Detailed information for compound 1442210

Basic information

Technical information
  • TDR Targets ID: 1442210
  • Name: N-butan-2-yl-2,3-di(furan-2-yl)quinoxaline-6- carboxamide
  • MW: 361.394 | Formula: C21H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 3.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)c1ccc2c(c1)nc(c(n2)c1ccco1)c1ccco1)C
  • InChi: 1S/C21H19N3O3/c1-3-13(2)22-21(25)14-8-9-15-16(12-14)24-20(18-7-5-11-27-18)19(23-15)17-6-4-10-26-17/h4-13H,3H2,1-2H3,(H,22,25)
  • InChiKey: UVQXSKDQDDXNFX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2,3-bis(2-furyl)-N-sec-butyl-quinoxaline-6-carboxamide
  • 2,3-bis(2-furyl)-N-sec-butyl-6-quinoxalinecarboxamide
  • EU-0027016

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Carica papaya Papain Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Echinococcus granulosus cathepsin b Papain   345 aa 321 aa 25.9 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 291 aa 24.1 %
Theileria parva cysteine proteinase, putative Papain   345 aa 350 aa 29.4 %
Plasmodium yoelii cysteine proteinase precursor Papain   345 aa 346 aa 30.6 %
Echinococcus multilocularis cathepsin L Papain   345 aa 352 aa 36.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Papain   345 aa 342 aa 30.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 298 aa 29.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Papain   345 aa 323 aa 26.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei berghepain-1 Papain   345 aa 345 aa 29.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Papain   345 aa 355 aa 30.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 373 aa 27.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Echinococcus multilocularis cathepsin L Papain   345 aa 355 aa 27.3 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 357 aa 26.9 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 281 aa 26.0 %
Theileria parva cysteine proteinase, putative Papain   345 aa 307 aa 29.0 %
Plasmodium knowlesi knowpain-1 Papain   345 aa 396 aa 29.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Papain   345 aa 320 aa 28.4 %
Plasmodium vivax vivapain-1 Papain   345 aa 360 aa 30.0 %
Echinococcus granulosus cathepsin L Papain   345 aa 316 aa 29.1 %
Onchocerca volvulus Papain   345 aa 307 aa 35.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 321 aa 29.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Theileria parva cysteine proteinase, putative Papain   345 aa 324 aa 32.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 318 aa 22.3 %
Babesia bovis papain family cysteine protease containing protein Papain   345 aa 342 aa 31.0 %
Onchocerca volvulus Papain   345 aa 326 aa 31.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 343 aa 25.4 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Papain   345 aa 324 aa 35.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Neospora caninum hypothetical protein Papain   345 aa 297 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 302 aa 24.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Papain   345 aa 313 aa 29.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Papain   345 aa 344 aa 23.3 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi cysteine protease, putative Papain   345 aa 344 aa 30.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Cathepsin L homolog Papain   345 aa 317 aa 33.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 280 aa 29.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 361 aa 24.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax unspecified product Papain   345 aa 358 aa 30.2 %
Brugia malayi cathepsin B-like cysteine proteinase Papain   345 aa 306 aa 26.1 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 299 aa 30.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Plasmodium vivax vivapain-3 Papain   345 aa 340 aa 33.2 %
Onchocerca volvulus Papain   345 aa 324 aa 32.1 %
Brugia malayi Papain family cysteine protease containing protein Papain   345 aa 308 aa 27.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum cysteine proteinase falcipain 1 Papain   345 aa 376 aa 30.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 392 aa 23.0 %
Echinococcus granulosus cathepsin L Papain   345 aa 356 aa 36.0 %
Onchocerca volvulus Papain   345 aa 312 aa 35.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Dictyostelium discoideum cathepsin L-like proteinase Papain   345 aa 330 aa 37.3 %
Onchocerca volvulus Protein MCM10 homolog Papain   345 aa 294 aa 34.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0768 0.0794
Schistosoma mansoni flap endonuclease-1 0.0028 0.0119 0.013
Loa Loa (eye worm) fibroinase 0.0047 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0047 0.0544 0.0544
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0087 0.1448 1
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0036 0.0297 0.0307
Loa Loa (eye worm) hypothetical protein 0.0087 0.1448 0.1448
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0026 0.0481
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0026 0.0481
Loa Loa (eye worm) ctsf protein 0.0047 0.0544 0.0544
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0188 0.1137
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0026 0.0481
Echinococcus multilocularis 0.0087 0.1448 0.1496
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2752 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0544 0.3641
