Detailed information for compound 1442692

Basic information

Technical information
  • TDR Targets ID: 1442692
  • Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methyl- 2-oxoquinolin-4-yl)sulfanylacetamide
  • MW: 412.502 | Formula: C22H24N2O4S
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNC(=O)CSc2cc(=O)n(c3c2cccc3)C)ccc1OC
  • InChi: 1S/C22H24N2O4S/c1-24-17-7-5-4-6-16(17)20(13-22(24)26)29-14-21(25)23-11-10-15-8-9-18(27-2)19(12-15)28-3/h4-9,12-13H,10-11,14H2,1-3H3,(H,23,25)
  • InChiKey: MOOAALLYJXBOLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(1-methyl-2-oxo-4-quinolyl)sulfanyl]acetamide
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(1-methyl-2-oxo-4-quinolyl)thio]acetamide
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(2-keto-1-methyl-4-quinolyl)thio]acetamide
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methyl-2-oxo-quinolin-4-yl)sulfanyl-ethanamide
  • EU-0026534
  • C463-0067
  • NCGC00108909-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.043 0.3117
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0244
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.049
Brugia malayi hypothetical protein 0.002 0.0013 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0065 0.0447
Brugia malayi Furin-like cysteine rich region family protein 0.0298 0.0988 0.1362
Brugia malayi CHE-14 protein 0.0085 0.0241 0.0332
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.0092
Brugia malayi Protein kinase domain containing protein 0.0095 0.0277 0.0382
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0191 0.0698
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0647 0.5815
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.005
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0013 0.0081
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0053 0.0058
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0053 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.043 0.3856
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.137 0.4741 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0053 0.0217
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.0039
Onchocerca volvulus 0.0036 0.007 0.0057
Brugia malayi SWIRM domain containing protein 0.0104 0.0307 0.0423
Schistosoma mansoni multidrug resistance protein 0.0031 0.0053 0.0447
Schistosoma mansoni ran 0.0021 0.0017 0.0121
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0626 0.2137 0.4179
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0307 0.2215
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0945 1
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0467
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Mycobacterium leprae Probable lipase LipE 0.0071 0.0191 0.6072
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0626 0.2137 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0191 0.0698
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0222
Echinococcus multilocularis tumor protein p63 0.0408 0.1372 0.1617
Echinococcus granulosus expressed conserved protein 0.0186 0.0594 0.4316
Schistosoma mansoni hypothetical protein 0.0305 0.1013 0.9122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0391 0.3498
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0017 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0031 0.0101
Onchocerca volvulus 0.0283 0.0935 0.0924
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Trichomonas vaginalis esterase, putative 0.0071 0.0191 0.1992
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0283 0.0935 0.1289
Onchocerca volvulus 0.0071 0.0191 0.0179
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0104 0.0307 0.0588
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0013 0.0033
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0133
Plasmodium falciparum importin beta, putative 0.0029 0.0044 0.0148
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0013 0.0033
Entamoeba histolytica hypothetical protein 0.0037 0.0072 0.1084
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0029 0.0046 0.0157
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0053 0.0058
Echinococcus multilocularis insulin receptor 0.0095 0.0277 0.0323
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0191 0.0264
Schistosoma mansoni kinesin eg-5 0.0026 0.0034 0.0277
Schistosoma mansoni hypothetical protein 0.0333 0.111 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0104 0.0307 0.0358
Leishmania major GTP-binding protein, putative 0.0021 0.0017 0.005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0191 0.0222
Schistosoma mansoni transient receptor potential channel 0.0064 0.0167 0.1471
Leishmania major hypothetical protein, conserved 0.0025 0.0031 0.0101
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0046 0.005
Echinococcus multilocularis snurportin 1 0.0305 0.1013 0.1192
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0191 0.1992
Brugia malayi tubulin alpha-2 chain 0.0017 0.0004 0.0005
Echinococcus multilocularis nibrin 0.002 0.0013 0.0011
Onchocerca volvulus 0.0283 0.0935 0.0924
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0307 0.1128
Brugia malayi ABC transporter family protein 0.0031 0.0053 0.0073
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0053 0.0525
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0044 0.0047
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0104 0.0307 0.2739
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0028 0.0042
Schistosoma mansoni hypothetical protein 0.0174 0.0553 0.4965
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0028 0.0042
Brugia malayi beta-lactamase 0.0071 0.0191 0.0264
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Loa Loa (eye worm) hypothetical protein 0.0032 0.0056 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0095
Schistosoma mansoni smdr2 0.0031 0.0053 0.0447
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0053 0.0361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0031
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0046 0.0077
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1474 0.5104 1
Echinococcus granulosus tar DNA binding protein 0.0128 0.0391 0.2828
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0031 0.0101
Brugia malayi alpha-tubulin 0.0017 0.0004 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0072 0.0501
