Detailed information for compound 1461889

Basic information

Technical information
  • TDR Targets ID: 1461889
  • Name: (8R,9S,13S,14S,17R)-17-[(Z)-2-(4-methoxypheny l)ethenyl]-13-methyl-7,8,9,11,12,14,15,16-oct ahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • MW: 404.541 | Formula: C27H32O3
  • H donors: 2 H acceptors: 2 LogP: 5.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C\[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCc2c1ccc(c2)O
  • InChi: 1S/C27H32O3/c1-26-14-12-23-22-10-6-20(28)17-19(22)5-9-24(23)25(26)13-16-27(26,29)15-11-18-3-7-21(30-2)8-4-18/h3-4,6-8,10-11,15,17,23-25,28-29H,5,9,12-14,16H2,1-2H3/b15-11-/t23-,24-,25+,26+,27+/m1/s1
  • InChiKey: CMHYUFRDMXRNOT-JYERZOKYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8R,9S,13S,14S,17R)-17-[(Z)-2-(4-methoxyphenyl)vinyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Brugia malayi Cytochrome P450 family protein 0.006 0.0448 0.0586
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Plasmodium vivax malate dehydrogenase, putative 0.0266 0.3061 1
Onchocerca volvulus 0.0128 0.1311 1
Trypanosoma brucei glycosomal malate dehydrogenase 0.0144 0.151 0.2922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus multilocularis malate dehydrogenase 0.0144 0.151 0.1776
Echinococcus granulosus 7TM GPCR rhodopsin 0.0128 0.1311 0.1286
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Toxoplasma gondii lactate dehydrogenase LDH2 0.0266 0.3061 1
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0215 0.0224
Leishmania major glycosomal malate dehydrogenase 0.0144 0.151 0.2922
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0128 0.1311 1
Onchocerca volvulus 0.0128 0.1311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0065 0.0199
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Brugia malayi neuropeptide F receptor 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1457 0.1713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Echinococcus multilocularis malate dehydrogenase 0.0144 0.151 0.1776
Plasmodium falciparum carbonic anhydrase 0.0223 0.2518 0.8208
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0412 0.492 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Echinococcus multilocularis serotonin receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.0975
Schistosoma mansoni malate dehydrogenase 0.0144 0.151 0.307
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0128 0.1311 0.1286
Trypanosoma brucei cytochrome P450, putative 0.006 0.0448 0.0819
Brugia malayi cathepsin L-like precursor 0.0039 0.018 0.0206
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0151 0.1597 0.1881
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0319 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.022 0.0192
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0412 0.492 0.6911
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Echinococcus multilocularis neuropeptide s receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis serotonin receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.04 0.0759
Echinococcus granulosus cathepsin l1 0.0039 0.018 0.0152
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Echinococcus granulosus L lactate dehydrogenase B chain 0.0266 0.3061 0.3041
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0144 0.151 0.2922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis malate dehydrogenase, putative 0.0086 0.0779 0.4764
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.1311 0.1537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0128 0.1311 0.1806
Echinococcus multilocularis protein dispatched 1 0.0048 0.029 0.0314
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0128 0.1311 0.2664
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Echinococcus multilocularis mitogen activated protein kinase 14 0.0426 0.5088 0.6064
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.022 0.0614
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0616 0.1924
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Leishmania major malate dehydrogenase 0.0144 0.151 0.2922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0065 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0616 0.2185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.038 0.0304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus granulosus cysteine protease 0.003 0.0065 0.0037
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0924 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0065 0.0199
Echinococcus granulosus flap endonuclease 1 0.0028 0.0034 0.0005
Brugia malayi Dopamine receptor protein 1 0.0128 0.1311 0.1806
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.1311 0.2664
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0067 0.0046
Echinococcus granulosus orexin receptor type 2 0.0128 0.1311 0.1286
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.4318 0.8478
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.022 0.0614
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis lamin dm0 0.0057 0.04 0.0445
Leishmania major mitochondrial malate dehydrogenase 0.0144 0.151 0.2922
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0616 0.194
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.018 0.0206
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0924 0.0898
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0067 0.0101
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Brugia malayi neuropeptide F receptor 0.0128 0.1311 0.1806
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Onchocerca volvulus 0.0128 0.1311 1
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0151 0.1597 0.5165
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0271 0.0552
Brugia malayi Tachykinin-like peptides receptor 99D 0.0128 0.1311 0.1806
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0222 0.0194
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Leishmania major cysteine peptidase A (CPA) 0.0059 0.0426 0.0775
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0943 0.1917
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.4318 0.8478
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0065 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0215 0.1158
