Detailed information for compound 1475008

Basic information

Technical information
  • TDR Targets ID: 1475008
  • Name: 2-[4-methyl-3-(2-oxo-2-phenylethyl)-1,3-thiaz ol-3-ium-5-yl]ethyl 3,5,7-trimethyladamantane -1-carboxylate
  • MW: 466.655 | Formula: C28H36NO3S+
  • H donors: 0 H acceptors: 2 LogP: 6.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)C[n+]1csc(c1C)CCOC(=O)C12CC3(C)CC(C2)(CC(C1)(C3)C)C
  • InChi: 1S/C28H36NO3S/c1-20-23(33-19-29(20)12-22(30)21-8-6-5-7-9-21)10-11-32-24(31)28-16-25(2)13-26(3,17-28)15-27(4,14-25)18-28/h5-9,19H,10-18H2,1-4H3/q+1
  • InChiKey: XUFGIZSDNNALQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-methyl-3-(2-oxo-2-phenyl-ethyl)thiazol-3-ium-5-yl]ethyl 3,5,7-trimethyladamantane-1-carboxylate
  • 3,5,7-trimethyl-1-adamantanecarboxylic acid 2-[4-methyl-3-(2-oxo-2-phenylethyl)-5-thiazol-3-iumyl]ethyl ester
  • 3,5,7-trimethyladamantane-1-carboxylic acid 2-[3-(2-keto-2-phenyl-ethyl)-4-methyl-thiazol-3-ium-5-yl]ethyl ester
  • 2-[4-methyl-3-(2-oxo-2-phenyl-ethyl)-1,3-thiazol-3-ium-5-yl]ethyl 3,5,7-trimethyladamantane-1-carboxylate
  • BAS 02072865

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi follicle stimulating hormone receptor 0.0064 0.0624 0.0624
Echinococcus granulosus sex peptide receptor 0.0064 0.0624 0.0624
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.1206 0.3641
Echinococcus multilocularis musashi 0.0058 0.053 0.053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.0624 0.0624
Brugia malayi G-protein coupled receptor 0.0064 0.0624 0.0624
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1113 0.3273
Onchocerca volvulus 0.0064 0.0624 0.4991
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.0624 0.0624
Schistosoma mansoni lamin 0.0058 0.053 0.053
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1113 0.3273
Trypanosoma cruzi cysteine proteinase, putative 0.0039 0.0208 0.0208
Onchocerca volvulus 0.0099 0.1206 1
Echinococcus multilocularis carbonic anhydrase 0.0338 0.5213 0.5213
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0225 0.3313 1
Echinococcus granulosus cathepsin l1 0.005 0.0403 0.0403
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0624 0.0624
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.1206 0.3558
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Toxoplasma gondii lactate dehydrogenase LDH1 0.0453 0.7124 1
Schistosoma mansoni myosin xvIII 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0043 0.013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.0624 0.0624
Schistosoma mansoni biogenic amine receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0225 0.3313 1
Echinococcus granulosus neuropeptide s receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0625 1 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.079 0.2285
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.0624 0.0624
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0218 0.3195 0.3195
Trypanosoma brucei glycosomal malate dehydrogenase 0.0218 0.3195 0.3195
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Brugia malayi neuropeptide F receptor 0.0064 0.0624 0.0624
Schistosoma mansoni lamin 0.0058 0.053 0.053
Entamoeba histolytica cysteine proteinase 1, putative 0.0039 0.0208 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.3213 0.3213
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0723 0.2079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0043 0.013
Echinococcus granulosus cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0957 0.2796
Onchocerca volvulus Cathepsin F homolog 0.0075 0.0819 0.6673
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0371 0.0371
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.1206 0.3641
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.0624 0.0624
Echinococcus granulosus cathepsin L cysteine proteinase 0.0075 0.0819 0.0819
Toxoplasma gondii cathepsin CPL 0.0075 0.0819 0.1106
Brugia malayi Papain family cysteine protease containing protein 0.0075 0.0819 0.0819
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0043 0.0043
Echinococcus granulosus malate dehydrogenase 0.0218 0.3195 0.3195
Onchocerca volvulus 0.0064 0.0624 0.4991
Onchocerca volvulus Cathepsin L homolog 0.0075 0.0819 0.6673
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Schistosoma mansoni carbonic anhydrase-related 0.0338 0.5213 0.5213
Brugia malayi Flap endonuclease-1 0.0028 0.0035 0.0035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.1206 0.3641
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0225 0.3313 0.3313
Schistosoma mansoni hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0957 0.2796
Schistosoma mansoni malate dehydrogenase 0.0218 0.3195 0.3195
Loa Loa (eye worm) hypothetical protein 0.0074 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0624 0.0624
Loa Loa (eye worm) malate dehydrogenase 0.0225 0.3313 0.3313
Entamoeba histolytica malate dehydrogenase, putative 0.0453 0.7124 1
Echinococcus multilocularis sex peptide receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Toxoplasma gondii malate dehydrogenase MDH 0.0453 0.7124 1
Schistosoma mansoni malate dehydrogenase 0.0225 0.3313 0.3313
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0624 0.0624
Entamoeba histolytica cysteine proteinase, putative 0.0075 0.0819 0.1106
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0172 0.0242
Loa Loa (eye worm) cysteine protease 0.0075 0.0819 0.0819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.1206 0.1652
