TDR Targets

Basic information

Technical information

TDR Targets ID: 1443618
Name: 2-amino-6-methyl-4-oxochromene-3-carbaldehyde
MW: 203.194 | Formula: C11H9NO3
H donors: 1 H acceptors: 2 LogP: 1.66 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=Cc1c(N)oc2c(c1=O)cc(cc2)C
InChi: 1S/C11H9NO3/c1-6-2-3-9-7(4-6)10(14)8(5-13)11(12)15-9/h2-5H,12H2,1H3
InChiKey: ZUOLPKRXZRWAFV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-6-methyl-4-oxo-chromene-3-carbaldehyde
2-amino-6-methyl-4-oxo-3-chromenecarboxaldehyde
2-amino-4-keto-6-methyl-chromene-3-carbaldehyde
SMR000169115
Oprea1_855705
5C-101
ZINC01390924
2-amino-6-methyl-4-oxo-4H-chromene-3-carbaldehyde
MLS000543146

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	alkaline phosphatase, placental-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	vacuolar alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	intestinal type alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma japonicum	ko:K01077 alkaline phosphatase [EC3.1.3.1], putative	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma japonicum	Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma mansoni	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma mansoni	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	intestinal type alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	vacuolar alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	intestinal type alkaline phosphatase 1	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0141	0.0487	0.0159
Schistosoma mansoni	immunophilin	0.0093	0.0264	0.0249
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2189	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0734	0.3241	0.3008
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0487	0.0487
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0141	0.0487	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0273	0.1098	0.0791
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2189	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0141	0.0487	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Brugia malayi	FAT domain containing protein	0.032	0.1318	0.1318
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0734	0.3241	0.3241
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0414	0.1754	0.147
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0093	0.0264	0.0264
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0487	0.0159
Onchocerca volvulus		0.0141	0.0487	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0909	0.4055	0.385
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0196	0.0743	0.0743
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.7919	0.7848
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1182	0.5322	0.5161
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0108	0.0333	0.5
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.118	0.5313	0.5152
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2189	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0141	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0414	0.1754	0.1754
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0734	0.3241	0.3008
Toxoplasma gondii	FATC domain-containing protein	0.0414	0.1754	0.1835
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0734	0.3241	0.3008
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0487	0.0159
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0196	0.0743	0.0743
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0487	0.0159
Echinococcus multilocularis	fk506 binding protein	0.0108	0.0333	0.0333
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0141	0.0487	0.0487
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0414	0.1754	0.1741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0108	0.0333	0.0333
Loa Loa (eye worm)	FKBP5 protein	0.0108	0.0333	0.0333
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0141	0.0487	0.5
Echinococcus multilocularis	alkaline phosphatase	0.0196	0.0743	0.0743
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0141	0.0487	0.0487
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0141	0.0487	0.0487
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0414	0.1754	0.147
Entamoeba histolytica	hypothetical protein	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1468	0.6652	0.6537
Echinococcus multilocularis	serine protein kinase ATM	0.0414	0.1754	0.1754
Schistosoma mansoni	immunophilin	0.0108	0.0333	0.0318
Schistosoma mansoni	hypothetical protein	0.032	0.1318	0.1304
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1743	0.7928	0.7856
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0108	0.0333	0.0333
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0487	0.0487
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2189	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2189	1	1
Leishmania major	hypothetical protein, conserved	0.0141	0.0487	0.0159
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0141	0.0487	0.0487
Plasmodium vivax	hypothetical protein, conserved	0.0141	0.0487	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0141	0.0487	0.0159
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0108	0.0333	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0487	0.0472
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0196	0.0743	0.0743
Leishmania major	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0414	0.1754	0.1754
Giardia lamblia	GTOR	0.2189	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0461	0.1974	0.1697
Schistosoma mansoni	immunophilin	0.0108	0.0333	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.032	0.1318	0.1019
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0141	0.0487	0.0159
Trypanosoma cruzi	target of rapamycin kinase 3	0.1743	0.7928	0.7856
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2189	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0461	0.1974	0.2153
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0093	0.0264	0.0264
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0108	0.0333	0.0333
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0487	0.0487
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0487	0.0472
Giardia lamblia	Hypothetical protein	0.0141	0.0487	0.0159
Echinococcus granulosus	alkaline phosphatase	0.0196	0.0743	0.0743
Echinococcus granulosus	serine protein kinase ATM	0.0414	0.1754	0.1754
Trichomonas vaginalis	conserved hypothetical protein	0.0273	0.1098	0.0791
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0141	0.0487	0.0159
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2189	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0734	0.3241	0.3008
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0487	0.0487
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0141	0.0487	0.0472
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1628	0.7394	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0414	0.1754	0.1754
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0141	0.0487	0.0487
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0141	0.0487	0.0159
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Schistosoma mansoni	hypothetical protein	0.0141	0.0487	0.0472
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1308	0.5907	0.5766
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Entamoeba histolytica	hypothetical protein	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.118	0.5313	0.5152
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.032	0.1318	0.1318
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0734	0.3241	0.3241
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0734	0.3241	0.3008
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0141	0.0487	0.0159