Echinococcus multilocularis fmrfamide receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0128 0.1311 0.1537
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Plasmodium falciparum lactate dehydrogenase, putative 0.0126 0.1278 0.4111
Schistosoma mansoni alpha-1 adrenergic receptor 0.0128 0.1311 0.2664
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) hypothetical protein 0.005 0.0311 0.0583
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi G protein-coupled receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0426 0.0476
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0215 0.0394
Echinococcus granulosus expressed conserved protein 0.0092 0.0849 0.0823
Echinococcus multilocularis G-protein coupled receptor, putative 0.0128 0.1311 0.1537
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0616 0.1924
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0448 0.0819
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus alpha 1A adrenergic receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis expressed conserved protein 0.0092 0.0849 0.0983
Echinococcus granulosus g-protein coupled receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.1311 0.1537
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0137 0.1422 0.2747
Trypanosoma brucei malate dehydrogenase-related 0.0126 0.1278 0.2463
Onchocerca volvulus 0.0128 0.1311 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Brugia malayi G-protein coupled receptor 0.0128 0.1311 0.1806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.005 0.0319 0.0599
Entamoeba histolytica malate dehydrogenase, putative 0.0266 0.3061 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Brugia malayi Melatonin receptor type 1A 0.0128 0.1311 0.1806
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Brugia malayi lactate dehydrogenase. 0.0266 0.3061 0.4282
Onchocerca volvulus Neuropeptide F receptor homolog 0.0128 0.1311 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0426 0.0476
Trypanosoma cruzi cysteine protease, putative 0.003 0.0065 0.0062
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0034 0.0037
Schistosoma mansoni carbonic anhydrase 0.0223 0.2518 0.5119
Plasmodium vivax lactate dehydrogenase 0.0266 0.3061 1
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0448 0.0819
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.038 0.1144
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Echinococcus multilocularis somatostatin receptor 0.0128 0.1311 0.1537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Plasmodium vivax vivapain-2 0.0059 0.0426 0.1295
Echinococcus granulosus dro:myosuppressin receptor 0.0128 0.1311 0.1286
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1311 0.1286
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0065 0.0103
Brugia malayi putative neuropeptide receptor NPR1 0.0128 0.1311 0.1806
Brugia malayi GnHR receptor homolog 0.0128 0.1311 0.1806
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0065 0.0103
Echinococcus granulosus intermediate filament protein 0.0057 0.04 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0059 0.0426 0.0809
Brugia malayi putative neuropeptide receptor 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Brugia malayi Dopamine receptor 0.0128 0.1311 0.1806
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0128 0.1311 0.2664
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0448 0.0853
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0412 0.492 0.6911
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1286
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.022 0.1188
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Onchocerca volvulus Cathepsin F homolog 0.0059 0.0426 0.2175
Echinococcus multilocularis orexin receptor type 2 0.0128 0.1311 0.1537
Toxoplasma gondii cathepsin CPL 0.0059 0.0426 0.1295
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.0426 0.1295
Echinococcus granulosus fmrfamide receptor 0.0128 0.1311 0.1286
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.022 0.1188
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0057 0.04 0.1948
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.0426 0.0398
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus carbonic anhydrase II 0.0412 0.492 0.4905
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Echinococcus multilocularis neuropeptide receptor A26 0.0128 0.1311 0.1537
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0175 0.0901
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Echinococcus multilocularis sex peptide receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Echinococcus granulosus malate dehydrogenase 0.0144 0.151 0.1486
Onchocerca volvulus 0.0059 0.0426 0.2175
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Echinococcus granulosus cytosolic malate dehydrogenase 0.0151 0.1597 0.1574
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.1311 0.2664
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Plasmodium vivax unspecified product 0.003 0.0065 0.0103
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0426 0.0476
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.0975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus malate dehydrogenase 0.0144 0.151 0.1486
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0128 0.1311 1
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0616 0.2185
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Loa Loa (eye worm) cysteine protease 0.0059 0.0426 0.0809
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0128 0.1311 0.2664
Leishmania major malate dehydrogenase, putative 0.0266 0.3061 0.599
Brugia malayi CHE-14 protein 0.0042 0.0215 0.0256
Brugia malayi intermediate filament protein 0.0057 0.04 0.0518
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0128 0.1311 0.2554
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0034 0.0112 0.019
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.0426 0.1295
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0215 0.0187
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0128 0.1311 0.2554
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1459 0.1435
Schistosoma mansoni L-lactate dehydrogenase 0.0266 0.3061 0.6222
