TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.317 | Formula: C14H16N6
H donors: 2 H acceptors: 4 LogP: 3.2 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1nc(Nc2ccccc2)nc(n1)NC(C)(C)C
InChi: 1S/C14H16N6/c1-14(2,3)20-13-18-11(9-15)17-12(19-13)16-10-7-5-4-6-8-10/h4-8H,1-3H3,(H2,16,17,18,19,20)
InChiKey: URDPLRPYVWZQSZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.2474	0.5893
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.009	0.0707	0.0659
Onchocerca volvulus		0.0074	0.0508	0.1163
Brugia malayi	Cathepsin L-like cysteine proteinase	0.005	0.0197	0.0469
Echinococcus granulosus	histone acetyltransferase MYST2	0.0058	0.0302	0.072
Leishmania major	cathepsin L-like protease	0.0131	0.1231	1
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Onchocerca volvulus		0.0051	0.0213	0.006
Schistosoma mansoni	alpha-amylase	0.009	0.0707	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0302	0.072
Onchocerca volvulus		0.0074	0.0508	0.1163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.0051	0.0122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0543	0.1293
Brugia malayi	hypothetical protein	0.0077	0.0543	0.1293
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0074	0.0508	1
Entamoeba histolytica	hypothetical protein	0.0077	0.0543	0.0494
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0213	0.0507
Trichomonas vaginalis	amylase, putative	0.009	0.0707	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0508	0.1211
Trichomonas vaginalis	starch branching enzyme II, putative	0.0364	0.4199	0.4169
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0074	0.0508	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0058	0.0302	0.072
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0074	0.0508	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Brugia malayi	Cathepsin L-like precursor	0.005	0.0197	0.0469
Onchocerca volvulus		0.0074	0.0508	0.1163
Echinococcus multilocularis	survival motor neuron protein 1	0.0252	0.2774	0.6607
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.009	0.0707	0.1683
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Mycobacterium ulcerans	glycogen branching protein	0.0364	0.4199	1
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Schistosoma mansoni	alpha-amylase	0.009	0.0707	0.1683
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0543	0.1293
Entamoeba histolytica	alpha-amylase family protein	0.009	0.0707	0.0659
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.0508	0.046
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.022	0.0524
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0213	0.0507
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.0364	0.4199	1
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0213	0.0507
Loa Loa (eye worm)	hypothetical protein	0.005	0.0197	0.0469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0197	0.0146
Echinococcus granulosus	muscleblind protein	0.0159	0.1593	0.3793
Entamoeba histolytica	beta/alpha-amylase precursor, putative	0.009	0.0707	0.0659
Toxoplasma gondii	1,4-alpha-glucan-branching enzyme	0.0364	0.4199	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0201	0.2116	0.504
Trypanosoma cruzi	cruzipain precursor, putative	0.0131	0.1231	1
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0508	0.1211
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.0508	0.1163
Loa Loa (eye worm)	hypothetical protein	0.005	0.0197	0.0469
Trichomonas vaginalis	amylase, putative	0.0364	0.4199	0.4169
Onchocerca volvulus		0.0074	0.0508	0.1163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Leishmania major	cathepsin L-like protease	0.0131	0.1231	1
Brugia malayi	mbt repeat family protein	0.0051	0.0213	0.0507
Brugia malayi	mbt repeat family protein	0.0051	0.0213	0.0507
Mycobacterium tuberculosis	1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme)	0.0364	0.4199	1
Entamoeba histolytica	alpha-amylase, putative	0.009	0.0707	0.0659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Echinococcus multilocularis	muscleblind protein	0.0159	0.1593	0.3793
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Echinococcus granulosus	cathepsin L	0.0038	0.0051	0.0122
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Onchocerca volvulus		0.026	0.2876	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0058	0.0302	0.072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.0213	0.0507
Echinococcus multilocularis	geminin	0.0181	0.1865	0.4441
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.0508	0.1211
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Echinococcus granulosus	cysteine protease	0.0038	0.0051	0.0122
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0939	0.2236
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0364	0.4199	0.4169
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0939	0.2236
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.0051	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0504	0.1201
Echinococcus multilocularis	cathepsin L	0.0038	0.0051	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.0508	0.1211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Trypanosoma cruzi	cysteine peptidase, putative	0.0131	0.1231	1
Brugia malayi	cathepsin L-like precursor	0.005	0.0197	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0364	0.4199	1
Loa Loa (eye worm)	alpha amylase	0.009	0.0707	0.1683
Trypanosoma cruzi	major cysteine proteinase, putative	0.007	0.0462	0.3483
Echinococcus granulosus	cathepsin l1	0.005	0.0197	0.0469
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.0508	0.1163
Entamoeba histolytica	hypothetical protein	0.0077	0.0543	0.0494
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0058	0.0302	0.072
Trichomonas vaginalis	alpha-amylase, putative	0.082	1	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.0197	0.0469
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.0508	0.1211
Toxoplasma gondii	glycosyltransferase	0.0364	0.4199	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.0508	0.1211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.0508	0.1211
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0504	0.1201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Plasmodium vivax	vivapain-2	0.0074	0.0508	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0074	0.0508	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1593	0.3793
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0058	0.0302	0.072
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0364	0.4199	0.4169
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0939	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1593	0.3793
Toxoplasma gondii	Alpha-amylase AMY3, putative	0.009	0.0707	0.0537
