Detailed information for compound 1465877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.355 | Formula: C19H18N2O7
  • H donors: 0 H acceptors: 2 LogP: 2.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1nnc(o1)c1cc(OC)c2c(c1)OCO2
  • InChi: 1S/C19H18N2O7/c1-22-12-5-10(6-13(23-2)16(12)25-4)18-20-21-19(28-18)11-7-14(24-3)17-15(8-11)26-9-27-17/h5-8H,9H2,1-4H3
  • InChiKey: SRWONXNWTPLDFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.005 0.0513
Schistosoma mansoni ap endonuclease 0.0041 0.005 0.0308
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.1947 0.2946 0.2946
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0012 0.0127
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Trypanosoma cruzi folylpolyglutamate synthetase 0.0646 0.0969 1
Toxoplasma gondii exonuclease III APE 0.0041 0.005 0.0513
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0002 0.002
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0646 0.0969 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0002 0.002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0041 0.0418
Brugia malayi beta-lactamase 0.0112 0.0158 0.163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 0.0037
Mycobacterium tuberculosis Conserved protein 0.0112 0.0158 0.0158
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramate-alanine ligase 0.3815 0.5785 0.5764
Brugia malayi ecdysteroid receptor 0.001 0.0002 0.002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0012
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.1947 0.2946 0.2911
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0192
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0219 0.032 0.3303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0087 0.0897
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.005 0.0308
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramoylalanine-D-glutamate ligase 0.0646 0.0969 0.0924
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0002 0.002
Onchocerca volvulus 0.0112 0.0158 0.163
Brugia malayi Pre-SET motif family protein 0.02 0.0291 0.3005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0002 0.002
Mycobacterium ulcerans beta-lactamase 0.0112 0.0158 0.0109
Schistosoma mansoni coup transcription factor 0.001 0.0002 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0057 0.0355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.005 0.0308
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0255
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0158 0.0158
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0646 0.0969 0.5998
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.02 0.0291 0.3005
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0158 0.0158
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0002 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.005 0.0513
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0029 0.0182
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0002 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0002 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0158 0.163
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0041 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0057 0.0355
Mycobacterium ulcerans lipase LipD 0.0112 0.0158 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Onchocerca volvulus 0.0112 0.0158 0.163
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0158 0.0158
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.6589 1 1
Toxoplasma gondii ABC1 family protein 0.0112 0.0158 0.163
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl pentapeptide synthase 0.6589 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.002
Treponema pallidum UDP-N-acetylmuramate--L-alanine ligase 0.3815 0.5785 0.5785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0012
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase 0.3815 0.5785 0.5764
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0087 0.0538
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.005 0.0513
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0041 0.0251
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl tripeptide synthase 0.1947 0.2946 0.2911
Onchocerca volvulus 0.0112 0.0158 0.163
Schistosoma mansoni folylpolyglutamate synthase 0.0646 0.0969 0.5998
Onchocerca volvulus 0.0228 0.0333 0.3439
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.6589 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.002
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0646 0.0969 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0041 0.0251
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0646 0.0969 1
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0646 0.0969 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0717 0.1077 0.1077
Mycobacterium leprae ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.6589 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0041 0.8156
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0158 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0158 0.163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0002 0.002
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0646 0.0969 0.5998
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0002 0.002
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0041 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0002 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0002 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0076
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0002 0.0012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0002 0.0012
Onchocerca volvulus 0.0046 0.0057 0.0585
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0057 0.0585
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.032
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) 0.3815 0.5785 0.5785
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0012
Schistosoma mansoni ap endonuclease 0.0041 0.005 0.0308
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0057 0.0355
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0158 0.163
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0158 0.163
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0158 0.163
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0158 0.163
Echinococcus multilocularis geminin 0.1071 0.1616 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0041 0.0418
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0012
Onchocerca volvulus 0.0029 0.0031 0.032
Trichomonas vaginalis set domain proteins, putative 0.0228 0.0333 0.3439
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0158 0.0978
Schistosoma mansoni hypothetical protein 0.1071 0.1616 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0012
Mycobacterium leprae possible ligase 0.0646 0.0969 0.0824
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0158 0.163
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0646 0.0969 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0002 0.0012
Brugia malayi FolC bifunctional protein 0.0646 0.0969 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0031 0.0192
Echinococcus granulosus GPCR family 2 0.0016 0.0012 0.0076
Mycobacterium ulcerans hypothetical protein 0.0112 0.0158 0.0109
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.002
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0646 0.0969 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0158 0.0978