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.1311 0.1286
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Onchocerca volvulus 0.0128 0.1311 1
Onchocerca volvulus 0.0059 0.0426 0.2175
Loa Loa (eye worm) acetyltransferase 0.0144 0.1511 0.2948
Plasmodium vivax vivapain-3 0.003 0.0065 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0128 0.1311 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0151 0.1597 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0924 0.1074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Echinococcus granulosus mitogen activated protein kinase 14 0.0426 0.5088 0.5074
Onchocerca volvulus 0.0059 0.0426 0.2175
Trypanosoma cruzi malate dehydrogenase, putative 0.0144 0.151 0.2922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Leishmania major cytochrome p450-like protein 0.006 0.0448 0.0819
Brugia malayi Cytochrome P450 family protein 0.006 0.0448 0.0586
Echinococcus granulosus allatostatin A receptor 0.0128 0.1311 0.1286
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.1311 0.2664
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.006 0.0448 0.0558
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.1311 0.1286
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0426 0.2175
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0128 0.1311 0.1286
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Brugia malayi Cathepsin L-like precursor 0.0039 0.018 0.0206
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0128 0.1311 0.1286
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0426 0.0865
Loa Loa (eye worm) hypothetical protein 0.0098 0.0924 0.1792
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0056 0.0387 0.0733
Echinococcus multilocularis cysteine protease 0.0059 0.0426 0.0476
Echinococcus granulosus lamin dm0 0.0057 0.04 0.0373
Onchocerca volvulus 0.0059 0.0426 0.2175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi P38 map kinase family protein 2 0.0426 0.5088 0.7149
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Echinococcus multilocularis tumor protein p63 0.0343 0.4036 0.4804
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis neuropeptide receptor 0.0248 0.2837 0.3367
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0266 0.3061 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0128 0.1311 0.2554
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0266 0.3061 0.3635
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1537
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0267
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1511 0.1777
Echinococcus multilocularis allatostatin A receptor 0.0128 0.1311 0.1537
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0426 0.0554
Leishmania major cytosolic malate dehydrogenase 0.0151 0.1597 0.3094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.018 0.0933
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Echinococcus granulosus neuropeptide receptor 0.0248 0.2837 0.2817
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0128 0.1311 0.2664
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0223 0.2518 0.3514
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0311 0.0392
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0151 0.1597 0.3094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0175 0.0466
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.0426 0.0398
Echinococcus multilocularis fmrfamide receptor 0.0128 0.1311 0.1537
Toxoplasma gondii hypothetical protein 0.0223 0.2518 0.8208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.018 0.0933
Brugia malayi Cathepsin L-like precursor 0.0039 0.018 0.0206
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0057 0.04 0.1948
Echinococcus granulosus sex peptide receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0034 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1311 0.2664
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0128 0.1311 0.1286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Echinococcus multilocularis musashi 0.0057 0.04 0.0445
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0426 0.0865
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0051 0.0335 0.063
Onchocerca volvulus 0.0059 0.0426 0.2175
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Toxoplasma gondii lactate dehydrogenase LDH1 0.0266 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.4318 0.8483
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0311 0.0392
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus granulosus L lactate dehydrogenase 0.014 0.1464 0.144
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1311 0.2664
Echinococcus granulosus neuropeptide receptor 0.0128 0.1311 0.1286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0448 0.0853
Leishmania major malate dehydrogenase, putative 0.0126 0.1278 0.2463
Brugia malayi ORL1-like opioid receptor 0.0128 0.1311 0.1806
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0144 0.151 0.2089
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Echinococcus granulosus G protein coupled receptor 139 0.0128 0.1311 0.1286
Loa Loa (eye worm) fibroinase 0.0059 0.0426 0.0809
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0412 0.492 0.9668
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.0426 0.0809
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0426 0.0775
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.1311 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0426 0.2506
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.018 0.0365
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1511 0.2089
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Entamoeba histolytica cysteine proteinase 2 0.003 0.0065 0.0103
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.4318 0.606
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0412 0.492 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.0418
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0026
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0412 0.492 0.9669
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0616 0.1924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0128 0.1311 0.1537
