Detailed information for compound 1468327

Basic information

Technical information
  • TDR Targets ID: 1468327
  • Name: methyl 2-(2,2-dimethylpropanoylamino)-6-(phen ylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridin e-3-carboxylate
  • MW: 386.508 | Formula: C21H26N2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(NC(=O)C(C)(C)C)sc2c1CCN(C2)Cc1ccccc1
  • InChi: 1S/C21H26N2O3S/c1-21(2,3)20(25)22-18-17(19(24)26-4)15-10-11-23(13-16(15)27-18)12-14-8-6-5-7-9-14/h5-9H,10-13H2,1-4H3,(H,22,25)
  • InChiKey: JVZMRYGPOUJAJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,2-dimethyl-1-oxopropyl)amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid methyl ester
  • 6-(benzyl)-2-(pivaloylamino)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid methyl ester
  • Oprea1_348526

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0494 0.0628 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0031 0.0488
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.1221
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Onchocerca volvulus 0.0121 0.0114 0.033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0047 0.0511
Loa Loa (eye worm) oxidoreductase 0.0494 0.0628 0.6749
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0031 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0031 0.0014
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Echinococcus granulosus sodium and chloride dependent glycine 0.0121 0.0114 0.1221
Brugia malayi Cytochrome P450 family protein 0.0104 0.009 0.036
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0066 0.0038 0.0409
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0014 0.015
Brugia malayi Cytochrome P450 family protein 0.0045 0.0009 0.0037
Echinococcus multilocularis nmda type glutamate receptor 0.0105 0.0091 0.098
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0186 0.0203 0.2183
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0187 0.2011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0017 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0017 0.0183
Schistosoma mansoni kinase 0.0054 0.0021 0.0221
Trypanosoma brucei trypanothione reductase 0.0051 0.0016 0.0262
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0106 0.009
Loa Loa (eye worm) hypothetical protein 0.0053 0.002 0.0217
Onchocerca volvulus 0.0494 0.0628 0.6419
Trichomonas vaginalis hypothetical protein 0.7288 1 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0066 0.0038 0.0409
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.7288 1 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.7288 1 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0713 0.093 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0041 0.0041
Schistosoma mansoni glutamate receptor NMDA 0.027 0.0319 0.3435
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0066 0.0038 0.0409
Brugia malayi Serotonin receptor 0.1843 0.249 1
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0009 0.01
Brugia malayi PAS domain containing protein 0.0049 0.0014 0.0056
Schistosoma mansoni glutamate receptor AMPA 0.0165 0.0175 0.188
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0092 0.037
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0494 0.0628 0.0619
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0494 0.0628 0.0619
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0494 0.0628 0.0612
Plasmodium vivax enoyl-acyl carrier protein reductase 0.7288 1 1
Onchocerca volvulus 0.0494 0.0628 0.6419
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.7288 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Mycobacterium tuberculosis Possible oxidoreductase 0.0494 0.0628 0.0612
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0494 0.0628 0.0619
Brugia malayi hypothetical protein 0.0121 0.0114 0.0456
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0092 0.099
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0121 0.0114 0.1221
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.0448 0.7137
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0066 0.0038 0.0409
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0092 0.1466
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0031 0.0329
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0494 0.0628 0.0619
Leishmania major trypanothione reductase 0.0051 0.0016 0.0262
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.0301 0.3242
Brugia malayi hypothetical protein 0.0164 0.0172 0.0692
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0041 0.0041
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.0063 0.0678
Plasmodium falciparum enoyl-acyl carrier reductase 0.7288 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0017 0.0183
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0494 0.0628 0.6749
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0494 0.0628 1
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.0187 0.2011
Loa Loa (eye worm) retinol dehydrogenase 12 0.0494 0.0628 0.6749
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0019 0.0019
Plasmodium falciparum transporter, putative 0.0121 0.0114 0.0097
Trypanosoma brucei polo-like protein kinase 0.0105 0.0092 0.1466
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0124 0.0107
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0713 0.093 1
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Echinococcus granulosus muscleblind protein 0.016 0.0167 0.1797
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0092 0.1466
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0494 0.0628 0.6749
Onchocerca volvulus 0.0713 0.093 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0494 0.0628 1
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0009 0.0148
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0017 0.0183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0017 0.0183
Schistosoma mansoni dihydropteridine reductase 0.0494 0.0628 0.6749
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0031 0.0021
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0494 0.0628 0.0619
Schistosoma mansoni alpha-glucosidase 0.015 0.0154 0.1651
Brugia malayi follicle stimulating hormone receptor 0.0257 0.0301 0.1211