Echinococcus multilocularis	Zinc finger, PHD finger	0.0141	0.0487	0.0487
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0141	0.0487	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0734	0.3241	0.3008
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0141	0.0487	0.0159
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0414	0.1754	0.147
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0734	0.3241	0.3008
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2189	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0414	0.1754	0.147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.7919	0.7848
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0414	0.1754	0.1741
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0141	0.0487	0.0487
Loa Loa (eye worm)	phosphatidylinositol 3	0.2189	1	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0734	0.3241	0.3231
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0734	0.3241	0.3008
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0734	0.3241	0.3241
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1308	0.5907	0.5766
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0141	0.0487	0.0472
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2189	1	1
Loa Loa (eye worm)	hypothetical protein	0.0461	0.1974	0.1974
Onchocerca volvulus		0.0141	0.0487	0.5
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Entamoeba histolytica	hypothetical protein	0.0141	0.0487	0.0159
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0487	0.0487
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1743	0.7928	0.7856
Echinococcus multilocularis		0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1308	0.5907	0.5766
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.032	0.1318	0.1318
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0487	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1098	0.1098
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0487	0.0472
Trichomonas vaginalis	PIKK family atypical protein kinase	0.118	0.5313	0.5152
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0264	0.0264
Schistosoma mansoni	alkaline phosphatase	0.0196	0.0743	0.0729
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0108	0.0333	0.0333
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1295	0.5847	0.5704
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0108	0.0333	0.0333
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2189	1	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0141	0.0487	0.0472
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0108	0.0333	0.0333
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0414	0.1754	0.147
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1182	0.5322	0.5161
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0196	0.0743	0.0743
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0196	0.0743	0.0743
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0141	0.0487	0.0159
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0414	0.1754	0.147
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	0.0159
Entamoeba histolytica	hypothetical protein	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.7919	0.7848
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0141	0.0487	0.0159
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0414	0.1754	0.1754
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0141	0.0487	0.0159
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0141	0.0487	0.0472
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.0487	0.0159
Loa Loa (eye worm)	hypothetical protein	0.032	0.1318	0.1318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.7919	0.7848
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1182	0.5322	0.5161
Loa Loa (eye worm)	phosphatidylinositol 3	0.0734	0.3241	0.3241
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0414	0.1754	0.1754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1628	0.7394	0.7304
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0196	0.0743	0.0743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1182	0.5322	0.5161
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.0487	0.0159
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2189	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0141	0.0487	0.0159
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0141	0.0487	0.0487
Leishmania major	hypothetical protein, unknown function	0.0141	0.0487	0.0159
Entamoeba histolytica	hypothetical protein	0.0414	0.1754	0.147
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0414	0.1754	0.147
Plasmodium vivax	hypothetical protein	0.0141	0.0487	1
Mycobacterium leprae	conserved hypothetical protein	0.0141	0.0487	0.5
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0141	0.0487	0.0487
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0141	0.0487	0.0159
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0487	0.0487
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1035	0.464	0.4455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.7919	0.7848
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0141	0.0487	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1869	0.8513	0.8462
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0487	0.0159
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0141	0.0487	1
Schistosoma mansoni	hypothetical protein	0.0102	0.0305	0.029
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0141	0.0487	0.0159
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2189	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0487	0.0487
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0487	0.0159
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0734	0.3241	0.3008
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2189	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0487	0.0487
Entamoeba histolytica	protein kinase rad3, putative	0.0414	0.1754	0.147
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2189	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0487	0.0487
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0734	0.3241	0.3008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0734	0.3241	0.3008
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0141	0.0487	0.0487
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0141	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0446	0.1903	0.1903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1421	0.6432	0.6309
Schistosoma mansoni	alkaline phosphatase	0.0196	0.0743	0.0729
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0487	0.0487
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0487	0.0159
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0273	0.1098	0.0791
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0108	0.0333	0.0318
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0487	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.2559	0.2303
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0141	0.0487	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1295	0.5847	0.5704

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 999 um	PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 518 ]	ChEMBL.	No reference
IC50 (functional)	= 3.36 um	PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 1512, 518 ]	ChEMBL.	No reference
IC50 (functional)	= 8.3 uM	PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1577, AID518, AID690]	ChEMBL.	No reference
IC50 (binding)	> 100 uM	PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518]	ChEMBL.	No reference
Potency (functional)	0.2079 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1607428

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1443618