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.0624 0.0624
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.0624 0.0624
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0225 0.3313 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.0624 0.0624
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.1206 0.1206
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.079 0.2385
Echinococcus granulosus lactate dehydrogenase a 0.0453 0.7124 0.7124
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Schistosoma mansoni carbonic anhydrase-related 0.0338 0.5213 0.5213
Onchocerca volvulus 0.0064 0.0624 0.4991
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Echinococcus granulosus hypothetical protein 0.0064 0.0624 0.0624
Plasmodium vivax vivapain-1 0.0039 0.0208 0.0293
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.0624 0.0624
Giardia lamblia Malate dehydrogenase 0.0225 0.3313 1
Echinococcus granulosus lactate dehydrogenase a 0.0453 0.7124 0.7124
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Brugia malayi neuropeptide F receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.1206 0.3641
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) oxidoreductase 0.0029 0.0043 0.0043
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.053 0.053
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0043 0.0043
Schistosoma mansoni amine GPCR 0.0064 0.0624 0.0624
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Schistosoma mansoni intermediate filament proteins 0.0058 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0453 0.7124 0.7124
Plasmodium vivax glutathione reductase, putative 0.0037 0.0172 0.0242
Onchocerca volvulus 0.0064 0.0624 0.4991
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.053 0.053
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.0624 0.0624
Schistosoma mansoni amine GPCR 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0208 0.0629
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Echinococcus multilocularis L lactate dehydrogenase 0.0254 0.3801 0.3801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0624 0.0624
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0225 0.3313 1
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Leishmania major cathepsin L-like protease 0.0219 0.3213 0.3213
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0453 0.7124 0.7124
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0957 0.2796
Schistosoma mansoni malate dehydrogenase 0.0453 0.7124 0.7124
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Plasmodium vivax lactate dehydrogenase 0.0453 0.7124 1
Echinococcus granulosus g protein coupled receptor 0.0064 0.0624 0.0624
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0624 0.0624
Echinococcus granulosus flap endonuclease 1 0.0028 0.0035 0.0035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0624 0.0624
Echinococcus granulosus tumor protein p63 0.0332 0.5101 0.5101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trypanosoma cruzi malate dehydrogenase, putative 0.0218 0.3195 0.3195
Onchocerca volvulus 0.0064 0.0624 0.4991
Loa Loa (eye worm) glutathione reductase 0.0037 0.0172 0.0172
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0624 0.0624
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0043 0.013
Trichomonas vaginalis malate dehydrogenase, putative 0.0199 0.2882 0.87
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0208 0.0244
Echinococcus granulosus carbonic anhydrase II 0.0625 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0075 0.0819 0.0819
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0625 1 1
Schistosoma mansoni neuropeptide receptor 0.0064 0.0624 0.0624
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.0624 0.0624
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0043 0.013
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trypanosoma cruzi cysteine protease, putative 0.0039 0.0208 0.0208
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Loa Loa (eye worm) malate dehydrogenase 0.0218 0.3195 0.3195
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Leishmania major cathepsin L-like protease 0.0219 0.3213 0.3213
Echinococcus multilocularis lactate dehydrogenase protein 0.0453 0.7124 0.7124
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus cysteine protease 0.0039 0.0208 0.0208
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0338 0.5213 0.5213
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0043 0.0043
Echinococcus multilocularis cathepsin L cysteine protease 0.0075 0.0819 0.0819
Schistosoma mansoni hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Dopamine receptor 0.0064 0.0624 0.0624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0208 0.0208
Brugia malayi G-protein coupled receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis allatostatin A receptor 0.0064 0.0624 0.0624
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0624 0.0624
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0043 0.006
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0624 0.0624
Echinococcus granulosus lamin 0.0058 0.053 0.053
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.005 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.005 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0371
Echinococcus multilocularis lamin dm0 0.0058 0.053 0.053
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Onchocerca volvulus 0.0049 0.0371 0.2816
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0218 0.3195 0.3195
