Detailed information for compound 1466595

Basic information

Technical information
  • TDR Targets ID: 1466595
  • Name: 2-(4-morpholin-4-ylphenyl)-4-phenylquinoline
  • MW: 366.455 | Formula: C25H22N2O
  • H donors: 0 H acceptors: 1 LogP: 5.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O1CCN(CC1)c1ccc(cc1)c1nc2ccccc2c(c1)c1ccccc1
  • InChi: 1S/C25H22N2O/c1-2-6-19(7-3-1)23-18-25(26-24-9-5-4-8-22(23)24)20-10-12-21(13-11-20)27-14-16-28-17-15-27/h1-13,18H,14-17H2
  • InChiKey: RQVHABFUCDGCFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-morpholinophenyl)-4-phenyl-quinoline
  • 2-(4-morpholinophenyl)-4-phenylquinoline
  • 2-(4-morpholin-4-ylphenyl)-4-phenyl-quinoline
  • ZINC03348530

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Brugia malayi hypothetical protein 0.0088 0.3343 0.3296
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.6725 0.6697
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.108 0.1017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0086 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.108 0.682
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0525 0.4697
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0172 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.169 0.1632
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.108 1
Brugia malayi hypothetical protein 0.0016 0.0171 0.0103
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.108 0.682
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0499
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0086 0.0341
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0069 0.0343
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0069 0.0234
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0086 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0556 0.4947
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0952 0.6071
Onchocerca volvulus 0.0014 0.0086 0.0045
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0086 0.0341
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1567 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0397 0.3269
Schistosoma mansoni survival motor neuron protein 0.0049 0.1618 0.2721
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0175 0.0896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0952 0.6071
Schistosoma mansoni alpha glucosidase 0.0037 0.108 0.1766
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0086 0.0546
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0556 0.4736
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.1037 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0556 0.4947
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.108 0.682
Loa Loa (eye worm) hypothetical protein 0.0048 0.1567 0.1509
Brugia malayi TAR-binding protein 0.0128 0.5075 0.504
Echinococcus granulosus survival motor neuron protein 1 0.024 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.3343 0.3296
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.108 1
Onchocerca volvulus 0.0049 0.1618 0.4305
Brugia malayi hypothetical protein 0.0025 0.0556 0.0491
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0086 0.0499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0087
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0499
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1567 0.1509
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0154
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0086 0.0546
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.108 0.1003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0069 0.0343
Schistosoma mansoni eyes absent homolog 0.0088 0.3343 0.5786
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.1037 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0556 0.4947
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.1567 1
Entamoeba histolytica hypothetical protein 0.0037 0.1072 0.6769
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5075 0.8863
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.108 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.108 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1037 0.0975
Entamoeba histolytica hypothetical protein 0.0037 0.1072 0.6769
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1072 0.1752
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1567 1
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0154
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.1567 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0525 0.4697
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1567 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0525 0.0443
Loa Loa (eye worm) hypothetical protein 0.0036 0.1037 0.0975
Brugia malayi hypothetical protein 0.0037 0.1072 0.1009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1567 1
Schistosoma mansoni hypothetical protein 0.0035 0.0987 0.1602
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.169 0.1632
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5075 0.8863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0987 0.0924
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0172 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0069 0.0343
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1567 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0104
Echinococcus granulosus GPCR family 2 0.0016 0.0172 0.0087
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0086 0.0341
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0016
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0341
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1567 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.108 1
Schistosoma mansoni alpha-glucosidase 0.0143 0.5715 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1072 0.0995
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.1037 0.6421
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.108 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0086 0.0546
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0087
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0069 0.0343
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1567 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1567 0.1509
Schistosoma mansoni alpha-glucosidase 0.0143 0.5715 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0086 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0952 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1567 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5075 0.8863
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0069 0.0343
Loa Loa (eye worm) oxidoreductase 0.0014 0.0086 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0016
Loa Loa (eye worm) RecQ helicase 0.0024 0.0525 0.0459
Onchocerca volvulus 0.0014 0.0086 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.169 0.1632
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0987 0.0924
Entamoeba histolytica hypothetical protein 0.0037 0.1072 0.6769
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1618 0.1559
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.6725 0.6697
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0069 0.0343
Loa Loa (eye worm) hypothetical protein 0.0088 0.3343 0.3296
Schistosoma mansoni hypothetical protein 0.0037 0.1072 0.1752
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0086 0.0499
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0069 0.0343
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.1037 0.6617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.1567 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1567 1
Brugia malayi RNA binding protein 0.0128 0.5075 0.504
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0087
Loa Loa (eye worm) hypothetical protein 0.0048 0.1567 0.1509
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0556 0.4999
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.108 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.169 0.1632
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.1567 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.6725 0.6702
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0069 0.0343
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0086 0.0499
Schistosoma mansoni hypothetical protein 0.0049 0.1618 0.2721
Onchocerca volvulus 0.0014 0.0086 0.0045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.1567 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.108 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1037 0.0975
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0183 0.1025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0556 0.0491
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0086 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5075 0.8863
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Onchocerca volvulus 0.0014 0.0086 0.0045
Entamoeba histolytica hypothetical protein 0.0037 0.1072 0.6769
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1072 0.0995
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0069 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0069 0.0343
Onchocerca volvulus 0.0048 0.1567 0.4166
Echinococcus multilocularis GPCR, family 2 0.0016 0.0172 0.0087
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.5075 0.504
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1567 0.1509
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.6725 0.6702
Mycobacterium ulcerans hypothetical protein 0.0048 0.1567 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.1037 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0069 0.0343
Loa Loa (eye worm) hypothetical protein 0.024 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0556 0.4999
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0069 0.0343
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0086 0.0499
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0086 0.0546
Loa Loa (eye worm) RNA binding protein 0.0128 0.5075 0.504
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0086 0.0546
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.108 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.108 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0086 0.0546
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.6725 0.6697
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.108 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.108 0.1003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0952 0.6071
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0086 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0128 0.5075 0.504
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.108 0.1017
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0154
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0172 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.1037 0.0975
Loa Loa (eye worm) hypothetical protein 0.0121 0.4781 0.4744
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0086 0.0499
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0556 0.4999
Leishmania major hypothetical protein, conserved 0.0025 0.0556 0.3409
Loa Loa (eye worm) hypothetical protein 0.0036 0.1037 0.0975
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.1567 1
Trypanosoma brucei glucosidase, putative 0.0037 0.108 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.1567 1
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.5075 0.504
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1567 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0525 0.0443
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.108 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0303 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.1567 0.1509
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0525 0.0459
Echinococcus multilocularis tar DNA binding protein 0.0128 0.5075 0.5032
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5075 0.8863
Onchocerca volvulus 0.0096 0.3666 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0086 0.0546
Echinococcus granulosus tar DNA binding protein 0.0128 0.5075 0.5032
Echinococcus multilocularis survival motor neuron protein 1 0.024 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.