Detailed information for compound 1443833

Basic information

Technical information
  • TDR Targets ID: 1443833
  • Name: 5,8-dimethyl-3-(phenylmethyl)-1-[[3-(trifluor omethyl)phenyl]methyl]pyrimido[5,6-b]indole-2 ,4-dione
  • MW: 477.478 | Formula: C27H22F3N3O2
  • H donors: 0 H acceptors: 2 LogP: 5.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1c(n2C)c(=O)n(c(=O)n1Cc1cccc(c1)C(F)(F)F)Cc1ccccc1
  • InChi: 1S/C27H22F3N3O2/c1-17-11-12-22-21(13-17)23-24(31(22)2)25(34)33(15-18-7-4-3-5-8-18)26(35)32(23)16-19-9-6-10-20(14-19)27(28,29)30/h3-14H,15-16H2,1-2H3
  • InChiKey: ZIYGZSSTCSPALL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(benzyl)-5,8-dimethyl-1-[3-(trifluoromethyl)benzyl]pyrimido[5,6-b]indole-2,4-quinone
  • E737-0610
  • NCGC00125027-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0187 0.0218
Echinococcus multilocularis neuroligin 0.0022 0.0041 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0373 0.0381
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0731 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0187 0.0218
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0235 0.024
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0418 0.0487
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0391 0.0664
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.0664
Trichomonas vaginalis set domain proteins, putative 0.0238 0.5487 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0391 0.93
Trypanosoma cruzi Emopamil binding protein, putative 0.0135 0.2903 0.3386
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0041 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.0713
Echinococcus multilocularis acetylcholinesterase 0.0132 0.2813 0.2871
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0731 0.1333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0418 0.0487
Echinococcus granulosus snurportin 1 0.0299 0.705 0.7197
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0418 0.0487
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0218 0.5209
Schistosoma mansoni ap endonuclease 0.0037 0.0418 0.0592
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0418 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0391 0.0713
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.19 0.194
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0391 0.93
Brugia malayi Bromodomain containing protein 0.0029 0.0218 0.0254
Onchocerca volvulus 0.0238 0.5487 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0391 0.0555
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0187 0.0191
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0098 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0235 0.0334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0391 0.0555
Mycobacterium leprae Probable lipase LipE 0.0036 0.0391 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.705 0.705
Mycobacterium ulcerans hypothetical protein 0.0036 0.0391 0.93
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0187 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0098 0.134
Trichomonas vaginalis esterase, putative 0.0036 0.0391 0.0713
Loa Loa (eye worm) hypothetical protein 0.0132 0.2813 0.2813
Schistosoma mansoni hypothetical protein 0.0029 0.0218 0.0309
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0418 0.0426
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0373 0.0381
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0418 0.0761
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0041 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0746 0.0746
Leishmania major hypothetical protein, conserved 0.0036 0.0391 0.0457
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Echinococcus multilocularis acetylcholinesterase 0.0132 0.2813 0.2871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0334
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0391 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.19 0.194
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0418 0.5711
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.2347
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0418 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0218 0.2975
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.0235
Mycobacterium ulcerans beta-lactamase 0.0036 0.0391 0.93
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0418 0.0487
Schistosoma mansoni importin beta-1 0.0028 0.0187 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0731 0.1037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0373 0.0529
Brugia malayi Carboxylesterase family protein 0.0022 0.0041 0.0048
Brugia malayi Carboxylesterase family protein 0.0022 0.0041 0.0048
Schistosoma mansoni gliotactin 0.0022 0.0041 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0391 0.0664
Loa Loa (eye worm) hypothetical protein 0.036 0.8572 0.8572
Brugia malayi Pre-SET motif family protein 0.0209 0.4758 0.555
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.1272
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.0664
Loa Loa (eye worm) carboxylesterase 0.0022 0.0041 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0731 0.0747
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0507 0.0518
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0053 0.0062
Onchocerca volvulus 0.006 0.0988 0.1739
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0391 0.0457
Loa Loa (eye worm) beta-lactamase 0.0036 0.0391 0.0391
Brugia malayi Pre-SET motif family protein 0.003 0.0235 0.0274
Echinococcus granulosus carboxylesterase 5A 0.0132 0.2813 0.2871
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0041 0.0059
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0418 0.0426
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0507 0.0518
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0218 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0731 0.1333
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0373 0.0529
Brugia malayi Carboxylesterase family protein 0.0022 0.0041 0.0048
Onchocerca volvulus Alhambra homolog 0.0029 0.0218 0.0323
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.2813 0.2813
Brugia malayi hypothetical protein 0.0025 0.0098 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0391 0.93
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0731 0.1333
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0391 0.0457
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.5313 1
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.2813 0.2871
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0218 0.0222
Echinococcus multilocularis peregrin 0.0029 0.0218 0.0222
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0418 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0418 0.0714
Brugia malayi beta-lactamase family protein 0.0036 0.0391 0.0457
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0391 0.0399
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0187 0.256
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0041 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0391 0.0457
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0391 0.0664