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.0624 0.0624
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.0624 0.4991
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Thioredoxin reductase 0.0037 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0723 0.2079
Brugia malayi AKH receptor 0.0064 0.0624 0.0624
Leishmania major cathepsin L-like protease 0.0219 0.3213 0.3213
Echinococcus multilocularis lactate dehydrogenase a 0.0453 0.7124 0.7124
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.079 0.1109
Schistosoma mansoni hypothetical protein 0.0338 0.5213 0.5213
Leishmania major malate dehydrogenase, putative 0.0453 0.7124 0.7124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.0624 0.0624
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0043 0.0011
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0043 0.0043
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.0624 0.0624
Loa Loa (eye worm) fibroinase 0.0075 0.0819 0.0819
Onchocerca volvulus 0.0075 0.0819 0.6673
Brugia malayi lactate dehydrogenase. 0.0453 0.7124 0.7124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus multilocularis lamin 0.0058 0.053 0.053
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0074 0.079 0.079
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0338 0.5213 0.5213
Onchocerca volvulus 0.0064 0.0624 0.4991
Loa Loa (eye worm) carbonic anhydrase 3 0.0625 1 1
Mycobacterium ulcerans malate dehydrogenase 0.0225 0.3313 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0043 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Schistosoma mansoni neuropeptide receptor 0.0064 0.0624 0.0624
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0218 0.3195 0.3195
Trypanosoma cruzi cysteine proteinase, putative 0.0039 0.0208 0.0208
Leishmania major cathepsin L-like protease 0.0075 0.0819 0.0819
Echinococcus multilocularis carbonic anhydrase 0.0338 0.5213 0.5213
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.0624 0.0624
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0075 0.0819 0.0819
Brugia malayi putative neuropeptide receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi cruzipain precursor, putative 0.0219 0.3213 0.3213
Schistosoma mansoni carbonic anhydrase 0.0338 0.5213 0.5213
Leishmania major malate dehydrogenase, putative 0.0199 0.2882 0.2882
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0624 0.0624
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus allatostatin A receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0043 0.0043
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0625 1 1
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0453 0.7124 0.5
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0225 0.3313 1
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0208 0.0244
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0957 0.2796
Echinococcus multilocularis carbonic anhydrase 0.0338 0.5213 0.5213
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0225 0.3313 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.1206 0.3641
Trypanosoma brucei cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Plasmodium falciparum cysteine proteinase falcipain 3 0.0075 0.0819 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1113 0.3273
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Onchocerca volvulus 0.0064 0.0624 0.4991
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis malate dehydrogenase 0.0218 0.3195 0.3195
Onchocerca volvulus 0.0075 0.0819 0.6673
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.053
Leishmania major carbonic anhydrase-like protein 0.0625 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0075 0.0819 0.1106
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.0624 0.0624
Brugia malayi Cathepsin L-like precursor 0.005 0.0403 0.0403
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0043 0.0043
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0043 0.006
Plasmodium falciparum L-lactate dehydrogenase 0.0453 0.7124 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus neuropeptide receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0035 0.0035
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0199 0.2882 0.4045
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Entamoeba histolytica cysteine protease, putative 0.0075 0.0819 0.1106
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Schistosoma mansoni biogenic amine receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis cysteine protease 0.0075 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0075 0.0819 0.115
Plasmodium vivax unspecified product 0.0039 0.0208 0.0293
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Toxoplasma gondii lactate dehydrogenase LDH2 0.0453 0.7124 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.1206 0.3558
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi Dopamine receptor protein 2 0.0064 0.0624 0.0624
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0624 0.0624
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0208 0.0244
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0625 1 1
Brugia malayi G protein-coupled receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0075 0.0819 0.0819
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Echinococcus multilocularis somatostatin receptor 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0338 0.5213 0.5213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0403 0.1216