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2423 0.8342
Echinococcus multilocularis cysteine protease 0.0047 0.0544 0.0562
Onchocerca volvulus 0.0047 0.0544 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2423 0.8342
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0544 0.036
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Mycobacterium tuberculosis Probable reductase 0.013 0.2423 0.8342
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0297 0.5462
Mycobacterium ulcerans oxidoreductase 0.0087 0.1448 0.5
Echinococcus multilocularis cathepsin L 0.0024 0.0026 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0087 0.1448 0.3426
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0191 0.351
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0768 0.0794
Trypanosoma cruzi UDP-galactopyranose mutase 0.0087 0.1448 0.7884
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Entamoeba histolytica SWIRM domain protein 0.0036 0.0297 0.5462
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0544 0.0562
Toxoplasma gondii SWIRM domain-containing protein 0.0036 0.0297 0.0867
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1448 1
Onchocerca volvulus 0.0047 0.0544 0.036
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0188 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0544 0.0562
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0544 0.036
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Mycobacterium tuberculosis Possible oxidoreductase 0.0087 0.1448 0.3426
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0026 0.0028
Loa Loa (eye worm) hypothetical protein 0.0465 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0191 0.351
Loa Loa (eye worm) hypothetical protein 0.0087 0.1448 0.1448
Trypanosoma brucei trypanothione reductase 0.0057 0.0768 0.4115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0544 0.0562
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0544 0.0544
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0036 0.0297 0.0307
Chlamydia trachomatis protoporphyrinogen oxidase 0.0087 0.1448 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.0191 0.0191
Mycobacterium ulcerans dehydrogenase 0.0087 0.1448 0.5
Echinococcus granulosus expressed protein 0.0451 0.9676 1
Leishmania major cathepsin L-like protease 0.0047 0.0544 0.2168
Onchocerca volvulus 0.0047 0.0544 0.036
Echinococcus granulosus flap endonuclease 1 0.0031 0.0188 0.0194
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0087 0.1448 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0544 0.0562
Leishmania major cathepsin L-like protease 0.0047 0.0544 0.2168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0544 0.3641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.0768 0.4606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0026 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0188 0.3454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Mycobacterium ulcerans monoamine oxidase 0.0087 0.1448 0.5
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1448 1
Toxoplasma gondii histone lysine-specific demethylase 0.0087 0.1448 1
Onchocerca volvulus 0.0047 0.0544 0.036
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0087 0.1448 0.1577
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0026 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2752 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0768 0.0768
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0544 0.036
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0026 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0297 0.5462
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0544 0.0544
Loa Loa (eye worm) glutathione reductase 0.0057 0.0768 0.0768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0768 0.522
Trypanosoma cruzi UDP-galactopyranose mutase 0.0087 0.1448 0.7884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0087 0.1448 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1829 1
Plasmodium falciparum flap endonuclease 1 0.0031 0.0188 0.1137
Brugia malayi hypothetical protein 0.0087 0.1448 0.1448
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Echinococcus granulosus cysteine protease 0.0024 0.0026 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0026 0.0481
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0188 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Echinococcus multilocularis expressed protein 0.0451 0.9676 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2423 0.8342
Leishmania major cathepsin L-like protease 0.0104 0.1829 1
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0544 0.2168
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0188 0.3454
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0544 0.0562
Echinococcus granulosus lysine specific histone demethylase 1A 0.0087 0.1448 0.1496
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2423 0.8342
Leishmania major cathepsin L-like protease 0.0104 0.1829 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0544 0.3641
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0544 0.0562
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0544 0.0592
Plasmodium falciparum thioredoxin reductase 0.0057 0.0768 0.522
