Detailed information for compound 1434453

Basic information

Technical information
  • TDR Targets ID: 1434453
  • Name: 3-hydroxy-1-methyl-3-[2-(5-methylthiophen-2-y l)-2-oxoethyl]indol-2-one
  • MW: 301.36 | Formula: C16H15NO3S
  • H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(s1)C(=O)CC1(O)C(=O)N(c2c1cccc2)C
  • InChi: 1S/C16H15NO3S/c1-10-7-8-14(21-10)13(18)9-16(20)11-5-3-4-6-12(11)17(2)15(16)19/h3-8,20H,9H2,1-2H3
  • InChiKey: BMDBFMHHKOMMNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-hydroxy-1-methyl-3-[2-(5-methyl-2-thienyl)-2-oxo-ethyl]indolin-2-one
  • 3-hydroxy-1-methyl-3-[2-(5-methyl-2-thienyl)-2-oxoethyl]-2-indolinone
  • 3-hydroxy-3-[2-keto-2-(5-methyl-2-thienyl)ethyl]-1-methyl-oxindole
  • 3-hydroxy-1-methyl-3-[2-(5-methylthiophen-2-yl)-2-oxo-ethyl]indol-2-one
  • 3-hydroxy-1-methyl-3-[2-(5-methyl-2-thienyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
  • MLS000674431
  • SMR000297389
  • STK272904