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0043 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Echinococcus multilocularis cathepsin L cysteine protease 0.0075 0.0819 0.0819
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0043 0.013
Leishmania major malate dehydrogenase 0.0218 0.3195 0.3195
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.0624 0.0624
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.0624 0.4991
Schistosoma mansoni opsin-like receptor 0.0064 0.0624 0.0624
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0099 0.1206 0.1206
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0624 0.0624
Brugia malayi Cathepsin L-like cysteine proteinase 0.005 0.0403 0.0403
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.0624 0.0624
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0208 0.0208
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1113 0.3273
Schistosoma mansoni L-lactate dehydrogenase 0.0453 0.7124 0.7124
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.0624 0.0624
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0035 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.0624 0.0624
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Echinococcus granulosus L lactate dehydrogenase B chain 0.0453 0.7124 0.7124
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Echinococcus granulosus orexin receptor type 2 0.0064 0.0624 0.0624
Brugia malayi AMP-binding enzyme family protein 0.0099 0.1206 0.1206
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.1206 0.3641
Onchocerca volvulus 0.0075 0.0819 0.6673
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.0624 0.0624
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0208 0.0208
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0208 0.0208
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0723 0.2079
Leishmania major mitochondrial malate dehydrogenase 0.0218 0.3195 0.3195
Echinococcus multilocularis orexin receptor type 2 0.0064 0.0624 0.0624
Entamoeba histolytica cysteine proteinase 2 0.0039 0.0208 0.0244
Onchocerca volvulus 0.0075 0.0819 0.6673
Loa Loa (eye worm) hypothetical protein 0.0074 0.079 0.079
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0075 0.0819 0.115
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus granulosus fmrfamide receptor 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0075 0.0819 0.6673
Echinococcus granulosus g protein coupled receptor 0.0064 0.0624 0.0624
Schistosoma mansoni amine GPCR 0.0064 0.0624 0.0624
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.0624 0.0624
Leishmania major cathepsin L-like protease 0.0075 0.0819 0.0819
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0208 0.0208
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.0624 0.0624
Schistosoma mansoni amine GPCR 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0208 0.0629
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni malate dehydrogenase 0.0225 0.3313 0.3313
Brugia malayi sulfakinin receptor protein 0.0064 0.0624 0.0624
Schistosoma mansoni biogenic amine receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Leishmania major cysteine peptidase A (CPA) 0.0075 0.0819 0.0819
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.0624 0.0624
Plasmodium vivax vivapain-2 0.0075 0.0819 0.115
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.0624 0.0624
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0338 0.5213 0.5213
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0035
Chlamydia trachomatis malate dehydrogenase 0.0225 0.3313 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0338 0.5213 0.5213
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0338 0.5213 0.5213
Echinococcus granulosus malate dehydrogenase 0.0218 0.3195 0.3195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0218 0.3195 0.3195
Plasmodium vivax vivapain-3 0.0039 0.0208 0.0293
Toxoplasma gondii hypothetical protein 0.0338 0.5213 0.7305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0075 0.0819 0.0819
Leishmania major glycosomal malate dehydrogenase 0.0218 0.3195 0.3195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Onchocerca volvulus 0.0064 0.0624 0.4991
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0225 0.3313 0.4623
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0723 0.2079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0208 0.0208
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.1206 0.1652
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0338 0.5213 0.5213
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi AMP-binding enzyme family protein 0.0099 0.1206 0.1206
Echinococcus granulosus intermediate filament protein 0.0058 0.053 0.053
Brugia malayi AMP-binding enzyme family protein 0.0099 0.1206 0.1206
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Plasmodium falciparum carbonic anhydrase 0.0338 0.5213 0.7318
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0043 0.0043
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.0624 0.0624
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.0624 0.0624
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Plasmodium falciparum malate dehydrogenase 0.0453 0.7124 1
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0225 0.3313 0.3313
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.1206 0.3558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0039 0.0208 0.0208
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0043 0.013
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0099 0.1206 0.1206
