Detailed information for compound 1421657

Basic information

Technical information
  • TDR Targets ID: 1421657
  • Name: ethyl 2-[(5-cyclopropyl1,2-oxazole-3-carbonyl )amino]-4,5,6,7-tetrahydro-1-benzothiophene-3 -carboxylate
  • MW: 360.427 | Formula: C18H20N2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)c2noc(c2)C2CC2)sc2c1CCCC2
  • InChi: 1S/C18H20N2O4S/c1-2-23-18(22)15-11-5-3-4-6-14(11)25-17(15)19-16(21)12-9-13(24-20-12)10-7-8-10/h9-10H,2-8H2,1H3,(H,19,21)
  • InChiKey: BIWJEFHETPCONI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[(5-cyclopropylisoxazole-3-carbonyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
  • 2-[[(5-cyclopropyl-3-isoxazolyl)-oxomethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • 2-[(5-cyclopropylisoxazole-3-carbonyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • ethyl 2-[(5-cyclopropyl-1,2-oxazol-3-yl)carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • MLS000116347
  • SMR000093324

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0064 0.2606 0.2266
Giardia lamblia ABC transporter 0.0181 0.9051 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.2914 0.2422
Entamoeba histolytica multidrug resistance protein, putative 0.0064 0.2606 0.2093
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.2914 0.2555
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0064 0.2606 0.2093
Brugia malayi ABC transporter 0.0064 0.2606 0.2606
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0064 0.2606 0.2232
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.2659 0.2287
Plasmodium vivax multidrug resistance protein 2, putative 0.0064 0.2606 0.2232
Brugia malayi ABC transporter family protein 0.0158 0.7759 0.7759
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0064 0.2606 0.2232
Schistosoma mansoni smdr1 0.0064 0.2606 0.2093
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.2914 0.2914
Schistosoma mansoni tar DNA-binding protein 0.0062 0.254 0.2022
Onchocerca volvulus 0.0199 1 0.5
Echinococcus granulosus multidrug resistance associated protein 7 0.0064 0.2606 0.0308
Giardia lamblia MRP-like ABC transporter 0.0064 0.2606 0.0351
Leishmania major ATP-binding cassette protein subfamily G, member 2, putative 0.0032 0.0884 0.0422
Trichomonas vaginalis abcb9, putative 0.0199 1 1
Schistosoma mansoni multidrug resistance protein 0.0064 0.2606 0.2093
Echinococcus multilocularis ATP binding cassette sub family B 0.0064 0.2606 0.0089
Brugia malayi ABC transporter 0.0059 0.2371 0.2371
Loa Loa (eye worm) hypothetical protein 0.0194 0.9765 0.9753
Schistosoma mansoni ABC transporter 0.0158 0.7759 0.7603
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0199 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0649 0.0176
Entamoeba histolytica P-glycoprotein-2 0.0199 1 1
Schistosoma mansoni multidrug resistance protein 0.0064 0.2606 0.2093
Loa Loa (eye worm) multidrug resistance protein 3 0.0199 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0064 0.2606 0.0308
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.2914 0.2422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.254 0.2162
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0199 1 1
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0064 0.2606 0.2413
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0199 1 1
Plasmodium falciparum multidrug resistance protein 2 0.0064 0.2606 0.2232
Brugia malayi ABC transporter transmembrane region family protein 0.0064 0.2606 0.2606
Brugia malayi ABC transporter family protein 0.0064 0.2606 0.2606
Plasmodium falciparum ABC transporter B family member 4, putative 0.0064 0.2606 0.2232
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.254 0.254
Echinococcus granulosus tar DNA binding protein 0.0062 0.254 0.0221
Loa Loa (eye worm) hypothetical protein 0.0199 1 1
Trypanosoma brucei ABC transporter, putative 0.0186 0.9286 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Plasmodium vivax ABC transporter B family member 4, putative 0.0064 0.2606 0.2232
Entamoeba histolytica P-glycoprotein-2, putative 0.0059 0.2371 0.1842
Schistosoma mansoni tar DNA-binding protein 0.0062 0.254 0.2022
Loa Loa (eye worm) TAR-binding protein 0.0062 0.254 0.2162
Entamoeba histolytica ATP-binding cassette protein, putative 0.0064 0.2606 0.2093
Loa Loa (eye worm) hypothetical protein 0.0064 0.2606 0.2232
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0199 1 1
Entamoeba histolytica P-glycoprotein-1 0.0199 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Loa Loa (eye worm) ABC transporter 0.0064 0.2606 0.2232
Plasmodium falciparum multidrug resistance-associated protein 1 0.0064 0.2606 0.2232