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Loa Loa (eye worm) hypothetical protein 0.0429 0.9179 0.9179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Echinococcus granulosus cathepsin l1 0.0032 0.0191 0.0197
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0087 0.1448 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0429 0.9179 1
Loa Loa (eye worm) hypothetical protein 0.0429 0.9179 0.9179
Plasmodium vivax vivapain-2 0.0047 0.0544 0.3641
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0087 0.1448 1
Echinococcus multilocularis cysteine protease 0.0047 0.0544 0.0562
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0087 0.1448 0.5
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0087 0.1448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0544 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0188 0.0896
Brugia malayi Cathepsin L-like precursor 0.0032 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0188 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Brugia malayi SWIRM domain containing protein 0.0036 0.0297 0.0297
Echinococcus granulosus lysine specific histone demethylase 1A 0.0429 0.9179 0.9487
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Plasmodium falciparum glutathione reductase 0.0057 0.0768 0.522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Schistosoma mansoni amine oxidase 0.0087 0.1448 0.1577
Brugia malayi Thioredoxin reductase 0.0057 0.0768 0.0768
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Onchocerca volvulus 0.0465 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0297 0.0297
Leishmania major cathepsin L-like protease 0.0047 0.0544 0.2168
Loa Loa (eye worm) hypothetical protein 0.0123 0.2269 0.2269
Plasmodium falciparum protoporphyrinogen oxidase 0.0087 0.1448 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0544 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0959 0.5172
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1829 1
Schistosoma mansoni SWI/SNF complex-related 0.0036 0.0297 0.0324
Plasmodium vivax vivapain-2 0.0047 0.0544 0.3641
Schistosoma mansoni amine oxidase 0.0087 0.1448 0.1577
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0087 0.1448 1
Onchocerca volvulus 0.0047 0.0544 0.036
Echinococcus granulosus cathepsin l1 0.0047 0.0544 0.0562
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0544 0.0544
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0026 0.0027
Loa Loa (eye worm) cysteine protease 0.0047 0.0544 0.0544
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0768 0.4115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Echinococcus granulosus cathepsin L 0.0024 0.0026 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0191 0.0208
Toxoplasma gondii cathepsin CPL 0.0047 0.0544 0.2825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0032 0.0191 0.0191
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0544 0.287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2752 1
Leishmania major trypanothione reductase 0.0057 0.0768 0.3536
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2423 0.8342
Leishmania major UDP-galactopyranose mutase 0.0087 0.1448 0.7676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0191 0.351
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Entamoeba histolytica cysteine protease, putative 0.0047 0.0544 1
Onchocerca volvulus 0.0047 0.0544 0.036
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0026 0.0028
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2423 0.7479
Leishmania major cathepsin L-like protease 0.0047 0.0544 0.2168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1829 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.0768 0.522
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0544 1
Onchocerca volvulus 0.0047 0.0544 0.036
Giardia lamblia hypothetical protein 0.0036 0.0297 1
Entamoeba histolytica SWIRM domain protein 0.0036 0.0297 0.5462
Brugia malayi amine oxidase, flavin-containing family protein 0.0123 0.2269 0.2269
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2752 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Leishmania major cathepsin L-like protease 0.0047 0.0544 0.2168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0026 0.0028
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0544 0.0592
Brugia malayi Cathepsin L-like precursor 0.0047 0.0544 0.0544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0544 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0087 0.1448 0.1496
Trypanosoma cruzi cruzipain precursor, putative 0.0104 0.1829 1
Entamoeba histolytica cysteine protease, putative 0.0024 0.0026 0.0481
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0088 0.1476 0.8043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0429 0.9179 0.9487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0544 1
Brugia malayi glutathione reductase 0.0057 0.0768 0.0768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0026 0.0481
Brugia malayi cathepsin L-like precursor 0.0032 0.0191 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0026 0.0481
Brugia malayi Flap endonuclease-1 0.0031 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.5462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1829 1
Leishmania major cathepsin L-like protease 0.0104 0.1829 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0544 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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