Detailed information for compound 1427986

Basic information

Technical information
  • TDR Targets ID: 1427986
  • Name: N-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylp henyl)-2-phenylsulfanylacetamide
  • MW: 477.597 | Formula: C22H27N3O5S2
  • H donors: 1 H acceptors: 3 LogP: 1.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(ccc1N1CCOCC1)S(=O)(=O)N1CCOCC1)CSc1ccccc1
  • InChi: 1S/C22H27N3O5S2/c26-22(17-31-18-4-2-1-3-5-18)23-20-16-19(32(27,28)25-10-14-30-15-11-25)6-7-21(20)24-8-12-29-13-9-24/h1-7,16H,8-15,17H2,(H,23,26)
  • InChiKey: GZFZTQLKKNBNOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-morpholino-5-morpholinosulfonyl-phenyl)-2-phenylsulfanyl-acetamide
  • N-(2-morpholino-5-morpholinosulfonylphenyl)-2-(phenylthio)acetamide
  • N-(2-morpholino-5-morpholinosulfonyl-phenyl)-2-(phenylthio)acetamide
  • N-(2-morpholin-4-yl-5-morpholin-4-ylsulfonyl-phenyl)-2-phenylsulfanyl-ethanamide
  • T5258039
  • MLS000776404
  • SMR000371380