Loa Loa (eye worm) hypothetical protein 0.0059 0.2371 0.1985
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0186 0.9286 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0064 0.2606 0.0089
Plasmodium vivax ABC transporter G family member 2, putative 0.0186 0.9286 0.9249
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0199 1 1
Entamoeba histolytica P-glycoprotein-5 0.0199 1 1
Trichomonas vaginalis ABC transporter, putative 0.0199 1 1
Trichomonas vaginalis abcb9, putative 0.0199 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Brugia malayi hypothetical protein 0.0025 0.0482 0.0482
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0154 0.7524 0.7352
Trypanosoma brucei ATP-binding cassette protein, putative 0.0186 0.9286 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0064 0.2606 0.2413
Loa Loa (eye worm) RNA binding protein 0.0062 0.254 0.2162
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0064 0.2606 0.2413
Schistosoma mansoni smdr2 0.0199 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0199 1 1
Leishmania major p-glycoprotein e 0.0064 0.2606 0.2232
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.5563 0.5338
Schistosoma mansoni multidrug resistance protein 0.0064 0.2606 0.2093
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0199 1 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0199 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Schistosoma mansoni multidrug resistance protein 0.0059 0.2371 0.1842
Schistosoma mansoni multidrug resistance protein 0.0064 0.2606 0.2093
Giardia lamblia ABC transporter, putative 0.0064 0.2606 0.0351
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0064 0.2606 0.2232
Schistosoma mansoni tar DNA-binding protein 0.0062 0.254 0.2022
Leishmania major ATP-binding cassette protein subfamily G, member 1, putative 0.0032 0.0884 0.0422
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0199 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Toxoplasma gondii ABC transporter family protein 0.0064 0.2606 0.2232
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0064 0.2606 0.2413
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0199 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0194 0.9765 0.9685
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0064 0.2606 0.2232
Plasmodium vivax multidrug resistance protein 1, putative 0.0199 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0064 0.2606 0.2093
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0064 0.2606 0.0308
Trichomonas vaginalis ABC transporter, putative 0.0199 1 1
Trypanosoma cruzi ABC transporter, putative 0.0032 0.0884 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0649 0.019
Schistosoma mansoni hypothetical protein 0.0034 0.0961 0.0333
Plasmodium falciparum ABC transporter G family member 2 0.0186 0.9286 0.9249
Echinococcus granulosus multidrug resistance associated protein 1 0.0064 0.2606 0.0308
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0199 1 1
Entamoeba histolytica P-glycoprotein-2 0.0199 1 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0064 0.2606 0.2266
Brugia malayi ABC transporter family protein 0.0064 0.2606 0.2606
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.2914 0.2622
Trypanosoma cruzi ABC transporter, putative 0.0028 0.0649 0.019
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0186 0.9286 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0186 0.9286 0.9042
Echinococcus granulosus ATP binding cassette sub family G 0.0186 0.9286 0.9064
Echinococcus granulosus ATP binding cassette sub family G 0.0186 0.9286 0.9064
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0064 0.2606 0.2093
Echinococcus multilocularis multidrug resistance protein 1 0.0199 1 1
Trichomonas vaginalis ABC transporter, putative 0.0199 1 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG107 0.0032 0.0884 0.0422
Toxoplasma gondii ATP-binding cassette G family transporter ABCG89 0.0032 0.0884 0.0422
Brugia malayi multidrug resistance related protein 1 0.0064 0.2606 0.2606
Brugia malayi MH2 domain containing protein 0.0118 0.5563 0.5563
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0064 0.2606 0.2232
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0064 0.2606 0.2413
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0199 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.2914 0.2622
Echinococcus granulosus ATP binding cassette sub family G 0.0186 0.9286 0.9064
Echinococcus granulosus multidrug resistance protein 1 0.0199 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1812 0.1397
Brugia malayi ABC transporter transmembrane region family protein 0.0059 0.2371 0.2371
