Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.5049 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.018 | 0.2833 | 0.561 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.018 | 0.2833 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.5049 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0286 | 0.0286 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.018 | 0.2833 | 0.561 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.018 | 0.2833 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.0286 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0286 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.018 | 0.2833 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.5049 | 0.5049 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5049 | 0.5049 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0286 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.