Detailed information for compound 1434765

Basic information

Technical information
  • TDR Targets ID: 1434765
  • Name: 4-chloro-N'-(6-methylpyridazin-3-yl)benzohydr azide
  • MW: 262.695 | Formula: C12H11ClN4O
  • H donors: 2 H acceptors: 3 LogP: 2.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)NNc1ccc(nn1)C
  • InChi: 1S/C12H11ClN4O/c1-8-2-7-11(15-14-8)16-17-12(18)9-3-5-10(13)6-4-9/h2-7H,1H3,(H,15,16)(H,17,18)
  • InChiKey: PTNWYMABEBWFTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N'-(6-methyl-3-pyridazinyl)benzohydrazide
  • ZINC00092868
  • BTB 07299
  • SR-01000645125-1
  • MLS000833716
  • N'1-(6-methylpyridazin-3-yl)-4-chlorobenzene-1-carbohydrazide
  • SMR000457237

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0111 0.0751 0.4757
Echinococcus granulosus tar DNA binding protein 0.0066 0.0412 0.0794
Loa Loa (eye worm) transcription factor SMAD2 0.0111 0.0751 0.4757
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0248 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0632
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0194 0.0374
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0207 0.0775
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0047 0.0267 0.1001
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.019 0.071
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.0495 0.0683
Echinococcus multilocularis mitogen activated protein kinase 3 0.0047 0.0267 0.0516
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0214 0.0295
Echinococcus multilocularis expressed protein 0.004 0.0214 0.0413
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1219 1
Schistosoma mansoni rotamase 0.004 0.0214 0.0413
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0267 0.0323
Mycobacterium ulcerans lipase LipD 0.0038 0.0194 0.1061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0194 0.0729
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1219 0.6876
Mycobacterium ulcerans hypothetical protein 0.0038 0.0194 0.1061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0327 0.2074
Loa Loa (eye worm) hypothetical protein 0.022 0.1578 1
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0072 0.027
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0412 0.0794
Mycobacterium tuberculosis Conserved protein 0.0038 0.0194 0.0729
Brugia malayi MH2 domain containing protein 0.0111 0.0751 0.1036
Onchocerca volvulus 0.0038 0.0194 0.0194
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0194 0.0729
Loa Loa (eye worm) RNA binding protein 0.0066 0.0412 0.2609
Loa Loa (eye worm) hypothetical protein 0.015 0.1049 0.6649
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0267 0.0323
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2592 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0327 0.0632
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1219 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0207 0.0775
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0267 0.1001
Brugia malayi Inositol-1 0.0037 0.019 0.0262
Schistosoma mansoni survival motor neuron protein 0.0045 0.0248 0.0478
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.019 0.0366
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.019 0.0366
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0194 0.0729
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0412 0.0794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0194 0.1061
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0214 0.0102
Echinococcus multilocularis survival motor neuron protein 1 0.022 0.1578 0.3045
Loa Loa (eye worm) hypothetical protein 0.0077 0.0495 0.3134
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0194 0.1061
Loa Loa (eye worm) hypothetical protein 0.015 0.1049 0.6649
Onchocerca volvulus 0.0038 0.0194 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0207 0.0775
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.019 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0194 0.0726
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.5182 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0194 0.0374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0194 0.0374
Plasmodium falciparum telomerase reverse transcriptase 0.0362 0.2664 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0047 0.0267 0.0516
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0194 0.1061
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0047 0.0267 0.1001
Brugia malayi Telomerase reverse transcriptase 0.0964 0.7243 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2592 1
Echinococcus granulosus microtubule associated protein 2 0.0694 0.5182 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0072 0.5
Mycobacterium tuberculosis Conserved protein 0.0038 0.0194 0.0729
Schistosoma mansoni inositol monophosphatase 0.0037 0.019 0.0366
Echinococcus granulosus survival motor neuron protein 1 0.022 0.1578 0.3045
Loa Loa (eye worm) inositol-1 0.0037 0.019 0.1201
Echinococcus multilocularis muscleblind protein 0.015 0.1049 0.2024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.019 0.1022
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0267 0.0323
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0412 0.2609
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0194 0.0729
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0267 0.1001
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0194 0.0469
Echinococcus multilocularis mitogen activated protein kinase 0.0047 0.0267 0.0516
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0194 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0194 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0194 0.0726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Schistosoma mansoni hypothetical protein 0.0045 0.0248 0.0478