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0731 0.0853
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0418 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.0713
Echinococcus granulosus acetylcholinesterase 0.0132 0.2813 0.2871
Giardia lamblia PHD finger protein 15 0.0029 0.0218 0.2975
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0391 0.0713
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0418 0.0487
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0098 0.2347
Plasmodium vivax importin-beta 2, putative 0.0028 0.0187 0.4483
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0391 0.0664
Brugia malayi RNA, U transporter 1 0.008 0.1495 0.1744
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.0664
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0391 0.9369
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0235 0.024
Brugia malayi hypothetical protein 0.0022 0.0041 0.0048
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0731 0.0853
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0418 1
Brugia malayi Carboxylesterase family protein 0.0132 0.2813 0.3281
Toxoplasma gondii ABC1 family protein 0.0036 0.0391 0.5351
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0391 0.0391
Plasmodium falciparum importin beta, putative 0.0028 0.0187 0.4483
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0391 0.0399
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0235 0.024
Trypanosoma cruzi C-8 sterol isomerase, putative 0.036 0.8572 1
Brugia malayi beta-lactamase family protein 0.0036 0.0391 0.0457
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0391 0.0664
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0731 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0731 0.0853
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0731 0.0853
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0041 0.0076
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0731 0.0747
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0391 0.0664
Echinococcus granulosus peregrin 0.0029 0.0218 0.0222
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0988 0.1402
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.2903 0.3386
Plasmodium vivax SET domain protein, putative 0.003 0.0235 0.5632
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0041 0.0042
Trypanosoma brucei protein kinase, putative 0.005 0.0731 0.0853
Onchocerca volvulus 0.0135 0.2903 0.5254
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1005 0.1005
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0731 0.0853
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0041 0.0059
Trypanosoma cruzi Emopamil binding protein, putative 0.0135 0.2903 0.3386
Brugia malayi jmjC domain containing protein 0.0096 0.19 0.2217
Brugia malayi jmjC domain containing protein 0.0035 0.0373 0.0435
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0041 0.0076
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.2903 0.3386
Brugia malayi Carboxylesterase family protein 0.0022 0.0041 0.0048
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.2813 0.399
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0731 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0334
Loa Loa (eye worm) hypothetical protein 0.0416 1 1
Brugia malayi MAP kinase sur-1 0.005 0.0731 0.0853
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0731 0.1333
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0418 0.0761
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0391 0.0664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0334
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0418 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.2903 0.3386
Loa Loa (eye worm) hypothetical protein 0.0184 0.4126 0.4126
Plasmodium falciparum phd finger protein, putative 0.0029 0.0218 0.5209
Loa Loa (eye worm) carboxylesterase 0.0132 0.2813 0.2813
Echinococcus multilocularis snurportin 1 0.0299 0.705 0.7197
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.0713
Leishmania major importin beta-1 subunit, putative 0.0023 0.0053 0.0062
Leishmania major hypothetical protein, conserved 0.0025 0.0098 0.0114
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0053 0.0097
Echinococcus granulosus neuroligin 0.0022 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0114
Trypanosoma brucei Emopamil binding protein, putative 0.0135 0.2903 0.3386
Schistosoma mansoni acetylcholinesterase 0.0022 0.0041 0.0059
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0731 0.0731
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0218 0.2975
Brugia malayi PHD-finger family protein 0.0029 0.0218 0.0254
Echinococcus granulosus importin subunit beta 1 0.0028 0.0187 0.0191
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0041 0.0042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0218 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0391 0.0457
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0097
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0041 0.0059
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0235 0.3217
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0391
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0041 0.0042
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0041 0.0059
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0731 0.0853
Leishmania major C-8 sterol isomerase-like protein 0.036 0.8572 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0218 0.0218
Brugia malayi ERG2 and Sigma1 receptor like protein 0.036 0.8572 1
Echinococcus multilocularis tumor protein p63 0.0408 0.9796 1
Loa Loa (eye worm) carboxylesterase 0.0022 0.0041 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0207 0.0212
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.4758 0.4758
Onchocerca volvulus 0.0036 0.0391 0.0642
Schistosoma mansoni hypothetical protein 0.0299 0.705 1
Brugia malayi beta-lactamase 0.0036 0.0391 0.0457
Onchocerca volvulus 0.0036 0.0391 0.0642
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0041
Onchocerca volvulus 0.0036 0.0391 0.0642
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0731 0.0853
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.2347
Toxoplasma gondii exonuclease III APE 0.0037 0.0418 0.5711
Echinococcus granulosus acetylcholinesterase 0.0132 0.2813 0.2871
Loa Loa (eye worm) hypothetical protein 0.006 0.0988 0.0988
Trypanosoma brucei C-8 sterol isomerase, putative 0.036 0.8572 1
Schistosoma mansoni jumonji domain containing protein 0.0076 0.1402 0.1989
Echinococcus granulosus tumor protein p63 0.0408 0.9796 1
Leishmania major hypothetical protein, conserved 0.0135 0.2903 0.3386
Brugia malayi Carboxylesterase family protein 0.0132 0.2813 0.3281
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0132 0.2813 0.2813
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0218 0.0222
Schistosoma mansoni ap endonuclease 0.0037 0.0418 0.0592
Onchocerca volvulus 0.003 0.0235 0.0356
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0731 0.0747

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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