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.0426 0.1295
Echinococcus multilocularis G protein coupled receptor 139 0.0248 0.2837 0.3367
Brugia malayi Dopamine receptor protein 2 0.0128 0.1311 0.1806
Brugia malayi Serotonin receptor 0.0128 0.1311 0.1806
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0222 0.0266
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0074 0.0616 0.3859
Echinococcus granulosus cathepsin l1 0.0059 0.0426 0.0398
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.1311 0.1286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0175 0.0466
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0426 0.0476
Mycobacterium ulcerans hypothetical protein 0.0074 0.0616 0.194
Brugia malayi G-protein coupled receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis mitogen activated protein kinase 11 0.0426 0.5088 0.6064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0311 0.0583
Echinococcus granulosus mitogen activated protein kinase 11 0.0426 0.5088 0.5074
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0924 0.2941
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Entamoeba histolytica malate dehydrogenase, putative 0.0151 0.1597 0.5165
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Schistosoma mansoni neuropeptide receptor 0.0248 0.2837 0.5767
Trichomonas vaginalis malate dehydrogenase, putative 0.0126 0.1278 0.7959
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Onchocerca volvulus 0.0059 0.0426 0.2175
Echinococcus granulosus lactate dehydrogenase protein 0.0266 0.3061 0.3041
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni hypothetical protein 0.0223 0.2518 0.5119
Plasmodium falciparum malate dehydrogenase 0.0266 0.3061 1
Loa Loa (eye worm) malate dehydrogenase 0.0144 0.151 0.2948
Onchocerca volvulus 0.005 0.0319 0.1232
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0616 0.194
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0065 0.0044
Echinococcus granulosus serotonin receptor 0.0128 0.1311 0.1286
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus neuropeptide s receptor 0.0128 0.1311 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1457 0.1433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Onchocerca volvulus 0.0128 0.1311 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0426 0.5088 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0223 0.2518 0.4935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Echinococcus granulosus somatostatin receptor 0.0128 0.1311 0.1286
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Brugia malayi AKH receptor 0.0128 0.1311 0.1806
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0394
Schistosoma mansoni adenoreceptor 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus multilocularis mitogen activated protein kinase 14 0.0426 0.5088 0.6064
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1511 0.3071
Echinococcus multilocularis cathepsin L 0.003 0.0065 0.0044
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0426 0.1295
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.04 0.0518
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus granulosus cathepsin L 0.003 0.0065 0.0037
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis dro:myosuppressin receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis L lactate dehydrogenase 0.014 0.1464 0.1721
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.1311 0.2554
Schistosoma mansoni lamin 0.0057 0.04 0.0813
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Schistosoma mansoni hypothetical protein 0.0034 0.0112 0.0227
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus multilocularis protein patched 0.0042 0.0215 0.0224
Schistosoma mansoni malate dehydrogenase 0.0151 0.1597 0.3247
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0426 0.0809
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0065 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1286
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Loa Loa (eye worm) malate dehydrogenase 0.0151 0.1597 0.3119
Brugia malayi sulfakinin receptor protein 0.0128 0.1311 0.1806
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Echinococcus multilocularis carbonic anhydrase II 0.0412 0.492 0.5863
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis neuropeptide receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0144 0.151 0.2922
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0187 0.2052 0.4015
Loa Loa (eye worm) hypothetical protein 0.0266 0.3061 0.6004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0128 0.1311 0.1806
Schistosoma mansoni histamine h1 receptor 0.0128 0.1311 0.2664
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Giardia lamblia Malate dehydrogenase 0.0151 0.1597 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0128 0.1311 0.2554
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0222 0.0232
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus multilocularis mitogen activated protein kinase 11 0.0426 0.5088 0.6064
Trypanosoma brucei carbonic anhydrase-like protein 0.0412 0.492 0.9668
Trypanosoma cruzi cruzipain precursor, putative 0.0156 0.1668 0.3234
Plasmodium vivax vivapain-1 0.003 0.0065 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Schistosoma mansoni growth hormone secretagogue receptor 0.0128 0.1311 0.2664
Brugia malayi G protein-coupled receptor F59B2.13 0.0128 0.1311 0.1806
Echinococcus granulosus cytosolic malate dehydrogenase 0.0151 0.1597 0.1574
Echinococcus granulosus lactate dehydrogenase a 0.0266 0.3061 0.3041
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0151 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) TYRA-2 protein 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0059 0.0426 0.2175
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Echinococcus multilocularis lactate dehydrogenase protein 0.0266 0.3061 0.3635
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0128 0.1311 0.1537
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.038 0.1144
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0151 0.1597 0.3094
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.1311 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Trypanosoma brucei cytosolic malate dehydrogenase 0.0151 0.1597 0.3094
