Detailed information for compound 1454854

Basic information

Technical information
  • TDR Targets ID: 1454854
  • Name: 6-(2,5-dimethoxyphenyl)-3-(3-ethoxyphenyl)-7H -[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
  • MW: 396.463 | Formula: C20H20N4O3S
  • H donors: 0 H acceptors: 2 LogP: 3.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)c1nnc2n1N=C(CS2)c1cc(OC)ccc1OC
  • InChi: 1S/C20H20N4O3S/c1-4-27-15-7-5-6-13(10-15)19-21-22-20-24(19)23-17(12-28-20)16-11-14(25-2)8-9-18(16)26-3/h5-11H,4,12H2,1-3H3
  • InChiKey: RGVLXCJEACYJJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC04325677
  • SMR000042969
  • MLS000081451
  • ST5422927

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus twik family of potassium channels 0.0062 0.0209 0.0205
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0131 0.0127
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0131 0.0127
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0209 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0062 0.0209 0.0209
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0131 0.0127
Echinococcus granulosus calcium activated potassium channel variant 0.0062 0.0209 0.0205
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0079 0.0075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0209 1
Brugia malayi Importin beta-1 subunit 0.0035 0.002 0.0089
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Brugia malayi CHE-14 protein 0.0051 0.0131 0.0729
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3618 0.3616
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1743 0.1739
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3618 0.3616
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Leishmania major calcium/potassium channel (CAKC), putative 0.0062 0.0209 0.5
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0597 0.3412
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0062 0.0209 0.1178
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0194 0.0194
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0062 0.0209 0.5
Echinococcus multilocularis potassium channel subfamily K 0.0062 0.0209 0.0205
Schistosoma mansoni hypothetical protein 0.0043 0.0079 0.0075
Schistosoma mansoni patched 1 0.0051 0.0131 0.0127
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3618 0.3616
Leishmania major ion transport protein-like protein 0.0062 0.0209 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0062 0.0209 0.1178
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis twik family of potassium channels 0.0062 0.0209 0.0205
Echinococcus granulosus potassium channel subfamily K 0.0062 0.0209 0.0205
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0062 0.0209 0.0209
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0948 0.0944
Loa Loa (eye worm) hypothetical protein 0.006 0.0191 0.0191
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Giardia lamblia Hypothetical protein 0.0062 0.0209 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0062 0.0209 0.1178
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0209 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0062 0.0209 0.1178
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3618 0.3616
Plasmodium falciparum potassium channel 0.0062 0.0209 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0062 0.0209 0.1178
Schistosoma mansoni calcium-activated potassium channel 0.0062 0.0209 0.0205
Plasmodium vivax potassium channel, putative 0.0062 0.0209 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.0114
Loa Loa (eye worm) uncoordinated protein 58 0.0062 0.0209 0.0209
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0062 0.0209 0.1178
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0062 0.0209 0.0205
Onchocerca volvulus 0.006 0.0191 0.9115
Onchocerca volvulus 0.0062 0.0209 1
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0209 0.5
Brugia malayi hypothetical protein 0.0043 0.0079 0.043
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus granulosus importin subunit beta 1 0.0035 0.002 0.0016
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0062 0.0209 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0209 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0597 1
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0062 0.0209 0.1178
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0062 0.0209 0.5
Echinococcus granulosus potassium channel subfamily K 8 0.0062 0.0209 0.0205
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis twik family of potassium channels 0.0062 0.0209 0.0205
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0004 0.0004
Echinococcus granulosus tumor protein p63 0.0408 0.2585 0.2582
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5508 0.5506
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0062 0.0209 0.1178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0063 0.0063
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.061 0.0606
Schistosoma mansoni survival motor neuron protein 0.0058 0.0181 0.0177
Leishmania major potassium channel subunit-like protein 0.0062 0.0209 0.5
Loa Loa (eye worm) hypothetical protein 0.0454 0.2901 0.2901
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0062 0.0209 0.1178
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0062 0.0209 0.0205
Onchocerca volvulus 0.0058 0.0181 0.8619
Mycobacterium ulcerans transmembrane cation transporter 0.0062 0.0209 0.5
Echinococcus granulosus potassium channel subfamily K 8 0.0062 0.0209 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0209 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0062 0.0209 0.1178
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0062 0.0209 0.5