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0051 0.0056
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0004 0.0005
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0029 0.0046 0.0382
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0281 0.0327
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0046 0.005
Brugia malayi hypothetical protein 0.0025 0.0031 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0191 0.0698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.043 0.3117
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.0934 0.6796
Schistosoma mansoni hypothetical protein 0.0333 0.111 1
Schistosoma mansoni ABC transporter 0.0025 0.0031 0.0242
Trypanosoma brucei ABC transporter, putative 0.0029 0.0046 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0028 0.0389
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0281 0.2503
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0069 0.0475
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0053 0.0525
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.027
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0053 0.0525
Plasmodium falciparum kinesin-5 0.0026 0.0034 0.0114
Trypanosoma cruzi ABC transporter, putative 0.0029 0.0046 0.0157
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0228 0.3549
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0046 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0042
Echinococcus granulosus replication factor c subunit 1 0.002 0.0013 0.0065
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0028 0.0053
Schistosoma mansoni tyrosine kinase 0.0159 0.0499 0.4473
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0307 0.2215
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0053 0.0361
Plasmodium falciparum telomerase reverse transcriptase 0.0784 0.269 1
Mycobacterium ulcerans dehydrogenase 0.0104 0.0307 0.0588
Echinococcus granulosus GPCR family 2 0.0032 0.0056 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0191 0.1992
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0046 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0042
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0283 0.0935 0.1289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.043 0.0504
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0191 0.0397
Leishmania major p-glycoprotein 0.0031 0.0053 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0042
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0013 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0191 0.1992
Echinococcus multilocularis protein dispatched 1 0.0097 0.0283 0.033
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0013 0.0141
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.002 0.002
Echinococcus granulosus nibrin 0.002 0.0013 0.0065
Plasmodium vivax importin-beta 2, putative 0.0029 0.0044 0.0148
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0241 0.028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0056 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0056 0.0061
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0221
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0104 0.0307 0.2739
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0298 0.2911
Brugia malayi RNA, U transporter 1 0.0081 0.0228 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0095
Plasmodium falciparum ABC transporter G family member 2 0.0029 0.0046 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.043 0.3856
Schistosoma mansoni tyrosine kinase 0.016 0.0505 0.4527
Loa Loa (eye worm) hypothetical protein 0.0198 0.0636 0.6269
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0013 0.0033
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0283 0.0935 0.1289
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0004 0.0005
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0053 0.049
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0228 0.3549
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0013 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.0934 0.1099
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0307 0.1128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0191 0.1695
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0034 0.0114
Trichomonas vaginalis ran, putative 0.0021 0.0017 0.0142
Schistosoma mansoni patched 1 0.0085 0.0241 0.2142
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0053 0.0361
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0013 0.0033
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Echinococcus granulosus epidermal growth factor receptor 0.016 0.0505 0.366
Mycobacterium tuberculosis Conserved protein 0.0071 0.0191 0.0397
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0467
Mycobacterium ulcerans beta-lactamase 0.0071 0.0191 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0391 0.3498
Brugia malayi Common central domain of tyrosinase family protein 0.0283 0.0935 0.1289
Loa Loa (eye worm) hypothetical protein 0.0283 0.0935 0.923
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0072 0.0081
Echinococcus granulosus snurportin 1 0.0305 0.1013 0.7374
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0228 0.3549
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.049
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.005
Trypanosoma brucei ATP-binding cassette protein, putative 0.0029 0.0046 0.0157
Onchocerca volvulus 0.0071 0.0191 0.0179
Onchocerca volvulus 0.0024 0.0028 0.0016
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Toxoplasma gondii histone lysine-specific demethylase 0.0104 0.0307 0.1128
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0186 0.0256
Schistosoma mansoni tyrosine kinase 0.0159 0.0499 0.4473
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0391 0.0539
Loa Loa (eye worm) hypothetical protein 0.006 0.0153 0.1474
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0391 0.3498
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0053 0.0781
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0191 0.0397
Onchocerca volvulus 0.0104 0.0307 0.0294
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0025 0.0222
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.002 0.0121
Schistosoma mansoni ran 0.0021 0.0017 0.0121
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0053 0.0184