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Schistosoma mansoni alpha-glucosidase 0.0169 0.1849 0.4064
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.083 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0392 0.0862
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0392 0.0862
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1248 0.3566
Schistosoma mansoni tyrosine kinase 0.0086 0.0877 0.1928
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0392 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0392 0.0927
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0061 0.0598 0.1315
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0061 0.0598 0.1315
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0392 0.4203
Onchocerca volvulus 0.0061 0.0598 0.2649
Schistosoma mansoni amine oxidase 0.0061 0.0598 0.1315
Mycobacterium tuberculosis Possible oxidoreductase 0.0061 0.0598 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2386 0.6745
Leishmania major UDP-galactopyranose mutase 0.0061 0.0598 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0476 0.1358
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0044 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0074 0.0251
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0476 0.1045
Loa Loa (eye worm) hypothetical protein 0.0034 0.0275 0.0785
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0455 0.1299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0402 0.0884
Plasmodium falciparum protoporphyrinogen oxidase 0.0061 0.0598 0.075
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.455 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0402 0.1149
Brugia malayi hypothetical protein 0.0061 0.0598 0.1709
Schistosoma mansoni hypothetical protein 0.0034 0.0275 0.0604
Echinococcus multilocularis GPCR, family 2 0.0016 0.0066 0.0145
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0145
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0392 0.0927
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0061 0.0598 0.075
Schistosoma mansoni cpg binding protein 0.003 0.0232 0.051
Echinococcus multilocularis geminin 0.0205 0.2258 0.4963
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0061 0.0598 0.075
Brugia malayi isocitrate dehydrogenase 0.0016 0.0066 0.0189
Schistosoma mansoni tyrosine kinase 0.0085 0.0867 0.1905
Brugia malayi MH2 domain containing protein 0.0118 0.1248 0.3566
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0506 0.7974
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0392 0.0927
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0066 0.0145
Schistosoma mansoni hypothetical protein 0.0014 0.0044 0.0097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0455 0.1299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0402 0.0884
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0402 0.0884
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0239 0.5296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0392 0.112
Echinococcus granulosus GPCR family 2 0.0016 0.0066 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.1849 0.4064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0392 0.0927
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Echinococcus multilocularis 0.0061 0.0598 0.1315
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2167 0.4762
Trypanosoma cruzi UDP-galactopyranose mutase 0.0061 0.0598 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0066 0.0188
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0392 0.0927
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0627 0.7156 0.6975
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0066 0.0188
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0476 0.1045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0392 0.0927
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0627 0.7156 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0275 0.0785
Echinococcus granulosus epidermal growth factor receptor 0.0086 0.0877 0.1928
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0146
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0066 0.0189
Schistosoma mansoni tyrosine kinase 0.0085 0.0867 0.1905
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0239 0.0243
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0402 0.1149
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0392 0.6124
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3501 1
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.083 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2167 0.4762
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0146
Schistosoma mansoni tyrosine kinase 0.0085 0.0867 0.1905
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0066 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0402 0.0884
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0061 0.0598 0.1315
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.083 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0066 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0239 0.3243
Brugia malayi SWIRM domain containing protein 0.0061 0.0598 0.1709
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0066 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0239 0.0243
Loa Loa (eye worm) TK/EGFR protein kinase 0.0159 0.1731 0.4945
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0392 0.6124
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0392 0.5902
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0627 0.7156 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1248 0.3566
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0146
Schistosoma mansoni cpg binding protein 0.003 0.0232 0.051
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0392 0.0927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0581 0.1276
Echinococcus granulosus lysine specific histone demethylase 1A 0.0061 0.0598 0.1315
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0598 0.0577
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0873 1 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0154
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0598 0.075
Onchocerca volvulus 0.0114 0.1205 0.5337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0402 0.0884
Brugia malayi hypothetical protein 0.003 0.0239 0.0682
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.1731 0.3805
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0213
Schistosoma mansoni hypothetical protein 0.0205 0.2258 0.4963
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0402 0.0884
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0066 0.0145
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Brugia malayi Furin-like cysteine rich region family protein 0.0159 0.1731 0.4945
Brugia malayi amine oxidase, flavin-containing family protein 0.0061 0.0598 0.1709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0402 0.0884
Echinococcus granulosus lysine specific histone demethylase 1A 0.0061 0.0598 0.1315
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0239 0.0243
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0145
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0239 0.3126
Trypanosoma brucei glucosidase, putative 0.0044 0.0392 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0239 0.3243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0392 0.112
Echinococcus granulosus geminin 0.0205 0.2258 0.4963
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0061 0.0598 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0086 0.0877 0.1928
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0074 0.0213
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.083 1
Echinococcus multilocularis 0.0049 0.0457 0.1005
Echinococcus granulosus dnaJ subfamily B 0.0402 0.455 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3501 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0066 0.0146
Schistosoma mansoni tyrosine kinase 0.0051 0.0476 0.1045
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2258 0.6372
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0627 0.7156 0.6975
Brugia malayi CXXC zinc finger family protein 0.0028 0.0213 0.061
Echinococcus multilocularis insulin receptor 0.0051 0.0476 0.1045
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.1731 0.3805
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2167 0.4762
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2167 0.6188
Brugia malayi hypothetical protein 0.002 0.0114 0.0325
Trypanosoma cruzi UDP-galactopyranose mutase 0.0061 0.0598 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0066 0.0146
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0213 0.061
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2386 0.6745
Schistosoma mansoni hypothetical protein 0.0402 0.455 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0061 0.0598 0.075
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0044 0.0097
Schistosoma mansoni tyrosine kinase 0.0086 0.0877 0.1928
Schistosoma mansoni hypothetical protein 0.0205 0.2258 0.4963
Leishmania major hypothetical protein, conserved 0.003 0.0239 0.3243
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.2258 1
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0074 0.0154
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0627 0.7156 0.7688
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0392 0.4203
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0066 0.0145
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0145
Echinococcus granulosus cpg binding protein 0.003 0.0232 0.051
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0074 0.033
Echinococcus multilocularis cpg binding protein 0.003 0.0232 0.051
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0476 0.1358
Loa Loa (eye worm) hypothetical protein 0.0049 0.0455 0.1299
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0188
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0061 0.0598 0.075
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0598 0.075
Echinococcus multilocularis protoporphyrinogen oxidase 0.0061 0.0598 0.1315
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0811 0.9288 1
Schistosoma mansoni tyrosine kinase 0.0159 0.1731 0.3805
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2167 0.6188
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0066 0.0189
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0392 0.0927
Loa Loa (eye worm) hypothetical protein 0.0061 0.0598 0.1709
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0627 0.7156 0.6975
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0063 0.0618 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0627 0.7156 0.5
Echinococcus granulosus insulin receptor 0.0051 0.0476 0.1045
Schistosoma mansoni alpha glucosidase 0.0044 0.0392 0.0862
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0086 0.0877 0.1928
Schistosoma mansoni cpg binding protein 0.0028 0.0213 0.0469
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0627 0.7156 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0392 0.6124
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0154
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3501 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0455 0.1299
Schistosoma mansoni amine oxidase 0.0061 0.0598 0.1315
Toxoplasma gondii histone lysine-specific demethylase 0.0061 0.0598 0.9638
Loa Loa (eye worm) hypothetical protein 0.003 0.0239 0.0682
Onchocerca volvulus 0.0028 0.0213 0.0945
Schistosoma mansoni tyrosine kinase 0.0051 0.0476 0.1045

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.13 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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