Detailed information for compound 1471342

Basic information

Technical information
  • TDR Targets ID: 1471342
  • Name: (E)-N-[2-(2,3-dihydro-1,4-benzodioxin-7-yl)et hyl]-3-(4-fluorophenyl)prop-2-enamide
  • MW: 327.35 | Formula: C19H18FNO3
  • H donors: 1 H acceptors: 1 LogP: 3.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccc(cc1)F)NCCc1ccc2c(c1)OCCO2
  • InChi: 1S/C19H18FNO3/c20-16-5-1-14(2-6-16)4-8-19(22)21-10-9-15-3-7-17-18(13-15)24-12-11-23-17/h1-8,13H,9-12H2,(H,21,22)/b8-4+
  • InChiKey: MWQHLMAQQRXYKA-XBXARRHUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-[2-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyl]-3-(4-fluorophenyl)acrylamide
  • ZINC03560269
  • MLS000389157
  • SMR000255430
  • T5734238

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0123 0.1372 0.3368
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0029 0.0071
Schistosoma mansoni RNA binding protein 0.0123 0.1372 0.1372
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0123 0.1372 1
Leishmania major hypothetical protein, conserved 0.0123 0.1372 1
Onchocerca volvulus 0.0123 0.1372 0.3321
Echinococcus multilocularis SWI:SNF matrix associated 0.0345 0.4072 0.4072
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0345 0.4072 0.4072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0409 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1631 0.4007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0029 0.0029
Brugia malayi YY1-associated factor 2 0.0123 0.1372 0.3368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0071
Echinococcus granulosus intermediate filament protein 0.0033 0.0276 0.0276
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0345 0.4072 1
Schistosoma mansoni lamin 0.0033 0.0276 0.0276
Echinococcus granulosus Zinc finger RanBP2 type 0.0123 0.1372 0.1372
Schistosoma mansoni hypothetical protein 0.0345 0.4072 0.4072
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0345 0.4072 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0123 0.1372 0.3321
Echinococcus granulosus lamin 0.0033 0.0276 0.0276
Echinococcus multilocularis lamin dm0 0.0033 0.0276 0.0276
Onchocerca volvulus 0.0123 0.1372 0.3321
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0029
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni hypothetical protein 0.0345 0.4072 0.4072
Echinococcus granulosus ring and YY1 binding protein 0.0123 0.1372 0.1372
Onchocerca volvulus 0.0345 0.4072 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Trypanosoma cruzi WLM domain containing protein, putative 0.0123 0.1372 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0071
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0123 0.1372 0.3368
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Loa Loa (eye worm) hypothetical protein 0.0123 0.1372 0.3368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0071
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0071
Onchocerca volvulus 0.0043 0.0409 0.0939
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0345 0.4072 1
Schistosoma mansoni fusion 0.0123 0.1372 0.1372
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0123 0.1372 0.2629
Schistosoma mansoni TRABID protein (C64 family) 0.0123 0.1372 0.1372
Brugia malayi nuclear receptor NHR-88 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0123 0.1372 0.3368
Leishmania major hypothetical protein, conserved 0.0123 0.1372 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3254 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0409 0.1004
Mycobacterium leprae Probable lipase LipE 0.0043 0.0409 0.5
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0345 0.4072 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0029 0.0029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0093 0.0227
Leishmania major hypothetical protein, conserved 0.0123 0.1372 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0071
Echinococcus multilocularis ring and YY1 binding protein 0.0123 0.1372 0.1372
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0029 0.0029
Mycobacterium ulcerans beta-lactamase 0.0043 0.0409 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0123 0.1372 0.3368
Brugia malayi nuclear hormone receptor 0.0012 0.0029 0.0071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0276 0.0678
Echinococcus multilocularis lamin 0.0033 0.0276 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Onchocerca volvulus 0.0043 0.0409 0.0939
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Echinococcus granulosus SWI:SNF matrix associated 0.0345 0.4072 0.4072
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0029 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Schistosoma mansoni intermediate filament proteins 0.0033 0.0276 0.0276
Echinococcus granulosus lamin dm0 0.0033 0.0276 0.0276
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0029
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0123 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0071
Toxoplasma gondii ran binding protein 0.0123 0.1372 0.2629
Onchocerca volvulus 0.0033 0.0276 0.0612
Echinococcus multilocularis SWI:SNF matrix associated 0.0345 0.4072 0.4072
Loa Loa (eye worm) hypothetical protein 0.0123 0.1372 0.3368
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0409 0.1004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0029 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0409 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Echinococcus multilocularis musashi 0.0033 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0345 0.4072 0.4072