Schistosoma mansoni tyrosinase precursor 0.0283 0.0935 0.8419
Mycobacterium tuberculosis Conserved protein 0.0071 0.0191 0.0397
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0028 0.0533
Brugia malayi beta-lactamase family protein 0.0071 0.0191 0.0264
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0626 0.2137 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0191 0.1695
Trichomonas vaginalis abcb9, putative 0.0031 0.0053 0.0525
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0307 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0241 0.2518
Schistosoma mansoni tyrosine kinase 0.016 0.0505 0.4527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.043 0.0593
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0056 0.0512
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0104 0.0307 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0391 0.3835
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0466
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0395
Onchocerca volvulus 0.006 0.0153 0.014
Toxoplasma gondii RNA-directed DNA polymerase 0.0784 0.269 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Schistosoma mansoni tyrosinase precursor 0.0283 0.0935 0.8419
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.1527 0.3217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0031
Schistosoma mansoni hypothetical protein 0.0037 0.0072 0.062
Schistosoma mansoni hypothetical protein 0.0069 0.0186 0.1643
Brugia malayi Tubulin alpha chain 0.0017 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0031
Schistosoma mansoni hypothetical protein 0.0082 0.023 0.2046
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0281 0.2023
Brugia malayi Pre-SET motif family protein 0.0251 0.0824 0.1135
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0031 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.0092
Plasmodium vivax telomerase reverse transcriptase, putative 0.0784 0.269 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0012
Trichomonas vaginalis abcb9, putative 0.0031 0.0053 0.0525
Echinococcus granulosus epidermal growth factor receptor 0.0298 0.0988 0.7191
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0104 0.0307 0.1128
Brugia malayi beta-lactamase family protein 0.0071 0.0191 0.0264
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0085 0.0241 0.2349
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0824 0.8123
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0391 0.3835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.007 0.0595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0244
Loa Loa (eye worm) hypothetical protein 0.0283 0.0935 0.923
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.043 0.0504
Schistosoma mansoni tyrosine kinase 0.0095 0.0277 0.2471
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0191 0.0397
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0044 0.0148
Schistosoma mansoni amine oxidase 0.0104 0.0307 0.2739
Echinococcus multilocularis kinesin family 1 0.02 0.0644 0.0756
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0626 0.2137 0.4179
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0167 0.1189
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0053 0.0525
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0051 0.0344
Echinococcus multilocularis expressed conserved protein 0.0186 0.0594 0.0698
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0191 0.0362
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.0505 0.0592
Leishmania major UDP-galactopyranose mutase 0.0104 0.0307 0.1128
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0013 0.0095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.005
Entamoeba histolytica kinesin, putative 0.0026 0.0034 0.0485
Onchocerca volvulus 0.0283 0.0935 0.0924
Brugia malayi tubulin alpha chain - mouse 0.0017 0.0004 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.043 0.3856
Mycobacterium tuberculosis Conserved protein 0.0071 0.0191 0.0397
Brugia malayi RNA binding protein 0.0128 0.0391 0.0539
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0784 0.269 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.002 0.0177
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0013 0.0011
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0053 0.0525
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0104 0.0307 0.1128
Entamoeba histolytica hypothetical protein 0.002 0.0013 0.0141
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0241 0.2349
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Brugia malayi hypothetical protein 0.002 0.0013 0.0018
Brugia malayi DKFZp564C0469 protein 0.002 0.0013 0.0018
Onchocerca volvulus 0.0283 0.0935 0.0924
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0056 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0391 0.3498
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0053 0.0781
Mycobacterium ulcerans oxidoreductase 0.0104 0.0307 0.0588
Schistosoma mansoni tyrosine kinase 0.0095 0.0277 0.2471
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0028 0.0533
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1474 0.5104 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0028 0.0389
Loa Loa (eye worm) hypothetical protein 0.0104 0.0308 0.3012
Giardia lamblia Kinesin-5 0.0026 0.0034 0.0114
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0053 0.0105
Brugia malayi TAR-binding protein 0.0128 0.0391 0.0539
Echinococcus granulosus geminin 0.0333 0.111 0.8084
Loa Loa (eye worm) tyrosinase 1 0.0283 0.0935 0.923
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.002 0.0121
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0056 0.0378
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0298 0.041
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0191 0.0397
Schistosoma mansoni DNA ligase IV 0.002 0.0013 0.0081
Brugia malayi Pre-SET motif family protein 0.0036 0.007 0.0096
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0053 0.0184
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0053 0.0361
Schistosoma mansoni hypothetical protein 0.0082 0.023 0.2046
Loa Loa (eye worm) hypothetical protein 0.0069 0.0186 0.1801
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0626 0.2137 0.794
Schistosoma mansoni multidrug resistance protein 0.0031 0.0053 0.0447
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0191 0.1992
