Detailed information for compound 1469629

Basic information

Technical information
  • TDR Targets ID: 1469629
  • Name: 1-indol-1-yl-3-(phenylamino)propan-2-ol
  • MW: 266.338 | Formula: C17H18N2O
  • H donors: 2 H acceptors: 1 LogP: 3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(Cn1ccc2c1cccc2)CNc1ccccc1
  • InChi: 1S/C17H18N2O/c20-16(12-18-15-7-2-1-3-8-15)13-19-11-10-14-6-4-5-9-17(14)19/h1-11,16,18,20H,12-13H2
  • InChiKey: CDLUOICURMZMFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-indolyl)-3-(phenylamino)propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0269 0.5011 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.005 0.0677 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Giardia lamblia Hypothetical protein 0.0148 0.2613 0.4467
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0269 0.5011 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0021 0.01 0.02
Onchocerca volvulus 0.0093 0.1535 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.005 0.0677 0.5
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0021 0.01 0.1482
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0438 0.0875
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0021 0.01 0.02
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0269 0.5011 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.0677 0.1175
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0438 0.0875
Loa Loa (eye worm) hypothetical protein 0.0093 0.1535 0.3063
Schistosoma mansoni chromatin regulatory protein sir2 0.0269 0.5011 0.5011
Plasmodium falciparum plasmepsin X 0.0021 0.01 0.1482
Plasmodium falciparum plasmepsin II 0.0021 0.01 0.1482
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.0677 0.1175
Onchocerca volvulus 0.0021 0.01 0.0654
Plasmodium falciparum plasmepsin III 0.0021 0.01 0.1482
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0148 0.2613 0.5215
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.02
Brugia malayi transcriptional regulator, Sir2 family protein 0.005 0.0677 0.1351
Plasmodium vivax NAD-dependent deacetylase, putative 0.005 0.0677 1
Brugia malayi hypothetical protein 0.0021 0.01 0.02
Schistosoma mansoni cathepsin D (A01 family) 0.0021 0.01 0.01
Plasmodium vivax plasmepsin IV, putative 0.0021 0.01 0.1482
Loa Loa (eye worm) sirtuin 4 0.005 0.0677 0.1351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0148 0.2613 0.5215
Plasmodium vivax plasmepsin V, putative 0.0021 0.01 0.1482
Schistosoma mansoni chromatin regulatory protein sir2 0.005 0.0677 0.0677
Loa Loa (eye worm) serotonin transporter b 0.0093 0.1535 0.3063
Brugia malayi transcriptional regulator, Sir2 family protein 0.005 0.0677 0.1351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Plasmodium vivax aspartyl protease, putative 0.0021 0.01 0.1482
Plasmodium falciparum transcriptional regulatory protein sir2b 0.005 0.0677 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0389 0.0587
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.0677 0.1175
Echinococcus granulosus chromatin regulatory protein sir2 0.0148 0.2613 0.5215
Plasmodium falciparum plasmepsin V 0.0021 0.01 0.1482
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0438 0.0875
Toxoplasma gondii histone deacetylase SIR2 0.005 0.0677 1
Schistosoma mansoni chromatin regulatory protein sir2 0.005 0.0677 0.0677
Plasmodium falciparum plasmepsin I 0.0021 0.01 0.1482
Plasmodium vivax aspartyl proteinase, putative 0.0021 0.01 0.1482
Plasmodium vivax aspartyl protease, putative 0.0021 0.01 0.1482
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0148 0.2613 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0389 0.0587
Brugia malayi hypothetical protein 0.0021 0.01 0.02
Onchocerca volvulus 0.0021 0.01 0.0654
Echinococcus granulosus serotonin transporter 0.0093 0.1535 0.3063
Schistosoma mansoni sodium/chloride dependent transporter 0.0093 0.1535 0.1535
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0093 0.1535 0.3063
Toxoplasma gondii histone deacetylase SIR2-like 0.005 0.0677 1
Schistosoma mansoni chromatin regulatory protein sir2 0.005 0.0677 0.0677
Toxoplasma gondii aspartyl protease 0.0021 0.01 0.1482
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0148 0.2613 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0021 0.01 0.02
Brugia malayi transcriptional regulator, Sir2 family protein 0.0148 0.2613 0.5215
Loa Loa (eye worm) hypothetical protein 0.0033 0.0339 0.0676
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.02
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.0677 0.1175
Plasmodium vivax aspartyl protease, putative 0.0021 0.01 0.1482
Plasmodium falciparum transcriptional regulatory protein sir2a 0.005 0.0677 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0269 0.5011 1
Loa Loa (eye worm) transcriptional regulator 0.0148 0.2613 0.5215
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0093 0.1535 0.1535
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0507 0.0507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Leishmania major silent information regulator 2, putative 0.0148 0.2613 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0148 0.2613 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0021 0.01 0.1482
Echinococcus multilocularis serotonin transporter 0.0093 0.1535 0.3063
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.005 0.0677 0.1351
Loa Loa (eye worm) transcriptional regulator 0.005 0.0677 0.1351
Brugia malayi NAD-dependent deacetylase SIRT1 0.0269 0.5011 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.005 0.0677 0.1351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Brugia malayi Eukaryotic aspartyl protease family protein 0.0021 0.01 0.02
Loa Loa (eye worm) hypothetical protein 0.0093 0.1535 0.3063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0148 0.2613 0.5117
Loa Loa (eye worm) hypothetical protein 0.0219 0.402 0.8022
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0021 0.01 0.02
Toxoplasma gondii aspartyl protease ASP3 0.0021 0.01 0.1482
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0148 0.2613 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0269 0.5011 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Plasmodium vivax hypothetical protein, conserved 0.005 0.0677 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0093 0.1535 0.5
Toxoplasma gondii aspartyl protease ASP1 0.0021 0.01 0.1482
Loa Loa (eye worm) norepinephrine transporter 0.0093 0.1535 0.3063
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.2613 0.2613
Plasmodium falciparum plasmepsin IV 0.0021 0.01 0.1482
Loa Loa (eye worm) aspartyl protease 6 0.0021 0.01 0.02
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0507 0.0507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0021 0.01 0.02
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.005 0.0677 0.1351
Mycobacterium tuberculosis Transcriptional regulatory protein 0.005 0.0677 0.5
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0148 0.2613 0.5117
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0148 0.2613 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.02
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.2613 0.2613
Echinococcus multilocularis chromatin regulatory protein sir2 0.0148 0.2613 0.5215
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.0677 0.1175
Loa Loa (eye worm) hypothetical protein 0.0093 0.1535 0.3063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0269 0.5011 1
Schistosoma mansoni cathepsin D (A01 family) 0.0021 0.01 0.01
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.2613 0.2613
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0269 0.5011 1
Plasmodium falciparum plasmepsin VIII, putative 0.0021 0.01 0.1482
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0438 0.0875
Loa Loa (eye worm) transcriptional regulator 0.005 0.0677 0.1351
Brugia malayi Pepsin A precursor 0.0021 0.01 0.02
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.01 0.01
Plasmodium falciparum plasmepsin VII 0.0021 0.01 0.1482
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0269 0.5011 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0093 0.1535 0.3063
Plasmodium falciparum plasmepsin IX 0.0021 0.01 0.1482
Plasmodium vivax aspartyl proteinase, putative 0.0021 0.01 0.1482
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.005 0.0677 0.1351
Plasmodium falciparum plasmepsin VI 0.0021 0.01 0.1482
Brugia malayi aspartic protease BmAsp-2, identical 0.0021 0.01 0.02

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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