Onchocerca volvulus 0.0077 0.0495 0.0495
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0327 0.0452
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0194 0.1061
Brugia malayi beta-lactamase family protein 0.0038 0.0194 0.0268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0194 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0194 0.0729
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0047 0.0267 0.1001
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0194 0.0729
Brugia malayi MAP kinase sur-1 0.0047 0.0267 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0327 0.0632
Mycobacterium tuberculosis Conserved protein 0.0038 0.0194 0.0729
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0072 0.027
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0072 0.3804
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.019 0.071
Onchocerca volvulus 0.0045 0.0248 0.0248
Plasmodium vivax telomerase reverse transcriptase, putative 0.0362 0.2664 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0047 0.0267 0.1001
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2592 0.9699
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0072 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0194 0.0726
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.016 0.0764
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0412 0.0794
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0194 0.1229
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.019 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0267 0.0516
Trypanosoma brucei protein kinase, putative 0.0047 0.0267 0.1001
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0412 0.0794
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.016 0.0525
Brugia malayi RNA binding protein 0.0066 0.0412 0.0568
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0214 0.1356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0632
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0207 0.0775
Brugia malayi Muscleblind-like protein 0.015 0.1049 0.1448
Echinococcus multilocularis muscleblind protein 1 0.015 0.1049 0.2024
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0362 0.2664 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0194 0.0268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0194 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2592 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0194 0.0729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0327 0.0632
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0047 0.0267 0.1693
Trypanosoma brucei telomerase reverse transcriptase 0.0362 0.2664 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0194 0.1061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.1739 1
Leishmania major hypothetical protein, conserved 0.0038 0.0194 0.0726
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.0495 0.0954
Schistosoma mansoni inositol monophosphatase 0.0037 0.019 0.0366
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0412 0.0794
Trichomonas vaginalis esterase, putative 0.0038 0.0194 0.0018
Brugia malayi TAR-binding protein 0.0066 0.0412 0.0568
Toxoplasma gondii RNA-directed DNA polymerase 0.0362 0.2664 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.019 0.071
Trichomonas vaginalis rotamase, putative 0.0039 0.0207 0.0072
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.5182 1
Echinococcus granulosus expressed protein 0.004 0.0214 0.0413
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0194 0.0018
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0362 0.2664 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.019 0.071
Toxoplasma gondii ABC1 family protein 0.0038 0.0194 0.0726
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0412 0.0568
Loa Loa (eye worm) beta-lactamase 0.0038 0.0194 0.1229
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0072 0.027
Leishmania major telomerase reverse transcriptase, putative 0.0362 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0632
Brugia malayi beta-lactamase family protein 0.0038 0.0194 0.0268
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Echinococcus granulosus muscleblind protein 0.015 0.1049 0.2024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0412 0.2609
Giardia lamblia Telomerase catalytic subunit 0.0362 0.2664 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0207 0.0775
Echinococcus granulosus mitogen activated protein kinase 0.0047 0.0267 0.0516
Brugia malayi hypothetical protein 0.022 0.1578 0.2178
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.1229
Trichomonas vaginalis rotamase, putative 0.004 0.0214 0.0102
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0047 0.0267 0.1001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0047 0.0267 0.1001
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.0495 0.0954
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0412 0.0794
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.019 0.0465
Onchocerca volvulus 0.0038 0.0194 0.0194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0194 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0267 0.0323
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0207 0.0533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0327 0.0632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2592 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.0495 0.0954
Brugia malayi beta-lactamase 0.0038 0.0194 0.0268

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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