Detailed information for compound 1415156

Basic information

Technical information
  • TDR Targets ID: 1415156
  • Name: 2-[[4-chloro-3-[(6-methylpyridin-2-yl)carbamo yl]phenyl]carbamoyl]cyclohexane-1-carboxylic acid
  • MW: 415.87 | Formula: C21H22ClN3O4
  • H donors: 3 H acceptors: 5 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCCC1C(=O)O)Nc1ccc(c(c1)C(=O)Nc1cccc(n1)C)Cl
  • InChi: 1S/C21H22ClN3O4/c1-12-5-4-8-18(23-12)25-20(27)16-11-13(9-10-17(16)22)24-19(26)14-6-2-3-7-15(14)21(28)29/h4-5,8-11,14-15H,2-3,6-7H2,1H3,(H,24,26)(H,28,29)(H,23,25,27)
  • InChiKey: JAMLLYYTRZICGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-chloro-3-[(6-methyl-2-pyridyl)carbamoyl]phenyl]carbamoyl]cyclohexane-1-carboxylic acid
  • 2-[[[4-chloro-3-[[(6-methyl-2-pyridyl)amino]-oxomethyl]phenyl]amino]-oxomethyl]-1-cyclohexanecarboxylic acid
  • 2-{[(4-chloro-3-{[(6-methyl-2-pyridinyl)amino]carbonyl}phenyl)amino]carbonyl}cyclohexanecarboxylic acid
  • MLS000052771
  • SMR000082576

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Brugia malayi PXA domain containing protein 0.0135 0.1342 0.1342
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0059 0.04 0.298
Echinococcus multilocularis plexin a4 0.0161 0.1664 0.1998
Echinococcus granulosus regulator of G protein signaling 3 0.0135 0.1342 0.1612
Schistosoma mansoni hypothetical protein 0.0061 0.0427 0.0427
Echinococcus multilocularis regulator of G protein signaling 7 0.0135 0.1342 0.1612
Trypanosoma cruzi aurora B kinase, putative 0.0059 0.04 1
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0698 0.8325 1
Schistosoma mansoni importin beta-1 0.0035 0.0099 0.0099
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0698 0.8325 0.8325
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0639 0.7589 0.7589
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Toxoplasma gondii aurora kinase 0.0059 0.04 1
Schistosoma mansoni protein kinase 0.0059 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0017 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0639 0.7589 0.7589
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0162 0.1204
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.04 0.298
Echinococcus multilocularis neuroglian 0.0064 0.0466 0.056
Brugia malayi PXA domain containing protein 0.0135 0.1342 0.1342
Echinococcus granulosus Immunoglobulin 0.0064 0.0466 0.056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0135 0.1342 0.1342
Echinococcus multilocularis snurportin 1 0.0372 0.4278 0.5138
Schistosoma mansoni hypothetical protein 0.0061 0.0427 0.0427
Loa Loa (eye worm) RGS-3 protein 0.0135 0.1342 0.1342
Brugia malayi regulator of G-protein signaling rgs-7 0.0135 0.1342 0.1342
Brugia malayi A-kinase anchor protein 10, precursor 0.0135 0.1342 0.1342
Echinococcus multilocularis axis inhibition protein axin 0.0135 0.1342 0.1612
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0135 0.1342 0.1342
Entamoeba histolytica protein kinase, putative 0.0059 0.04 0.298
Echinococcus multilocularis Regulator of G protein signaling 20 0.0135 0.1342 0.1612
Leishmania major protein kinase, putative 0.0059 0.04 1
Schistosoma mansoni nephrin 0.0064 0.0466 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0698 0.8325 1
Schistosoma mansoni regulator of G protein signaling 0.0135 0.1342 0.1342
Echinococcus granulosus roundabout 2 0.0064 0.0466 0.056
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0059 0.04 0.298
Echinococcus granulosus importin subunit beta 1 0.0035 0.0099 0.0119
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0017 0.013
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0064 0.0466 0.0466
Loa Loa (eye worm) AUR protein kinase 0.0059 0.04 0.04
Giardia lamblia Aurora kinase 0.0059 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0571 0.0571
Echinococcus multilocularis beta adrenergic receptor kinase 0.0639 0.7589 0.9115