Loa Loa (eye worm) CYP4Cod1 0.006 0.0448 0.0853
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Echinococcus multilocularis g-protein coupled receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus neuropeptide FF receptor 2 0.0128 0.1311 0.1286
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0128 0.1311 0.1537
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0144 0.151 0.2922
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1537
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Echinococcus granulosus lactate dehydrogenase a 0.0266 0.3061 0.3041
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Chlamydia trachomatis malate dehydrogenase 0.0151 0.1597 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0061 0.046 0.2723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni myosin xvIII 0.0128 0.1311 0.2664
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.4318 0.8478
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0065 0.0062
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0065 0.0037
Loa Loa (eye worm) intermediate filament protein 0.0057 0.04 0.0759
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0426 0.5088 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Echinococcus granulosus lamin 0.0057 0.04 0.0373
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Brugia malayi larval opioid receptor 0.0128 0.1311 0.1806
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0128 0.1311 0.2554
Plasmodium vivax vivapain-2 0.0059 0.0426 0.1295
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Echinococcus multilocularis conserved hypothetical protein 0.0684 0.8371 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Echinococcus granulosus peptide allatostatin:somatostatin 0.0128 0.1311 0.1286
Schistosoma mansoni neuropeptide f receptor 76f 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0144 0.151 0.2922
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Loa Loa (eye worm) carbonic anhydrase 3 0.0412 0.492 0.9669
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.0426 0.1295
Schistosoma mansoni patched 1 0.0042 0.0215 0.0437
Echinococcus multilocularis neuropeptide FF receptor 2 0.0128 0.1311 0.1537
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0151 0.1597 0.2212
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) ctsf protein 0.0059 0.0426 0.0809
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0426 0.2175
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0112 0.011
Schistosoma mansoni malate dehydrogenase 0.0266 0.3061 0.6222
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0128 0.1311 0.1806
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0126 0.1278 0.4111
Echinococcus granulosus tumor protein p63 0.0343 0.4036 0.4019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Schistosoma mansoni malate dehydrogenase 0.0151 0.1597 0.3247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0426 0.1295
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.022 0.0614
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0215 0.0187
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0128 0.1311 0.1286
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0223 0.2518 0.3514
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Brugia malayi RE15519p 0.0128 0.1311 0.1806
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0222 0.0407
Echinococcus granulosus neuropeptide receptor A26 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) hypothetical protein 0.0057 0.04 0.0759
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Echinococcus multilocularis lamin 0.0057 0.04 0.0445
Schistosoma mansoni lamin 0.0057 0.04 0.0813
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0065 0.0044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.1311 0.2664
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Brugia malayi follicle stimulating hormone receptor 0.0128 0.1311 0.1806
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0271 0.0552
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Leishmania major carbonic anhydrase-like protein 0.0412 0.492 0.9668
Onchocerca volvulus 0.0128 0.1311 1
Plasmodium falciparum L-lactate dehydrogenase 0.0266 0.3061 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0412 0.492 0.9668
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0151 0.1597 0.1881
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.018 0.0482
Echinococcus granulosus 7tm_1 domain containing protein 0.0128 0.1311 0.1286
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0128 0.1311 0.2664
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Mycobacterium ulcerans malate dehydrogenase 0.0151 0.1597 1
Schistosoma mansoni intermediate filament proteins 0.0057 0.04 0.0813
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.1062 0.2033
Echinococcus multilocularis cysteine protease 0.0059 0.0426 0.0476
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Brugia malayi Serotonin receptor 0.0584 0.7104 1
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0065 0.0062
Toxoplasma gondii malate dehydrogenase MDH 0.0266 0.3061 1
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0128 0.1311 0.2554
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Trypanosoma cruzi malate dehydrogenase, putative 0.0126 0.1278 0.2463
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0128 0.1311 0.1806
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Schistosoma mansoni L-lactate dehydrogenase 0.0126 0.1278 0.2598

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) = 20 % Relative binding affinity of Z isomers to human ERalpha-HBD at 4C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 32 % Relative binding affinity of E isomers to human ERalpha-HBD at 25 degree C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 36 % Relative binding affinity of E isomers to human ERalpha-HBD at 4C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 39 % Relative binding affinity of Z isomers to human ERalpha-HBD at 25 degree C compared to [3H]-estradiol ChEMBL. 15974584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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