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0269 0.0314
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0391 0.3498
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0029 0.0046 0.0157
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0017 0.0016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0053 0.0525
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0222
Schistosoma mansoni multidrug resistance protein 0.0031 0.0053 0.0447
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0013 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.0039
Schistosoma mansoni topbp1 0.002 0.0013 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0029 0.0046 0.0157
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0053 0.0184
Brugia malayi ABC transporter family protein 0.0025 0.0031 0.0042
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0467
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0153 0.1345
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0053 0.0184
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0053 0.049
Plasmodium vivax SET domain protein, putative 0.0036 0.007 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.007 0.0078
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0017 0.005
Entamoeba histolytica hypothetical protein 0.0037 0.0072 0.1084
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0046 0.0308
Mycobacterium ulcerans hypothetical protein 0.0071 0.0191 0.0362
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0031 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0307 0.1128
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0013 0.0095
Brugia malayi ShTK domain containing protein 0.0283 0.0935 0.1289
Echinococcus multilocularis GPCR, family 2 0.0032 0.0056 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0031 0.0101
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0053 0.0525
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.007 0.0245
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0053 0.0361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0028 0.0053
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0053 0.0184
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0053 0.0361
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.0092
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.0277 0.1998
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0025 0.0078
Schistosoma mansoni tyrosine kinase 0.0298 0.0988 0.8895
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0013 0.0033
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0044 0.0148
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0307 0.064
Plasmodium vivax ABC transporter G family member 2, putative 0.0029 0.0046 0.0157
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0636 0.4623
Brugia malayi Importin beta-1 subunit 0.0029 0.0044 0.006
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0053 0.0781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0028 0.0042
Entamoeba histolytica ABC transporter, putative 0.0029 0.0046 0.0667
Chlamydia trachomatis protoporphyrinogen oxidase 0.0104 0.0307 0.1408
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0283 0.0935 0.1289
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0072 0.062
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0533
Entamoeba histolytica hypothetical protein 0.0023 0.0025 0.033
Giardia lamblia Telomerase catalytic subunit 0.0784 0.269 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.043 0.4227
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0191 0.0362
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0053 0.0058
Echinococcus granulosus tumor protein p63 0.0408 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0053 0.0058
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.005
Mycobacterium ulcerans lipase LipD 0.0071 0.0191 0.0362
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Entamoeba histolytica Ran family GTPase 0.0021 0.0017 0.0211
Brugia malayi amine oxidase, flavin-containing family protein 0.0104 0.0307 0.0423
Echinococcus multilocularis 0.0092 0.0267 0.0311
Brugia malayi multidrug resistance protein 3 0.0031 0.0053 0.0073
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0241 0.1732
Echinococcus granulosus insulin receptor 0.0095 0.0277 0.1998
Loa Loa (eye worm) hypothetical protein 0.0071 0.0191 0.1858
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.007 0.0481
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0028 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0191 0.0698
Giardia lamblia Replication factor C, subunit 1 0.002 0.0013 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0031 0.0101
Schistosoma mansoni importin beta-1 0.0029 0.0044 0.036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0191 0.0397
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0053 0.0361
Brugia malayi topoisomerase 0.002 0.0013 0.0018
Echinococcus multilocularis geminin 0.0333 0.111 0.1307
Echinococcus multilocularis 0.0104 0.0307 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0095
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0626 0.2137 0.4179
Loa Loa (eye worm) hypothetical protein 0.0101 0.0298 0.2911
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0069 0.0077
Brugia malayi hypothetical protein 0.0104 0.0307 0.0423
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0096 0.0281 0.2744
Entamoeba histolytica hypothetical protein 0.0037 0.0072 0.1084
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0089
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0034 0.0048
Schistosoma mansoni hypothetical protein 0.0082 0.023 0.2046
Mycobacterium ulcerans hypothetical protein 0.0024 0.0028 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0155 0.1501
Brugia malayi Telomerase reverse transcriptase 0.2087 0.7253 1
Onchocerca volvulus 0.0031 0.0053 0.0041
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Chlamydia trachomatis DNA ligase 0.002 0.0013 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2435 0.8469 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0191 0.1858
Schistosoma mansoni amine oxidase 0.0104 0.0307 0.2739
Leishmania major importin beta-1 subunit, putative 0.0023 0.0025 0.0078
Schistosoma mansoni topbp1 0.002 0.0013 0.0081
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0626 0.2137 0.4504
