Detailed information for compound 1434474

Basic information

Technical information
  • TDR Targets ID: 1434474
  • Name: N-[2-(4-acetamidophenyl)-1,3-dioxoisoindol-4- yl]acetamide
  • MW: 337.329 | Formula: C18H15N3O4
  • H donors: 2 H acceptors: 4 LogP: 1.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)N1C(=O)c2c(C1=O)cccc2NC(=O)C
  • InChi: 1S/C18H15N3O4/c1-10(22)19-12-6-8-13(9-7-12)21-17(24)14-4-3-5-15(20-11(2)23)16(14)18(21)25/h3-9H,1-2H3,(H,19,22)(H,20,23)
  • InChiKey: ZRTORLVCXQGQOO-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[2-(4-acetamidophenyl)-1,3-dioxo-isoindolin-4-yl]acetamide
  • N-[2-(4-acetamidophenyl)-1,3-dioxo-4-isoindolinyl]acetamide
  • N-[2-(4-acetamidophenyl)-1,3-diketo-isoindolin-4-yl]acetamide
  • N-[2-(4-acetamidophenyl)-1,3-dioxo-isoindol-4-yl]ethanamide
  • MLS000700690
  • N-{4-[4-(acetylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]phenyl}acetamide
  • SMR000226273
  • ZINC00353894
  • Oprea1_056795
  • AG-690/33365050
  • Oprea1_055276

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.276 0.6381
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0313 0.0311
Loa Loa (eye worm) hypothetical protein 0.0128 0.1515 0.4605
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0326 0.0644
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1123 0.2245
Plasmodium vivax glutathione reductase, putative 0.0099 0.1139 0.1199
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0015 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0301 0.0911
Schistosoma mansoni cpg binding protein 0.003 0.0253 0.0498
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0286
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0402 0.04
Echinococcus multilocularis dna polymerase eta 0.0022 0.0161 0.016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0075 0.0123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0301 0.0498
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2976 0.9051
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0075 0.0074
Brugia malayi hypothetical protein 0.0016 0.0077 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0326 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Brugia malayi ecdysteroid receptor 0.0033 0.0301 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Trypanosoma brucei unspecified product 0.0022 0.0161 0.0834
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.017 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0189 0.0107
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.1139 0.3463
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0005 0.0016
Brugia malayi nuclear receptor NHR-67 0.0016 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.018 0.218 0.663
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0151 0.0248
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0176 0.2121 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0514
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0112 0.1306 0.139
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0128 0.1515 0.2516
Echinococcus granulosus muscleblind protein 0.018 0.218 0.3622
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.002
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0301 0.0594
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0344 0.4278 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0075 0.0141
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.3099 0.9426
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0299
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0285 0.3522 0.8198
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.1147 0.1146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0301 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0301 0.0915
Schistosoma mansoni hypothetical protein 0.004 0.0383 0.0758
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0075 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0313 0.2254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0301 0.0911
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0301 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0161 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0301 0.0915
Onchocerca volvulus 0.0033 0.0301 0.0677
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0161 0.0834
Mycobacterium ulcerans hypothetical protein 0.0023 0.017 0.0086
Schistosoma mansoni 3-dehydroquinate synthase 0.0112 0.1306 0.2614
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0097
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0313 0.0517
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0005 0.0012
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0005 0.0004
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0151 0.0063
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0301 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.058 0.0962
Brugia malayi SWIRM domain containing protein 0.0022 0.0151 0.0458
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0313 0.0467
Onchocerca volvulus 0.0023 0.017 0.0285
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0402 0.0742
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0286
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0005 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0301 0.0915
Brugia malayi ecdysone receptor 0.0016 0.0075 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Schistosoma mansoni gabp alpha 0.0071 0.0778 0.1554
Toxoplasma gondii thioredoxin reductase 0.0099 0.1139 0.1142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0286
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1104 1
Schistosoma mansoni nuclear receptor 0.0016 0.0075 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0301 0.0594
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0005 0.0006
Mycobacterium tuberculosis Probable reductase 0.0226 0.276 0.6381
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0151 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0161 0.0106
Echinococcus multilocularis protein dispatched 1 0.0047 0.0476 0.0475
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0005 0.0004
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0778 0.2364
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0233 0.0704
Trichomonas vaginalis set domain proteins, putative 0.0276 0.3403 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0288 0.3553 0.397
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0151 0.0149
Brugia malayi nuclear receptor RXR 0.0016 0.0075 0.0229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0301 0.0498
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0665 0.202
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0005 0.0012
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.276 0.6381
Echinococcus multilocularis 0.0022 0.0151 0.0149
Brugia malayi glutathione reductase 0.0099 0.1139 0.3465
Schistosoma mansoni hypothetical protein 0.004 0.0383 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0313 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0301 0.0498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.058 0.1765