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Brugia malayi ABC transporter family protein 0.0199 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0186 0.9286 0.9042
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0199 1 1
Schistosoma mansoni multidrug resistance protein 0.0199 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0186 0.9286 0.9249
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0064 0.2606 0.2606
Entamoeba histolytica ATP-binding cassette protein, putative 0.0064 0.2606 0.2093
Echinococcus granulosus ATP binding cassette sub family B 0.0064 0.2606 0.0308
Schistosoma mansoni multidrug resistance protein 0.0199 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Trypanosoma brucei ATP-binding cassette protein subfamily G 0.0032 0.0884 0.0456
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0032 0.0884 0.0456
Entamoeba histolytica P-glycoprotein 6, putative 0.0064 0.2606 0.2093
Giardia lamblia Multidrug resistance-associated protein 1 0.0064 0.2606 0.0351
Loa Loa (eye worm) ABC transporter 0.0158 0.7759 0.7645
Loa Loa (eye worm) hypothetical protein 0.0049 0.1812 0.1397
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1812 0.1812
Leishmania major p-glycoprotein 0.0199 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.254 0.2022
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0186 0.9286 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0064 0.2606 0.2413
Entamoeba histolytica P-glycoprotein 5, putative 0.0199 1 1
Entamoeba histolytica hypothetical protein 0.0064 0.2606 0.2093
Trichomonas vaginalis taga, putative 0.0199 1 1
Plasmodium vivax ABC transporter B family member 7, putative 0.0064 0.2606 0.2232
Echinococcus granulosus multidrug resistance protein 1 0.0139 0.6751 0.5741
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0064 0.2606 0.2232
Plasmodium vivax ABC transporter B family member 3, putative 0.0064 0.2606 0.2232
Loa Loa (eye worm) hypothetical protein 0.0028 0.0649 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0884 0.0456
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0199 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0199 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0186 0.9286 0.9249
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0199 1 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0059 0.2371 0.1842
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Trichomonas vaginalis abcb9, putative 0.0199 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0199 1 1
Trypanosoma cruzi ABC transporter, putative 0.0028 0.0649 0.019
Entamoeba histolytica P-glycoprotein 6, putative 0.0064 0.2606 0.2093
Entamoeba histolytica ABC transporter, putative 0.0186 0.9286 0.9236
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0064 0.2606 0.2413
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0186 0.9286 1
Schistosoma mansoni hypothetical protein 0.0154 0.7524 0.7352
Echinococcus multilocularis ATP binding cassette sub family B 0.0064 0.2606 0.0089
Plasmodium vivax ABC transporter B family member 6, putative 0.0064 0.2606 0.2232
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0064 0.2606 0.2232
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0186 0.9286 0.9249
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0199 1 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0199 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.2606 0.2232
Echinococcus multilocularis 0.0064 0.2606 0.0089
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0064 0.2606 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0199 1 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0064 0.2606 0.2232
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0064 0.2606 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0961 0.0961
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0199 1 1
Loa Loa (eye worm) ABC transporter 0.0064 0.2606 0.2232
Schistosoma mansoni multidrug resistance protein 0.0064 0.2606 0.2093
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0064 0.2606 0.2266
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0064 0.2606 0.2093
Leishmania major pentamidine resistance protein 1 0.0064 0.2606 0.2232
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0064 0.2606 0.2232
Plasmodium falciparum ABC transporter B family member 7, putative 0.0064 0.2606 0.2232
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0064 0.2606 0.5
Trypanosoma cruzi ABC transporter, putative 0.0186 0.9286 1
Leishmania major ABC-thiol transporter 0.0064 0.2606 0.2232
Entamoeba histolytica P-glycoprotein 5, putative 0.0059 0.2371 0.1842