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0494 0.0628 0.2521
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0121 0.0114 0.1221
Chlamydia trachomatis oxoacy-ACP reductase 0.0494 0.0628 0.052
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0092 0.1466
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0092 0.1466
Mycobacterium tuberculosis Probable reductase 0.0115 0.0106 0.009
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.7288 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0713 0.093 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0057 0.061
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0494 0.0628 0.0628
Leishmania major pteridine reductase 1 0.0494 0.0628 1
Loa Loa (eye worm) glutamate receptor 2 0.0165 0.0175 0.188
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0031 0.0329
Schistosoma mansoni hypothetical protein 0.0189 0.0207 0.223
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0047 0.0511
Echinococcus multilocularis muscleblind protein 1 0.016 0.0167 0.1797
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0713 0.093 1
Schistosoma mansoni glutamate receptor AMPA 0.0165 0.0175 0.188
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0016 0.0262
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Loa Loa (eye worm) hypothetical protein 0.0164 0.0172 0.1853
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0114 0.0097
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0409
Schistosoma mansoni glutamate receptor kainate 0.0165 0.0175 0.188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0047 0.0511
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0031 0.0021
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0121 0.0114 0.0456
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0106 0.009
Brugia malayi Muscleblind-like protein 0.016 0.0167 0.0671
Brugia malayi hypoxia-induced factor 1 0.0151 0.0155 0.0622
Trypanosoma brucei oxidoreductase-like protein 0.0494 0.0628 1
Echinococcus granulosus nmda type glutamate receptor 0.0171 0.0183 0.1963
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0106 0.009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0494 0.0628 0.0619
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0066 0.0038 0.0409
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0494 0.0628 0.0619
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.0448 0.7137
Loa Loa (eye worm) cytochrome P450 family protein 0.0104 0.009 0.0964
Loa Loa (eye worm) hypothetical protein 0.0186 0.0203 0.2181
Leishmania major cytochrome p450-like protein 0.0045 0.0009 0.0148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0253 0.0237
Schistosoma mansoni sodium-dependent amino acid transporter 0.0121 0.0114 0.1221
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0619
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0494 0.0628 1
Giardia lamblia Kinase, PLK 0.0105 0.0092 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0494 0.0628 0.0628
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0494 0.0628 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0167 0.1797
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0124 0.0107
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0494 0.0628 0.0612
Echinococcus multilocularis glutamate receptor 2 0.0165 0.0175 0.188
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0019 0.0019
Echinococcus multilocularis serotonin transporter 0.0713 0.093 1
Echinococcus granulosus serotonin transporter 0.0713 0.093 1
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.0063 0.0678
Treponema pallidum sodium- and chloride- dependent transporter 0.0713 0.093 0.5
Brugia malayi Glutamate receptor 2 precursor 0.0165 0.0175 0.0702
Echinococcus granulosus sodium and chloride dependent glycine 0.0121 0.0114 0.1221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0017 0.0183
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.0448 0.7137
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0494 0.0628 0.0527
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0092 0.099
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0494 0.0628 0.0612
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0114
Schistosoma mansoni sodium/chloride dependent transporter 0.0121 0.0114 0.1226
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0092 0.099
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0203 0.2183
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0124 0.0018
Brugia malayi glutathione reductase 0.0051 0.0016 0.0066
Onchocerca volvulus 0.0121 0.0114 0.033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0106 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0017 0.0183
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0016 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Brugia malayi Thioredoxin reductase 0.0051 0.0016 0.0066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0203 0.2183
Echinococcus granulosus glutamate NMDA receptor subunit 0.0343 0.0419 0.4509
Leishmania major oxidoreductase-like protein 0.0494 0.0628 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0063 0.0034 0.0368
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0612
Plasmodium falciparum amino acid transporter, putative 0.0121 0.0114 0.0097
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0494 0.0628 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0186 0.0203 0.2183
Echinococcus granulosus nmda type glutamate receptor 0.0105 0.0091 0.098
Echinococcus multilocularis glutamate receptor 2 0.0186 0.0203 0.2183
Brugia malayi Cytochrome P450 family protein 0.0045 0.0009 0.0037
Trypanosoma brucei pteridine reductase 1 0.0494 0.0628 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0121 0.0114 0.1221
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0009 0.0148
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0494 0.0628 0.6749
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0092 0.099
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Schistosoma mansoni glutamate receptor kainate 0.0165 0.0175 0.188
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0187 0.2011