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0072 0.0072
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0029 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.1372 1
Brugia malayi ecdysteroid receptor 0.0012 0.0029 0.0071
Brugia malayi brahma associated protein 60 kDa 0.0345 0.4072 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0029 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0029 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0071
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0123 0.1372 0.3368
Leishmania major hypothetical protein, conserved 0.0123 0.1372 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0345 0.4072 0.4072
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0345 0.4072 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0071
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0093 0.0227
Brugia malayi SWIB/MDM2 domain containing protein 0.0345 0.4072 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0123 0.1372 0.1372
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0029
Schistosoma mansoni brg-1 associated factor 0.0345 0.4072 0.4072
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0029 0.0029
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0123 0.1372 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0123 0.1372 1
Brugia malayi beta-lactamase 0.0043 0.0409 0.1004
Onchocerca volvulus 0.0043 0.0409 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0071
Brugia malayi brahma associated protein 60 kDa 0.0345 0.4072 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0409 0.0409
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0551 0.1354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Loa Loa (eye worm) brahma associated protein 0.0345 0.4072 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0345 0.4072 0.4072
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0409 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0029 0.0029
Onchocerca volvulus 0.0123 0.1372 0.3321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Leishmania major hypothetical protein, conserved 0.0123 0.1372 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0029 0.0029
Onchocerca volvulus 0.0123 0.1372 0.3321
Mycobacterium ulcerans hypothetical protein 0.0043 0.0409 0.5
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0123 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Schistosoma mansoni lamin 0.0033 0.0276 0.0276
Brugia malayi MH2 domain containing protein 0.0144 0.1631 0.4007
Plasmodium vivax hypothetical protein, conserved 0.0345 0.4072 1
Schistosoma mansoni coup transcription factor 0.0012 0.0029 0.0029
Brugia malayi beta-lactamase family protein 0.0043 0.0409 0.1004
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0123 0.1372 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0071
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0123 0.1372 0.1372
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0123 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0276 0.0678
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0123 0.1372 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0551 0.1354
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1631 0.4007
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0029 0.0029
Loa Loa (eye worm) beta-lactamase 0.0043 0.0409 0.1004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0071
Mycobacterium ulcerans lipase LipD 0.0043 0.0409 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0409 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0029 0.0029
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0276 0.0678
Echinococcus multilocularis zinc finger protein Ran binding 0.0123 0.1372 0.1372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Trypanosoma brucei hypothetical protein, conserved 0.0123 0.1372 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0123 0.1372 0.1372
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0123 0.1372 0.3368
Onchocerca volvulus 0.0033 0.0276 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0071
Echinococcus granulosus zinc finger protein Ran binding 0.0123 0.1372 0.1372
Brugia malayi steroid hormone receptor 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0269 0.0661
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0409 0.5
Schistosoma mansoni zinc finger protein 0.0123 0.1372 0.1372
Brugia malayi intermediate filament protein 0.0033 0.0276 0.0678
Brugia malayi beta-lactamase family protein 0.0043 0.0409 0.1004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Chlamydia trachomatis DNA topoisomerase I 0.0345 0.4072 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.1372 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0345 0.4072 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0409 0.1004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.4072 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0123 0.1372 0.1372
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0029 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0029 0.0029
Trypanosoma cruzi WLM domain containing protein, putative 0.0123 0.1372 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0123 0.1372 0.3368
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0276 0.0678
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0029
Chlamydia trachomatis SWIB complex protein 0.0345 0.4072 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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