Loa Loa (eye worm) hypothetical protein 0.0028 0.0649 0.0176
Schistosoma mansoni multidrug resistance protein 0.0199 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0064 0.2606 0.2232
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.5563 0.5338
Trypanosoma brucei multidrug resistance protein E 0.0064 0.2606 0.2413
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0064 0.2606 0.2266
Echinococcus multilocularis ATP binding cassette sub family B 0.0064 0.2606 0.0089
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0032 0.0884 0.0456
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0064 0.2606 1
Loa Loa (eye worm) ABC transporter 0.0064 0.2606 0.2232
Loa Loa (eye worm) hypothetical protein 0.0064 0.2606 0.2232
Echinococcus multilocularis multidrug resistance associated protein 1 0.0064 0.2606 0.0089
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0064 0.2606 0.2413
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.2914 0.0711
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0064 0.2606 0.2232
Loa Loa (eye worm) hypothetical protein 0.0059 0.2371 0.1985
Loa Loa (eye worm) hypothetical protein 0.0034 0.0961 0.0503
Trypanosoma brucei p-glycoprotein 0.0064 0.2606 0.2413
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Echinococcus multilocularis multidrug resistance protein 1 0.0139 0.6751 0.5645
Trypanosoma cruzi multidrug resistance protein E, putative 0.0064 0.2606 0.2413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1812 0.1812
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0064 0.2606 0.2232
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0064 0.2606 0.2093
Entamoeba histolytica P-glycoprotein-2, putative 0.0199 1 1
Trypanosoma brucei ABC transporter, putative 0.0032 0.0884 0.0456
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0194 0.9765 0.9692
Loa Loa (eye worm) hypothetical protein 0.0199 1 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0186 0.9286 0.9236
Brugia malayi hypothetical protein 0.0028 0.0649 0.0649
Brugia malayi RE11181p 0.0028 0.0649 0.0649
Echinococcus multilocularis ATP binding cassette sub family G 0.0186 0.9286 0.9042
Echinococcus granulosus multidrug resistance protein 1 0.0139 0.6751 0.5741
Plasmodium falciparum ABC transporter B family member 6, putative 0.0064 0.2606 0.2232
Plasmodium falciparum ABC transporter B family member 3, putative 0.0064 0.2606 0.2232
Giardia lamblia Multidrug resistance-associated protein 1 0.0064 0.2606 0.0351
Brugia malayi ABC transporter transmembrane region family protein 0.0064 0.2606 0.2606
Echinococcus granulosus multidrug resistance protein 1 0.0199 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0199 1 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.0064 0.2606 0.2232
Echinococcus multilocularis ATP binding cassette sub family B 0.0064 0.2606 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0062 0.254 0.2022
Echinococcus multilocularis multidrug resistance protein 1 0.0199 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.2914 0.0502
Brugia malayi TAR-binding protein 0.0062 0.254 0.254
Entamoeba histolytica P-glyco protein 6, putative 0.0199 1 1
Brugia malayi hypothetical protein 0.0064 0.2606 0.2606
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0199 1 1
Trichomonas vaginalis ABC transporter, putative 0.0199 1 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG87 0.0032 0.0884 0.0422
Brugia malayi RNA binding protein 0.0062 0.254 0.254
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0064 0.2606 0.2266
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0199 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0884 0.0456
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0199 1 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG96 0.0032 0.0884 0.0422
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0139 0.6751 0.5741
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0199 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 5, putative 0.0032 0.0884 0.0422
Brugia malayi ABC transporter family protein 0.0064 0.2606 0.2606
Plasmodium vivax ABC transporter B family member 5, putative 0.0064 0.2606 0.2232
Plasmodium falciparum multidrug resistance-associated protein 2 0.0064 0.2606 0.2232
Toxoplasma gondii ABC transporter, putative 0.0064 0.2606 0.2232
Brugia malayi P-glycoprotein-like protein 0.0064 0.2606 0.2606
Entamoeba histolytica ABC transporter, putative 0.0064 0.2606 0.2093

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) 66.7 uM PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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