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0176 0.2121 0.2326
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0313 0.2254
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0301 0.0594
Trypanosoma brucei trypanothione reductase 0.0099 0.1139 1
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.1139 0.1199
Plasmodium vivax chorismate synthase 0.0699 0.8805 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0288 0.3553 0.397
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0196 0.0597
Loa Loa (eye worm) RNA binding protein 0.0062 0.0665 0.202
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0151 0.0458
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0518
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0302 0.0499
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0402 0.1218
Trichomonas vaginalis glutaminase, putative 0.0267 0.3288 0.9644
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0128 0.1515 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0301 0.0911
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0095 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Echinococcus granulosus FTZ F1 alpha 0.0481 0.6018 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0313 0.1639
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0005 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0313 0.0249
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0313 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0301 0.0915
Loa Loa (eye worm) hypothetical protein 0.018 0.218 0.663
Schistosoma mansoni cpg binding protein 0.0028 0.0233 0.0457
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0313 1
Schistosoma mansoni coup transcription factor 0.0033 0.0301 0.0594
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.1139 1
Echinococcus multilocularis muscleblind protein 0.018 0.218 0.2179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0286
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0161 0.0106
Leishmania major hypothetical protein, conserved 0.0025 0.0189 0.0388
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0326 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0176 0.2121 1
Echinococcus multilocularis expressed conserved protein 0.009 0.1029 0.1028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.01 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0301 0.0911
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0189 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0301 0.0915
Leishmania major trypanothione reductase 0.0099 0.1139 1
Echinococcus multilocularis ets variant gene 4 0.001 0.0005 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0518
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Echinococcus multilocularis protein patched 0.0041 0.0402 0.04
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0307 0.3799 0.4252
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0301 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Brugia malayi TAR-binding protein 0.0062 0.0665 0.2023
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0022 0.0151 0.0063
Schistosoma mansoni nuclear receptor 0.0016 0.0075 0.0141
Brugia malayi hypothetical protein 0.0018 0.01 0.0303
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0288 0.3553 0.3931
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0112 0.1306 0.2915
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0075 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0313 0.1639
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0022 0.0151 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Chlamydia trachomatis dehyroquinate synthase 0.0112 0.1306 0.139
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0161 0.0075
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0301 0.0594
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 0.0048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.01 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0313 0.1639
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1104 0.3357
Plasmodium falciparum glutathione reductase 0.0099 0.1139 0.1199
Echinococcus granulosus dna polymerase kappa 0.0022 0.0161 0.0265
Schistosoma mansoni amine oxidase 0.0022 0.0151 0.0292
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0161 0.0834
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0778 0.1292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0301 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0665 0.202
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0301 0.0915
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0161 0.049
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0151 0.0063
Brugia malayi Thioredoxin reductase 0.0099 0.1139 0.3465
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.057 0.0485
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0301 0.0915
Brugia malayi hypothetical protein 0.0016 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0161 0.016
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0313 0.0249
Plasmodium falciparum thioredoxin reductase 0.0034 0.0313 0.0249
Schistosoma mansoni amine oxidase 0.0022 0.0151 0.0292
Onchocerca volvulus 0.0022 0.0151 0.0226
Plasmodium falciparum chorismate synthase 0.0699 0.8805 1
Brugia malayi steroid hormone receptor 0.0033 0.0301 0.0915
Mycobacterium ulcerans monoamine oxidase 0.0022 0.0151 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0644
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.01 0.0303
Loa Loa (eye worm) hypothetical protein 0.006 0.0647 0.1965
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0075 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.017 0.0097
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.017 0.0207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0313 0.2254
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0015 0.0014
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0307 0.3799 0.4252
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0005 0.0004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0075 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0299
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2104 0.5993
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0288 0.3553 0.8243
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0299
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0075 0.0229
Brugia malayi tailless protein 0.0016 0.0075 0.0229
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.199 0.5754
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.01 0.0299
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0161 0.0106
Brugia malayi nuclear receptor NHR-88 0.0033 0.0301 0.0915
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0005 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2104 0.5993
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0012
Schistosoma mansoni hypothetical protein 0.04 0.4982 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0075 0.0123
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0402 0.0665
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0075 0.0141
