TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.352 | Formula: C18H19FN2O6
H donors: 0 H acceptors: 4 LogP: 3.44 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)CN(C(C)(C)C)C(=O)COC(=O)c1ccc(o1)[N+](=O)[O-]
InChi: 1S/C18H19FN2O6/c1-18(2,3)20(10-12-4-6-13(19)7-5-12)15(22)11-26-17(23)14-8-9-16(27-14)21(24)25/h4-9H,10-11H2,1-3H3
InChiKey: VXRWKHPPVFGSFO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Reverse transcriptase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	polyprotein of retrotransposon Tca8	Reverse transcriptase	259 aa	238 aa	26.5 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	245 aa	25.7 %
Candida albicans	hypothetical protein	Reverse transcriptase	259 aa	223 aa	29.1 %
Candida albicans	ReverseTranscriptase similar to fruit fly Tom element	Reverse transcriptase	259 aa	244 aa	27.9 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	208 aa	26.4 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	222 aa	22.5 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	226 aa	24.3 %
Trypanosoma congolense	Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative	Reverse transcriptase	259 aa	237 aa	29.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	trypanothione reductase	0.0042	0.0011	0.003
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0182	0.0189	0.0184
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0096	0.0079	0.2977
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0012	0.0007
Brugia malayi	diacylglycerol acyltransferase	0.1081	0.1333	0.1333
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0011	0.005
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0182	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0291	0.0327	0.5771
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0182	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0189	0.3294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Leishmania major	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0182	0.0189	0.0184
Echinococcus multilocularis	sterol O acyltransferase 1	0.0182	0.0189	0.0184
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.1798	0.2245	0.2245
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0398	0.0464	0.2053
Loa Loa (eye worm)	hypothetical protein	0.09	0.1101	0.1101
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0182	0.0189	0.0189
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0182	0.0189	0.0184
Loa Loa (eye worm)	hypothetical protein	0.7896	1	1
Toxoplasma gondii	hypothetical protein	0.0182	0.0189	0.0823
Entamoeba histolytica	hypothetical protein	0.0182	0.0189	0.5
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0182	0.0189	0.0184
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Onchocerca volvulus		0.0037	0.0004	0.0012
Trypanosoma cruzi	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Onchocerca volvulus		0.0037	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0189	0.0189
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0182	0.0189	0.0184
Entamoeba histolytica	hypothetical protein, conserved	0.0182	0.0189	0.5
Schistosoma mansoni	sterol O-acyltransferase 1	0.0182	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Onchocerca volvulus		0.1798	0.2245	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.0257	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0004	0.0004
Echinococcus multilocularis	methionine tRNA synthetase	0.0056	0.0029	0.0025
Leishmania major	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Onchocerca volvulus		0.0037	0.0004	0.0012
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0182	0.0189	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0049	0.002	0.002
Echinococcus granulosus	methionine tRNA synthetase	0.0056	0.0029	0.0025
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0182	0.0189	0.0184
Trypanosoma cruzi	GUP1, putative	0.0182	0.0189	0.0823
Trypanosoma brucei	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0181	0.0188	0.0184
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0181	0.0188	0.0188
Schistosoma mansoni	hypothetical protein	0.0182	0.0189	0.0189
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Leishmania major	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.1081	0.1333	1
Schistosoma mansoni	hypothetical protein	0.0167	0.0169	0.0169
Onchocerca volvulus		0.0233	0.0253	0.1121
Brugia malayi	Glycosylation related protein 12, isoform	0.0198	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Toxoplasma gondii	methionyl-tRNA synthetase	0.0056	0.0029	0.011
Trypanosoma cruzi	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Brugia malayi	beta-lactamase	0.0037	0.0004	0.0004
Brugia malayi	glutathione reductase	0.0042	0.0011	0.0011
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.1081	0.1333	0.1333
Leishmania major	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.0093	1
Toxoplasma gondii	hypothetical protein	0.0186	0.0194	0.0847
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.1798	0.2245	0.2245
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.7896	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0182	0.0189	0.3294
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.1798	0.2245	1
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0182	0.0189	0.0184
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0011	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0189	0.3294
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0182	0.0189	0.0189
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0056	0.0029	0.5
Brugia malayi	methionyl-tRNA synthetase	0.0056	0.0029	0.0029
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0182	0.0189	0.0184
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.002	0.002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.002	0.002
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0056	0.0029	0.011
Brugia malayi	GNT-I family protein	0.0584	0.0701	0.0701
Loa Loa (eye worm)	hhat protein	0.0182	0.0189	0.0189
Loa Loa (eye worm)	hhat protein	0.0182	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Schistosoma mansoni	zinc finger protein	0.0182	0.0189	0.0189
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0056	0.0029	0.0537
Toxoplasma gondii	dgat2l1-prov protein	0.1798	0.2245	1
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Toxoplasma gondii	diacylglycerol acyltransferase	0.0398	0.0464	0.2053
Loa Loa (eye worm)	pax transcription factor protein 2	0.0233	0.0253	0.0253
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0096	0.0079	0.2977
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0182	0.0189	0.0184
Onchocerca volvulus		0.0182	0.0189	0.0833
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0182	0.0189	0.5
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0056	0.0029	0.0029
Brugia malayi	MBOAT family protein	0.0182	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0189	0.3294
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0096	0.0079	0.8466
Trichomonas vaginalis	porcupine, putative	0.0182	0.0189	0.3294