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0158 0.163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0002 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0031 0.032
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.0327 0.2024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0066 0.0682
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0031 0.0192
Leishmania major folylpolyglutamate synthetase 0.0646 0.0969 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0041 0.0418
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Brugia malayi Pre-SET motif family protein 0.0029 0.0031 0.032
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.005 0.0513
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0087 0.0538
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0002 0.0012
Mycobacterium tuberculosis Conserved protein 0.0112 0.0158 0.0158
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0012 0.0127
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0158 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.005 0.0513
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0041 0.0251
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Brugia malayi beta-lactamase family protein 0.0112 0.0158 0.163
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.005 0.0513
Mycobacterium tuberculosis Conserved protein 0.0112 0.0158 0.0158
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0002 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0041 0.0425
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.0327 0.2024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0066 0.0682
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0031 0.0192
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.005 0.0513
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.1947 0.2946 0.2833
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0076
Loa Loa (eye worm) FolC protein 0.0646 0.0969 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0041 0.8156
Echinococcus multilocularis GPCR, family 2 0.0016 0.0012 0.0076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0418
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Mycobacterium ulcerans UDP-N-acetylmuramate--L-alanine ligase 0.3815 0.5785 0.5764
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.005 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0087 0.0897
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0646 0.0969 1
Schistosoma mansoni survival motor neuron protein 0.0046 0.0057 0.0351
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0041 0.0418
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0041 0.0418
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0012 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0087 0.0538
Brugia malayi steroid hormone receptor 0.001 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0192
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0012
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0646 0.0969 0.5998
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0066 0.0682
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0158 0.163
Mycobacterium ulcerans UDP-N-acetylmuramyl tripeptide synthase 0.0646 0.0969 0.0924
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Treponema pallidum folylpolyglutamate synthetase (folC) 0.1947 0.2946 0.2946
Treponema pallidum UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD) 0.1947 0.2946 0.2946
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0012 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.002
Brugia malayi beta-lactamase family protein 0.0112 0.0158 0.163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0425
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0057 0.0355
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0041 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0057 0.0355
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0012
Loa Loa (eye worm) beta-lactamase 0.0112 0.0158 0.163
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0087 0.0538
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0012 0.0127
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0158 0.0978
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0031 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0158 0.0978
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0002 0.002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0158 0.163
Schistosoma mansoni hypothetical protein 0.1071 0.1616 1
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.005 0.0513
Brugia malayi hypothetical protein 0.0223 0.0327 0.3375
Chlamydia trachomatis bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase 0.3815 0.5785 0.4025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0002 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.005 0.0513
Mycobacterium ulcerans UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 0.1947 0.2946 0.2911
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0012 0.0076
Mycobacterium tuberculosis Possible ligase 0.0646 0.0969 0.0969
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0041 0.0251
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0041 0.0418
Brugia malayi follicle stimulating hormone receptor 0.0219 0.032 0.3303
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0002 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0158 0.0109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0002 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0012 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0057 0.0591
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.005 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0031 0.032
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0041 0.0418
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0158 0.163
Onchocerca volvulus 0.001 0.0002 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0002 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0779 0.1171 0.7249
Loa Loa (eye worm) hypothetical protein 0.0223 0.0327 0.3375
Trichomonas vaginalis esterase, putative 0.0112 0.0158 0.163
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) 0.6589 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0041 0.0418
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.002
Echinococcus granulosus geminin 0.1071 0.1616 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0057 0.0591
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0158 0.0158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0057 0.0355
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0646 0.0969 0.5998
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0076
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0158 0.0158
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0041 0.0251
Schistosoma mansoni hypothetical protein 0.0046 0.0057 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0112 0.0158 0.163
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.002
Leishmania major hypothetical protein, conserved 0.0112 0.0158 0.163
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.005 0.0513
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0002 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0057 0.0355

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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