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0075 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0301 0.0677
Plasmodium vivax SET domain protein, putative 0.0035 0.0326 0.0264
Chlamydia trachomatis chorismate synthase 0.0699 0.8805 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0086
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0161 0.016
Schistosoma mansoni glutaminase 0.0267 0.3288 0.6596
Brugia malayi Pre-SET motif family protein 0.0243 0.2976 0.9051
Loa Loa (eye worm) glutathione reductase 0.0099 0.1139 0.3463
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.01 0.0303
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0151 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Brugia malayi Ets-domain containing protein 0.0071 0.0778 0.2368
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0075 0.0141
Schistosoma mansoni hypothetical protein 0.0095 0.1088 0.2176
Plasmodium falciparum glutathione reductase 0.0034 0.0313 0.0249
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0313 0.0249
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0299
Brugia malayi Pre-SET motif family protein 0.0035 0.0326 0.0991
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0172 0.0025
Brugia malayi CHE-14 protein 0.0041 0.0402 0.1222
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.058 0.1156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0301 0.0498
Leishmania major DNA polymerase eta, putative 0.0022 0.0161 0.0106
Schistosoma mansoni hypothetical protein 0.004 0.0383 0.0758
Loa Loa (eye worm) fli-1 protein 0.0215 0.262 0.7967
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0286
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0075 0.0074
Echinococcus multilocularis protein C ets 2 0.001 0.0005 0.0004
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0151 0.0063
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0313 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0189 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0987
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Brugia malayi hypothetical protein 0.0025 0.0189 0.0575
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0518
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Echinococcus multilocularis cpg binding protein 0.003 0.0253 0.0252
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0778 0.0777
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.3082 0.7149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0161 0.0106
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0313 0.0951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0005 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0196 0.0597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.058 0.0579
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.017 0.0086
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0151 0.0248
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0301 0.0594
Brugia malayi nuclear hormone receptor 0.0033 0.0301 0.0915
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0313 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.058 0.1156
Onchocerca volvulus 0.0035 0.0326 0.0752
Loa Loa (eye worm) hypothetical protein 0.0041 0.0402 0.1218
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.3082 0.7102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0301 0.0594
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0199
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0189 0.0388
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0301 0.0594
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0189 0.1095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0301 0.0498
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0005 0.0006
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0112 0.1306 0.2915
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0301 0.0915
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0665 0.1326
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0313 0.0187
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0301 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0161 0.0185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0301 0.0299
Loa Loa (eye worm) hypothetical protein 0.0022 0.0161 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0301 0.0915
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0075 0.0123
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1104 0.1102
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0151 0.0063
Schistosoma mansoni patched 1 0.0041 0.0402 0.0797
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0301 0.0498
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0075 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 0.0048
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0075 0.0229
Leishmania major DNA polymerase kappa, putative 0.0022 0.0161 0.0106
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0301 0.0299
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.1139 0.2517
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.276 0.6381
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0665 0.1326
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Brugia malayi Ets-domain containing protein 0.001 0.0005 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0301 0.0915
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0301 0.0299
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0005 0.0006
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0151 0.0149
Brugia malayi conserved hypotetical protein 0.0016 0.0075 0.0229
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0161 0.0313
Schistosoma mansoni hypothetical protein 0.004 0.0383 0.0758
Brugia malayi RNA binding protein 0.0062 0.0665 0.2023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.1515 0.4608
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0189 0.0107
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0313 0.0249
Toxoplasma gondii chorismate synthase, putative 0.0699 0.8805 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0313 0.0547
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0005 0.0012
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0161 0.0106
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0313 0.0249
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.1147 0.1904
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.01 0.0189
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0151 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0301 0.0299
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0326 0.0539
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.276 0.6322
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0151 0.0063
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0022 0.0151 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Echinococcus multilocularis muscleblind protein 1 0.018 0.218 0.2179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.058 0.1762
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.01 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.058 0.0579
Echinococcus granulosus tar DNA binding protein 0.0062 0.0665 0.1103