Giardia lamblia	1,4-alpha-glucan branching enzyme	0.0364	0.4199	0.5
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.0213	0.0507
Entamoeba histolytica	hypothetical protein	0.0077	0.0543	0.0494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0197	0.0146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Brugia malayi	hypothetical protein	0.0252	0.2774	0.6607
Schistosoma mansoni	starch branching enzyme II	0.0364	0.4199	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0051	0.0122
Entamoeba histolytica	hypothetical protein	0.009	0.0707	0.0659
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0074	0.0508	0.1211
Echinococcus granulosus	cathepsin l1	0.0074	0.0508	0.1211
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Schistosoma mansoni	alpha-amylase	0.009	0.0707	0.1683
Schistosoma mansoni	hypothetical protein	0.0309	0.35	0.8336
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Trypanosoma cruzi	cysteine peptidase, putative	0.0131	0.1231	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Loa Loa (eye worm)	MBCTL1	0.0058	0.0302	0.072
Toxoplasma gondii	alpha amylase, catalytic domain-containing protein	0.0364	0.4199	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0074	0.0508	0.1211
Trichomonas vaginalis	set domain proteins, putative	0.026	0.2876	0.284
Loa Loa (eye worm)	fibroinase	0.0074	0.0508	0.1211
Echinococcus granulosus	survival motor neuron protein 1	0.0252	0.2774	0.6607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Entamoeba histolytica	alpha-amylase, putative	0.009	0.0707	0.0659
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.0213	0.0507
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Entamoeba histolytica	alpha-amylase family protein	0.082	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.0197	0.0469
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.0213	0.0507
Onchocerca volvulus		0.0074	0.0508	0.1163
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0508	0.3875
Schistosoma mansoni	alpha-amylase	0.009	0.0707	0.1683
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.0213	0.0507
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Loa Loa (eye worm)	ctsf protein	0.0074	0.0508	0.1211
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.009	0.0707	0.5
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.0213	0.006
Trichomonas vaginalis	alpha-amylase, putative	0.082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0707	0.0659
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0201	0.2116	0.504
Trypanosoma cruzi	cysteine peptidase, putative	0.0131	0.1231	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.0508	0.046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.0508	0.046
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.0213	0.0507
Leishmania major	cathepsin L-like protease	0.0131	0.1231	1
Trichomonas vaginalis	alpha-amylase, putative	0.0731	0.8859	0.8853
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0939	0.2236
Trichomonas vaginalis	alpha-amylase, putative	0.082	1	1
Trichomonas vaginalis	alpha-amylase, putative	0.082	1	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0504	0.1201
Echinococcus granulosus	cathepsin L cysteine protease	0.0038	0.0051	0.0122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Onchocerca volvulus	Cathepsin F homolog	0.0074	0.0508	0.1163
Entamoeba histolytica	hypothetical protein	0.0077	0.0543	0.0494
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0106	0.0919	0.7358
Echinococcus multilocularis	cysteine protease	0.0074	0.0508	0.1211
Schistosoma mansoni	hypothetical protein	0.009	0.0707	0.1683
Loa Loa (eye worm)	cysteine protease	0.0074	0.0508	0.1211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046
Chlamydia trachomatis	1,4-alpha-glucan branching enzyme	0.0364	0.4199	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0058	0.0302	0.072
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0543	0.1293
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.0508	0.046
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0051	0.0122
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.0508	0.1211
Echinococcus multilocularis	cysteine protease	0.0074	0.0508	0.1211
Onchocerca volvulus		0.0051	0.022	0.0087
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0508	0.046
Schistosoma mansoni	hypothetical protein	0.0077	0.0543	0.1293
Echinococcus multilocularis	trehalose 6 phosphate hydrolase	0.009	0.0707	0.1683
Plasmodium vivax	vivapain-2	0.0074	0.0508	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.0508	0.1211
Trichomonas vaginalis	amylase, putative	0.082	1	1
Echinococcus granulosus	trehalose 6 phosphate hydrolase	0.009	0.0707	0.1683
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0051	0.0122
Trichomonas vaginalis	alpha-amylase, putative	0.009	0.0707	0.0659
Echinococcus multilocularis	alpha glucosidase	0.009	0.0707	0.1683
Echinococcus granulosus	alpha glucosidase	0.009	0.0707	0.1683
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Onchocerca volvulus		0.0074	0.0508	0.1163
Loa Loa (eye worm)	alpha amylase	0.009	0.0707	0.1683
Echinococcus multilocularis	muscleblind protein 1	0.0159	0.1593	0.3793
Schistosoma mansoni	hypothetical protein	0.0181	0.1865	0.4441
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0197	0.0146
Entamoeba histolytica	alpha-amylase family protein	0.009	0.0707	0.0659
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.009	0.0707	0.1683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0131	0.1231	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.2774	0.6607
Schistosoma mansoni	survival motor neuron protein	0.0051	0.022	0.0524
Brugia malayi	1,4-alpha-glucan branching enzyme	0.0364	0.4199	1
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.0364	0.4199	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0197	0.0469
Onchocerca volvulus		0.0074	0.0508	0.1163
Trichomonas vaginalis	amylase, putative	0.082	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0508	0.046
Brugia malayi	Pre-SET motif family protein	0.0229	0.2474	0.5893
Schistosoma mansoni	hypothetical protein	0.0051	0.022	0.0524
Brugia malayi	Cathepsin L-like precursor	0.0074	0.0508	0.1211
Brugia malayi	Muscleblind-like protein	0.0159	0.1593	0.3793
Schistosoma mansoni	alpha-amylase	0.009	0.0707	0.1683
Echinococcus granulosus	geminin	0.0181	0.1865	0.4441
Schistosoma mansoni	hypothetical protein	0.0181	0.1865	0.4441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0508	0.046

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 2.2387 um	PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1594004

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1445069