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Mycobacterium tuberculosis Probable oxidoreductase 0.0494 0.0628 0.0612
Mycobacterium ulcerans oxidoreductase 0.0494 0.0628 0.0619
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0087 0.0066 0.0711
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0057 0.061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.0187 0.0751
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0017 0.0183
Echinococcus multilocularis sodium and chloride dependent glycine 0.0121 0.0114 0.1221
Toxoplasma gondii thioredoxin reductase 0.0051 0.0016 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0016 0.0177
Onchocerca volvulus 0.0121 0.0114 0.033
Brugia malayi Glutamate receptor 1 precursor 0.0165 0.0175 0.0702
Echinococcus multilocularis nmda type glutamate receptor 0.0171 0.0183 0.1963
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0494 0.0628 1
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0494 0.0628 0.0527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0017 0.0068
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0092 0.0075
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0713 0.093 0.3735
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.002 0.0081
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.7288 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0031 0.0021
Loa Loa (eye worm) hypothetical protein 0.016 0.0167 0.1797
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0612
Schistosoma mansoni sodium/chloride dependent transporter 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Echinococcus multilocularis muscleblind protein 0.016 0.0167 0.1797
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0343 0.0419 0.4509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.002 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Schistosoma mansoni glutamate receptor NMDA 0.0343 0.0419 0.4509
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0106 0.009
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0494 0.0628 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Schistosoma mansoni alpha-glucosidase 0.015 0.0154 0.1651
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0494 0.0628 0.0612
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0066 0.0038 0.0409
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0456
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0494 0.0628 0.0628
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0494 0.0628 0.2521
Echinococcus granulosus glutamate receptor 2 0.012 0.0112 0.12
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0121 0.0114 0.1221
Echinococcus multilocularis geminin 0.0189 0.0207 0.223
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0494 0.0628 0.0612
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0203 0.2183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.002 0.0217
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Echinococcus multilocularis NMDA receptor 0.0066 0.0038 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0494 0.0628 0.0619
Echinococcus granulosus geminin 0.0189 0.0207 0.223
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0092 0.0092
Schistosoma mansoni glutamate receptor kainate 0.0165 0.0175 0.188
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0009 0.01
Plasmodium vivax amine transporter, putative 0.0121 0.0114 0.0097
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0203 0.2183
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0009 0.0148
Loa Loa (eye worm) glutathione reductase 0.0051 0.0016 0.0177
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0494 0.0628 0.6749
Echinococcus multilocularis sodium and chloride dependent glycine 0.0121 0.0114 0.1221
Loa Loa (eye worm) hypothetical protein 0.0121 0.0114 0.1221
Echinococcus multilocularis glutamate receptor 2 0.012 0.0112 0.12
Echinococcus granulosus glutamate receptor subunit protein glur 0.0066 0.0038 0.0409
Loa Loa (eye worm) hypothetical protein 0.0363 0.0448 0.4816
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.0448 0.1799
Loa Loa (eye worm) hypothetical protein 0.0713 0.093 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0009 0.01
Loa Loa (eye worm) hypothetical protein 0.0494 0.0628 0.6749
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0203 0.2183
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0494 0.0628 0.0619
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0031 0.0329
Mycobacterium tuberculosis Possible oxidoreductase 0.0494 0.0628 0.0612
Loa Loa (eye worm) serotonin transporter b 0.0713 0.093 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0456
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0016 0.0177
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0203 0.2183
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0494 0.0628 0.0612
Toxoplasma gondii hypothetical protein 0.0121 0.0114 0.0114
Loa Loa (eye worm) norepinephrine transporter 0.0713 0.093 1
Loa Loa (eye worm) glutamate receptor 1 0.0165 0.0175 0.188
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0456
Echinococcus granulosus single minded 2 0.0043 0.0006 0.0061
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0121 0.0114 0.1221
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0047 0.0191
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0124 0.0107
Loa Loa (eye worm) solute carrier family 6 member 4 0.0713 0.093 1
Schistosoma mansoni ATP-binding cassette transporter 0.0165 0.0175 0.188
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0031 0.0329
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0121 0.0114 0.0114
Echinococcus granulosus glutamate receptor 2 0.0186 0.0203 0.2183
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0155 0.1665
Toxoplasma gondii hypothetical protein 0.0121 0.0114 0.0114
Schistosoma mansoni single-minded 0.0049 0.0014 0.015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.0187 0.2011
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0494 0.0628 0.0619
Schistosoma mansoni hypothetical protein 0.0189 0.0207 0.223

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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