Detailed information for compound 1420725

Basic information

Technical information
  • TDR Targets ID: 1420725
  • Name: N-[1-[2-(cyclohexylamino)-2-oxoethyl]piperidi n-4-yl]-4-methoxybenzamide
  • MW: 373.489 | Formula: C21H31N3O3
  • H donors: 2 H acceptors: 2 LogP: 2.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NC1CCN(CC1)CC(=O)NC1CCCCC1
  • InChi: 1S/C21H31N3O3/c1-27-19-9-7-16(8-10-19)21(26)23-18-11-13-24(14-12-18)15-20(25)22-17-5-3-2-4-6-17/h7-10,17-18H,2-6,11-15H2,1H3,(H,22,25)(H,23,26)
  • InChiKey: RRWWCXXTUZNZMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-[2-(cyclohexylamino)-2-oxo-ethyl]-4-piperidyl]-4-methoxy-benzamide
  • N-[1-[2-(cyclohexylamino)-2-oxoethyl]-4-piperidinyl]-4-methoxybenzamide
  • N-[1-[2-(cyclohexylamino)-2-keto-ethyl]-4-piperidyl]-4-methoxy-benzamide
  • N-[1-[2-(cyclohexylamino)-2-oxo-ethyl]piperidin-4-yl]-4-methoxy-benzamide
  • ASN 06463740
  • N-(1-Cyclohexylcarbamoylmethyl-piperidin-4-yl)-4-methoxy-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0034 0.0106
Loa Loa (eye worm) hypothetical protein 0.0145 0.1868 0.5878
Brugia malayi Muscleblind-like protein 0.0145 0.1868 0.5878
Loa Loa (eye worm) hypothetical protein 0.0049 0.0373 0.1173
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0346 0.109
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0231 0.0198
Loa Loa (eye worm) hypothetical protein 0.0145 0.1868 0.5878
Echinococcus granulosus hypothetical protein 0.0132 0.1668 0.1639
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0174 0.0549
Echinococcus granulosus expressed conserved protein 0.0062 0.0575 0.0543
Schistosoma mansoni alpha-glucosidase 0.0139 0.1768 0.174
Brugia malayi intermediate filament protein 0.0027 0.0034 0.0106
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.2116 0.6658
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0575 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0059 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0034 0.0106
Mycobacterium ulcerans hypothetical protein 0.0029 0.0071 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0174 0.3034
Brugia malayi hypothetical protein 0.0119 0.1464 0.4606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1057 0.1027
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0152 0.0477
Echinococcus granulosus beta catenin 0.0054 0.0462 0.0429
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2116 0.2089
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.2116 0.2089
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1057 0.1027
Mycobacterium tuberculosis Conserved alanine and leucine rich protein 0.0029 0.0071 0.5
Loa Loa (eye worm) HMP-2 protein 0.0054 0.0462 0.1453
Trypanosoma brucei glucosidase, putative 0.0036 0.0174 1
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0152 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0152 0.0118
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0034 0.0106
Trichomonas vaginalis hypothetical protein 0.0093 0.1055 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0152 0.0118
Brugia malayi hypothetical protein 0.023 0.3178 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0526 0.1656
Onchocerca volvulus Cirhin homolog 0.0054 0.0456 0.2953
Echinococcus multilocularis protein pangolin J 0.0134 0.17 0.1672
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0071 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Echinococcus granulosus survival motor neuron protein 1 0.023 0.3178 0.3154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0071 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0106
Toxoplasma gondii hypothetical protein 0.0062 0.0575 1
Plasmodium falciparum phd finger protein, putative 0.0028 0.0059 1
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.3178 0.3154
Echinococcus granulosus protein pangolin J 0.0134 0.17 0.1672
Echinococcus granulosus proteasome assembly chaperone 2 0.0093 0.1055 0.1025
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0059 1
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0054 0.0462 0.1453
Schistosoma mansoni survival motor neuron protein 0.0047 0.0346 0.0314
Onchocerca volvulus Alhambra homolog 0.0028 0.0059 0.0179
Echinococcus multilocularis expressed conserved protein 0.0152 0.1971 0.1944
Schistosoma mansoni beta-catenin 0.0054 0.0462 0.0429
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0059 0.0187
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0059 0.1033
Brugia malayi Bromodomain containing protein 0.0028 0.0059 0.0187
Onchocerca volvulus 0.0047 0.0346 0.2186
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0059 0.0026
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.2116 0.6658
Echinococcus multilocularis muscleblind protein 0.0145 0.1868 0.184
Echinococcus granulosus peregrin 0.0028 0.0059 0.0026
Brugia malayi hypothetical protein 0.0062 0.0575 0.181
Loa Loa (eye worm) hypothetical protein 0.0119 0.1464 0.4606
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0174 0.3034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2116 0.2089
Schistosoma mansoni hypothetical protein 0.0029 0.0071 0.0037
Brugia malayi jmjC domain containing protein 0.0093 0.1057 0.3327
Echinococcus multilocularis expressed conserved protein 0.0062 0.0575 0.0543
Schistosoma mansoni hypothetical protein 0.0047 0.0346 0.0314
Schistosoma mansoni hypothetical protein 0.0093 0.1055 0.1025
Echinococcus multilocularis peregrin 0.0028 0.0059 0.0026
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0059 0.0026
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.0119 0.1464 0.4606
Echinococcus multilocularis proteasome assembly chaperone 2 0.0093 0.1055 0.1025
Schistosoma mansoni alpha glucosidase 0.0036 0.0174 0.0141
Echinococcus granulosus muscleblind protein 0.0145 0.1868 0.184
Brugia malayi PHD-finger family protein 0.0028 0.0059 0.0187
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0059 0.1033
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0071 0.5
Onchocerca volvulus Huntingtin homolog 0.0119 0.1464 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1868 0.184
Loa Loa (eye worm) hypothetical protein 0.023 0.3178 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0071 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0059 0.0026
Schistosoma mansoni hypothetical protein 0.0132 0.1668 0.1639
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0152 0.0118
Entamoeba histolytica hypothetical protein 0.0093 0.1055 1
Echinococcus multilocularis beta catenin 0.0054 0.0462 0.0429
Brugia malayi jmjC domain containing protein 0.0034 0.0152 0.0477
Onchocerca volvulus Huntingtin homolog 0.0119 0.1464 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0762 0.0731
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0174 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.1768 0.174
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0174 0.0549
Echinococcus granulosus expressed conserved protein 0.0479 0.704 0.703
Onchocerca volvulus 0.0093 0.1064 0.7204
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0231 0.0198
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0174 0.3034
Schistosoma mansoni hypothetical protein 0.0152 0.1971 0.1944
Giardia lamblia PHD finger protein 15 0.0028 0.0059 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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