Loa Loa (eye worm) TK/EGFR protein kinase 0.0298 0.0988 0.9752
Treponema pallidum DNA ligase (lig) 0.002 0.0013 0.5
Plasmodium falciparum protoporphyrinogen oxidase 0.0104 0.0307 0.1128
Echinococcus multilocularis protoporphyrinogen oxidase 0.0104 0.0307 0.0358
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0024 0.0028 0.0052
Loa Loa (eye worm) beta-lactamase 0.0071 0.0191 0.1858
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0046 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.007 0.0595
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0069 0.0095
Onchocerca volvulus 0.0071 0.0191 0.0179
Toxoplasma gondii ABC1 family protein 0.0071 0.0191 0.0698
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0269 0.1941
Loa Loa (eye worm) RNA binding protein 0.0128 0.0391 0.3835
Loa Loa (eye worm) ShTK domain-containing protein 0.0283 0.0935 0.923
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.016 0.0505 0.366
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0391 0.0457
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0636 0.0877
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.007 0.0595
Onchocerca volvulus 0.0286 0.0945 0.0934
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0191 0.137
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0053 0.0525
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0013 0.0095
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0636 0.0747
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0053 0.0525
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0056 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.007 0.0595
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0053 0.0525
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0191 0.0397
Plasmodium vivax kinesin-5 0.0026 0.0034 0.0114
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0104 0.0307 0.1128
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0013 0.0095
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0053 0.0781
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0028 0.0389
Loa Loa (eye worm) ABC transporter 0.0025 0.0031 0.0266
Schistosoma mansoni transient receptor potential channel 0.0096 0.0281 0.2503
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1013 1
Schistosoma mansoni tyrosine kinase 0.0159 0.0499 0.4473
Echinococcus granulosus importin subunit beta 1 0.0029 0.0044 0.0291
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0053 0.0058
Leishmania major telomerase reverse transcriptase, putative 0.0784 0.269 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0053 0.0525
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0636 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0029 0.0046 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0645
Schistosoma mansoni transient receptor potential channel 0.0064 0.0167 0.1471
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0013 0.0033
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0046 0.0077
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0017 0.005
Loa Loa (eye worm) ShTK domain-containing protein 0.0283 0.0935 0.923
Entamoeba histolytica hypothetical protein 0.0037 0.0072 0.1084
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0034 0.0304
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0053 0.0058
Trichomonas vaginalis taga, putative 0.0031 0.0053 0.0525
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.0277 0.2709
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0784 0.269 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0031 0.0101
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0191 0.1992
Trichomonas vaginalis abcb9, putative 0.0031 0.0053 0.0525
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0241 0.1732
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0228 0.3549
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0191 0.0397
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0167 0.0192
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0053 0.0781
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0298 0.041
Echinococcus granulosus kinesin family 1 0.02 0.0644 0.4679
Giardia lamblia ABC transporter 0.0029 0.0044 0.0148
Mycobacterium ulcerans monoamine oxidase 0.0104 0.0307 0.0588
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Leishmania major hypothetical protein, conserved 0.0071 0.0191 0.0698
Trypanosoma brucei telomerase reverse transcriptase 0.0784 0.269 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0104 0.0307 0.1128
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0467
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0012
Echinococcus multilocularis epidermal growth factor receptor 0.0298 0.0988 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0095
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0167 0.0192
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0053 0.0781
Brugia malayi hypothetical protein 0.0037 0.0072 0.01
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0053 0.0525
Loa Loa (eye worm) hypothetical protein 0.0104 0.0307 0.3003
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0013 0.0033
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0013 0.0095
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.0277 0.0323
Schistosoma mansoni hypothetical protein 0.0082 0.023 0.2046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0307 0.064
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0044 0.0148
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0167 0.1189
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0191 0.6072
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.0039
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0031
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0046 0.0077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0056 0.0378
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0104 0.0307 0.1128
Loa Loa (eye worm) hypothetical protein 0.0036 0.007 0.0653
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0228 0.3549
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0053 0.0525
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0626 0.2137 0.794
Echinococcus multilocularis protein patched 0.0085 0.0241 0.028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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