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.276 0.6381
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0097
Echinococcus granulosus dna polymerase eta 0.0022 0.0161 0.0265
Brugia malayi Muscleblind-like protein 0.018 0.218 0.6632
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0112 0.1306 0.28
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.058 0.0962
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0301 0.0594
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0313 0.2254
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Loa Loa (eye worm) glutaminase 0.0267 0.3288 1
Schistosoma mansoni zinc finger protein 0.0016 0.0075 0.0141
Brugia malayi hypothetical protein 0.0018 0.01 0.0303
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0301 0.0594
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0005 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.058 0.1156
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0402 0.0665
Echinococcus granulosus protein C ets 2 0.001 0.0005 0.0006
Brugia malayi Fli-1 protein 0.0215 0.262 0.7968
Mycobacterium tuberculosis Possible oxidoreductase 0.0022 0.0151 0.016
Plasmodium falciparum thioredoxin reductase 0.0099 0.1139 0.1199
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.017 0.0086
Onchocerca volvulus 0.0276 0.3403 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0176 0.2121 0.2326
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0161 0.049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0651 0.1298
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.057
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0313 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0665 0.1326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0301 0.0911
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0075 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0644
Mycobacterium ulcerans dehydrogenase 0.0022 0.0151 0.0063
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0005 0.0006
Echinococcus granulosus dnaJ subfamily B 0.04 0.4982 0.8278
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0161 0.0834
Mycobacterium ulcerans chorismate synthase 0.0699 0.8805 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.3099 0.9426
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0665 0.0664
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0301 0.0915
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0075 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0301 0.0915
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0301 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0301 0.0915
Mycobacterium ulcerans glutaminase 0.0267 0.3288 0.3665
Schistosoma mansoni ets-related 0.0215 0.262 0.5253
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0313 0.1639
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0161 0.0834
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0075 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.199 0.5642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0644
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0128 0.1515 0.3033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.017 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.3082 0.7149
Brugia malayi hypothetical protein 0.0022 0.0151 0.0458
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0075 0.0225
Brugia malayi Ets-domain containing protein 0.0071 0.0778 0.2368
Loa Loa (eye worm) hypothetical protein 0.0096 0.1104 0.3354
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0301 0.0677
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1104 0.1832
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0161 0.0075
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0075 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1631 0.163
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0075 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0301 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0665 0.1326
Brugia malayi transcription factor E74 isoform 0.001 0.0005 0.0016
Echinococcus granulosus cpg binding protein 0.003 0.0253 0.0419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.017 0.0207
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0301 0.0677
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0514
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.276 0.6381
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4982 0.4981
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0665 0.2023
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0161 0.0834
Brugia malayi nuclear receptor RXR 0.0018 0.01 0.0303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3099 0.9062
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0911
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0326 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.1515 0.4608
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0075 0.0229
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0075 0.0123
Schistosoma mansoni cpg binding protein 0.003 0.0253 0.0498
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0454
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0301 0.0911
Loa Loa (eye worm) hypothetical protein 0.0051 0.052 0.1579
Loa Loa (eye worm) DR-78 0.0016 0.0075 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0665 0.1326
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0161 0.0265
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0189 0.0388
Loa Loa (eye worm) glutaminase 2 0.0267 0.3288 1
Brugia malayi hypothetical protein 0.0016 0.0075 0.0229
Brugia malayi CXXC zinc finger family protein 0.0028 0.0233 0.0708
Echinococcus multilocularis FTZ F1 alpha 0.0128 0.1515 0.1514
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0005 0.0004
Brugia malayi nuclear receptor NHR-88 0.0016 0.0075 0.0229
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0199
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1631 0.2709
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.3082 0.7149
Schistosoma mansoni DNA polymerase eta 0.0022 0.0161 0.0313
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0313 0.1639
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0161 0.0106
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0344 0.4278 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0313 0.0617
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0161 0.0185
Mycobacterium ulcerans oxidoreductase 0.0022 0.0151 0.0063
Onchocerca volvulus 0.0028 0.0233 0.0473
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0301 0.0299
Echinococcus granulosus expressed conserved protein 0.009 0.1029 0.1708
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0151 0.016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0161 0.0313
Brugia malayi glutaminase DH11.1 0.0267 0.3288 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0225
Brugia malayi nuclear hormone receptor 0.0016 0.0075 0.0229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0313 0.1639

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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