Loa Loa (eye worm) hypothetical protein 0.0099 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Loa Loa (eye worm) hypothetical protein 0.0074 0.079 0.079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0043 0.0043
Brugia malayi ORL1-like opioid receptor 0.0064 0.0624 0.0624
Brugia malayi larval opioid receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.0624 0.0624
Echinococcus granulosus carbonic anhydrase 0.0338 0.5213 0.5213
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0172 0.0395
Brugia malayi Cathepsin L-like precursor 0.005 0.0403 0.0403
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Leishmania major cathepsin L-like protease 0.0075 0.0819 0.0819
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0035
Echinococcus granulosus lactate dehydrogenase protein 0.0453 0.7124 0.7124
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis cathepsin L 0.0039 0.0208 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.3213 0.3213
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0075 0.0819 0.2473
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.1206 0.1652
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.018 0.018
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0043 0.013
Mycobacterium ulcerans hypothetical protein 0.0099 0.1206 0.3641
Brugia malayi RE15519p 0.0064 0.0624 0.0624
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0058 0.053 0.4189
Echinococcus granulosus neuropeptide receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis carbonic anhydrase II 0.0625 1 1
Echinococcus granulosus cathepsin L 0.0039 0.0208 0.0208
Schistosoma mansoni L-lactate dehydrogenase 0.0199 0.2882 0.2882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Echinococcus multilocularis serotonin receptor 0.0064 0.0624 0.0624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0208 0.0208
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus granulosus g protein coupled receptor 0.0064 0.0624 0.0624
Echinococcus granulosus g-protein coupled receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0624 0.0624
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.0624 0.0624
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0624 0.0624
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.0624 0.0624
Brugia malayi glutathione reductase 0.0037 0.0172 0.0172
Schistosoma mansoni histamine h1 receptor 0.0064 0.0624 0.0624
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.0624 0.0624
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.1206 0.1206
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0625 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.0624 0.0624
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0338 0.5213 0.5213
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Echinococcus granulosus carbonic anhydrase 0.0338 0.5213 0.5213
Echinococcus granulosus L lactate dehydrogenase 0.0254 0.3801 0.3801
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0043 0.0011
Plasmodium vivax malate dehydrogenase, putative 0.0453 0.7124 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0625 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi Serotonin receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0403 0.1216
Echinococcus granulosus serotonin receptor 0.0064 0.0624 0.0624
Brugia malayi GnHR receptor homolog 0.0064 0.0624 0.0624
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) intermediate filament protein 0.0058 0.053 0.053
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0624 0.0624
Trypanosoma brucei trypanothione reductase 0.0037 0.0172 0.0172
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) ctsf protein 0.0075 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0058 0.053 0.4189
Trypanosoma cruzi malate dehydrogenase, putative 0.0199 0.2882 0.2882
Plasmodium falciparum flap endonuclease 1 0.0028 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.0064 0.0624 0.0624
Plasmodium falciparum cysteine proteinase falcipain 1 0.0039 0.0208 0.0293
Trichomonas vaginalis malate dehydrogenase, putative 0.0097 0.1178 0.3556
Leishmania major cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Onchocerca volvulus 0.0064 0.0624 0.4991
Schistosoma mansoni cathepsin F (C01 family) 0.0075 0.0819 0.0819
Schistosoma mansoni carbonic anhydrase-related 0.0338 0.5213 0.5213
Echinococcus multilocularis tumor protein p63 0.0332 0.5101 0.5101
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.001
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0218 0.3195 0.3195
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Schistosoma mansoni neuropeptide receptor 0.0064 0.0624 0.0624
Brugia malayi hypothetical protein 0.0064 0.0624 0.0624
Trichomonas vaginalis malate dehydrogenase, putative 0.0123 0.1609 0.4856
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0513 0.0513
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0403 0.0518
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0624 0.0624
Trypanosoma brucei carbonic anhydrase-like protein 0.0625 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0035 0.0107
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.005 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable reductase 0.0084 0.0957 0.2796
Toxoplasma gondii thioredoxin reductase 0.0037 0.0172 0.0193
Plasmodium falciparum glutathione reductase 0.0037 0.0172 0.0242
Echinococcus granulosus lamin dm0 0.0058 0.053 0.053
Entamoeba histolytica malate dehydrogenase, putative 0.0225 0.3313 0.4623