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.0019 0.0007
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0608 0.3258 1
Echinococcus multilocularis microtubule associated protein 2 0.0702 0.3819 0.3819
Toxoplasma gondii exonuclease III APE 0.0099 0.0238 0.122
Echinococcus multilocularis vesicular acetylcholine transporter 0.0435 0.2235 0.2235
Trichomonas vaginalis alpha-glucosidase, putative 0.0366 0.1825 0.5577
Brugia malayi Alpha-L-fucosidase family protein 0.1386 0.7871 0.838
Echinococcus multilocularis lysosomal alpha glucosidase 0.1642 0.9391 0.9391
Trypanosoma brucei cytochrome P450, putative 0.0062 0.0019 0.0006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0017 0.0034
Loa Loa (eye worm) hypoxia-induced factor 1 0.0143 0.0499 0.0531
Brugia malayi MAP kinase sur-1 0.0062 0.0017 0.0007
Echinococcus granulosus neutral alpha glucosidase AB 0.0366 0.1825 0.1816
Trichomonas vaginalis alpha-glucosidase, putative 0.0366 0.1825 0.5577
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0099 0.0238 0.0253
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.0238 0.5
Leishmania major glycosyl hydrolase-like protein 0.0213 0.0914 0.4977
Schistosoma mansoni alpha-l-fucosidase 0.1386 0.7871 0.9282
Brugia malayi Cytochrome P450 family protein 0.0132 0.0437 0.0453
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0017 0.0006
Echinococcus multilocularis synaptic vesicular amine transporter 0.0558 0.296 0.296
Trichomonas vaginalis alpha-glucosidase, putative 0.0213 0.0914 0.2766
Schistosoma mansoni beta-galactosidase 0.0146 0.0519 0.0611
Trypanosoma brucei glycosyl hydrolase-like protein 0.0213 0.0914 0.496
Treponema pallidum sodium- and chloride- dependent transporter 0.0234 0.1043 1
Echinococcus granulosus synaptic vesicular amine transporter 0.0558 0.296 0.2952
Brugia malayi Cytochrome P450 family protein 0.0062 0.0019 0.0008
Schistosoma mansoni ap endonuclease 0.0099 0.0238 0.028
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0608 0.3258 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0467 0.2423 0.258
Echinococcus granulosus L aminoadipate semialdehyde 0.0181 0.0728 0.0717
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0435 0.2235 0.1944
Loa Loa (eye worm) alpha-L-fucosidase 0.1386 0.7871 0.8382
Loa Loa (eye worm) hypothetical protein 0.0213 0.0914 0.0973
Brugia malayi Cytochrome P450 family protein 0.0062 0.0019 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0213 0.0914 0.2766
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.0238 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0213 0.0914 0.2766
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.0234 0.1043 0.1111
Loa Loa (eye worm) hypothetical protein 0.0155 0.057 0.0607
Brugia malayi exodeoxyribonuclease III family protein 0.0099 0.0238 0.0242
Loa Loa (eye worm) hypothetical protein 0.0467 0.2423 0.258
Trichomonas vaginalis alpha-glucosidase, putative 0.0213 0.0914 0.2766
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1129 0.1202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0032 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0099 0.0238 0.0227
Brugia malayi hypothetical protein 0.0155 0.057 0.0595
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0011 0.0013
Trypanosoma brucei glucosidase, putative 0.0366 0.1825 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1642 0.9391 1
Schistosoma mansoni vesicular amine transporter 0.0558 0.296 0.3491
Echinococcus granulosus lysosomal alpha glucosidase 0.1642 0.9391 0.939
Loa Loa (eye worm) serotonin transporter b 0.0234 0.1043 0.1111
Onchocerca volvulus 0.1488 0.848 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0213 0.0914 0.426
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0366 0.1825 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0234 0.1043 0.123
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0213 0.0914 0.496
Trichomonas vaginalis sucrase-isomaltase, putative 0.0366 0.1825 0.5577
Brugia malayi Glycosyl hydrolases family 31 protein 0.0366 0.1825 0.1933
Trichomonas vaginalis alpha-glucosidase, putative 0.0366 0.1825 0.5577
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0213 0.0914 0.496
Loa Loa (eye worm) hypothetical protein 0.0234 0.1043 0.1111
Loa Loa (eye worm) hypothetical protein 0.0146 0.0519 0.0552
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.0238 0.068
Leishmania major cytochrome p450-like protein 0.0062 0.0019 0.004
Brugia malayi Abnormal catecholamine distribution protein 1 0.0558 0.296 0.3144
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0099 0.0238 0.0227
Loa Loa (eye worm) hypothetical protein 0.0234 0.1043 0.1111
Echinococcus multilocularis L aminoadipate semialdehyde 0.0181 0.0728 0.0728
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0099 0.0238 0.5
Schistosoma mansoni ap endonuclease 0.0099 0.0238 0.028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0032 0.0032
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0017 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0213 0.0914 0.2766
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0366 0.1825 0.5577
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0017 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.0702 0.3819 0.4503
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0366 0.1825 0.1943
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0032 0.0116
Trichomonas vaginalis alpha-glucosidase, putative 0.0366 0.1825 0.5577
Schistosoma mansoni sodium/chloride dependent transporter 0.0234 0.1043 0.123
Loa Loa (eye worm) hypothetical protein 0.0181 0.0728 0.0775
Echinococcus granulosus beta galactosidase 0.0146 0.0519 0.0508
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0181 0.0728 0.0858
Loa Loa (eye worm) hypothetical protein 0.0146 0.0519 0.0552
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0213 0.0914 0.024
Echinococcus granulosus microtubule associated protein 2 0.0702 0.3819 0.3812
Onchocerca volvulus 0.0467 0.2423 0.2187
Mycobacterium ulcerans alpha-L-fucosidase 0.1744 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0366 0.1825 1
Brugia malayi hypothetical protein 0.0467 0.2423 0.2571
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0011 0.0011
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0017 0.0017
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0181 0.0728 0.0764
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0099 0.0238 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0032 0.0926
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0366 0.1825 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.1642 0.9391 0.9391
Brugia malayi vesicular acetylcholine transporter unc-17 0.0435 0.2235 0.2371
Trichomonas vaginalis maltase-glucoamylase, putative 0.0366 0.1825 0.5577
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0435 0.2235 0.238
Trypanosoma cruzi hypothetical protein, conserved 0.0366 0.1825 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0032 0.0038
Brugia malayi Glycosyl hydrolases family 31 protein 0.0213 0.0914 0.0962
Schistosoma mansoni alpha-glucosidase 0.1488 0.848 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.1642 0.9391 1
Loa Loa (eye worm) norepinephrine transporter 0.0234 0.1043 0.1111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0099 0.0238 0.122
Onchocerca volvulus 0.0234 0.1043 0.0407
Echinococcus multilocularis neutral alpha glucosidase AB 0.0366 0.1825 0.1825
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0558 0.296 0.3152
Echinococcus granulosus serotonin transporter 0.0234 0.1043 0.1033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0099 0.0238 0.122
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0017 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0366 0.1825 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0099 0.0238 1
Echinococcus multilocularis serotonin transporter 0.0234 0.1043 0.1043
Echinococcus multilocularis beta galactosidase 0.0146 0.0519 0.0519
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0366 0.1825 0.5577
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0099 0.0238 0.1249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0032 0.0021
Schistosoma mansoni alpha glucosidase 0.0366 0.1825 0.2152
Trichomonas vaginalis alpha-glucosidase, putative 0.0213 0.0914 0.2766
Trichomonas vaginalis maltase-glucoamylase, putative 0.0213 0.0914 0.2766
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0234 0.1043 0.11
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.0238 0.068
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0019 0.0006
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1744 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0366 0.1825 0.5577
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0019 0.002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0017 0.0019
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0032 0.0082
Loa Loa (eye worm) solute carrier family 6 member 4 0.0234 0.1043 0.1111
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0019 0.0006
Schistosoma mansoni alpha-glucosidase 0.1488 0.848 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0132 0.0437 0.0465
Loa Loa (eye worm) CYP4Cod1 0.0062 0.0019 0.002
Echinococcus granulosus vesicular acetylcholine transporter 0.0435 0.2235 0.2226
Brugia malayi hypoxia-induced factor 1 0.0143 0.0499 0.052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0099 0.0238 0.122
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0032 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0019 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0099 0.0238 0.0238
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1129 0.1192
Trichomonas vaginalis alpha-glucosidase, putative 0.0213 0.0914 0.2766
Schistosoma mansoni vesicular acetylcholine transporter 0.0435 0.2235 0.2635
Leishmania major alpha glucosidase II subunit, putative 0.0366 0.1825 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0032 0.0021

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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