Schistosoma mansoni plexin 0.0134 0.1331 0.1331
Loa Loa (eye worm) plexin A 0.0161 0.1664 0.1664
Brugia malayi hypothetical protein 0.0135 0.1342 0.1342
Echinococcus multilocularis Immunoglobulin 0.0064 0.0466 0.056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0017 0.013
Entamoeba histolytica hypothetical protein 0.0028 0.0017 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.04 0.04
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0466 0.0466
Echinococcus granulosus semaphorin 5B 0.0061 0.0427 0.0513
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0504 0.5914 0.7104
Schistosoma mansoni z-protein (S1r protein) 0.0135 0.1342 0.1342
Echinococcus multilocularis roundabout 2 0.0064 0.0466 0.056
Schistosoma mansoni semaphorin 5-related 0.0061 0.0427 0.0427
Brugia malayi Regulator of G protein signaling domain containing protein 0.0135 0.1342 0.1342
Schistosoma mansoni serine/threonine protein kinase 0.0639 0.7589 0.7589
Schistosoma mansoni plexin 0.0073 0.0571 0.0571
Brugia malayi Sema domain containing protein 0.0061 0.0427 0.0427
Echinococcus granulosus regulator of G protein signaling 3 0.0135 0.1342 0.1612
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Echinococcus multilocularis expressed protein 0.0135 0.1342 0.1612
Trichomonas vaginalis AGC family protein kinase 0.0059 0.04 0.298
Schistosoma mansoni vesicular amine transporter 0.0064 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Loa Loa (eye worm) AUR protein kinase 0.0059 0.04 0.04
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0135 0.1342 1
Echinococcus granulosus snurportin 1 0.0372 0.4278 0.5138
Schistosoma mansoni axis inhibition protein axin 0.0135 0.1342 0.1342
Brugia malayi hypothetical protein 0.0061 0.0427 0.0427
Brugia malayi serine/threonine protein kinase 6 0.0059 0.04 0.04
Echinococcus granulosus regulator of G protein signaling 7 0.0135 0.1342 0.1612
Echinococcus granulosus Regulator of G protein signaling 20 0.0135 0.1342 0.1612
Echinococcus granulosus beta-adrenergic receptor kinase 0.0639 0.7589 0.9115
Entamoeba histolytica protein kinase, putative 0.0059 0.04 0.298
Echinococcus multilocularis aurora kinase A 0.0059 0.04 0.048
Brugia malayi RNA, U transporter 1 0.0099 0.0895 0.0895
Brugia malayi Plexin repeat family protein 0.0134 0.1331 0.1331
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0135 0.1342 0.1612
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0099
Echinococcus granulosus axis inhibition protein axin 0.0135 0.1342 0.1612
Schistosoma mansoni regulator of G protein signaling 0.0135 0.1342 0.1342
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0064 0.0466 0.056
Schistosoma mansoni hypothetical protein 0.0372 0.4278 0.4278
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0099 0.0119
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Schistosoma mansoni regulator of G protein signaling 0.0135 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0134 0.1331 0.1331
Entamoeba histolytica protein kinase , putative 0.0059 0.04 0.298
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0833 1 1
Echinococcus multilocularis regulator of G protein signaling 0.0135 0.1342 0.1612
Schistosoma mansoni serine/threonine protein kinase 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0698 0.8325 0.8325
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0059 0.04 0.048
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0698 0.8325 0.8325
Echinococcus multilocularis regulator of G protein signaling 3 0.0135 0.1342 0.1612
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0064 0.0466 0.0466
Entamoeba histolytica hypothetical protein 0.0135 0.1342 1
Trypanosoma brucei aurora B kinase 0.0059 0.04 1
Entamoeba histolytica hypothetical protein 0.0135 0.1342 1
Brugia malayi hypothetical protein 0.0061 0.0427 0.0427
