.2127
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Mycobacterium ulcerans	hypothetical protein	0.0094	0.1567	0.9326
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Plasmodium vivax	heat shock protein 86, putative	0.0032	0.0371	0.219
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0488	0.9201	1
Loa Loa (eye worm)	hypothetical protein	0.0488	0.9201	0.92
Echinococcus multilocularis	dnaJ subfamily B	0.0402	0.7533	0.8186
Trypanosoma brucei	Monooxygenase, putative	0.0094	0.1567	0.7984
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.012	0.0582
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0099	0.1672	1
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0041	0.0552	0.0594
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0371	0.1866
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0024	0.002
Trypanosoma brucei	kynurenine 3-monooxygenase, putative	0.0094	0.1567	0.7984
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Trypanosoma brucei	Heat shock protein 83, putative	0.0032	0.0371	0.1867
Trypanosoma cruzi	hypothetical protein, conserved	0.0094	0.1567	0.7984
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0371	0.189
Echinococcus multilocularis	protein MICAL 3	0.0094	0.1567	0.1698
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Loa Loa (eye worm)	hypothetical protein	0.0529	1	1
Loa Loa (eye worm)	hypothetical protein	0.0488	0.9201	0.92
Mycobacterium ulcerans	heat shock protein 90	0.0025	0.0245	0.0862
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Schistosoma mansoni	endoplasmin	0.0032	0.0371	0.0397
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0025	0.0245	0.0862
Mycobacterium ulcerans	oxidoreductase	0.0099	0.1672	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0032	0.0371	0.1407
Plasmodium vivax	hypothetical protein, conserved	0.0099	0.1672	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0371	0.1866
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.012	0.006
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0245	0.1248
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.012	0.006
Toxoplasma gondii	SWIRM domain-containing protein	0.0041	0.0552	0.3005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.012	0.0582
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.1961	0.1957
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0117	0.0571
Trypanosoma brucei	unspecified product	0.0019	0.012	0.0583
Echinococcus granulosus	cpg binding protein	0.006	0.0907	0.098
Schistosoma mansoni	heat shock protein	0.0032	0.0371	0.0397
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.011	0.0104
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Treponema pallidum	heat shock protein 90	0.0025	0.0245	1
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.1961	1
Schistosoma mansoni	hypothetical protein	0.0094	0.1567	0.1698
Schistosoma mansoni	cpg binding protein	0.0056	0.0845	0.0913
Mycobacterium ulcerans	oxidoreductase	0.0094	0.1567	0.9326
Schistosoma mansoni	hypothetical protein	0.0402	0.7533	0.8186
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Toxoplasma gondii	histone lysine-specific demethylase	0.0099	0.1672	0.9174
Echinococcus multilocularis	cpg binding protein	0.006	0.0907	0.098
Echinococcus multilocularis	dna polymerase eta	0.0019	0.012	0.0124
Echinococcus multilocularis	geminin	0.0166	0.2976	0.323
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0371	0.1866
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0103	0.1739	0.9541
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.011	0.0534
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1961	1
Schistosoma mansoni	kinase	0.0058	0.0875	0.0945
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.009	0.0092
Entamoeba histolytica	hypothetical protein	0.0041	0.0552	0.2792
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1567	0.1562
Giardia lamblia	hypothetical protein	0.0041	0.0552	0.2385
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Echinococcus granulosus	geminin	0.0166	0.2976	0.323
Mycobacterium ulcerans	dehydrogenase	0.0099	0.1672	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0845	0.084
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.012	0.0582
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Loa Loa (eye worm)	hypothetical protein	0.0019	0.012	0.0114
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.011	0.0562
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0025	0.0245	0.0924
Schistosoma mansoni	ap endonuclease	0.0018	0.011	0.0114
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.012	0.0582
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0025	0.0245	0.026
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1672	0.1668
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.1961	0.2127
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0552	0.0546
Entamoeba histolytica	SWIRM domain protein	0.0041	0.0552	0.2792
Giardia lamblia	Grp94/Hsp90	0.0025	0.0245	0.0727
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Leishmania major	hypothetical protein, conserved	0.0094	0.1567	0.7984
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0099	0.1672	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.012	0.0124
Schistosoma mansoni	ap endonuclease	0.0018	0.011	0.0114
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0099	0.1672	1
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0371	0.1867
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0024	0.002
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Toxoplasma gondii	exonuclease III APE	0.0018	0.011	0.0575
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.012	0.0124
Echinococcus granulosus	endoplasmin	0.0025	0.0245	0.026
Echinococcus multilocularis	heat shock protein 90	0.0025	0.0245	0.026
Leishmania major	heat shock protein 83-1	0.0032	0.0371	0.1866
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0488	0.9201	1
Schistosoma mansoni	amine oxidase	0.0099	0.1672	0.1813
Schistosoma mansoni	monoxygenase	0.0094	0.1567	0.1698
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0024	0.002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.009	0.0092
Trypanosoma cruzi	heat shock protein 90, putative	0.0025	0.0245	0.1222
Schistosoma mansoni	hypothetical protein	0.0166	0.2976	0.323
Trypanosoma brucei	polo-like protein kinase	0.0114	0.1961	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0099	0.1672	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.012	0.0124
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0099	0.1672	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.011	0.0534
Mycobacterium ulcerans	monoamine oxidase	0.0099	0.1672	1
Leishmania major	hypothetical protein, conserved	0.0094	0.1567	0.7984
Mycobacterium leprae	possibleputative FAD-linked oxidoreductase	0.0094	0.1567	0.9262
Trypanosoma cruzi	heat shock protein 90, putative	0.0032	0.0371	0.1866
Leishmania major	DNA polymerase eta, putative	0.0019	0.012	0.0582
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.012	0.0583
Echinococcus granulosus	dna polymerase kappa	0.0019	0.012	0.0124
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0099	0.1672	1
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0245	0.1248
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0099	0.1672	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.012	0.0583
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0371	0.1867

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10.6213 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	33.8078 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1547634

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1411644