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis potassium channel subfamily K 8 0.0062 0.0209 0.0205
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0062 0.0209 1
Trypanosoma cruzi ion transport protein, putative 0.0062 0.0209 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.0181 0.0177
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0062 0.0209 0.1178
Brugia malayi RNA, U transporter 1 0.0099 0.0461 0.2627
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0063 0.0339
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.0114
Mycobacterium ulcerans ion transport protein 0.0062 0.0209 0.5
Echinococcus multilocularis calcium activated potassium channel variant 0.0062 0.0209 0.0205
Loa Loa (eye worm) hypothetical protein 0.0119 0.0597 0.0597
Echinococcus multilocularis protein patched 0.0051 0.0131 0.0127
Toxoplasma gondii ion channel protein 0.0062 0.0209 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Toxoplasma gondii ion channel protein 0.0062 0.0209 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0597 0.0594
Plasmodium falciparum potassium channel 0.0062 0.0209 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0062 0.0209 0.1178
Trypanosoma brucei calcium-activated potassium channel, putative 0.0062 0.0209 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0062 0.0209 0.1178
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Onchocerca volvulus 0.0062 0.0209 1
Onchocerca volvulus 0.0062 0.0209 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0062 0.0209 0.1178
Onchocerca volvulus 0.0062 0.0209 1
Echinococcus granulosus twik family of potassium channels 0.0062 0.0209 0.0205
Trypanosoma cruzi ion transport protein, putative 0.0062 0.0209 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0131 0.0131
Leishmania major hypothetical protein, conserved 0.0062 0.0209 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0062 0.0209 0.1178
Schistosoma mansoni calcium-activated potassium channel 0.0971 0.6451 0.6449
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.021 0.021
Plasmodium vivax potassium channel, putative 0.0062 0.0209 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2335 0.2335
Loa Loa (eye worm) hypothetical protein 0.0329 0.2044 0.2044
Onchocerca volvulus 0.0062 0.0209 1
Onchocerca volvulus 0.0062 0.0209 1
Echinococcus multilocularis small conductance calcium activated potassium 0.1487 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0062 0.0209 0.0205
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1743 0.1739
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Schistosoma mansoni hypothetical protein 0.0062 0.0209 0.0205
Schistosoma mansoni hypothetical protein 0.0372 0.2335 0.2332
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0194 0.1092
Onchocerca volvulus 0.0062 0.0209 1
Echinococcus multilocularis snurportin 1 0.0372 0.2335 0.2332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0194 0.1092
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0004
Brugia malayi hypothetical protein 0.0062 0.0209 0.1178
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0948 0.0944
Loa Loa (eye worm) hypothetical protein 0.0641 0.4187 0.4187
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0062 0.0209 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus granulosus snurportin 1 0.0372 0.2335 0.2332
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0062 0.0209 0.2507
Leishmania major hypothetical protein, conserved 0.0062 0.0209 0.5
Echinococcus multilocularis protein dispatched 1 0.0058 0.018 0.0176
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0062 0.0209 0.1178
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.0114
Schistosoma mansoni importin beta-1 0.0035 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis importin subunit beta 1 0.0035 0.002 0.0016
Schistosoma mansoni hypothetical protein 0.0041 0.0063 0.0059
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Brugia malayi hypothetical protein 0.0286 0.1743 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0079 0.0075
Echinococcus multilocularis tumor protein p63 0.0408 0.2585 0.2582
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0191 0.0187
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0062 0.0209 0.1178
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0062 0.0209 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5508 0.5506
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Schistosoma mansoni twik family of potassium channels-related 0.0062 0.0209 0.0205
Brugia malayi hypothetical protein 0.0062 0.0209 0.1178
Loa Loa (eye worm) hypothetical protein 0.1487 1 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5508 0.5506
Schistosoma mansoni calcium-activated potassium channel 0.1487 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0286 0.1743 0.1743
Echinococcus granulosus expressed conserved protein 0.0112 0.0548 0.0544
Schistosoma mansoni hypothetical protein 0.1487 1 1
Echinococcus multilocularis potassium channel subfamily K 8 0.0062 0.0209 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0209 1
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0062 0.0209 0.0205
Onchocerca volvulus 0.0062 0.0209 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0597 0.0594
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0181 0.1015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0209
Echinococcus multilocularis expressed conserved protein 0.0112 0.0548 0.0544
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.651 0.6509
Loa Loa (eye worm) TWK-7 protein 0.0062 0.0209 0.0209
Loa Loa (eye worm) TWK-28 protein 0.0062 0.0209 0.0209

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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