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.0624 0.0624
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.008 0.008
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Onchocerca volvulus 0.0075 0.0819 0.6673
Echinococcus multilocularis cysteine protease 0.0075 0.0819 0.0819
Onchocerca volvulus Cathepsin L homolog 0.0075 0.0819 0.6673
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Schistosoma mansoni opsin-like receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis lactate dehydrogenase a 0.0453 0.7124 0.7124
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0624 0.0624
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.0624 0.0624
Onchocerca volvulus 0.0064 0.0624 0.4991
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0624 0.0624
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0075 0.0819 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0403 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Echinococcus multilocularis serotonin receptor 0.0064 0.0624 0.0624
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0043 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0624 0.0624
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0225 0.3313 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.1206 0.3558
Leishmania major cathepsin L-like protease 0.0075 0.0819 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.0819 0.2473
Plasmodium vivax vivapain-2 0.0075 0.0819 0.115
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Cathepsin L-like precursor 0.0075 0.0819 0.0819
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0028 0.0028
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.018 0.018
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0225 0.3313 0.3313
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0957 0.2796
Echinococcus multilocularis lactate dehydrogenase a 0.0453 0.7124 0.7124
Onchocerca volvulus 0.0064 0.0624 0.4991
Echinococcus granulosus somatostatin receptor 0.0064 0.0624 0.0624
Echinococcus granulosus cathepsin l1 0.0075 0.0819 0.0819
Schistosoma mansoni amine GPCR 0.0064 0.0624 0.0624
Schistosoma mansoni adenoreceptor 0.0064 0.0624 0.0624
Brugia malayi cathepsin L-like precursor 0.005 0.0403 0.0403
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0957 0.2796
Echinococcus granulosus cathepsin L cysteine protease 0.0039 0.0208 0.0208
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.0624 0.0624
Brugia malayi Dopamine receptor protein 1 0.0064 0.0624 0.0624
Leishmania major cathepsin L-like protease 0.0075 0.0819 0.0819
Schistosoma mansoni opsin-like receptor 0.0064 0.0624 0.0624
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.0624 0.0624
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0338 0.5213 0.5213
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0624 0.0624
Trichomonas vaginalis malate dehydrogenase, putative 0.0225 0.3313 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0043 0.0043
Onchocerca volvulus 0.005 0.0403 0.3093
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.0624 0.0624
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0043 0.0043
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0624 0.0624
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0194 0.2796 0.2796
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Brugia malayi Serotonin receptor 0.0064 0.0624 0.0624
Plasmodium falciparum thioredoxin reductase 0.0037 0.0172 0.0242
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0624 0.0624
Brugia malayi Melatonin receptor type 1A 0.0064 0.0624 0.0624
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0624 0.0624
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0043 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0075 0.0819 0.0819
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.3213 0.3213
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.0624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.3213 0.3213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0624 0.0624
Plasmodium falciparum lactate dehydrogenase, putative 0.0199 0.2882 0.4045
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.079 0.1109
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0819 0.0819
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.0624 0.0624
Trypanosoma cruzi major cysteine proteinase, putative 0.0157 0.2185 0.2185
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0074 0.079 0.079
Leishmania major trypanothione reductase 0.0037 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Echinococcus granulosus carbonic anhydrase 0.0338 0.5213 0.5213
Onchocerca volvulus 0.0075 0.0819 0.6673
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.1206 0.3641
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0208 0.0244
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0624 0.0624
Echinococcus multilocularis malate dehydrogenase 0.0218 0.3195 0.3195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0075 0.0819 0.0819
Brugia malayi intermediate filament protein 0.0058 0.053 0.053
Trypanosoma brucei malate dehydrogenase-related 0.0199 0.2882 0.2882
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0043 0.013
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.0819 0.2473
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0208 0.0208
Entamoeba histolytica cysteine protease, putative 0.0039 0.0208 0.0244

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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