Leishmania major	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0198	0.021	0.021
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0096	0.0079	0.2977
Trypanosoma brucei	RNA helicase, putative	0.0167	0.0169	0.0737
Trypanosoma cruzi	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0056	0.0029	0.011
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0035	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Trypanosoma cruzi	GUP1, putative	0.0182	0.0189	0.0823
Leishmania major	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Echinococcus multilocularis	alpha 1,3 mannosyl glycoprotein	0.0584	0.0701	0.0697
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0181	0.0188	0.0188
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0398	0.0464	0.0464
Leishmania major	diacylglycerol acyltransferase, putative	0.1798	0.2245	1
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.7896	1	1
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0398	0.0464	0.0464
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.7896	1	1
Leishmania major	methionyl-tRNA synthetase, putative	0.0056	0.0029	0.011
Loa Loa (eye worm)	MBOAT family protein	0.0182	0.0189	0.0189
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0181	0.0188	0.0188
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0181	0.0188	0.0188
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0181	0.0188	0.0184
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0004	0.0004
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0182	0.0189	0.0189
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0004	0.0004
Brugia malayi	diacylglycerol acyltransferase family protein	0.1798	0.2245	0.2245
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0181	0.0188	0.0184
Schistosoma mansoni	alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase	0.0584	0.0701	0.0701
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0011	0.005
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0056	0.0029	0.2781
Schistosoma mansoni	hypothetical protein	0.0398	0.0464	0.0464
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.1798	0.2245	1
Loa Loa (eye worm)	MBOAT family protein	0.0182	0.0189	0.0189
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0182	0.0189	0.5
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.1081	0.1333	0.1329
Brugia malayi	beta-lactamase family protein	0.0037	0.0004	0.0004
Brugia malayi	MBOAT family protein	0.0182	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.0182	0.0189	0.0823
Brugia malayi	MBOAT family protein	0.0182	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0584	0.0701	0.0701
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0011	0.0011
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.0093	0.3517
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0004	0.0004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0181	0.0188	0.0184
Toxoplasma gondii	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.0198	0.021	0.0916
Brugia malayi	MBOAT family protein	0.0182	0.0189	0.0189
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.1081	0.1333	0.1333
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0182	0.0189	0.0184
Plasmodium vivax	methionine--tRNA ligase, putative	0.0056	0.0029	0.0186
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0182	0.0189	0.0184
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.0093	0.3517
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0012	0.0007
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.1081	0.1333	0.1329
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0056	0.0029	0.0978
Entamoeba histolytica	vacuolar protein sorting 26	0.0182	0.0189	0.5
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0004	0.0004
Treponema pallidum	alginate O-acetylation protein (algI)	0.0182	0.0189	0.5
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.0093	0.3517
Echinococcus granulosus	sterol O acyltransferase 1	0.0182	0.0189	0.0184
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0398	0.0464	0.2053
Echinococcus granulosus	alpha 13 mannosyl glycoprotein	0.0584	0.0701	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0584	0.0701	0.0701
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0182	0.0189	0.5
Brugia malayi	MBOAT family protein	0.0182	0.0189	0.0189
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0011	0.003
Plasmodium falciparum	methionine--tRNA ligase	0.0056	0.0029	0.0136
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.1081	0.1333	0.5929
Schistosoma mansoni	methionine-tRNA synthetase	0.0056	0.0029	0.0029
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0182	0.0189	0.0184
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0011	0.0263
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Brugia malayi	Hhat protein	0.0182	0.0189	0.0189
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.1081	0.1333	1
Mycobacterium tuberculosis	Probable reductase	0.0096	0.0079	0.2977
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0189	0.0189
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0181	0.0188	0.0188
Giardia lamblia	Methionyl-tRNA synthetase	0.0056	0.0029	0.5
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0182	0.0189	0.0184
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0182	0.0189	0.0189
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0011	0.003
Brugia malayi	beta-lactamase family protein	0.0037	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0096	0.0079	0.2977
Mycobacterium ulcerans	hypothetical protein	0.0398	0.0464	1
Brugia malayi	Thioredoxin reductase	0.0042	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0189	0.0189
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.002	0.002
Trypanosoma brucei	trypanothione reductase	0.0042	0.0011	0.003
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0189	0.0189
Leishmania major	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0004	0.0004
Mycobacterium tuberculosis	Probable dehydrogenase	0.0096	0.0079	0.2977
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.0564	1
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0398	0.0464	0.2053
Trypanosoma brucei	glycerol uptake protein, putative	0.0182	0.0189	0.0823
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0056	0.0029	0.0441
Brugia malayi	Pax transcription factor protein 2	0.0233	0.0253	0.0253
Loa Loa (eye worm)	MBOAT family protein	0.0182	0.0189	0.0189
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.1798	0.2245	1
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.1081	0.1333	0.5929

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	> 100 uM	Cytotoxicity against human MT4 cells after 3 days by MTT assay	ChEMBL.	21193314
IC50 (binding)	= 8.5 uM	Inhibition RNase H activity of HIV1 reverse transcriptase expressed in Escherichia coli stain BL21(DE3)pLysS	ChEMBL.	21193314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1642783

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1462959