Echinococcus granulosus defective proboscis extension response 0.0064 0.0466 0.056
Brugia malayi plexin A 0.0161 0.1664 0.1664
Echinococcus granulosus neuroglian 0.0064 0.0466 0.056
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0059 0.04 1
Brugia malayi serine/threonine-protein kinase 6 0.0059 0.04 0.04
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0135 0.1342 0.1342
Loa Loa (eye worm) sema domain-containing protein 0.0061 0.0427 0.0427
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0059 0.04 0.048
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0077 0.0628 0.0628
Echinococcus granulosus aurora kinase A 0.0059 0.04 0.048
Brugia malayi serine/threonine kinase 12 0.0059 0.04 0.04
Echinococcus granulosus plexin a4 0.0161 0.1664 0.1998
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Onchocerca volvulus 0.0134 0.1331 1
Echinococcus multilocularis Immunoglobulin 0.0064 0.0466 0.056
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0628 0.0628
Trichomonas vaginalis AGC family protein kinase 0.0059 0.04 0.298
Entamoeba histolytica hypothetical protein 0.0135 0.1342 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0059 0.04 1
Echinococcus granulosus axis inhibition protein axin 0.0135 0.1342 0.1612
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0059 0.04 0.298
Echinococcus granulosus regulator of G protein signaling 7 0.0135 0.1342 0.1612
Schistosoma mansoni regulator of G protein signaling 0.0135 0.1342 0.1342
Echinococcus multilocularis hypothetical protein 0.0061 0.0427 0.0513
Echinococcus multilocularis regulator of G protein signaling 7 0.0135 0.1342 0.1612
Echinococcus granulosus expressed protein 0.0135 0.1342 0.1612
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0135 0.1342 0.1342
Echinococcus multilocularis semaphorin 5B 0.0061 0.0427 0.0513
Brugia malayi Sema domain containing protein 0.0061 0.0427 0.0427
Brugia malayi regulator of G-protein signaling egl-10 0.0135 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Schistosoma mansoni cell adhesion molecule 0.0064 0.0466 0.0466
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0135 0.1342 0.1342
Trichomonas vaginalis AGC family protein kinase 0.0059 0.04 0.298
Brugia malayi hypothetical protein 0.0135 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Echinococcus multilocularis regulator of G protein signaling 3 0.0135 0.1342 0.1612
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Echinococcus granulosus twitchin 0.0068 0.0512 0.0615
Loa Loa (eye worm) sema domain-containing protein 0.0061 0.0427 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4278 0.4278
Trichomonas vaginalis AGC family protein kinase 0.0059 0.04 0.298
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Loa Loa (eye worm) AUR protein kinase 0.0059 0.04 0.04
Entamoeba histolytica tyrosin kinase, putative 0.004 0.0162 0.1204
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1342 1
Echinococcus multilocularis axis inhibition protein axin 0.0135 0.1342 0.1612
Echinococcus granulosus G protein coupled receptor kinase 1 0.0504 0.5914 0.7104
Schistosoma mansoni hypothetical protein 0.0073 0.0571 0.0571
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0135 0.1342 0.1612
Schistosoma mansoni axis inhibition protein axin 0.0135 0.1342 0.1342
Brugia malayi hypothetical protein 0.0064 0.0466 0.0466
Schistosoma mansoni regulator of G protein signaling 0.0135 0.1342 0.1342
Brugia malayi Importin beta-1 subunit 0.0035 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0135 0.1342 0.1342
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0064 0.0466 0.056
Loa Loa (eye worm) PXA domain-containing protein 0.0135 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Echinococcus granulosus semaphorin 1A 0.0061 0.0427 0.0513

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0041 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.